Love Data Week in the time of COVID-19: A content analysis of Love Data Week 2021 events.

A primary role for data-focused librarians is building community through traditional and novel modes of in-person outreach, including consultations, training, and themed events such as Love Data Week. Unfortunately, the COVID-19 pandemic rendered in-person events impossible. However, Love Data Week 2021 persisted in an online format, allowing data-focused librarians a unique chance to initiate outreach to geographically dispersed constituents.

Degradable multifunctional gold-liposomes as an all-in-one theranostic platform for image-guided radiotherapy.

To improve tumor destruction and minimize adverse effects to healthy tissues, image-guided radiation therapy (IGRT) has been developed to allow for the accurate delivery of radiation energy to tumor sites facilitated by real-time imaging. Nevertheless, the current IGRT platform still suffers from the limitation of poor tissue contrast, resulting in the incidental irradiation of healthy tissue. Gold nanoparticles (GNPs) have been identified as promising candidates to simultaneously improve both radiotherapy and imaging, thereby improving both the accuracy and safety of IGRT.

Efficient and Economic Heparin Recovery from Porcine Intestinal Mucosa Using Quaternary Ammonium-Functionalized Silica Gel.

Heparin, usually isolated from porcine intestinal mucosa, is an active pharmaceutical ingredient of great material value. Traditionally, diverse types of commercial resins were employed as an adsorbent for heparin retrieval from biological samples. However, more recent years have encouraged the advent of new cost-effective adsorbents to achieve enhanced heparin retrieval.

A Nanomedicine Structure-Activity Framework for Research, Development, and Regulation of Future Cancer Therapies.

Despite their clinical success in drug delivery applications, the potential of theranostic nanomedicines is hampered by mechanistic uncertainty and a lack of science-informed regulatory guidance. Both the therapeutic efficacy and the toxicity of nanoformulations are tightly controlled by the complex interplay of the nanoparticle's physicochemical properties and the individual patient/tumor biology; however, it can be difficult to correlate such information with observed outcomes. Additionally, as nanomedicine research attempts to gradually move away from large-scale animal testing, the need for computer-assisted solutions for evaluation will increase.

Effects of Air Pollution on Disease Activity and Health-Related Quality of Life of Systemic Lupus Erythematous Patients: An Iranian Observational Longitudinal Study.

Introduction: Air pollution is one of the environmental factors that influences the pathogenesis of systemic autoimmune diseases, followed by the development and spread of inflammation and increased oxidative damage. Only a few studies have been conducted on the impact of air pollution on disease activity in patients with lupus, which mostly have focused on PM particles.

Materials And Methods: We longitudinally studied 50 patients with lupus bimonthly in a 6-month period in Mashhad, one of the polluted cities of Iran.

Microfluidic chip interfacing microdialysis and mass spectrometry for in vivo monitoring of nanomedicine pharmacokinetics in real time.

Although liposomes have demonstrated significant clinical success as drug delivery vehicles, pharmacokinetic (PK) profiling of liposomal nanomedicines remains difficult due to technical challenges accurately measuring low concentrations of free drug in complex biological matrices. Microdialysis (MD) is well established as a powerful in vivo sampling tool for PK studies, but non-volatile salts present in the microdialysate are incompatible with mass spectrometry (MS) analysis without tedious sample pre-treatment. To address this issue, a µSPE-based microfluidic chip was fabricated to interface MD with MS.

Screening of antimicrobials, fragrances, UV stabilizers, plasticizers and preservatives in sewage treatment plants (STPs) and their risk assessment in India.

Community/industrial wastewater is the prime source of anthropogenic chemicals, its treatment is often a daunting task and unaffordable for many countries. Emerging Contaminants (ECs) have been drained into wastewater after continuous use/misuse and Conventional treatments in STPs do not remove them completely. ECs including antimicrobial agents, synthetic musks, Benzotriazole UV stabilizers (BUVSs), plasticizers, and preservatives are frequently reported in environment, and cause health effects to non-target organisms.

A universal monoclonal antibody-aptamer conjugation strategy for selective non-invasive bioparticle isolation from blood on a regenerative microfluidic platform.

Simultaneous isolation of various circulating tumor cell (CTC) subtypes from whole blood is useful in cancer diagnosis and prognosis. Microfluidic affinity separation devices are promising for CTC separation because of their high throughput capacity and automatability. However, current affinity agents, such as antibodies (mAbs) and aptamers (Apts) alone, are still suboptimal for efficient, consistent, and versatile cell analysis.

An Individualized Coach Development Program for Older Adult Player-Coaches in a Masters Football League in Colombia.

Coaches contribute toward helping older adults achieve quality sport experiences, but there are few resources grounded in adult-oriented psychosocial approaches from which they can learn. The purpose of this Participatory Action Research study was to facilitate a personalized professional development program for a Colombian football (soccer) league of older adult men using an evidence-based self-assessment tool for Masters coaches. Data were collected from 23 coaches, who were also players in the league, via interviews, workshops, and observations.

Aquatic and human health risk assessment of Humanogenic Emerging Contaminants (HECs), Phthalate Esters from the Indian Rivers.

Phthalate esters (PEs) one of the widely used plasticizers, and are known for their environmental contamination and endocrine disruption. Hence, it is important to study their distribution in a riverine environment. This study was aimed to determine the Spatio-temporal trends of 16 PEs in surface water, sediment and fish from rivers in southern India, and to assess their environmental health risks.

Shyness, emotion processing, and objective quality of life among adults with schizophrenia: an ERP study.

: Although individual differences in temperament have been shown to influence Quality of Life (QoL) among individuals with schizophrenia, there exists considerable heterogeneity in such outcomes suggesting moderating factors. Here we used event-related potential (ERP) methodology to examine whether the processing of facial emotions moderated the association between shyness and objective QoL among adults with schizophrenia.: Forty stable outpatients with schizophrenia completed measures of shyness and QoL.

Nursing Leadership Style, Training Methods, and Use of Electronic Health Records by Nurses in Jordanian Hospitals: A Descriptive Study.

Aim: The study aimed to assess the level of practice of nursing leadership characteristics during the implementation of electronic health records as perceived by nurses.

Method: A cross-sectional survey design was used in this study. The study recruited 213 nurses from five hospitals which had recently implemented electronic health solution.

Does diversity foster individualism? The relation of racial-ethnic diversity to individualism-collectivism across the 50 American States.

Recent longitudinal research by others analyzing the relation between racial-ethnic diversity and individualism-collectivism in the 50 American states over the period 2000-2018 suggests that racial-ethnic diversity promotes individualism. The present study used a cross-sectional approach based on 2013 data to determine whether a relation mirroring the longitudinal pattern exists between racial-ethnic diversity and individualism-collectivism across the 50 states. Two measures of state racial-ethnic diversity were related to four measures of state individualism-collectivism using Pearson correlation and partial correlation controlling for state socioeconomic status.

Barriers to Providing Smoking Cessation Intervention by Nursing Students: What is the Solution in Nursing Education?

Aim: This study aimed to explore the barriers that hinder nursing students from providing comprehensive smoking cessation interventions for their clients.

Method: A mixed method study combining a self-administered questionnaire and one open-ended question were used to collect data from 152 nursing students at the university in Canada. Data were analyzed using descriptive statistics and thematic analysis.

Facilitating Age-Conscious Student Development through Lecture-Based Courses on Aging.

Ageism is pervasive and socially normalized, and population aging has created a need to understand how views of aging and of older people, typically considered to be people over the age of 65, can be improved. This study sought to understand how undergraduate students' attitudes towards older adults and the aging process may be influenced after completing a typical, lecture-based undergraduate course on aging that lacked service-learning components. Two undergraduate student cohorts (n = 40) at two Canadian universities participated in semi-structured focus groups/interviews, describing how the course may have impacted their perceptions of the aging process and of older adults.

Applicability of the linearized Poisson-Boltzmann theory to contact angle problems and application to the carbon dioxide-brine-solid systems.

In colloidal science and bioelectrostatics, the linear Poisson Boltzmann equation (LPBE) has been used extensively for the calculation of potential and surface charge density. Its fundamental assumption rests on the premises of low surface potential. In the geological sequestration of carbon dioxide in saline aquifers, very low pH conditions coupled with adsorption induced reduction of surface charge density result in low pH conditions that fit into the LPB theory.

Psychometric Validation of the Sexual Distress Scale in Male and Female Portuguese Samples.

Background: The Female Sexual Distress Scale and the Female Sexual Distress Scale-Revised-herein called the Sexual Distress Scale (SDS and SDS-R)-are among the most widely used self-report instruments to assess sexual distress, but no version for use in the Portuguese population is available to date.

Aim: The current study aimed to validate the Portuguese version of the SDS/SDS-R in samples of women and men with and without distressing sexual problems.

Methods: A sample of 1,109 participants without distressing sexual problems (761 women) and 382 participants with distressing sexual problems (283 women), ages ranging from 18 to 72 years, were used to examine the psychometric properties of the Portuguese SDS and SDS-R.

Graphene and graphene oxide with anticancer applications: Challenges and future perspectives.

Graphene-based materials have shown immense pertinence for sensing/imaging, gene/drug delivery, cancer therapy/diagnosis, and tissue engineering/regenerative medicine. Indeed, the large surface area, ease of functionalization, high drug loading capacity, and reactive oxygen species induction potentials have rendered graphene- (G-) and graphene oxide (GO)-based (nano)structures promising candidates for cancer therapy applications. Various techniques namely liquid-phase exfoliation, Hummer's method, chemical vapor deposition, chemically reduced GO, mechanical cleavage of graphite, arc discharge of graphite, and thermal fusion have been deployed for the production of G-based materials.

Efficient Heparin Recovery from Porcine Intestinal Mucosa Using Zeolite Imidazolate Framework-8.

Heparin is one of the most valuable active pharmaceutical ingredients, and it is generally isolated from porcine intestinal mucosa. Traditionally, different types of commercial resins are employed as an adsorbent for heparin uptake; however, using new, less expensive adsorbents has attracted more interest in the past few years to enhance the heparin recovery. Zeolite imidazolate framework-8 (ZIF-8), as a metal-organic framework (MOF) with a high surface area, porosity, and good stability at high temperatures, was selected to examine the heparin recovery.

Manitoba 2020: How centralizing the healthcare supply chain helped with pandemic management.

A case study design was used to understand Manitoba's response to accessing Personal Protective Equipment (PPE) in the first wave of the global coronavirus pandemic. By evolving early on in the pandemic to a provincially led structure dedicated to the healthcare supply chain, Manitoba was able to avoid major shortages in access to PPE. Leadership was focused on the possibilities for action and implementation (ie, dynamic, adaptive, and collaborative) rather than trying to respond within the status quo (ie, a more linear and traditional approach).

Neural processing: Cracking the code to extract relevant social information.

How does the brain decode sensory features from social signals? A new study in electric fish provides an elegant model where mixed selectivity coding and corollary discharges at the thalamic level can guide decision making in social behavior.

Exacerbated Protein Oxidation and Tyrosine Nitration through Nitrite-Enhanced Fenton Chemistry.

Nitrite is a common additive used during meat curing to prevent microbial contamination and retain an attractive red color in the product. However, the effects of nitrite on Fenton reactions catalyzed by free iron in meat products are not well understood, although such processes can induce protein oxidation and nitration, affecting the nutritional and aesthetic quality of meat products. This contribution reveals the mechanism through which nitrite affects Fenton reactions that generate reactive nitrogen and oxygen species by increasing the availability of Fe, facilitating its reduction and stabilizing Fe, and accelerating Fe/Fe cycling, leading to exacerbated oxidative and nitrosative stress on proteins, with implications not only for meat processing but also in many biological and environmental processes due to the ubiquitous presence of iron, hydrogen peroxide, and nitrite in nature.

Discovery and Development of Antibacterial Agents: Fortuitous and Designed.

Today, antibacterial drug resistance has turned into a significant public health issue. Repeated intake, suboptimal and/or unnecessary use of antibiotics, and, additionally, the transfer of resistance genes are the critical elements that make microorganisms resistant to conventional antibiotics. A substantial number of antibacterials that were successfully utilized earlier for prophylaxis and therapeutic purposes have been rendered inadequate due to this phenomenon.

Neuroprotective potential of flavonoid rich Ascophyllum nodosum (FRAN) fraction from the brown seaweed on an Aβ induced Alzheimer's model of Drosophila.

Background: In Alzheimer Disease (AD) pathogenesis, aggregation of Aβ fibrils strongly correlates with memory dysfunction and neurotoxicity. Till date, no promising cures for AD. Report shows that flavonoids contributed anti-oxidant, anti-cancer and neuroprotection activity by regulating the mitochondrial machinery.