9 results match your criteria: "Cardarelli National Hospital[Affiliation]"

Introduction: Certolizumab pegol (CZP) is an anti-tumor necrosis factor alpha (TNFα) approved for the treatment of moderate to severe plaque psoriasis (PSO). However, data on its real-world use is currently limited. The objective of this study was to describe the 1-year real-world effectiveness of CZP, its impact on health-related quality of life (HRQoL), and safety outcomes in patients with moderate to severe PSO in multi-country settings.

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Article Synopsis
  • The treatment of hidradenitis suppurativa (HS) has been challenging, with adalimumab being the only FDA-approved biologic since 2015 and a real-life effectiveness of about 60%.
  • Recently, on October 31, 2023, the FDA approved secukinumab for moderate to severe HS, aiming to improve limited treatment options.
  • A study showed that 57.1% of 21 HS patients experienced significant improvement after 16 and 52 weeks of treatment with secukinumab, indicating it may be a safe and effective option for those who did not respond to adalimumab.
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We report three patients who initially showed prolonged fever, lung parenchymal consolidation and laboratory findings of pneumonia, and secondarily presented a clinical picture ascribed to Kawasaki syndrome. Two of these children developed coronary artery dilations, which regressed upon echocardiography after 12 months. In the case of infants showing broncho-pulmonary abnormalities with slow resolution, active inflammatory parameters and high fever persistence, pediatricians should consider atypical Kawasaki syndrome as a possible alternative diagnosis.

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Intracranial arteriovenous fistulas (AVFs) are rare vascular cerebral lesions composed of one or more cortical-pial arterial feeders directly connected with a single draining vein. They differ from the other AV malformations in that they lack a nidus and are located outside the dural leaflets. Because of high flow and pressure AVFs have a high risk of hemorrhage and if untreated cause death in up to 63% of cases.

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Cerebral vascular reserve was measured by means of the transcranial Doppler (TCD) technique from carbon dioxide (CO2) tests, in healthy individuals and patients with unilateral internal carotid artery (ICA) occlusion. The percentage changes in middle cerebral arteries blood flow velocity (VMCA) per mmHg of pCO2 variations (reactivity index, RI) were separately computed during hypocapnia and hypercapnia, the latter obtained by a rebreathing maneuver. Clinical data have been compared with predictions obtained using an original mathematical model of intracranial dynamics, in order to search a theoretical explanation of the hemodynamic events observed during clinical testing.

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