1 results match your criteria: "Canada and Ontario Institute for Cancer Research[Affiliation]"
ABC: a tool to identify SNVs causing allele-specific transcription factor binding from ChIP-Seq experiments.
Bioinformatics
September 2015
Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada and Ontario Institute for Cancer Research, Toronto, ON, Canada Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada and Ontario Institute for Cancer Research, Toronto, ON, Canada Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada and Ontario Institute for Cancer Research, Toronto, ON, Canada.
Motivation: Detection of allelic imbalances in ChIP-Seq reads is a powerful approach to identify functional non-coding single nucleotide variants (SNVs), either polymorphisms or mutations, which modulate the affinity of transcription factors for chromatin. We present ABC, a computational tool that identifies allele-specific binding of transcription factors from aligned ChIP-Seq reads at heterozygous SNVs. ABC controls for potential false positives resulting from biases introduced by the use of short sequencing reads in ChIP-Seq and can efficiently process a large number of heterozygous SNVs.
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