A Preliminary and Evaluation of the Effect and Action Mechanism of 17-AAG Combined With Azoles Against Azole-Resistant spp.

Invasive candidiasis is the primary reason for the increased cases of mortality in a medical environment. The resistance spectra of species to antifungal drugs have gradually expanded. Particularly, the resistance spectra of are the most prominent.

Interactions of Antifungal Agents and Everolimus Against Species.

Multiple cellular activities, including protein and lipid synthesis, ribosome biogenesis, and metabolic processes, are regulated by the target of rapamycin (TOR) pathway. Recent research suggests that the TOR might play an important role in various physiological functions of pathogenic fungi, such as nutrient sensing, stress response, and cell cycle progression. Given their robust immunosuppressant and antitumor activities, TOR inhibitors are widely used in clinical settings.

The Synergistic Effect of Tacrolimus (FK506) or Everolimus and Azoles Against and Species and .

and infections in humans are generally chronic and stubborn. The use of azoles alone cannot usually inhibit the growth of these fungi. To further explore the combined effect of multiple drugs and potential mechanisms of action, we tested the antifungal effects of tacrolimus (FK506) and everolimus in combination with azoles and on 15 clinical strains of / species and detected the level of Rhodamine 6G, ROS activity, and apoptosis.

In vitro synergistic effect of minocycline combined with antifungals against Cryptococcus neoformans.

Background: Cryptococcus neoformans infections occur in immunocompromised patients, especially those with HIV infection, chemoradiotherapy after cancer, and organ transplantation. Infection can cause pneumonia and meningoencephalitis in severe cases with a high mortality rate if not treated. Although fluconazole and amphotericin B are the first-line treatments for cryptococcosis, the rate of fluconazole resistance has increased significantly due to long-term use.