49 results match your criteria: "Cancer Institute and Hospital of Tianjin Medical University[Affiliation]"
DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1.
Cell Rep
July 2024
RNA Institute, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China. Electronic address:
Article Synopsis
- DOT1L is responsible for adding methyl groups to histone H3 at lysine 79, influencing gene activation or repression, but its full regulatory roles are still being studied.
- Research shows that the protein DCAF1, which is part of the E3 ligase complex connected to HIV regulation, interacts with DOT1L and H3K79me2; inhibiting these can boost HIV-1 reactivation driven by TNF-α/NF-κB signaling.
- The study highlights how DOT1L-mediated histone modifications may regulate HIV reactivation and suggests that targeting the DOT1L/DCAF1 pathway could be a potential therapeutic approach for treating HIV.
The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson's Disease.
Front Neurosci
October 2021
School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
Parkinson's disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.
View Article and Find Full Text PDFRetraction Note to: Slug down-regulation by RNA interference inhibits invasion growth in human esophageal squamous cell carcinoma.
BMC Gastroenterol
October 2021
Department of Surgery, The Affiliated Hospital of Medical College, QingDao University, QingDao, 266003, Shan Dong Province, People's Republic of China.
Single-Cell Analysis of the Pan-Cancer Immune Microenvironment and scTIME Portal.
Cancer Immunol Res
August 2021
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Single-cell sequencing opens a new era for the investigation of tumor immune microenvironments (TIME). However, at single-cell resolution, a pan-cancer analysis that addresses the identity and diversity of TIMEs is lacking. Here, we first built a pan-cancer single-cell reference of TIMEs with refined subcell types and recognized new cell type-specific transcription factors.
View Article and Find Full Text PDFCompetition between PAF1 and MLL1/COMPASS confers the opposing function of LEDGF/p75 in HIV latency and proviral reactivation.
Sci Adv
May 2020
State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases, Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Transcriptional status determines the HIV replicative state in infected patients. However, the transcriptional mechanisms for proviral replication control remain unclear. In this study, we show that, apart from its function in HIV integration, LEDGF/p75 differentially regulates HIV transcription in latency and proviral reactivation.
View Article and Find Full Text PDF[Numerical simulation of the focal region modulation to realize uniform temperature distribution during high-intensity focused ultrasound brain tumor therapy].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
December 2018
School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 30070,
The temperature during the brain tumor therapy using high-intensity focused ultrasound (HIFU) should be controlled strictly. This research aimed at realizing uniform temperature distribution in the focal region by adjusting driving signals of phased array transducer. The three-dimensional simulation model imitating craniotomy HIFU brain tumor treatment was established based on an 82-element transducer and the computed tomography (CT) data of a volunteer's head was used to calculate and modulate the temperature distributions using the finite difference in time domain (FDTD) method.
View Article and Find Full Text PDF[Clinical significance of NS1-BP expression in esophageal squamous cell carcinoma].
Zhonghua Zhong Liu Za Zhi
January 2018
Department of Radiation Oncology, Cancer Institute and Hospital of Tianjin Medical University, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center of Cancer, Tianjin 300060, China.
Article Synopsis
- The study investigates the clinical relevance of NS1-BP expression in esophageal squamous cell carcinoma (ESCC) patients and its impact on cell proliferation and apoptosis.
- It analyzed 98 tumor and 30 normal tissue samples, finding that NS1-BP was down-regulated in a significant portion of ESCC tissues compared to normal tissues, which correlated with poorer survival rates.
- Results demonstrated that low NS1-BP expression is an independent predictor of reduced sensitivity to treatment and shorter disease-free survival, confirming its potential as a therapeutic target.
Moderate hypofractionated radiotherapy is more effective and safe for localized prostate cancer patients: a meta-analysis.
Oncotarget
January 2017
Department of Radiotherapy, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, People's Republic of China.
To compare the efficacy and safety of moderate hypofractionated radiotherapy (H-RT) with those of conventional radiotherapy (C-RT) in patients with localized prostate cancer, we conducted extensive literature searches of The Web of Science, Embase, Pubmed and Cochrane Library databases. We identified nine studies with 5969 patients for a meta-analysis. We calculated pooled risk ratios (RRs) and the 95% confidence intervals (CIs) for multiple parameters and performed statistical analysis using RevMan 5.
View Article and Find Full Text PDF[Comparative study between thoracoscopic and open esophagectomy on perioperative complications and stress response].
Zhonghua Wei Chang Wai Ke Za Zhi
April 2016
Department of Esophageal Cancer, Cancer Institute and Hospital of Tianjin Medical University, National Cancer Clinical Medical Research Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Article Synopsis
- The study compares perioperative complications and stress responses between thoracoscopic and open esophagectomy in patients with esophageal cancer.
- The analysis included 154 patients undergoing thoracoscopic procedures and 113 undergoing open surgery, revealing that thoracoscopic surgery had lower rates of specific complications like nerve paralysis and respiratory issues.
- Although thoracoscopic esophagectomy showed fewer pulmonary complications, there were no significant differences in stress responses, such as hormone levels, between the two surgical methods.
Effectiveness and safety of CT-guided (125)I seed brachytherapy for postoperative locoregional recurrence in patients with non-small cell lung cancer.
Brachytherapy
July 2017
Department of Esophageal Oncology, Key Laboratory of Cancer Prevention and Therapy, Cancer Institute and Hospital of Tianjin Medical University, Tianjin, R. P. China. Electronic address:
Article Synopsis
- The study evaluated the safety and effectiveness of CT-guided (125)I seed brachytherapy (CTISB) in 38 non-small cell lung cancer (NSCLC) patients who experienced locoregional recurrence (LRR).
- Among the patients, some received combined chemotherapy, and results showed that after two months, 87% of patients had a positive response to treatment, with a median overall survival of 21 months.
- The findings suggest that CTISB is an effective option for managing local cancer control in selected NSCLC patients with limited recurrence, demonstrating minimal trauma.
[Effectsof the time interval and the endocrine therapy on the prognosis and consistency of the biological indicatorsin patients with bilateral primary breast cancer].
Zhonghua Yi Xue Za Zhi
January 2016
Center of Breast Cancer, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China.
Article Synopsis
- The study examined how the time gap between two breast cancers and previous endocrine therapy impacts biological indicators and prognosis in bilateral primary breast cancer (BPBC) patients.
- A review of clinical data from 133 BPBC patients showed that longer time intervals reduced the consistency of biological indicators, with estrogen receptors (ER) remaining more consistent than progestin hormone receptors (PR).
- Despite changes in consistency of biological indicators related to time interval and therapy, these factors did not influence overall patient survival rates.
Primary bone natural killer/T cell lymphoma, nasal type without EBV infection: a case report.
Int J Clin Exp Pathol
November 2016
Cancer Institute and Hospital of Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin 300060, China.
Article Synopsis
- Primary bone NK/T cell lymphoma is an uncommon type of cancer, as illustrated by a case involving a 52-year-old man who developed NK leukemia after initially presenting with the lymphoma.
- The patient experienced low-grade fever for four months, and imaging revealed enlargement of the liver and spleen without swollen lymph nodes.
- Diagnosis required a bone sample, showing specific markers on the neoplastic cells, which helps differentiate it from other types of lymphoma or leukemia that can also affect bones.
[Clinical characteristics and prognosis in 20 patients with spindle cell carcinoma of the breast].
Zhonghua Zhong Liu Za Zhi
January 2015
The Second Department of Breast Cancer Surgery, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China. Email:
Article Synopsis
- The study aimed to analyze the clinical characteristics, diagnosis, and prognosis of spindle cell carcinoma of the breast (SpCC) among 20 female patients treated between 2004 and 2013.
- Most tumors were misdiagnosed using common imaging techniques, with diagnosis confirmed post-surgery through histopathological analysis, revealing low positive rates for estrogen and progesterone receptors and high levels of Ki-67.
- The findings indicated that SpCC is rare with poor survival outcomes, highlighting the need for aggressive treatment strategies, primarily radical resection, due to its high invasiveness and low expression of traditional breast cancer markers.
[Analysis of early lymph node metastasis pattern and prognosis in thoracic esophageal squamous cell carcinoma].
Zhonghua Wei Chang Wai Ke Za Zhi
September 2014
Department of Esophageal Tumor, Cancer Institute and Hospital of Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Prevention and Therapy for Tumor of Tianjin City, Tianjin 300060, China.
Article Synopsis
- The study examined early lymph node metastasis in patients with thoracic esophageal squamous cell carcinoma to assess its impact on survival.
- Data from 126 patients who underwent surgery were analyzed, revealing that common metastasis sites included the upper mediastinum, paraesophageal areas, and the left gastric artery.
- Findings indicated that certain metastasis patterns, particularly involving the subcarinal and middle/lower thoracic paraesophageal regions, are independent risk factors for survival and should be considered in prognosis evaluations using the 7th edition UICC-AJCC TNM classification.
Article Synopsis
- HPP1 is a tumor suppressor gene that is often silenced in colon cancer due to promoter hypermethylation and suppression by c-Myc.
- Treatment with HDAC inhibitors reactivates HPP1 in colon cancer cell lines, indicating an epigenetic mechanism involving histone deacetylation.
- Our research shows that c-Myc collaborates with HDAC3 to regulate HPP1, suggesting potential therapeutic targets for cancer treatment.
[Adenoid cystic carcinoma of the breast:report of 25 cases].
Zhonghua Zhong Liu Za Zhi
February 2014
The Cancer Prevention Center, National Clinical Research Center for Cancer, Cancer institute and Hospital of Tianjin Medical University; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. Email:
Article Synopsis
- The study analyzed the clinical features and treatment outcomes of 25 breast adenoid cystic carcinoma (ACC) patients, mostly postmenopausal women with a median age of 53.
- The most common symptom was a breast lump, predominantly found in the upper outer quadrant, and only two patients showed positive lymph node metastasis after axillary dissection.
- Despite its rarity, breast ACC generally has a good prognosis, but further research is needed to clarify the role of adjuvant therapy due to low rates of hormone receptor expression.
Granulomatous mastitis: presentation, treatment, and outcome.
Am Surg
March 2014
Department of Breast Cancer Surgery, Cancer Institute and Hospital of Tianjin Medical University, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
[Differences and clinical significance of receptor expression between primary and locally recurrent breast tumor tissues].
Zhonghua Zhong Liu Za Zhi
May 2013
Department of Breast Cancer, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China.
Objective: To compare the difference of receptor expression between primary and locally recurrent breast tumor tissues, and analyze their impact on survival of the patients.
Methods: The expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) of primary and locally recurrent breast tumor tissues of 70 breast cancer patients were analyzed by immunohistochemistry or fluorescence in situ hybridization. The impact of the differences on overall survival (OS) and post-recurrence survival (PRS) of the patients was analyzed.
[Metastatic characteristics of lymph node in supraclavicular zone and radiotherapy target volume for limited-stage small cell lung cancer].
Zhonghua Yi Xue Za Zhi
May 2013
Department of Radiation Oncology, Cancer Institute and Hospital of Tianjin Medical University, Tianjin, China.
Article Synopsis
- The objective of the study was to analyze supraclavicular lymph node metastasis characteristics in limited-stage small cell lung cancer (LS-SCLC) to determine an effective radiotherapy range.
- The research involved reviewing patients with LS-SCLC, categorizing the supraclavicular area into five subregions, and highlighting that 60 patients showed a 34.5% rate of metastasis, with specific regions having higher frequencies of metastasis.
- The findings suggest that elective radiation target volumes should include bilateral supraclavicular nodes, particularly for patients with mediastinal lymph node involvement, and recommend including the outer margin of the internal jugular vein in treatment plans.
Clinical significance of E-cadherin, β-catenin, vimentin and S100A4 expression in completely resected squamous cell lung carcinoma.
J Clin Pathol
November 2013
Department of Lung Cancer, Cancer Institute and Hospital of Tianjin Medical University, , Tianjin, China.
Article Synopsis
- This study aimed to evaluate the expression levels of E-cadherin, β-catenin, vimentin, and S100A4 in patients with squamous cell lung carcinoma (SqCC) to determine their prognostic significance.
- Immunohistochemical analyses of tumor samples from 204 patients showed significant correlations between E-cadherin and key clinicopathological factors like T stage and lymph node metastasis; high E-cadherin levels were associated with better overall and disease-free survival.
- The findings suggest that assessing E-cadherin and S100A4 could help predict outcomes for SqCC patients, with E-cadherin being a positive prognostic factor and high
[Prognosis analysis of 310 patients with pathological stage pN3 gastric cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
June 2013
Department of Gastric Cancer, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China.
Article Synopsis
- The study analyzed the characteristics and survival rates of 310 patients with pN3 stage gastric cancer who underwent radical surgery from 2000 to 2006.
- The overall 5-year survival rate was low at 14.6%, with the rates varying depending on pN3a or pN3b classification and tumor depth.
- Key findings indicated that depth of tumor invasion, surgical methods, and the ratio of metastatic lymph nodes significantly influenced patient survival outcomes, highlighting the importance of pN3 staging in predicting prognosis.
A modified method for reducing renal injury in zoledronic Acid treatment of hypercalcemia and adverse skeletal events.
Indian J Palliat Care
January 2013
Department of Nuclear Medicine, Cancer Institute and Hospital of Tianjin Medical University, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Aims: In this paper, we have reported a previously undescribed risk factor of deterioration of renal function in zoledronic acid treatment of skeletal metastasis - high serum calcium level. Based on this consideration, a modified method of treatment of hypercalcemia (HCM) with zoledronic acid is suggested in this paper.
Material And Methods: Bone scan findings of 1090 cancer patients were analyzed, of which 26 had intense renal parenchymal uptake as a result of HCM or bone metastases.
[Prognostic analysis of 450 patients with lung squamous cancer].
Zhonghua Wai Ke Za Zhi
February 2013
Tianjin Lung Center, Key Laboratory of Cancer Prevention and Therapy, Department of Lung Cancer, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China.
Article Synopsis
- The study analyzed 450 cases of lung squamous cancer patients who underwent complete resection between 2004 and 2007, revealing a 5-year survival rate of 52.4%.
- Key factors influencing prognosis were identified as preoperative N status, N stage, and TNM stage, with adjuvant chemotherapy improving survival rates for certain stages.
- Combined chemoradiotherapy showed the highest survival rate for stage IIIA patients, while lymph node dissection standards significantly impacted overall survival outcomes.
Does the extent of lymph nodes dissection affect the prognosis of resected stage IA non-small cell lung cancer?
Clin Transl Oncol
January 2014
Key Laboratory of Cancer Prevention of Tianjin, Cancer Institute and Hospital of Tianjin Medical University, Huan Hu Xi Road, He Xi District, Tianjin, People's Republic of China.
Article Synopsis
- The study focuses on how the extent of lymph node dissections in stage IA non-small cell lung cancer (NSCLC) impacts patient prognosis following curative surgery.
- Results showed that larger lymph node dissections (measured by the number of nodes dissected) led to improved disease-free survival (DFS), indicating that more extensive dissections are beneficial for controlling the disease.
- However, while more dissections revealed more tumor residuals, this did not necessarily enhance the patients' innate immunity, which did not show a significant correlation with survival rates.
The recurrence and survival of oral squamous cell carcinoma: a report of 275 cases.
Chin J Cancer
November 2013
Department of Head and Neck Surgery, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, P. R. China.
Article Synopsis
- Oral squamous cell carcinoma (OSCC) has a 32.7% recurrence rate, with significant recurrence factors identified, including T stage, degree of differentiation, and pN stage.
- The time to recurrence varies widely, with a median time of 14 months post-surgery for the patients studied.
- Patients with recurrence have significantly lower survival rates at 2 and 5 years compared to those without recurrence, highlighting the need for improved treatment strategies like extended local excision and adjuvant chemoradiotherapy.