Treatment of discoid lupus erythematosus scarring alopecia with deucravacitinib: A case report.

Discoid lupus erythematosus is a chronic, recurring, autoimmune skin disease causing annular, scarring plaques on the head and neck. Deucravacitinib, a tyrosine kinase 2 inhibitor in the Janus kinase inhibitor family, represents an emerging treatment option in systemic lupus erythematosus with potential applicability to discoid lupus erythematosus. We describe a 48-year-old woman with multiple treatment-refractory scalp plaques and associated alopecia treated with deucravacitinib.

A case of treatment-resistant erosive pustular dermatosis of the scalp.

Erosive pustular dermatosis is a rare and chronic inflammatory condition of the scalp which can be mistaken for cutaneous malignancy, precancerous lesions, dermatitis or pyoderma gangrenosum. The recurrent and resistant characteristics of erosive pustular dermatosis of the scalp pose a challenge to successful management and remission of the condition. The purpose of this case report is to provide management options and treatment recommendations for refractory cases of erosive pustular dermatosis of the scalp.

Myths and misconceptions of intimate partner violence among sexual and gender minorities: a qualitative exploration.

Background: Intimate partner violence (IPV), referring to different forms of violence or abuse between two or more intimate partners, negatively impacts physical and mental health, performance in various settings, and familial functioning, leading to long-term adverse outcomes. Sexual and gender minority (SGM) individuals tend to experience similar or greater frequencies of IPV compared to their cisheterosexual counterparts. Stigma and discrimination toward sexual and gender diversity can lead to myths and misconceptions about relationship dynamics among SGM individuals, which can contribute to IPV occurrence within the community.

Higher physical activity levels are related to faecal microbiota diversity and composition in young adults.

Increasing physical activity (PA) is recognised as an efficacious approach for preventing and treating cardiometabolic diseases. Recently, the composition of microorganisms living within the gut has been proposed as an important appropriate target for treating these diseases. Whether PA is related to faecal microbiota diversity and composition in humans remains to be ascertained.

'Setting the Benchmark' Part 3: Contextualising the Match Demands of Specialised Positions at the FIFA Women's World Cup Australia and New Zealand 2023.

This study aimed to benchmark the match demands of specialised positions at the FIFA Women's World Cup Australia and New Zealand 2023. With FIFA's official approval, all sixty-four games at the tournament were analysed using an optical tracking system alongside FIFA's Enhanced Football Intelligence metrics. During a typical match, defensive and central midfielders covered 5-15% more total distance than centre backs, wide defenders and centre forwards (P < 0.

Quantitative assessment of orthodontic treatments performed by graduate orthodontic students of an International School of Dentistry.

Context: Assessing and monitoring treatment quality within graduate courses are vital for maintaining high standards and addressing areas needing improvement. In this study, we evaluated the treatment quality delivered by measuring the total scores obtained from the comprehensive clinical assessment (CCA) index and the objective grading system (OGS) index.

Aims: This study aimed to evaluate the quality of orthodontic treatments administered by graduate students by using the CCA index and OGS index.

Skeletal and dental effects of skeletally anchored forsus fatigue resistant devices during class II malocclusion treatment: A meta-analysis and systematic review.

Objective: To evaluate and compare the skeletal and dental treatment effects of Class II malocclusion cases using skeletally anchored Forsus (miniscrew-anchored FRD or miniplate-anchored FRD), with conventional Forsus FRD.

Materials And Methods: Unrestricted electronic search of six databases and additional manual searches were performed up to July 2023. Randomized controlled trials having one treatment arm with skeletal anchored Forsus FRD in treatment of Class II malocclusion and another matched treatment group treated with conventional Forsus FRD were included in this review.

Extracellular vimentin amplifies inflammation: Perspectives for immune injury and therapeutics for periodontitis.

Periodontitis is an inflammatory disease triggered by microbial biofilms that promote immune dysfunction and tissue destruction of tooth-supporting tissues. The search for soluble mediators that amplify inflammatory responses and matrix degradation in periodontal tissues has implicated extracellular vimentin (ECV) as a signaling ligand and damage-associated molecular pattern in the pathogenesis of periodontitis. Intracellular vimentin filaments are essential for the structural integrity of cells and the preservation of matrix homeostasis.

Identifying causal neural oscillations underlying working memory.

Electroencephalography is instrumental in understanding neurophysiological mechanisms underlying working memory. While numerous studies have associated electroencephalography features to working memory, understanding causal relationships leads to better characterization of the neurophysiological mechanisms that are directly linked to working memory. Personalized causal modeling is a tool to discover these direct links between brain features and working memory performance.

IBD in the elderly population: Epidemiology, long-term disease course, surgery rates and biological use - data from the Veszprem county cohort between 1977-2020.

Background And Aims: Limited data are available on long-term disease outcomes in elderly-onset (EO) inflammatory bowel diseases (IBD) from well-defined population-based cohorts. Our aim was to analyze incidence, disease course, surgery rates and therapeutic strategies of EO IBD in a prospective population-based cohort.

Methods: EO IBD was defined if diagnosis was established at ≥60years of age.

Recombinant Human Tissue Kallikrein-1 for Treating Acute Ischemic Stroke and Preventing Recurrence.

Novel strategies are needed for the treatment of acute ischemic stroke when revascularization therapies are not clinically appropriate or are unsuccessful. rKLK1 (recombinant human tissue kallikrein-1), a bradykinin-producing enzyme, offers a promising potential solution. In animal studies of acute stroke, there is a marked 36-fold increase in bradykinin B2 receptor on brain endothelial cells of the ischemic region.

Human Auditory-Motor Networks Show Frequency-Specific Phase-Based Coupling in Resting-State MEG.

Perception and production of music and speech rely on auditory-motor coupling, a mechanism which has been linked to temporally precise oscillatory coupling between auditory and motor regions of the human brain, particularly in the beta frequency band. Recently, brain imaging studies using magnetoencephalography (MEG) have also shown that accurate auditory temporal predictions specifically depend on phase coherence between auditory and motor cortical regions. However, it is not yet clear whether this tight oscillatory phase coupling is an intrinsic feature of the auditory-motor loop, or whether it is only elicited by task demands.

Metabolic interventions as adjunctive therapies to insulin in type 1 diabetes: Current clinical landscape and perspectives.

Type 1 diabetes (T1D) is classically characterized as an autoimmune disease wherein the immune system erroneously attacks insulin-producing pancreatic β-cells, causing insulin insufficiency and severe metabolic dysregulation. However, intensive investigation and numerous clinical trials with immunotherapies have been largely unable to significantly alter the course of disease. Currently, there is no effective way to prevent or cure T1D, and insulin remains the cornerstone of T1D treatment.

Patterned Antigens on DNA Origami Controls the Structure and Cellular Uptake of Immune Complexes.

Immune complexes (ICs), formed via antibody (Ab)-antigen (Ag) binding, trigger diverse immune responses, which are critical for natural immunity and have uses for vaccines and immunotherapies. While IC-elicited immune responses depend on its structure, existing methods for IC synthesis produce heterogeneous assemblies, which limits control over their cellular interactions and pharmacokinetics. In this study, we demonstrate the use of DNA origami to create synthetic ICs with defined shape, size, and solubility by displaying Ags in prescribed spatial patterns.

Priority actions for Fusarium head blight resistance in durum wheat: Insights from the wheat initiative.

Fusarium head blight (FHB), mainly caused by Fusarium graminearum and Fusarium culmorum, is a major wheat disease. Significant efforts have been made to improve resistance to FHB in bread wheat (Triticum aestivum), but more work is needed for durum wheat (Triticum turgidum spp. durum).

Long-term Complications From Peripheral Nerve Blocks After Pediatric Orthopaedic Lower Extremity Procedures: A Systematic Review.

Background: Peripheral nerve blocks (PNBs) are frequently utilized as a regional anesthetic in pediatric orthopaedic surgery for postoperative pain control and reduced time to discharge; however, short- and long-term complications after these procedures are variably reported.

Purpose: To identify the frequency of long-term complications in pediatric patients who received regional anesthesia for a lower extremity orthopaedic procedure.

Study Design: Systematic review; Level of evidence, 4.

Impact of Day 11 Methotrexate Dose Adjustments due to Mucositis on the Outcomes Following Allogeneic Stem Cell Transplant in the Setting of Anti Thymocyte Globulin (ATG) Based GVHD Prophylaxis.

Background: Dose adjustments of Day 11 Methotrexate (MTx) for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation (HCT) are common due to mucositis, renal injury, or other reasons. The impact of omitting or adjusting doses of MTx in the era of ATG-based GVHD prophylaxis remains unexplored.

Methods: We retrospectively analyzed the outcomes of all adult patients undergoing allogeneic HCT who received ATG-based GVHD prophylaxis at The Ottawa Hospital from January 2019 to December 2022.

e-Health Interventions for Promoting Physical Activity in Aging Adults: A Scoping Review.

The use of e-health interventions to promote physical activity (PA) among older adults has significantly increased in recent years. This review aims to comprehensively summarize the various e-health modalities and strategies used to encourage PA in aging adults. A systematic search of Medline, Embase, CINAHL, AMED, and PubMed databases was conducted to identify studies on e-health interventions targeting PA promotion in individuals aged 50 and older, published between 2012 and 2023.

Influence of Regular Statin Intake on Prostate-Specific Antigen Values, Prostate Cancer Incidence and Overall Survival in a Prospective Screening Trial (ERSPC Aarau).

Objective: While statins have demonstrated a variety of antineoplastic effects in preclinical studies, several retrospective clinical studies and observational studies have not shown a consistent chemopreventive benefit against prostate cancer (PCa). Therefore, in this population-based cohort study, we examined the association of statin intake on prostate specific antigen (PSA) values and risk of development of PCa.

Method: N = 4,314 men from the Swiss section of the European Randomized Study of Screening for Prostate Cancer (ERSPC) were evaluated.

How well is the female population represented in clinical trials with infusion therapies for Parkinson's disease? A systematic review and metanalysis.

Background: Parkinson's disease (PD) is a neurodegenerative disorder affecting both sexes, but differences exist between male and female in clinical manifestations, functional impact of symptoms and hormonal influences. Therefore, representativeness of females in PD trials indirectly determines the external validity of the clinical research in this field.

Objective: To estimate the representativeness of female in infusion therapy trials for advanced PD.