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Effect of N-acetyl-l-cysteine on insulin resistance caused by prolonged free fatty acid elevation.
J Endocrinol
April 2015
Department of PhysiologyUniversity of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of MedicineUniversity of Toronto, Toronto, Ontario, CanadaToronto General Research InstituteUniversity Health Network, Toronto, Ontario, CanadaBanting and Best Diabetes CentreUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceUniversity of Toronto, Toronto, Ontario, CanadaSchool of PharmacyUniversity of Waterloo, Waterloo, Ontario, Canada Department of PhysiologyUniversity of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of MedicineUniversity of Toronto, Toronto, Ontario, CanadaToronto General Research InstituteUniversity Health Network, Toronto, Ontario, CanadaBanting and Best Diabetes CentreUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceUniversity of Toronto, Toronto, Ontario, CanadaSchool of PharmacyUniversity of Waterloo, Waterloo, Ontario, Canada Department of PhysiologyUniversity of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of MedicineUniversity of Toronto, Toronto, Ontario, CanadaToronto General Research InstituteUniversity Health Network, Toronto, Ontario, CanadaBanting and Best Diabetes CentreUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceUniversity of Toronto, Toronto, Ontario, CanadaSchool of PharmacyUniversity of Waterloo, Waterloo, Ontario, Canada Department of PhysiologyUniversity of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8Department of MedicineUniversity of Toronto, Toronto, Ontario, CanadaToronto General Research InstituteUniversity Health Network, Toronto, Ontario, CanadaBanting and Best Diabetes CentreUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceUniversity of Toronto, Toronto, Ontario, CanadaSchool of PharmacyUniversity of Waterloo
Circulating free fatty acids (FFAs) are elevated in obesity and cause insulin resistance. The objective of the current study was to determine whether the antioxidant N-acetyl-l-cysteine (NAC) prevented hepatic and peripheral insulin resistance caused by prolonged elevation of plasma FFAs. Chronically cannulated Wistar rats received saline (SAL), Intralipid plus heparin (IH), IH plus NAC, or NAC i.
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