Exploring the coupling coordination relationship and obstacle factors of rural revitalization, new-type urbanization, and digital economy in China.

The digital economy injects new vitality into rural revitalization and new-type urbanization to achieve rural industrial transformation, while the countryside and the city provide the soil for the development of the digital economy. This research establishes the rural revitalization (RR), new-type urbanization (NU), and digital economy (DE) system and uses the coupled coordination degree (CCD) model and obstacle degree (OD) model to study the spatiotemporal evolution characteristics and obstacle factors of the composite system in China from 2011 to 2021. The result showed that: (1) the comprehensive development level of the composite systems is on an upward trend year by year, but still shows a low-quality state; (2) the CCD of China's provinces shows a spatial evolution pattern of high in the east and low in the west; (3) The obstacle factors of the RR, NU, DE subsystem are mainly involved the number of rural doctors and health workers, local financial income per capita and science and technology expenditure, and the digital finance coverage breadth index.

Long-term health consequences and costs of changes in alcohol consumption in England during the COVID-19 pandemic.

Background And Aims: The COVID-19 pandemic led to changes in alcohol consumption in England. Evidence suggests that one-fifth to one-third of adults increased their alcohol consumption, while a similar proportion reported consuming less. Heavier drinkers increased their consumption the most and there was a 20% increase in alcohol-specific deaths in England in 2020 compared with 2019, a trend continuing through 2021 and 2022.

A systematic epidemiological trends analysis study in global burden of multiple myeloma and 29 years forecast.

Multiple myeloma is a prevalent hematologic cancer. This investigation analyzes the latest global, regional, and national data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Data on the incidence, prevalence, disability-adjusted life years, and mortality rates of multiple myeloma, including estimates and 95% uncertainty intervals, were sourced from the 2021 Global Burden of Diseases Study.

Population attributable fractions for modifiable risk factors of neonatal, infant, and under-five mortality in 48 low- and middle-income countries.

Background: Identifying the modifiable risk factors for childhood mortality using population-attributable fractions (PAFs) estimates can inform public health planning and resource allocation in low- and middle-income countries (LMICs). We estimated PAFs for key population-level modifiable risk factors of neonatal, infant, and under-five mortality in LMICs.

Methods: We used the most recent Demographic and Health Survey data sets (2010-22) from 48 LMICs, encompassing 35 sub-Saharan African countries and 13 countries from South and Southeast Asia (n = 506 989).

Economic burden of musculoskeletal disorders in Tanzania: results from a community-based survey.

Objectives: To identify, measure and value the economic burden of musculoskeletal (MSK) disorders in the Kilimanjaro region, Tanzania.

Design: Community-based cross-sectional survey (undertaken between January and September 2021).

Setting: Hai district, Kilimanjaro, Tanzania.

What is the current scope of research assessing patients' and clinicians' perspectives on clozapine treatment? A comprehensive scoping review.

Objectives: Clozapine is continuously underused. The existing systematic reviews addressing barriers to clozapine prescribing primarily focus on clinical staff's attitudes and perceived barriers to prescribing. However, a preliminary literature search revealed additional literature on the subject not previously included in systematic reviews, including literature on patient perspectives.

Consolidation in an Era of Population Health and Value-Based Care: Implications For Effectiveness, Costs, and Equity.

Consolidation of health care providers, and vertical integration of physicians with hospitals and/or payers has accelerated over the past 15 years. Although there is potential for consolidation to improve patient care, efficiencies and reduce overhead costs, participants in our conference identified that almost all research on consolidation has shown increased cost without improvement in outcomes or the experience of care. To provide a framework for considering the impact of consolidation, future research and analysis we offer 4 themes: (1) to move forward, we need to look back at historical drivers, value creation, and unintended consequences; (2) not all consolidation is created equally; (3) real-time, continuous evaluation is critical for improvement; and (4) a policy blueprint is desperately needed.

Heterotopic ossification: Current developments and emerging potential therapies.

This review aimed to provide a comprehensive analysis of the etiology, epidemiology, pathology, and conventional treatment of heterotopic ossification (HO), especially emerging potential therapies. HO is the process of ectopic bone formation at non-skeletal sites. HO can be subdivided into two major forms, acquired and hereditary, with acquired HO predominating.

The global, regional, and national burden of type 2 diabetes mellitus attributable to low physical activity from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.

Background: Low physical activity (LPA) is a leading risk factor for type 2 diabetes mellitus (T2DM). We examine the temporal and spatial trends in the burden of T2DM attributable to LPA at the global, regional, and country scales.

Methods: Data were obtained from the Global Burden of Disease Study 2021.

Cost-effectiveness of digoxin versus beta blockers in permanent atrial fibrillation: the Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF) randomised trial.

Background: Atrial fibrillation (AF) is a major and increasing burden on health services. This study aimed to evaluate the cost-effectiveness of digoxin versus beta-blockers for heart rate control in patients with permanent AF and symptoms of heart failure.

Methods: RAte control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) was a randomised, open-label, blinded, endpoint trial embedded in the UK National Health Service (NHS) to directly compare low-dose digoxin with beta-blockers (ClinicalTrials.

Artificial Intelligence in Computer-Aided Drug Design (CADD) Tools for the Finding of Potent Biologically Active Small Molecules: Traditional to Modern Approach.

Computer-Aided Drug Design (CADD) entails designing molecules that could potentially interact with a specific biomolecular target and promising their potential binding. The stereo- arrangement and stereo-selectivity of small molecules (SMs)--based chemotherapeutic agents significantly influence their therapeutic potential and enhance their therapeutic advantages. CADD has been a well-established field for decades, but recent years have observed a significant shift toward acceptance of computational approaches in both academia and the pharmaceutical industry.

Types of dietary sugars and carbohydrates, cardiometabolic risk factors, and risk of diabetes: a cohort study from the general Danish population.

Background: The role of carbohydrates in diabetes risk is of particular interest due to conflicting results. This study aims to examine the prospective association between types of dietary carbohydrates (fiber, starch, total sugar, glucose, fructose, lactose, maltose, and added sugar) and the risk of diabetes. Further, this study examines the cross-sectional associations between these nutrients and cardiometabolic risk factors.

The association between childhood hunger experiences and health in middle and old age: a longitudinal study over 10 years.

Background: A significant relationship is present between childhood hunger experiences (CHEs) and health, but explorations of the longitudinal persistence of this relationship and its mediating mechanisms are still lacking. This study aims to evaluate the effects of CHEs on health in middle and old age and determine the underlying mechanisms.

Methods: Using data from the five 2011-2020 China Health and Retirement Longitudinal Study (CHARLS) and the 2014 China Life History Survey Questionnaire, a sample of 9,909 individuals aged 45 years and older who participated in all six surveys was obtained.

Instruments for Evaluating Undergraduate Medical Education in Complementary and Integrative Medicine: A Systematic Review.

The provision of courses in complementary and integrative medicine (CIM) varies widely between medical schools. To effectively improve CIM education, it is essential to use robust evaluation instruments that measure the impact of different educational interventions. This review aimed to identify and critically appraise qualitative and quantitative instruments used to evaluate CIM courses in undergraduate medical education.

Bibliometric analysis and trends related to dental tourism: Qualitative, social, economic and ethical implications.

This article delves into the multifaceted realm of dental tourism, scrutinizing patient incentives, economic ramifications, and ethical aspects. An in-depth 2023 analysis discerns research gaps, underscoring the necessity for a more exhaustive investigation to enrich the understanding of the global oral healthcare landscape. Utilizing bibliometric analysis method, the study examines the worldwide trajectory of scientific publications on dental tourism.

A power dependence model of the impact of leader impostorism on supervisor support and undermining: The moderating role of power distance.

Leaders, often perceived as possessing exceptional confidence and competence, are not immune to feelings of self-doubt. Leader impostorism describes the experience that one's attributes, experiences, skills, and abilities fall short of the standards expected in the leadership role, resulting in a sense of deception in fulfilling leadership responsibilities. While existing research has examined the antecedents and individual outcomes of leader impostorism, its implications for leaders' treatment of subordinates remain largely unexplored.

"Identity politics" is economic policy.

In the wake of the November 2024 US election, several commentators have suggested that the US Democratic Party abandon its commitment to so-called "identity politics," which they identify as elitist, condescending, and divisive. They argue that rather than focusing on these "cultural" issues, progressives should prioritize economic concerns. Yet identity politics, at a fundamental level, is driven, and dominated, by economic concerns.

Stabilizing effect of HP-β-CD on infliximab in liquid formulations and a solid formulation produced by electrospinning.

The development of stable biopharmaceutical formulations, such as monoclonal antibodies, poses a great challenge in the pharmaceutical industry. This study investigated the stabilizing effect of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) in liquid and solid formulations of infliximab during processing and storage. The solid formulation was produced by a scaled-up high-speed electrospinning method, resulting in a product suitable for reconstitution with excellent dissolution properties.

Circulating tumour DNA in predicting and monitoring survival of patients with locally advanced rectal cancer undergoing multimodal treatment: long-term results from a prospective multicenter study.

Background: Neoadjuvant chemoradiotherapy (nCRT) is the standard for locally advanced rectal cancer (LARC). However, distant metastasis remains the primary cause of treatment failure. Early identification of high-risk individuals for personalized treatment may offer a solution.

Parent-child relationship and junior high academic performance: Differentiated impacts of fathers and mothers with self - efficacy as a mediator.

This study aimed to address the overlooked differences in the effects of father-child and mother-child relationships on junior high school students' academic performance. Utilizing data from the China Education Panel Survey, it explored these relationships' impacts on overall and subject-specific academic achievements and the mediating role of self-efficacy. Findings revealed both relationships had positive effects, with the mother-child relationship being more prominent.

Long-term effects of attention deficit hyperactivity disorder (ADHD) on social functioning and health care outcomes.

Introduction: Research on the long-term effects of treatment for attention deficit hyperactivity disorder (ADHD) on educational and social outcomes is limited. This study aims to evaluate long-term social functioning outcomes in patients with ADHD and the potential effects of pharmacological treatment for ADHD.

Methods: We used National Patient Registry data from 1995 to 2016 to identify patients diagnosed with ADHD and those collecting ADHD medication.

Can ecosystem services supply match local residents' perception: Linking macro-ESs and micro-individual perceptions in the Yellow River Basin.

Residents' satisfaction perceptions of ecosystem services (ESs) are essential for the ecological protection and high-quality development of the Yellow River Basin (YRB). Existing studies lacks large-scale survey of local residents' satisfaction perception at urban scale within river basins, and has not effectively explored the matching relationship between the ESs supply and the perceptions of local residents. To address this gap, this study develops a database on nine ESs supply and individual perceptions of the YRB, constructs a comprehensive framework to quantify the matching of ESs supply and local residents' satisfaction perceptions, and proposes targeted strategy.

From policy to progress: Environmental taxation to mitigate air pollution in OECD countries.

Environmental taxes play a critical role in mitigating air pollution and fostering sustainability by internalizing the social costs of environmental damage. By imposing financial disincentives on polluters, these taxes encourage cleaner practices and technological innovation. Using panel ARDL models, this study examines the impact of environmental taxes on CO₂ emissions across 38 OECD countries, accounting for cross-sectional dependence, non-stationarity, and heterogeneity.