2,198 results match your criteria: "Candidiasis Cutaneous"
Silver nanoparticles loaded with pomegranate peel extract and hyaluronic acid mediate recovery of cutaneous wounds infected with .
Front Cell Infect Microbiol
December 2024
Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Smart innovative nanocomposites based on active ingredients and metallic nanoparticles with effective wound healing and antifungal properties are efficient in overcoming the limitations of traditional therapeutic products. Open wounds provide an ideal niche for colonization by () which poses substantial global health issues owing to delayed wound healing and disordered healing mechanisms. Therefore, proficient innovative therapies that control infection and promote wound healing are of imperative importance for the management of wounds and prevention of infection and possible complications.
View Article and Find Full Text PDFPrevalence and Comparison of Superficial-Cutaneous Fungal Infections Before and During the COVID-19 Pandemic in Shiraz, Iran: A Retrospective Study (2018-2021).
Indian J Microbiol
December 2024
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
The use of personal protective equipment such as gloves and masks and protective measures such as repeated contact of hands with water and skin disinfectants are recommended to prevent the spread of Corona virus disease 2019 (COVID-19). However, these hygiene measures may cause skin injury and skin diseases, including superficial-cutaneous-fungal infections (SCFIs). The aim of this study was to determine the prevalence and comparison of SCFIs before and during the COVID-19 pandemic.
View Article and Find Full Text PDFRetrospective Investigation of the Utility of Potassium Hydroxide Smear in the Diagnosis and Management of Cutaneous Fungal Infections by Dermatologists.
Indian J Dermatol
October 2024
From the Department of Medicine, Division of Dermatology, National University Hospital Singapore, Singapore, 5 Lower Kent Ridge Rd, Singapore.
Background: Superficial cutaneous fungal infections are common dermatologic conditions. A significant proportion do not present with typical clinical findings. However, the 10% potassium hydroxide (KOH) smear, a simple bedside test, is often underused when diagnosing cutaneous fungal infections.
View Article and Find Full Text PDFClinical and molecular profile of 20 patients with DOCK8 deficiency-a single-center experience from Southern India.
Immunol Res
December 2024
Paediatric Immunology and Rheumatology Unit, Aster CMI Hospital, Bengaluru, India.
DOCK8 deficiency is the most common cause of autosomal recessive hyper-IgE syndrome (AR-HIES). The clinical spectrum is wide resulting in combined immunodeficiency, atopy, autoimmunity, and malignancies. To study the clinical and molecular profile of 20 patients with DOCK8 deficiency.
View Article and Find Full Text PDFArticle Synopsis
- - Vulval disease has a significant impact on quality of life but is often overlooked in research, leading to unclear data on its epidemiology and treatment options.
- - This study aimed to profile patients at a specialized vulval dermatology clinic and gather expert consensus on key data items for a future national database.
- - Findings highlighted that most patients are White British with long symptom durations and multiple diagnoses; consensus was reached on 18 important data items to improve patient care and support ongoing research.
Lack of TYK2 signaling enhances host resistance to Candida albicans skin infection.
Nat Commun
December 2024
Centre of Biological Sciences, University of Veterinary Medicine Vienna, Vienna, Austria.
Candida albicans is the most common human fungal pathogen, causing diseases ranging from local to life-threating systemic infections. Tyrosine kinase 2 (TYK2), a crucial mediator in several cytokine signaling pathways, has been associated with protective functions in various microbial infections. However, its specific contribution in the immune response to fungal infections has remained elusive.
View Article and Find Full Text PDFThe refractory nailbed ulceration caused by after nail extraction.
Med Mycol Case Rep
December 2024
Department of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, China.
An 82-year-old female patient presented to our clinic with refractory nailbed ulceration accompanied by pain in her left fourth toe. Six months prior, she had undergone nail removal surgery to address a persistent paronychia that had not resolved for four months. Crust, necrotic tissue, and secretion on the nailbed were taken for microbiological examination, and was discovered in culture.
View Article and Find Full Text PDFPhenotypes of 126 Moroccan HIES patients according to NIH Score.
Tunis Med
October 2024
Laboratory of Clinical Immunology, Inflammation, and Allergy (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Article Synopsis
- Hyper-IgE syndrome (HIES) is an inherited immune disorder marked by high IgE levels, chronic eczema, and recurrent staphylococcal infections.
- This study examined Moroccan patients likely suffering from HIES, focusing on their clinical and immunological features based on specific NIH criteria over a 25-year period.
- Findings revealed a wide range of symptoms, with eczema and skin infections being the most common, emphasizing the need for molecular analysis for accurate diagnosis and treatment in light of overlapping symptoms.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Congenital Sepsis with -A Rare Event in the Neonatal Period: Report of Two Cases and Literature Review.
Microorganisms
September 2024
Faculty of Medicine, Lucian Blaga University Sibiu, 550169 Sibiu, Romania.
Article Synopsis
- Two case reports of male neonates diagnosed with CSC are presented, highlighting risk factors and clinical presentations: one term infant with a rash and candidemia, and one premature infant with multiple organ involvement.
- The study emphasizes the need for careful medical history-taking and heightened awareness among healthcare providers for early detection and treatment of CSC, aiming to enhance outcomes for affected infants.
Bioadhesive polymer in antifungal drug delivery for therapeutic treatment of candidiasis.
J Adv Pharm Technol Res
July 2024
Faculty of Pharmacy, Universiti Teknologi MARA, Cawangan Selangor, Kampus Puncak Alam, Puncak Alam, Selangor, Malaysia.
Article Synopsis
- * There is a strong necessity for effective antifungal treatments due to the severity of some Candida infections, leading to the development of controlled drug delivery strategies aiming for better release and targeting of antifungal agents.
- * The article reviews how bioadhesive polymers can improve drug delivery systems for antifungal medications, promoting sustained release and reducing dosing frequency while also evaluating the effectiveness and mechanisms of these systems in treating candidiasis.
Exploring the Arsenal of Novel Antifungal Drug Targets for Combating Fungal Infections.
Curr Pharm Biotechnol
September 2024
Department of Pharmacology, Parul Institute of Pharmacy, Parul University, Limda, Waghodia, Vadodara, Gujarat, India.
Article Synopsis
- *There is increasing concern over antifungal resistance, as more than 10% of Candida bloodstream cases show resistance to common treatments like fluconazole, highlighting the need for more accessible and affordable new antifungal medications.
- *Fungi are adaptable organisms that absorb nutrients through their filamentous hyphae, utilizing complex metabolic pathways and displaying both sexual and asexual reproduction, which enhances their survival across various environments.
Treatment-emergent Candida infections in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis treated with ixekizumab: an integrated safety analysis of 25 clinical studies.
Expert Opin Drug Saf
October 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, USA.
Article Synopsis
- This safety analysis examines the occurrence of mucosal/cutaneous Candida infections in patients using ixekizumab (IXE) for treating psoriasis, psoriatic arthritis, and axial spondyloarthritis.
- Data from 25 clinical studies indicated a low incidence rate of 1.2-2.0 per 100 patient-years, with most infections being mild, typically single occurrences, and largely resolved during the studies without requiring treatment discontinuation.
- Overall, the findings suggest that the risk of Candida infections with IXE is low and usually mild-to-moderate in severity, with effective management strategies in place.
Revolutionizing treatment for topical fungal infections: evaluating penetration-enhancer-containing vesicles as a fluconazole delivery system: and dermal testing.
Pharm Dev Technol
October 2024
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Fungal infections pose a significant challenge in numerous developing nations and worldwide, necessitating urgent solutions. Oral administration of antifungal medications often leads to severe adverse reactions. Hence, employing topical delivery systems is preferred to ensure efficient dermal delivery of antifungal agents while minimizing side effects.
View Article and Find Full Text PDFSuccessful combined treatment with surgery and ALA-PDT for cutaneous infection by candida tropicalis: A case report and literature review.
Photodiagnosis Photodyn Ther
October 2024
Department of Plastic & Cosmetic Surgery, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing 400042, PR China. Electronic address:
Article Synopsis
- Traditional treatments rely on antifungal medications, which can lead to liver issues and require long-term use, highlighting the need for new therapies.
- A case study showed that using a combination of surgery and ALA photodynamic therapy effectively treated a skin infection from Candida tropicalis, leading to significant improvement after just one session.
Candidiasis in sp.-A Review of New Advances on the Disease.
Animals (Basel)
July 2024
Instituto de Medicina Veterinária, Universidade Federal do Pará, Castanhal 68740-970, PA, Brazil.
Article Synopsis
- - Candidiasis is a serious fungal infection affecting a variety of animals, including two-toed sloths, with the article detailing its causes, prevalence, and contributing factors such as stress and poor nutrition.
- - The review describes how the infection manifests in sloths, noting symptoms like oral thrush and skin lesions, and outlines diagnostic methods to effectively identify the condition.
- - The article also discusses treatment options, including antifungal medications, and emphasizes prevention tactics like proper care and health monitoring to reduce the spread and impact of candidiasis.
Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications.
J Lipids
July 2024
Department of Pharmaceutics National Institute of Pharmaceutical Education and Research, Guwahati, Assam 781101, India.
Article Synopsis
- - Topical drug delivery using nanocarriers has improved the treatment of skin and eye conditions, addressing challenges faced by traditional formulations.
- - Cubosomes, due to their unique liquid crystalline structure, enhance drug bioadhesion, retention, and sustained release, making them effective for various medications.
- - The review discusses the manufacturing and biological hurdles of using cubosomes in treating conditions like psoriasis, glaucoma, and more, as well as the success of patented products in the cosmeceuticals market.
Biologics Versus JAK Inhibitors. Part II: Risk of Infections. A Narrative Review.
Dermatol Ther (Heidelb)
August 2024
Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Villarroel 170, 08036, Barcelona, Spain.
Article Synopsis
- The study reviews infection risks associated with biological drugs (BD) and Janus kinase inhibitors (JAKi) specifically in dermatology, noting that while the overall infection rates are low, they remain higher than the general population.
- It highlights that certain JAKi and anti-TNF agents, particularly tofacitinib, have a greater association with infection risks, including specific infections like tuberculosis and candidiasis.
- The analysis suggests careful monitoring for patients on these treatments and calls for more long-term studies to better understand these risks.
Infectious Aspects of Chronic Wounds.
Clin Geriatr Med
August 2024
Icahn School of Medicine at Mount Sinai, New York, NY 10010, USA. Electronic address:
Article Synopsis
- Treating chronic wounds presents difficulties for healthcare providers, particularly in distinguishing between colonization and infection, and knowing when to apply systemic antibiotics.
- There is a lack of standardized guidelines for managing these infections, making wound care more of an art than a science.
- Recent progress has been made in diagnosing and managing infected wounds, with the article focusing on infections common in older adults, such as cutaneous candidiasis and osteomyelitis.
A Preterm Infant of Congenital Cutaneous Candidiasis With Elevated Plasma (1, 3) β-D-glucan Level.
Pediatr Infect Dis J
June 2024
Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Candida albicans skin infection in diabetic patients: An updated review of pathogenesis and management.
Mycoses
June 2024
Centre for Sustainability of Mineral and Resource Recovery Technology (Pusat SMaRRT), Universiti Malaysia Pahang Al-Sultan Abdullah, Kuantan, Pahang, Malaysia.
Article Synopsis
- - Candida species are common on human skin and can cause skin infections, especially in individuals with weakened immune systems, such as those with diabetes, which increases susceptibility to these infections.
- - The review highlights various types of candidiasis related to diabetes, including oral, vaginal, and skin infections, and emphasizes the need for effective preventative measures and treatments.
- - It calls for more research and collaboration to better understand and manage the relationship between diabetes and candidiasis, aiming to develop improved antifungal treatments.
Naringenin-Zinc Oxide Nanocomposites Amalgamated Polymeric Gel Augmented Drug Delivery and Attenuated Experimental Cutaneous Candidiasis in Balb/c Mice: In Vitro and In Vivo Studies.
AAPS PharmSciTech
June 2024
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.
Article Synopsis
- Naringenin (NRG) is effective against Candida albicans, a fungus that causes skin infections, and its formulation with ZnO nanomaterials enhances its antifungal properties.
- The newly developed NRG-Zn nanocomposite shows improved skin permeation and retention compared to naringenin alone, resulting in better antifungal efficacy in laboratory tests and animal models.
- The NRG-Zn-CS-Gel demonstrates significant reduction in fungal burden in infected mice, and histopathological analysis indicates healing and reduced inflammation, suggesting its potential as a treatment for skin infections.
A rare incidence of severe dermatological toxicities triggered by concomitant administration of all-trans retinoic acid and triazole antifungal in patients with acute promyelocytic leukemia: a case series and review of the literature.
J Med Case Rep
May 2024
Section of Malignant Haematology, National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, Pakistan.
Background: All-trans retinoic acid (ATRA) is an indispensable part of the treatment of acute promyelocytic leukemia (APL). Although, mild cutaneous toxicities like mucocutaneous xerosis, rash, and pruritus are well reported, ATRA associated severe dermatological toxicities are extremely rare. ATRA is primary metabolized by cytochrome P450 (CYP450) enzyme system, and triazole antifungals are notorious for their strong inhibitory effect on CYP450.
View Article and Find Full Text PDFEfficacy and safety of bimekizumab in patients with moderate-to-severe hidradenitis suppurativa (BE HEARD I and BE HEARD II): two 48-week, randomised, double-blind, placebo-controlled, multicentre phase 3 trials.
Lancet
June 2024
European Hidradenitis Suppurativa Foundation, Dessau, Germany; Departments of Dermatology, Venereology, Allergology, and Immunology, Staedtisches Klinikum Dessau, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.
Article Synopsis
- Bimekizumab, a monoclonal antibody targeting IL-17F and IL-17A, is being tested as a treatment for moderate-to-severe hidradenitis suppurativa, a condition with limited treatment options.
- The BE HEARD I and II trials were 48-week, randomized, double-blind studies that evaluated the efficacy and safety of various dosing regimens of bimekizumab compared to a placebo in over 1,000 patients.
- Results showed significant improvement in patients receiving bimekizumab every 2 weeks, meeting the primary efficacy goal of at least a 50% reduction in disease symptoms by week 16.