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Salvianolic acid B prevents steroid-induced osteonecrosis of the femoral head via PPARγ expression in rats.
Exp Ther Med
February 2017
Department of Educational Administration, Cangzhou Medical College in Hebei, Cangzhou, Hebei 061001, P.R. China.
Article Synopsis
- Salvianolic acid B (Sal B) is a phenolic compound that shows promise in protecting against cerebral ischemia injury through its antioxidation and neuroprotective properties.
- Recent research indicates that Sal B may also help prevent steroid-induced osteonecrosis of the femoral head by improving histopathological scores, inhibiting osteoclast differentiation, and promoting the osteogenesis of mesenchymal stem cells in rat models.
- The treatment with Sal B affects specific proteins related to bone metabolism, suggesting it works by modulating PPARγ expression, which may provide a potential therapeutic approach for managing steroid-induced osteonecrosis.