IMRT sparing of normal tissues in locoregional treatment of breast cancer.

Purpose: This clinical study was designed to prospectively evaluate the acute and moderately-late cardiac and lung toxicities of intensity modulated radiation therapy delivered by helical tomotherapy (IMRT-HT) for locoregional breast radiation treatment including the internal mammary nodes (IMN).

Material/methods: 30 patients with stage III breast cancers have been accrued in this study. All patients received adjuvant chemotherapy.

Towards an accurate and robust method based on fuzzy logic principles for the reconstruction and quantification of large volumes from MR and CT images.

The authors have previously evaluated a new method of volume reconstruction and quantification from MR images, based on fuzzy logic (FL) principles. The technique is evaluated here for larger and more complex structures by investigating its accuracy and robustness using MR and CT images. Four large (50-71 cm(3)) and complex (e.

Helical tomotherapy for locoregional irradiation including the internal mammary chain in left-sided breast cancer: dosimetric evaluation.

Purpose: To compare a standard 3- or 4-field technique to intensity modulated radiotherapy with helical tomotherapy (IMRT-HT) in the planning of locoregional breast radiation including the internal mammary chain (IMC).

Methods And Materials: For 10 women with stage III left-sided breast cancer with a planning target volume (PTV) defined by the breast/chest wall and regional nodes, radiotherapy to a dose of 50 Gy in 25 fractions was planned using a standard 3- or 4-field technique and using IMRT-HT. Various metrics were extracted from dose-volume histograms, and were compared using the paired Student's t-test.