2 results match your criteria: "Cancer Center of Daping Hospital Army Medical University[Affiliation]"
Neoadjuvant immunochemotherapy (NAIC) achieves superior clinical benefits over neoadjuvant chemotherapy (NAC) in multiple types of human cancers, including gastric adenocarcinoma (GAC). However, it is poorly understood how the malignant epithelial cells and tumor immune microenvironment (TIME) might respond distinctly to NAIC and NAC that underlies therapeutic efficacy. Here treatment-naive and paired tumor tissues from multiple centers were subjected to pathological, immunological, and transcriptomic analysis.
View Article and Find Full Text PDFAPEX1 in intestinal epithelium triggers neutrophil infiltration and intestinal barrier damage in ulcerative colitis.
Free Radic Biol Med
November 2024
Cancer Center of Daping Hospital Army Medical University, Chongqing 400042, China. Electronic address:
Article Synopsis
- Ulcerative colitis (UC) generates reactive oxygen species and DNA damage, with base excision repair (BER) enzymes like APEX1 playing a crucial role in maintaining DNA integrity, yet their specific relationship with UC is not well understood.
- *A study on colon tissue from UC patients revealed that APEX1 expression is linked to the severity of inflammatory bowel disease and neutrophil activity, suggesting it influences inflammatory processes in UC.
- *APEX1 deficiency leads to reduced chemokine production and neutrophil activation, alleviating colitis symptoms, which highlights APEX1's potential as a target for clinical therapies in treating IBD.*