1 results match your criteria: "Canada. 3Joslin Diabetes Center and Harvard Medical School[Affiliation]"
Muscle-specific inhibition of the classical nuclear factor-κB pathway is protective against diaphragmatic weakness in murine endotoxemia.
Crit Care Med
July 2014
1Meakins-Christie Laboratories and Respiratory Division, McGill University, Montreal, QC, Canada. 2Royal Military College Saint-Jean, Saint-Jean-sur-Richelieu, QC, Canada. 3Joslin Diabetes Center and Harvard Medical School, Boston, MA.
Article Synopsis
- The study examines how inhibiting nuclear factor-κB specifically in diaphragm muscle fibers may protect against weakness during sepsis.
- In experiments with wild-type and genetically modified mice, researchers found that endotoxemia increased proinflammatory cytokines and reduced diaphragm muscle strength in wild-type mice, while modified mice showed normalized force production despite increased caspase-3 activity.
- Overall, the findings suggest that targeting nuclear factor-κB in diaphragm muscles could mitigate inflammation and protect muscle function during severe infections like sepsis.