Neostigmine for non-mild acute pancreatitis: A systematic review and meta-analysis of randomized controlled trials.

The therapeutic value of neostigmine as a prokinetic drug in acute pancreatitis (AP), especially in non-mild AP, including moderately severe and severe AP remains controversial. This meta-analysis aimed to investigate the efficacy of neostigmine treatment in patients with non-mild AP. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases up to 24 December 2022 for RCTs comparing neostigmine plus conventional treatment versus the conventional treatment alone in patients with non-mild AP.

Bacteria and Dry Eye: A Narrative Review.

(1) Background: Dry eye is a multifactorial disease of the ocular surface, the incidence of which has been increasing sharply. The pathogenesis of dry eye, especially in terms of the bacterial flora, has drawn great attention. Additionally, the potential treatment methods need to be explored.

Left Ventricular Longitudinal Systolic Function in Septic Shock Patients with Normal Ejection Fraction: A Case-control Study.

Background: Septic cardiomyopathy is a common finding in septic shock patients. The accepted definition of septic cardiomyopathy is often based on the left ventricular ejection fraction (LVEF). The aim of this study was to determine whether the left ventricular longitudinal systolic function was more sensitive than the LVEF in heart function appraisal of septic shock patients.

Efficacy and safety of fosaprepitant in the prevention of nausea and vomiting following highly emetogenic chemotherapy in Chinese people: A randomized, double-blind, phase III study.

The prevention of chemotherapy-induced nausea and vomiting was one of the most challenging supportive care issues in oncology, especially to highly emetogenic chemotherapy (HEC). A total of 645 patients were randomized into fosaprepitant group (fosaprepitant/placebo 150 mg d1 in combination with granisetron and dexamethasone) or aprepitant group (aprepitant/placebo 125 mg d1; 80 mg d2-d3 plus granisetron and dexamethasone).The primary endpoint was the percentage of patients who had a complete response (CR) over the entire treatment course (0-120 hr, overall phase [OP]).

Molecular characteristics of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae causing intra-abdominal infections from 9 tertiary hospitals in China.

Background: Recently, the emergence of multidrug-resistant organisms such as extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae has raised considerable concern regarding the appropriate treatment of intra-abdominal infections (IAIs). In this study, we investigated the molecular characteristics of ESBL among clinical isolates of Escherichia coli and Klebsiella pneumoniae causing IAIs and their pattern of antimicrobial resistance, which can provide useful information about the epidemiology and risk factors associated with these infections.

Materials And Methods: One hundred sixty-seven E.

Antimicrobial Susceptibilities of Aerobic and Facultative Gram-Negative Bacilli from Intra-abdominal Infections in Patients from Seven Regions in China in 2012 and 2013.

To evaluate the antimicrobial susceptibility of Gram-negative bacilli that caused hospital-acquired and community-acquired intra-abdominal infections (IAIs) in China between 2012 and 2013, we determined the susceptibilities to 12 antimicrobials and the extended-spectrum β-lactamase (ESBL) statuses of 3,540 IAI isolates from seven geographic areas in China in a central laboratory using CLSI broth microdilution and interpretive standards. Most infections were caused by Escherichia coli (46.3%) and Klebsiella pneumoniae (19.

In vitro activity of flomoxef and comparators against Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis producing extended-spectrum β-lactamases in China.

The objective of this study was to better understand the in vitro activity of flomoxef against clinical extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. A total of 401 ESBL-producing isolates, including 196 Escherichia coli, 124 Klebsiella pneumoniae and 81 Proteus mirabilis, were collected consecutively from 21 hospitals in China in 2013. Minimum inhibitory concentrations (MICs) were determined by broth microdilution methods.

A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China.

The objective of this study was to investigate the susceptibility of hospital-associated (HA) and community-associated (CA) Escherichia coli and Klebsiella pneumoniae isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 to 2011, the minimum inhibitory concentrations (MICs) of 12 antibiotics against 3074 E. coli and 1025 K.

Predictive role of cerebrospinal fluid hydrogen sulfide in central nervous system leukemia.

Background: Central nervous system leukemia (CNSL) is an important relapse in children with acute lymphoblastic leukemia (ALL). We investigated the possible role of endogenous hydrogen sulfide (H(2)S) of cerebrospinal fluid (CSF) in predicting CNSL.

Methods: From August 2008 to December 2010, 380 children were enrolled in this study at Shijitan Hospital, China.

[A clinical analysis of 137 cases of influenza A(H1N1)].

Objective: To analyze the epidemiology and clinical characteristics of influenza A (H1N1).

Methods: A retrospective analysis was performed on the clinical data of 137 cases of influenza A (H1N1) admitted into our hospital during May to August 2009.

Results: In the early stage, most cases were imported from the US, Australia, Canada and the UK.

[An analysis of the prognostic factors of acute myocardial infarction in different gender].

Objective: To analyse the prognostic factors of ST-elevation acute myocardial infarction men and women.

Methods: The data of 904 in-hospital patients with ST-elevation myocardial infarction were collected from the database of our hospital during 2003 - 2004 and 728 of them were followed-up. The patients were divided into groups of male and female.

[The effect of HAART to serum soluble interleukin-2 receptors in AIDS patients].

Objective: To approach the effect of HAART to serum soluble interleukin-2 receptors in AIDS patients.

Methods: 90 cases of AIDS patients were chosen for detection of their slL-2R levels by enzyme-linked immunosorbent assay (ELISA), peripheral blood CD4 T cell counts by flow cytometry and viral load by Branch DNA amplification.

Results: The slL-2R levels were (3154 +/- 905) m9icrog/ml before HAART and (2216 +/- 884) pg/ml after( P < 0.

[Study of lymphocyte subsets and its activated-molecules in patients with paroxysmal nocturnal hemoglobinuria].

Objective: To investigate the relationship between subsets of lymphocytes and between its activated status and the clinical manifestations in patients with PNH, and to unfold immunological mechanism in the pathogenesis of PNH.

Methods: The peripheral blood mononuclear cells (PBMNC) from 18 PNH patients and 20 controls were separated into two subpopulations using anti-CD(59) monoclonal antibody combined with goat-anti-mouse IgG immunomagnetic beads. CD(3)(+), CD(4)(+) and CD(8)(+) lymphocyte subsets were detected by flow cytometry.

[An investigation of immunoreactive substances in normal gingival tissue and periodontitis tissue].

In order to study the effects of NO, endothelin (ET), substancep (SP) and caleiton gene-related paptide (CGRP) immunoreactive substances in chronic periodontitis tissue and the relationship with periodontitis, immunohistochemical and histochemical staining methods were used respectively to detect the expression of the above immunoreactive substances in 20 patients with chronic periodontitis. Quantitative analysis showed that NO and ET in periodontitis tissues were increased significantly (P < 0.01), particularly the content of ET, in comparison to normal tissue.

Pathological changes of oxytalan fibers in the human gingiva of chronic periodontitis.

The gingiva samples were obtained from 40 patients with chronic periodontitis after flap operation and 20 cases having healthy gingiva after ectopic wisdom tooth extraction. We investigated the oxytalan fibers by light microscopy (LM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The results demonstrated that under normal conditions numerous oxytalan fibers were widely and evenly distributed throughout the periodontal tissues.

[Vascular parkinsonism: verified clinicopathological correlation in a case].

Classifications of Parkinsonism in the past have induced an "arteriosclerotic" variety and vascular etiology has thus been proposed. However, controversy exists whether such an entity actually exists, because there has not been a single pathologically verified case with adequate clinical correlation. We report a case with clinical syndrome indistinguishable from Parkinson disease and postmortem examination revealing extensive lacunar infarction of the basal ganglia without evidence of coexistent Parkinson disease.

[Double valve replacement in 400 cases].

From 1985 to 1992, 400 patients received mitral and aortic double valve replacement. Of the patients, 218 were male and 187 female. In early operative days, 6.

[A study on the relation between cerebral lesion and cognitive defect in multi-infarct patients].

240 cases of multi-infarct patients with more than two cerebral infarct lesions in CT findings were collected successively from 1991 to 1992. 42.92% of them were shown to have cognitive defect with a series of neuropsychological tests.

[Noninvasive diagnosis of thoracic outlet syndrome].

Doppler ultrasound and photoplethysmography for the diagnosis of thoracic outlet syndrome was described in this article. There were 14 cases clinically confirmed, 16 cases highly suspected, and 10 cases of normal control. The positive rates were 92% (13/14), 50% (8/16) and 0% (0/10) respectively.

[Diabetic myocardiopathy].

Three cases of diabetic myocardiopathy having history of diabetes, angina and left ventricular dysfunction of various degrees and confirmed by coronary angiography and endomyocardial biopsy were reported. Electrocardiography showed significant ST-T changes simulating coronary insufficiency but without definite localization. As to the treatment, nitrate preparations, inotropic agents such as strophanthin K, digoxin etc.

[Effect of yellow daphne on levels of plasma and decidual estradiol, prostaglandins, progesterone and its receptor in early pregnancy].

The changes of plasma concentration of estradiol (E2), progesterone (P) and prostaglandins (PG) and decidual level of prostaglandins and progesterone receptor (PR) after injection of Yellow Daphne for induction of abortion were observed. The results showed that the treatment with Yellow Daphne could induce degeneration and necrosis of decidual tissues as well as increase of PGE2 and PGF2 alpha concentration with lowering of PR level in the tissue. On the other hand, plasma level of PGE2 and PGF2 alpha remained unchanged and the levels of E2 and P declined.

[Methotrexate-citrovorum factor individualized reduced dose therapy for ectopic pregnancy: report of 20 cases].

In twenty patients with ectopic pregnancy who received treatment using methotrexate-citrovorum factor in an individualized reduced dose regimen 17 cases were successfully treated, 4 required one course of therapy, 8 required two courses, 4 required three courses, only 1 required four courses, according to the difference in the speed of hCG reduction. The success rate was 85.0%, two cases got intrauterine pregnancy within 6 months after the treatment.

[The appliance of image analysis in the diagnosis of oral Lichen Planus and it's malignant change].

After the Feulgen dying,if the normal oral mucous,oral Lichen planus as well as the pathological cut sheets with atypical dysplasia and malignant change in defferent degrees,use the image analysis technique to measure the morphologic parameters of the nucleus(including nuclear surface area,perimeter maximum nuclear diameter,minimum nulear diameter,equivalent circle diameter,morphological factor) and the amount of DNA,5CER acts as an indes of distinguishing malignancy or benignancy,the value of 5CER in malignant is more than 10% and in benignant is less than 10%.The result of the analysis from the optical microscope differs from the optical microscope differs form the image analysis.There are so many personal factors in the qualitative analysis by optical microscope that it because quite imperative to research for a new diagnosing way.

[A long-term observation on cystic hypophysoma and craniopharyngioma treated by colloidal 32P transnasosphenoid injection].

Six patients suffering from cystic hypophysoma and one from craniopharyngioma treated with intracavitary radiation by colloidal 32P transnasophenoid injection were studied. After injection, the headache was eliminated and vision improved in all cases, visual field enlarged in 4, and sexuality improved in 5 male cases. All the patients recovered their normal daily life and work in 2-12 year's follow-up period.