Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by NaSO.

In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of NaSO. In this work, we employed readily available iodofluoroethane and NaSO as fluoroalkylthiolation reagents, featuring mild conditions and a wide range of indole substrates. In addition, fluoroalkylthiolated 2,3'-biindole derivatives can also be prepared by this method.