1 results match your criteria: "Cancer program QIMR Berghofer Medical Research Institute[Affiliation]"
Murine Models of Myelofibrosis.
Cancers (Basel)
August 2020
Cancer program QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Article Synopsis
- Myelofibrosis (MF) is a serious subtype of myeloproliferative neoplasm (MPN) with a typically poor prognosis, highlighting the need for better understanding of its causes.
- Key mutations in three genes (JAK2, CALR, and MPL) frequently appear in MPN and can trigger the disease in animal models, indicating their significance in MF development.
- Research using these animal models has provided insights into MF's progression from earlier stages of MPN, like essential thrombocythemia and polycythemia vera, and has opened doors to potential new therapies.