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WAT apoC-I secretion: role in delayed chylomicron clearance in vivo and ex vivo in WAT in obese subjects.

J Lipid Res

June 2016

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada Montreal Diabetes Research Center (MDRC), Montréal, Québec, Canada

Reduced white adipose tissue (WAT) LPL activity delays plasma clearance of TG-rich lipoproteins (TRLs). We reported the secretion of apoC-I, an LPL inhibitor, from WAT ex vivo in women. Therefore we hypothesized that WAT-secreted apoC-I associates with reduced WAT LPL activity and TRL clearance.

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