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Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I).
Pain
October 2010
Department of Anesthesia, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6 Department of Neurology & Neurosurgery, McGill University, 3801 University Ave., Montreal, Quebec, Canada H3A 2B4 Department of Psychology, McGill University, 1205 Dr. Penfield Ave., Montreal, Quebec, Canada H3A 1B1 Department of Pharmacology & Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6 Faculty of Dentistry, McGill University, 3640 University Ave., Montreal, Quebec, Canada H3A 2B2 Alan Edwards Centre for Research on Pain, McGill University, 740 Dr. Penfield Ave., Montreal, Quebec, Canada H3A 1A4 McGill University Health Centre Research Institute, 2155 Guy St., Montreal, Quebec, Canada H3H 2R9.
Chronic post-ischemic pain (CPIP) is an animal model of CRPS-I developed using a 3-h ischemia-reperfusion injury of the rodent hind paw. The contribution of local endothelin to nociception has been evaluated in CPIP mice by measuring sustained nociceptive behaviors (SNBs) following intraplantar injection of endothelin-1 or -2 (ET-1, ET-2). The effects of local BQ-123 (ETA-R antagonist), BQ-788 (ETB-R antagonist), IRL-1620 (ETB-R agonist) and naloxone (opioid antagonist) were assessed on ET-induced SNBs and/or mechanical and cold allodynia in CPIP mice.
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