Intravenous flurbiprofen axetil to relieve cancer-related multiple breakthrough pain: a clinical study.

Objective: To compare the treatment effect reducing cancer-related multiple breakthrough pain (BTP) between immediate release morphine sulfate (IRMS) and flurbiprofen axetil.

Methods: Eligible patients with refractory BTP were divided into two groups; the control group received IRMS for rescue care; the flurbiprofen group received intravenous flurbiprofen axetil. Patients were asked to assess the effect of rescue medication on their most severe pain.

[Treatment and prognosis of stage IV alveolar soft part sarcoma].

Objective: To analyze the clinical features, treatment and prognosis of Stage IV alveolar soft part sarcoma.

Methods: To analyze the clinical and pathological features, therapeutic methods and follow-up results in 21 patients with stage IV alveolar soft part sarcoma. There were 11 males and 10 females, in the age of 26-57 years (average 37.

The effect of the extent of lymph node dissection for stage IA non-small-cell lung cancer on patient disease-free survival.

Background: Systematic LN dissection has been proposed as 1 of the important parts of the standard surgery for NSCLC for decades. However, controversy exists as to whether extensive LN dissection has benefit for early stage NSCLC patients. The aim of the present study was to investigate whether the extent of dissection affects the DFS of stage IA patients.

PTPN22 and CTLA-4 gene polymorphisms in resected thymomas and thymus for myasthenia gravis.

Background: Myasthenia gravis (MG) is an autoimmune disease of striated muscle tissue mediated by autoantibodies. MG is often treated with thymectomy. Protein tyrosine phosphatase non-receptor 22 (PTPN22) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) have recently been found to be the genes that predispose to autoimmune diseases.

Risk factors for metastasis to para-aortic lymph nodes in gastric cancer: a single institution study in China.

Background: Para-aortic lymph node (PAN) dissection is performed in some gastric cancer patients with extensive lymph node involvement. However, there is no consensus on selection of patients that will benefit from this high risk dissection. This study was to identify risk factors for PAN metastasis in gastric cancer.

[Mammographic and pathological features of triple-negative breast cancer].

Objective: To retrospectively evaluate the mammographic imaging findings and pathologic changes of the so-called "triple-negative" breast cancer (ER(-)/PR(-)/HER-2(-) breast cancer), and to compare them with the ER(+)/PR(+)/HER-2(-) and ER(-)/PR(-)/HER-2(+) breast cancer patients.

Methods: Five hundred cases of breast cancer treated in Cancer Institute and Hospital of Tianjin University from January to June of 2010 were included in this study. There were 112 cases of triple-negative breast cancer, 310 cases of ER(+)/PR(+)/HER-2(-) breast cancer, and 78 cases of ER(-)/PR(-)/HER-2(+) breast cancer.

Expression of Human Endogenous Retrovirus Type K Envelope Protein is a Novel Candidate Prognostic Marker for Human Breast Cancer.

We previously observed that the HERV type K (HERV-K) envelope (env) protein was expressed in the majority of human breast tumors from a U.S. cohort of women from Texas.

A retrospective clinicopathologic study of remnant gastric cancer after distal gastrectomy.

Introduction: Remnant gastric cancer (RGC) is a unique clinical entity with relatively less frequency in gastric cancer series and often reported to be detected at advanced stages and had poor prognosis.

Methods: A total of 112 patients with RGCs from July 1991 to July 2008 were enrolled in this retrospective analysis.

Results: A total number of 112 cases were composed of 20 (17.

[A retrospective analysis of clinic-pathological characteristics and prognostic factors for 204 cases of primary gastric lymphoma].

Objective: To explore the clinicopathological characteristics and prognostic factors of primary gastric lymphoma (PGL).

Methods: The clinical data of 204 patients with PGL was reviewed and analyzed. There were 106 males and 98 females, their age were 19 to 85 years (average age was 53.

[Retrospective analysis of relative prognostic factors in stage III soft tissue sarcomas with standard treatments].

Objective: To investigate the outcome of standard treatment in stage III soft tissue sarcomas and the prognostic factors in these patients.

Methods: Clinical, pathological, and therapeutic information of 67 patients with stage III soft tissue sarcomas were collected from Tianjin Medical University Cancer Hospital from January 2003 to January 2006. All these patients were treated with the same treatment program.

[Treatment and prognostic analysis of 1638 patients with non-small cell lung cancer].

Objective: To study the prognosis and prognostic factors of non-small-cell lung carcinoma (NSCLC) according the new TNM stage system.

Methods: Clinic data of 1638 inpatient cases admitted from January 2001 to January 2005 were retrospectively reviewed. There were 1083 male and 555 female patients in the study and the average age was 59.

[Comparison of the effect of rh-endostatin on intratumoral and myocardial micrangium in mice].

Objective: To compare the effect of rh-endostatin on micrangium in tumor and myocardial tissue in nude mice.

Methods: Nude mice were randomized into 4 groups (10 mice in each group), blank control group (without tumor burden, received NS 100 µl×d(-1) injection), drug control group (without tumor burden, received rh-endostatin 400 µg×d(-1) injection), model group (with tumor burden, received NS 100 µl×d(-1) injection) and treatment group (with tumor burden, received rh-endostatin 400 µg×d(-1) injection) for 28 days. The tumor volume and body weight of the mice were measured before and after administration.

[Use of uncut Roux-en-Y reconstruction after distal gastrectomy for gastric cancer].

Objective: To evaluate the clinical efficacy of uncut Roux-en-Y reconstruction after distal gastrectomy for gastric cancer.

Methods: Clinical data of 419 patients who underwent distal gastrectomy for gastric cancer with complete follow-up data between March 2005 and March 2008 in the Cancer Institute and Hospital of Tianjin Medical University. Patients were divided into B I (138 cases with Billroth I reconstruction), M-B II (108 cases with modified Billroth II reconstruction), RY (46 cases with Roux-en-Y reconstruction) and Uncut RY (127 cases with uncut Roux-en-Y reconstruction) according to reconstructive methods.

[A retrospective analysis of clinicopathological characteristics and prognostic factors of gastric stump cancer].

Objective: To explore the clinicopathological characteristics and prognostic factors of gastric stump cancer(GSC).

Methods: The clinical data of 138 patients with GSC treated from January 1992 to July 2008 were reviewed and analyzed. The patients included 122 males and 16 females with a mean age of 61.

[Primary malignant fibrous histiocytoma of the lung: a report of 20 cases].

Background And Objective: Primary malignant fibrous histiocytoma (MFH) of the lung is a type of rare sarcoma which showed a lack of detailed guidance about treatment and prognosis. The clinical features, treatment methods and prognosis of primary MFH of the lung were analyzed by this study to reveal some information of this disease.

Methods: The clinical data and survival state of 20 patients with primary pulmonary MFH treated in Cancer Institute and Hospital of Tianjin Medical University were collected.

[Analysis of treatment and prognosis in 132 patients with gastric gastrointestinal stromal tumors].

Objective: To investigate the clinicopathological characteristics, diagnosis, treatment and prognostic factors of gastric gastrointestinal stromal tumors(GIST) in the stomach.

Methods: The clinicopathological data of 132 patients with gastric GIST between January 1998 and December 2008 were analyzed retrospectively, and the prognostic factors were evaluated.

Results: Tumor locations were the cardia or fundus (50, 37.

[A clinical and prognostic retrospective analysis of IIIA-N2 non-small cell lung cancer].

Objectives: To analyze the clinical conditions of postoperative patients with IIIA-N2 non-small cell lung cancer (NSCLC) and the prognostic factors related with survival of NSCLC, and to investigate the influence of operation and therapy on prognosis.

Methods: Clinical data of 657 inpatient cases with IIIA-N2 NSCLC admitted from January 2000 to December 2005 was retrospectively reviewed. The Kaplan-Meier method was used for survival analysis.

[Clinical and prognostic analysis of skip N2 metastases in stage IIIA-N2 non-small cell lung cancer].

Objective: To investigate the clinicopathologic factors and the distribution pattern of N2 lymph nodes, to analyze the relationship between the survival rate and skip metastasis of non-small cell lung cancer (NSCLC) patients.

Methods: The clinical data of 478 patients with a pN2 stage who underwent resection for non-small cell lung cancer from January 2000 to December 2004 was retrospectively analyzed. Skip group and non-skip group were defined.

[Prognostic analysis on primary duodenal adenocarcinoma].

Objective: To investigate the prognostic factors of primary duodenal adenocarcinoma.

Methods: The medical records of 67 patients with primary duodenal adenocarcinoma treated in our hospital from January 1990 to December 2005 were retrospectively analyzed. Prognostic factors were analyzed by univariable and multivariable analysis.

[Apoptosis resistance induced by leptin and its mechanism in breast cancer cells].

Objective: To explore the apoptosis resistance induced by Leptin and its mechanism in breast cancer cells in vitro.

Methods: The leptin-mediated reduction of docetaxel-induced apoptosis in human breast cancer T47D cells was evaluated by TransAM ELISA, MTT and caspase-9 assay. The leptin-promoted survivin expression was analyzed by Western-blot and RT-PCR.

[Correlation between thyroid-stimulating hormone-peroxiredoxin1 signaling pathway and invasion of papillary thyroid carcinoma].

Objective: In order to assess the significance of thyroid-stimulating hormone receptor (TSHR), peroxiredoxin1 (Prx1), thioredoxin1 (Trx1), hypoxia inducible factor-1 (HIF-1)alpha in invasion and metastasis of papillary thyroid carcinoma (PTC).

Methods: The 34 paraffin-embedded specimen of classical PTC, 39 of tall cell variant of PTC and normal thyroid tissues adjacent to cancer operated in Tianjin Cancer Hospital from 2003 to 2007 were tested. The expressions of TSHR, Prx1, Trx1, HIF-1alpha in the specimen were assayed by immunohistochemical staining.

Experimental study on the treatment of intracerebral glioma xenograft with human cytokine-induced killer cells.

Objective. To investigate the phenotype changes and proliferation activities of cytokine-induced killer cells (CIKs) and lymphokine-activated killer cells (LAKs) from healthy donor, and the cytotoxicities of CIKs and LAKs to human in vitro glioma cell lines U251 and U87. Therapy of CIK intratumoral injection was evaluated in nude mouse models.

[Construction of recombinant adenovirus vector expressing extracellular domain of TbetaR-II-RANTES fusion gene and its anti-tumor effects].

Objective: To construct a recombinant adenovirus vector expressing TbetaR-II extracellular domain-RANTES fusion gene and evaluate its anti-tumor effects.

Methods: Mouse origin TbetaR-II extracellular domain and RANTES gene were amplified by RT-PCR. The TbetaR-II extracellular domain-RANTES fusion gene was amplified by overlapping PCR method.

Th1 polarization and apoptosis-inducing activity of CD4+ T -cells in cytokine-induced killers might favor the antitumor cytotoxicity of cytokine-induced killers in vivo.

Objective: The cytokines induced killers (CIKs) treatment is an emerging adoptive immunotherapy with greater antitumor activity than lymphocyte-activated killers (LAKs). Our previous study suggested that CD4+ T-cells in CIKs (CD4+ CIKs) might contribute to the CIK-mediated therapy in vivo. In this experiment, we studied the mechanisms that might be involved.