[Change of early serum TNF-alpha and IL-6 levels in acute cerebral infarction and its significances].

Objective: To investigate the change of early serum TNF-alpha and IL-6 levels in acute cerebral infarction and its significances.

Methods: Serum TNF-alpha and IL-6 levels in 30 health subjects and 35 patients with acute cerebral infarction (ACI) within 6 hours of onset were measured by enzyme linked immunosorbent assay (ELISA); neurological deficits scores (NDS) in all cases were determined, and Spearman test was used for correlation.

Results: The serum levels of TNF-alpha and IL-6 in ACI group were markedly higher than those in health subjects and there was a positive correlation of TNF-alpha and IL-6 levels with 6 h NDS (rs=0.