805 results match your criteria: "Canada M5S 3G3; Rotman Research Institute[Affiliation]"

Photosynthetic capacity is often quantified by the Rubisco-limited photosynthetic capacity (i.e. maximum carboxylation rate, V).

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Adaptive Huber Regression.

J Am Stat Assoc

April 2019

Honorary Professor, School of Data Science, Fudan University, Shanghai, China and Frederick L. Moore '18 Professor of Finance, Department of Operations Research and Financial Engineering, Princeton University, NJ 08544.

Big data can easily be contaminated by outliers or contain variables with heavy-tailed distributions, which makes many conventional methods inadequate. To address this challenge, we propose the adaptive Huber regression for robust estimation and inference. The key observation is that the robustification parameter should adapt to the sample size, dimension and moments for optimal tradeoff between bias and robustness.

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There is growing interest in characterizing the neural mechanisms underlying the interactions between attention and memory. Current theories posit that reflective attention to memory representations generally involves a fronto-parietal attentional control network. The present study aimed to test this idea by manipulating how a particular short-term memory (STM) representation is accessed, that is, based on its input sensory modality or semantic category, during functional magnetic resonance imaging (fMRI).

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Sex and gender differences in cognitive and brain reserve: Implications for Alzheimer's disease in women.

Front Neuroendocrinol

January 2021

Department of Psychology, University of Toronto, 100 St. George Street, Toronto, ON M5S 3G3, Canada; Rotman Research Institute, Baycrest Hospital, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada; Tema Genus, Linköping University, TEMA-huset, Entrance 37, Room E433, Campus Valla, Linköping, Sweden.

Women represent ⅔ of the cases of Alzheimer's disease (AD). Current research has focused on differential risks to explain higher rates of AD in women. However, factors that reduce risk for AD, like cognitive/brain reserve, are less well explored.

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Introduction: We assessed the utility of a battery of neuropsychological, neurocognitive, physiological (balance, ataxia, postural tremor), and neuroimaging measures for studying the effects of blast waves in breachers-a population repeatedly exposed to low-level blast during military training and operations.

Materials And Methods: Data were collected from four nonoverlapping samples, in the course of similarly structured 4-day breacher training exercises in successive years involving a combination of indoor and outdoor blast events. In all cases, self-report and neuropsychological measures were administered once at baseline (i.

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Prenatal disruption of D1R-SynGAP complex causes cognitive deficits in adulthood.

Prog Neuropsychopharmacol Biol Psychiatry

March 2021

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, M5T 1R8, Canada; Department of Physiology, Medical Sciences Building, 3rd Floor University of Toronto, 1 King's College Circle, M5S 1A8, Canada; Psychiatry, 250 College Street, 8th floor, Toronto, Ontario, M5T 1R8, Canada; Institutes of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

γ-aminobutyric acid (GABA)-ergic interneurons are essential for the physiological function of the mammalian central nervous system. Dysregulated GABAergic interneuron function has been implicated in the pathophysiology of a number of neurodevelopmental disorders including schizophrenia and autism spectrum disorder. Tangential migration is an important process to ensure the proper localization of GABAergic interneurons.

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Self-regulation is a core aspect of human functioning that helps facilitate the successful pursuit of personal goals. There has been a proliferation of theories and models describing different aspects of self-regulation both within and outside of psychology. All of these models provide insights about self-regulation, but sometimes they talk past each other, make only shallow contributions, or make contributions that are underappreciated by scholars working in adjacent areas.

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Relating goal-directed behaviour to grazing in persons with obesity with and without eating disorder features.

J Eat Disord

October 2020

Clinical Psychology Unit, School of Psychology, University of Sydney, Level 3, Building M02F, 94 Mallett St, Camperdown, NSW 2050 Australia.

Background: Both obesity and eating disorders (ED) have been associated with reductions in purposeful, flexible goal-directed behaviour, and with an overreliance on more rigid habitual behaviour. It is currently unknown whether grazing, an eating style which is common in both conditions, is related to goal-directed behaviour. The current study therefore aimed to relate grazing to goal-directed behaviour in a group of participants with obesity with and without ED features, compared to a healthy-weight control group.

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Prevailing theories posit that the hippocampus rapidly learns stimulus conjunctions during novel experiences, whereas the neocortex learns slowly through subsequent, off-line interaction with the hippocampus. Parallel evidence, however, shows that the medial prefrontal cortex (mPFC; a critical node of the neocortical network supporting long-term memory storage) undergoes rapid modifications of gene expression, synaptic structure, and physiology at the time of encoding. These observations, along with impaired learning with disrupted mPFC, suggest that mPFC neurons may exhibit rapid neural plasticity during novel experiences; however, direct empirical evidence is lacking.

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Advanced vehicle technologies and road safety: A scoping review of the evidence.

Accid Anal Prev

November 2020

School of Rehabilitation Science, Faculty of Health Science, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada; McMaster Institute for Research in Aging, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.

The proliferation of Advanced Vehicle Technologies (AVTs) has generated both excitement and concern among researchers, policymakers, and the general public. An increasing number of driver assistance systems are already available in today's automobiles; many of which are expected to become standard. Therefore, synthesizing the available evidence specific to the safety of AVTs is critical.

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Article Synopsis
  • - Working memory issues in individuals with autism correlate with more severe symptoms and negative outcomes, but the underlying brain mechanisms are not well understood, particularly concerning theta and alpha neural oscillations.
  • - A study using magnetoencephalography with adults with autism and controls found differences in how each group’s brains synchronized theta and alpha waves during working memory tasks, despite similar overall task performance.
  • - The results indicate distinct neural network engagements in autism, especially during the maintenance phase of working memory, which could inform understanding of cognitive impairments and highlight the importance of evaluating the specific components of working memory.
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Article Synopsis
  • The Stop Signal Reaction Time (SSRT) is a measurement related to how quickly the brain can stop a response, initially proposed by Logan in 1994 without considering trial types.
  • In 2017, two new indices—mixture SSRT and weighted SSRT—were introduced to better analyze SSRT over time, but a time series approach was still lacking.
  • A recent study compared a time series-based SSRT to Logan's original SSRT, finding that the new approach yields significantly larger SSRT estimates by incorporating factors like reactive and proactive inhibition effects.
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Systematic analysis for the relationship between obesity and tuberculosis.

Public Health

September 2020

Center for Heart Lung Innovation, University of British Columbia, 166-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

Objectives: Underweight or low body mass index (BMI) is an established risk factor for active tuberculosis. Recent evidence, however, suggests that overweight is associated with lower incidence of tuberculosis. The objective of this systematic review and meta-analysis is to understand the relationship between obesity and tuberculosis and document the extent of association between the two conditions over the range of BMI from underweight to obesity.

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Older adults with lower autobiographical memory abilities report less age-related decline in everyday cognitive function.

BMC Geriatr

August 2020

Department of Psychology, University of Toronto, 4th floor, Sidney Smith Hall, 100 St. George Street, Toronto, ON, M5S 3G3, Canada.

Background: Individuals differ in how they remember the past: some richly re-experience specific details of past episodes, whereas others recall only the gist of past events. Little research has examined how such trait mnemonics, or lifelong individual differences in memory capacities, relate to cognitive aging. We specifically examined trait episodic autobiographical memory (AM, the tendency to richly re-experience episodic details of past events) in relation to complaints of everyday cognitive functioning, which are known to increase with age.

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Impact of COVID-19 on household waste flows, diversion and reuse: The case of multi-residential buildings in Toronto, Canada.

Resour Conserv Recycl

January 2021

Toronto Environmental Alliance, 30 Duncan Street. Suite B1, Toronto, Ontario, Canada M5V 2C3.

The COVID-19 pandemic has had numerous environmental consequences, including impacts on municipal waste management systems. Changes in consumption and waste disposal patterns and behaviours during the lockdown period have produced new challenges for solid waste management and waste diversion activities. This paper develops a conceptual model that reflects short-term changes in waste flows from households that are due to COVID-19 disruptions, focusing on the case of multi-residential buildings in Toronto, Canada.

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Large stocks of peatland carbon and nitrogen are vulnerable to permafrost thaw.

Proc Natl Acad Sci U S A

August 2020

Department of Earth and Environmental Sciences, Lehigh University, Bethlehem, PA 18015.

Northern peatlands have accumulated large stocks of organic carbon (C) and nitrogen (N), but their spatial distribution and vulnerability to climate warming remain uncertain. Here, we used machine-learning techniques with extensive peat core data ( > 7,000) to create observation-based maps of northern peatland C and N stocks, and to assess their response to warming and permafrost thaw. We estimate that northern peatlands cover 3.

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The impact of the Syrian conflict on population well-being.

Nat Commun

August 2020

School of Public Health, LKS Faculty of Medicine, University of Hong Kong, 1/F Patrick Manson Building (North Wing), 7 Sassoon Road, Pokfulam, Hong Kong, China.

The United Nations described the Syrian conflict as the worst man-made disaster since World War II. We adopted a global perspective in examining the impact of the Syrian conflict on Syrians' physical, mental, and social well-being using the Gallup World Poll. Face-to-face interview data of 11,452 Syrian participants from 2008 to 2015 show that Syrians' physical (e.

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Mnemonic prediction errors bias hippocampal states.

Nat Commun

July 2020

Department of Psychology, Columbia University, New York, NY, 10027, USA.

When our experience violates our predictions, it is adaptive to upregulate encoding of novel information, while down-weighting retrieval of erroneous memory predictions to promote an updated representation of the world. We asked whether mnemonic prediction errors promote hippocampal encoding versus retrieval states, as marked by distinct network connectivity between hippocampal subfields. During fMRI scanning, participants were cued to internally retrieve well-learned complex room-images and were then presented with either an identical or a modified image (0-4 changes).

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Background: Medications for smoking cessation are currently only effective in helping a minority of smokers quit. Drug development is slow and expensive; as such, there is much interest in optimizing the effectiveness of existing treatments and medications. Current standard doses of nicotine replacement therapy are not effective for many smokers, and in many cases, the amount of nicotine provided is much less than when a smoker is smoking their usual number of cigarettes.

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Background: Ontario's human-rights legislation and institutions' support for students with disabilities have influenced these students' increased enrolment in the postsecondary environment. Yet more attention is paid to in-classroom than to out-of-classroom experiences. Students with disabilities enrolled in nursing are least likely to be accommodated.

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Human rights language has become a common method of internationally denouncing violent, discriminatory or otherwise harmful practices, notably by framing them as reprehensible violations of those fundamental rights we obtain by virtue of being human. While often effective, such women's rights discourse becomes delicate when used to challenge practices, which are of important cultural significance to the communities in which they are practiced. This paper analyses human rights language to challenge the gender disparity in access to health care and in overall health outcomes in certain countries where such disparities are influenced by important cultural values and practices.

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Can the AUDIT consumption items distinguish lower severity from high severity patients seeking treatment for alcohol use disorder?

J Subst Abuse Treat

July 2020

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, 33 Russell St., Toronto, Ontario M5S 2S1, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 33 Russell St., Toronto, Ontario M5S 2S1, Canada; Department of Psychiatry, University of Toronto, 250 College St., Toronto, Ontario M5T 1R8, Canada; Department of Psychology, University of Toronto, 100 St. George Street, Toronto, ON M5S 3G3, Canada. Electronic address:

Brief screening tools based on the Alcohol Use Disorders Identification Test (AUDIT) consumption items (e.g., AUDIT-C and AUDIT-3) are commonly used in general medical settings to identify at-risk drinkers who may benefit from alcohol interventions.

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Communication and oscillatory synchrony between distributed neural populations are believed to play a key role in multiple cognitive and neural functions. These interactions are mediated by long-range myelinated axonal fiber bundles, collectively termed as white matter. While traditionally considered to be static after development, white matter properties have been shown to change in an activity-dependent way through learning and behavior-a phenomenon known as white matter plasticity.

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