[Using tension-band laminoplasty as a management for cervical ossification of posterior longitudinal ligament].

Objective: To evaluate the effectiveness of Tension-band Laminoplasty (TBL) as a management for cervical ossification of posterior longitudinal ligament (OPLL).

Methods: Forty-six patients with cervical OPLL and undergone TBL in our department were chosen for the present study, including 33 male and 13 female. The mean age was 59 years (36 - 77 years).

[Applicable value of ultrasound-guided renal biopsy in diagnosis of kidney diseases].

Objective: To explore the applicable value of ultrasound guidance in percutaneous renal biopsy.

Methods: 168 patients with kidney diseases underwent ultrasound-guided renal biopsy. Pathological examination was conducted.

[Osteonecrosis of the jaw associated with the use of bisphosphonates in multiple myeloma: report of four cases and literature review].

Objective: To summarize the clinical features of osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients treated with bisphosphonate.

Methods: The clinical data of 4 patients with bisphosphonate-related (ONJ) in MM were reported and literatures were reviewed.

Results: In these patients, 3 males and 1 female, aged 59-73, pamidronate combined with chemotherapy, high dose glucocorticosteroid, and anti-angiogenic drug had been used for 12-44 months before the occurrence of ONJ.

[Study on the prevalence of diabetes mellitus among acute coronary syndrome inpatients in a multiprovincial study in China].

Objective: To demonstrate the current prevalence and treatment status of diabetes mellitus (DM) among inpatients with acute coronary syndrome (ACS) in China.

Methods: Sixty-four hospitals, including 32 secondary hospitals and 32 tertiary hospitals were selected for baseline survey. Fifty inpatients diagnosed with ACS were recruited consecutively from hospitals participated in this study.

[Effect of gas exchange at maximal intensity on exercise capacity in patients with chronic obstructive pulmonary disease].

Objective: To investigate the effect of gas exchange at maximal intensity on exercise capacity in patients with chronic obstructive pulmonary disease (COPD).

Methods: Forty-two male patients with COPD and 26 normal subjects performed incremental exercise test on cycle ergometer. Oxygen uptake and carbon dioxide output were measured continuously on the breath-by-breath mode.

The effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on cynomolgus (Macaca fascicularis) monkeys.

Background: This study aimed to retrospectively analyze the effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on adolescent cynomolgus monkeys.

Methods: A total of 12 monkeys (six STZ-DM and six controls) were monitored for fasting glucose levels and locomotor activities, tested for hematological and serum parameters, measured for body weight and somatometric values.

Results: Fasting glucose was maintained at high levels in STZ-DM monkeys.

Radical resection of 202 pediatric craniopharyngiomas with special reference to the surgical approaches and hypothalamic protection.

Objective: The goal of this study was to disclose the appropriate surgical approaches to radically removing pediatric craniopharyngiomas with optimal hypothalamic protection.

Methods: In 202 patients undergoing primary surgery from April 1997 to December 2002, eight approaches were used to remove craniopharyngiomas in the sellar region and the third ventricle. Among the eight approaches, the transcallosal-interseptal-interforniceal approach was used in 89 cases, the unilateral transfrontal interhemispheric approach in 68 cases, the pterional approach in 20 cases, and the other five approaches in 25 cases.

Bolus shaping of contrast medium to adapt k-space sampling: adjusting injection protocol of magnetic resonance angiography for optimal images in a 3-T system.

Purpose: To explore the possibility of shaping bolus of contrast medium to adapt k-space sampling to improve image quality in a 3-T system.

Materials And Methods: Eighty patients suspected of having renal arterial disease or atherosclerosis were divided into four groups and underwent imaging with different high-spatial-resolution three-dimensional contrast-enhanced magnetic resonance angiography (MRA) scanning and injection protocol combinations. A group of 20 patients were injected single-dose contrast medium with a centric view ordering for k-space filling.

[Megakaryocytic dysplasia and leukemia associated phenotype in elderly patients with acute myeloid leukemia].

This study was purposed to investigate the megakaryocytic dysplasia and leukemia-associated phenotypes (LAP) of acute myeloid leukemia (AML) in the elderly. The megakaryocytic dysplasia, lineage infidelity, asynchronous antigen expression, total WBC count, and karyotypes were observed in the 147 none M(3)-AML patients. Logistic regression were used to analyzed the difference between the elderly (age > or = 60) and the control.

The association between pre-infarction angina and care-seeking behaviors and its effects on early reperfusion rates for acute myocardial infarction.

Objective: To examine the association between pre-infarction angina (PA) and care-seeking behaviors and its effects on early reperfusion rates for patients with ST-elevation myocardial infarction (STEMI).

Methods: Between November 1, 2005 and December 31, 2006, a prospective, cross-sectional, and multicenter survey was conducted in 19 hospitals in Beijing and included consecutive patients with STEMI admitted within 12 h of onset of symptoms. Data were collected by structured interviews and medical records review.

[A prospective study of serum high density lipoprotein cholesterol, cardiovascular and cerebrovascular risk in a Chinese muti-provinces cohort].

Objective: To evaluate the association between serum HDL-C and the risk of cardiovascular diseases (CHD) in subjects aged 35-64 years.

Methods: A prospective study was carried out in 11 provinces from 1992 to 2002. The association of baseline HDL-C level and cardiovascular disease occurrence was analyzed in 30384 subjects aged 35-64 years using Cox multivariate proportional hazards regression.

Effect of brimonidine on retinal ganglion cell survival in an optic nerve crush model.

Purpose: To investigate the effect of brimonidine on the retinal ganglion cell survival in an optic nerve crush model.

Design: Experimental animal study.

Methods: Twenty-four Sprague-Dawley rats were divided into a study group of eight animals receiving intraperitoneal injections of brimonidine (1 mg/kg) and into a control group of 12 animals receiving intraperitoneal saline injections.

[Cochlear implantation in the ossified cochlear].

Objective: To explore the problems and describe clinical experiences associated with multichannel cochlear implantation in patients with cochlear ossification.

Methods: Seven cochlear implant cases with bilateral cochlear ossification from 1996 to 2006 in Beijing Tongren Hospital were retrospectively reviewed, 4 of which were the consequence of meningitis. Three patients' cochlear were completely ossified, 1 patient's tympanic scala was completely ossified, 1 patient's cochlear was partially ossified, and 2 patients' cochlear were partially fibrotic.

Dosage dependence of the effect of Ginkgo biloba on the rat retinal ganglion cell survival after optic nerve crush.

Purpose: To investigate the dosage dependence of the Ginkgo biloba effect on retinal ganglion cell survival in the rat optic nerve crush model.

Methods: The study included 56 Sprague-Dawley rats, the right optic nerve of which was crushed in a standardized manner. Two hours after the crush and once daily during the follow-up, the animals received intragastral applications of saline (saline group; n=13), or of a G.

[Relative factors analysis including carcinoma marker, molecular margin and clinical factors on laryngeal carcinoma recurrence].

Objective: To investigate the factors of laryngeal carcinoma recurrence, 103 patients of laryngeal carcinoma were analyzed retrospectively on carcinoma marker, molecular margin and clinical factors with univariate analysis and multivariate analysis.

Method: CyclinD1, p27, p53 and eIF4E in primary site and surgery margins were detected in laryngeal carcinoma recurrence group and unrecurrence group with immunohistochemical staining to explore the significance of CyclinD1, p27, p53 and eIF4E on laryngeal carcinoma recurrence; The clinical data of 103 patients of laryngeal carcinoma were analyzed retrospectively to investigate the clinical factors of laryngeal carcinoma recurrence; At last above three factors were analyzed with multivariate analysis.

Result: There was significant difference between laryngeal carcinoma recurrence group and unrecurrence group about CyclinD1, p27 and p53 in laryngeal primary site; There was no significant difference between laryngeal carcinoma recurrence group and unrecurrence group about eIF4E.

[Neuronal activity in the globus pallidus internus in parkinsonian patients with rigidity and bradykinesia].

Objective: To investigate the neuronal activities in the globus pallidus internus (GPi) related to parkinsonian rigidity and bradykinesia

Methods: Twenty-six patients (M: 13 and F: 13) with parkinsonian syndromes of rigidity and bradykinesia, aged (58 +/- 11) with the duration of disease of (5.5 +/- 3.4) years, underwent pallidotomy.

In vitro amoebacidal activity of photodynamic therapy on Acanthamoeba.

Aim: To evaluate the effectiveness of Hypocrellins B (HB) photodynamic therapy (PDT) on Acanthamoeba trophozoites and cysts, and its cytotoxic potential on the corneal epithelial cells and stromal cells in vitro.

Methods: Acanthamoeba trophozoites and cysts (5 x 10(4)/ml) were incubated with various concentrations of HB, followed by exposure to light (>470 nm) for 30 min at a fluence rate of 50 mW/cm(2). Survival rate was assessed using the live/dead viability/cytotoxicity assay and non-nutrient agar--Escherichia coli culture assay.

[Expression and its significance of eosinophil major basic protein in chronic rhinosinusitis].

Objective: To evaluate the expression of eosinophil major basic protein (MBP) in chronic rhinosinusitis (CRS) and discuss the role of MBP in the pathogenesis in CRS.

Method: Thirty-eight nasal mucus obtained from CRS patients were used to detect the expression of MBP by Elisa assay. Thirty nasal mucus samples from health people were used as control.

[The impact of quality of cardiopulmonary resuscitation on post-resuscitation inflammatory reaction in a porcine cardiac arrest model].

Objective: To evaluate the effects of quality of non-standard cardiopulmonary resuscitation (N-CPR) and new guidelines recommended standard CPR (S-CPR) on post-resuscitation inflammatory reaction in a cardiac arrest (CA) porcine model.

Methods: Eighteen pigs were randomly divided into two groups, and ventricular fibrillation (VF) was induced by programmed electrical stimulation after giving anesthesia, intubation tube and mechanical ventilation. S-CPR (n=9): CPR was consistent with recommendation of the 2005 guidelines.

A comparative study on in vitro and in vivo effects of topical vasodilators in human internal mammary, radial artery and great saphenous vein.

Objective: As an important prognostic factor of coronary artery bypass grafting (CABG), graft vasospasm can be observed in all currently used graft conduits. Radial artery (RA) vasospasm is more prone to occur in comparisons with internal mammary artery (IMA) and great saphenous vein (GSV). There is still controversy about which antispasmodic agent is superior to different grafts, especially to RA conduits.

Late-onset bilateral lens dislocation and glaucoma associated with a novel mutation in FBN1.

Purpose: To describe the clinical and genetic findings in one Chinese family with late-onset bilateral lens dislocation and secondary glaucoma.

Methods: One family including three affected members and 16 unaffected family members was examined clinically. After informed consent was obtained, genomic DNA was extracted from venous blood of all participants.

Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency.

Background: While providing potent immunosuppression for liver transplant recipients, calcineurin inhibitors (CNI) exhibit nephrotoxicity as a major side effect. The purpose of this study was to evaluate the safety and efficacy of conversion from CNI to sirolimus (SRL) among liver transplant recipients with CNI-induced chronic nephrotoxicity.

Methods: Between January 2004 and June 2005, we performed conversion in 16 recipients after a median period of 8.

Histological evaluation of direct pulp capping with a self-etching adhesive and calcium hydroxide on human pulp tissue.

Aim: To evaluate human pulp tissue response following direct pulp capping with a self-etching adhesive: Clearfil SE BOND (SB).

Methodology: Forty-five sound teeth from 20 subjects were used. Forty-one teeth had their pulp mechanically exposed at the base of a Class 1 cavity preparation and were divided into two groups: group 1, teeth were capped with SB (n = 21), and group 2, with calcium hydroxide cement (CH) (n = 20).

[Effects of total rhizoma panacis japonica saponins (tRPJS) on nitric oxide synthase in hippocampus region following rat ischemic cerebral injury].

Objective: To observe the protective effects of total rhizoma panacis japonica saponins (tRPJS) on cerebral ischemia injury in rats.

Method: The rat model of local cerebral ischemia by using thread method, produced the chronic forebrain ischemic by using the permanent occlusion of bilateral common carotid arteries in rats. Investigating the influence of tRPJS on the activity of NOS and iNOS in hippocampus region.

[Outcome of cochlear implantation in prelingual pediatric auditory neuropathy].

Objective: To explore the electrophysiological results and rehabilitation outcome of two prelingually deafened pediatric cochlear implant patients with auditory neuropathy.

Methods: Preoperative audiological evaluation, intra-postoperative electrically evoked auditory brainstem response (EABR) and neural response telemetry (NRT) record for the two cases were conducted in Beijing Tongren Hospital. A one year follow-up was performed.