5 results match your criteria: "Cancer Center West China Hospital Sichuan University Chengdu Sichuan China.[Affiliation]"
Gastrointestinal tumors, the second leading cause of human mortality, are characterized by their association with inflammation. Currently, progress in the early diagnosis and effective treatment of gastrointestinal tumors is limited. Recent whole-genome analyses have underscored their profound heterogeneity and extensive genetic and epigenetic reprogramming.
View Article and Find Full Text PDFExosomes are nanoscale vesicles of cellular origin. One of the main characteristics of exosomes is their ability to carry a wide range of biomolecules from their parental cells, which are important mediators of intercellular communication and play an important role in physiological and pathological processes. Exosomes have the advantages of biocompatibility, low immunogenicity, and wide biodistribution.
View Article and Find Full Text PDFFrailty trajectory predicts subsequent cognitive decline: A 26-year population-based longitudinal cohort study.
MedComm (2020)
June 2023
Department of Biotherapy and National Clinical Research Center for Geriatrics, Cancer Center West China Hospital Sichuan University Chengdu Sichuan China.
Frailty refers to a decline in the physiological functioning of one or more organ systems. It remained unclear whether variations in the trajectory of frailty over time were associated with subsequent cognitive change. The aim of the current study was to investigate the association between frailty trajectories and subsequent cognitive decline based on the Health and Retirement Study (HRS).
View Article and Find Full Text PDFArticle Synopsis
- Cancer cells grow uncontrollably and change their metabolism to support this growth, a process influenced by genes, growth factors, and interactions with surrounding cells.
- The metabolic changes are complex and vary by tumor type and environment, often making tumors resistant to standard treatments.
- Understanding these metabolic pathways can help develop new cancer therapies, and ongoing research is essential for uncovering how these metabolic alterations work and how to target them effectively.
Pathogenesis and treatment of multiple myeloma.
MedComm (2020)
June 2022
Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu Sichuan China.
Multiple myeloma (MM) is the second-ranking malignancy in hematological tumors. The pathogenesis of MM is complex with high heterogeneity, and the development of the disease is a multistep process. Chromosomal translocations, aneuploidy, genetic mutations, and epigenetic aberrations are essential in disease initiation and progression.
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