Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee.

Objective: Glucosamine products have been used extensively for the management of pain in osteoarthritis (OA). We investigated the efficacy of the hydrochloride salt of glucosamine on pain and disability in knee OA.

Methods: At Week -2, subjects were examined, randomized, and instructed to take only prescribed acetaminophen for pain.