1,154,777 results match your criteria: "Canada ; Mazankowski Alberta Heart Institute[Affiliation]"

Fluoride Exposure and Children's IQ Scores: A Systematic Review and Meta-Analysis.

JAMA Pediatr

January 2025

Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.

Importance: Previous meta-analyses suggest that fluoride exposure is adversely associated with children's IQ scores. An individual's total fluoride exposure comes primarily from fluoride in drinking water, food, and beverages.

Objective: To perform a systematic review and meta-analysis of epidemiological studies investigating children's IQ scores and prenatal or postnatal fluoride exposure.

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  • Soft robotics is being explored for rehabilitation, offering potential benefits for individuals recovering upper limb motor function after injuries, with an emphasis on increased safety and comfort compared to traditional rigid robotics.
  • The article reviews clinical evidence from 37 studies on 13 different soft upper limb devices used in both clinical and home environments, assessing their effectiveness and user experience.
  • It aims to guide future developments in soft robotic rehabilitation by providing recommendations for design and application, highlighting the importance of understanding user needs and clinical outcomes.
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  • Photoresponsive drug delivery systems offer enhanced cancer treatment but face issues with size and limited light penetration.
  • A new near infrared responsive system was created using azobenzene-modified silica nanoparticles that release a drug upon specific light excitation.
  • The design allows for targeted delivery to cancer cell nuclei, facilitating DNA damage and cell destruction, making it a promising approach for effective cancer therapy.
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  • MASLD (formerly NAFLD) is a significant cause of liver disease and there are limited treatment options available to prevent liver fat accumulation.
  • Research indicates that vasoactive intestinal peptide-producing neurons (VIP-neurons) impact fat absorption and IL-22 production, which may help protect the liver.
  • In experiments on mice, decreased communication between VIP-neurons and type 3 innate lymphoid cells (ILC3) led to increased IL-22 production and reduced liver fat, suggesting this neuroimmune pathway could be a promising target for new therapies.
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  • The study analyzed health behaviors of children and youth in rural versus urban areas who participated in the Generation Health Clinic in British Columbia, focusing on diet, physical activity, and sleep from 2015 to 2019.
  • Urban children had healthier eating habits, such as more family meals and less frequent consumption of sports drinks, compared to their rural counterparts.
  • No notable differences in health behaviors were observed among adolescents, indicating that geographical location is an important factor in tailoring family-based weight management programs.
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Priority Clinical Actions for Outpatient Management of Nonhospitalized Traumatic Brain Injury.

J Neurotrauma

January 2025

Zuckerberg San Francisco General Hosptial and Trauma Center, University of California, San Francisco, San Francisco, California, USA.

Outpatient care following nonhospitalized traumatic brain injury (TBI) is variable, and often sparse. The National Academies of Sciences, Engineering, and Medicine's 2022 report on highlighted the need to improve the consistency and quality of TBI care in the community. In response, the present study aimed to identify existing evidence-based guidance and specific clinical actions over the days to months following nonhospitalized TBI that should be prioritized for implementation in primary care.

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  • Ruxolitinib cream, shown to be safe and effective in a phase 3 study, has demonstrated its anti-inflammatory and itch-relieving properties in children aged 2-11 with mild to moderate atopic dermatitis (AD).
  • The study focused on assessing safety, tolerability, pharmacokinetics, and quality of life while using the cream at maximum levels over longer periods, with 29 children participating and applying the cream twice daily for 4 weeks, followed by individualized usage.
  • Results indicated that 31% of participants experienced treatment-related adverse events, but no severe health issues arose, and significant improvements in skin condition and quality of life were sustained for up to 52 weeks.
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Purpose: Class III obesity (body mass index [BMI] ≥ 40 kg·m) is associated with high rates of Cesarean deliveries and postpartum hemorrhage, with increased maternal and fetal morbidity. The doses of oxytocin and carbetocin are two to four times higher at Cesarean delivery in patients with class III obesity. We sought to investigate the efficacy of carbetocin 80 µg iv compared with oxytocin 1 IU iv (plus infusion) at elective Cesarean delivery in parturients with class III obesity.

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Use of nicotine products, prescription drug products, and other methods to stop smoking by US adults in the 2022 National Health Interview Survey.

Intern Emerg Med

January 2025

Department of Social and Behavioral Sciences, School of Global Public Health, New York University, New York, NY, USA.

Article Synopsis
  • A recent CDC survey analyzed methods used by US adults to stop smoking, showing that around 2.9 million adults successfully quit for at least 6 months in the last year.
  • Most successful quitters were younger, educated, male, non-Hispanic White, and commonly used nicotine products, especially e-cigarettes, compared to less popular options like prescription drugs.
  • The study highlights that many adults still try to quit smoking without support, suggesting a need for targeted interventions to help those who struggle the most in quitting, using proven methods.
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  • The study investigates the degradation of ciprofloxacin (CIP) using a photocatalyst made from CoFeO@3D-TiO and graphene aerogel, achieving complete removal under specific conditions within 60 minutes while showing high reusability.
  • Intermediate products from the degradation process were found to be non-toxic to E. coli, and total organic carbon (TOC) analysis showed 86% mineralization of CIP, indicating successful transformation of non-biological sewage to biodegradable effluent.
  • The research emphasizes the effectiveness of photocatalysis over simple adsorption with a significantly faster reaction rate, showcasing the potential environmental benefits of using the synthesized photocatalyst under visible light.
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  • Tarhana is a traditional fermented food known for its nutritional benefits and shelf life, and this study explored how adding pea protein isolate (PPI) affects its properties.
  • As the amount of PPI increased in tarhana, the protein content rose significantly, reaching over 76% in the highest PPI formulation, and also increased the antioxidant capacity and key polyphenols.
  • The study found that PPI not only improved the digestibility of the protein and lowered the glycemic index of tarhana, making it healthier, but also showed potential for enhancing the nutritional profile of this traditional food.
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Incarceration is associated with higher mortality after trauma: An unreported health care disparity.

J Trauma Acute Care Surg

January 2025

From the Division of Plastic and Reconstructive Surgery, Department of Surgery (H.N.-P.), Albany Medical Center, Albany, New York; Johns Hopkins Bloomberg School of Public Health (H.N.-P., E.R.H.); Division of Acute Care Surgery, Department of Surgery (J.P.B., E.R.H.), Johns Hopkins Medicine, Baltimore, Maryland; Division of General Surgery, Department of Surgery (J.P.B.), University of British Columbia, Vancouver, British Columbia, Canada; and Department of Plastic and Reconstructive Surgery (C.S.H.), WakeMed Health and Hospitals, Raleigh, North Carolina.

Background: While the United States has the highest incarceration rate worldwide, at nearly 1% of the adult population (more than 2 million people), insights regarding health disparities in this population remain limited. This retrospective cohort study represents the largest national database analysis of incarcerated trauma patients to date and investigates whether incarceration status is an independent risk factor for poor outcomes after trauma for US adults.

Methods: We analyzed data from the National Trauma Data Bank from 2017 to 2018.

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Equity, diversity, and inclusion (EDI) in veterinary medicine affects veterinarians, students, clients, and the regional availability of veterinary services. Veterinary students from 5 colleges in Canada and 5 colleges in the United States were surveyed about their challenges, experiences, and perceptions related to EDI, resulting in 456 responses (10.4%).

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Time is a central dimension against which perception, action, and cognition play out. From anticipating when future events will happen to recalling how long ago previous events occurred, humans and animals are exquisitely sensitive to temporal structure. Empirical evidence seems to suggest that estimating time prospectively (i.

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Mnong Râlâm is a South Bahnaric language (Austroasiatic) that is traditionally described as preserving a voicing contrast in onset obstruents, contrary to other languages of the Mnong/Phnong continuum. Acoustic results yield evidence that this voicing distinction is less robust than previously suggested and is redundant with a register contrast realized on following vowels through modulations of F1 at vowel onset (and more limited variations of F2 and voice quality). A perception experiment also shows that F1 weighs heavier than closure voicing in identification.

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  • Pulmonary sequestration is a rare congenital lung issue where abnormal lung tissue is supplied by a wrong artery, most commonly seen in the intralobar form.
  • Patients often experience symptoms like recurrent coughing up blood and lung infections.
  • Surgical treatment involves carefully removing the affected tissue while protecting healthy lung, with techniques to minimize the risk of bleeding from the abnormal arteries during the procedure.
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The Hallmarks of Predictive Oncology.

Cancer Discov

January 2025

Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California.

As the field of artificial intelligence evolves rapidly, these hallmarks are intended to capture fundamental, complementary concepts necessary for the progress and timely adoption of predictive modeling in precision oncology. Through these hallmarks, we hope to establish standards and guidelines that enable the symbiotic development of artificial intelligence and precision oncology.

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  • The study aimed to evaluate the safety and effectiveness of alfapump for controlling ascites and improving patients' quality of life.
  • Results showed a significant reduction in the need for therapeutic paracentesis (TP) after implanting alfapump, with most patients experiencing over a 50% decrease in sessions.
  • While some complications led to device removal, overall, the alfapump improved symptoms and physical health, suggesting it could be a viable option for patients with refractory ascites.
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As a tool for operationalizing basic psychological needs theory (an aspect of self-determination theory), the Basic Psychological Needs Satisfaction and Frustration Scale (BPNSFS) has become the primary self-report measure. Here, with a sample of 807 Canadian military members, we confirm the BPNSFS six content factor structure and, in supporting that structure, demonstrate the differential association of satisfaction and frustration scales with psychological functioning variables that are external to the factor analysis. Although the specific content interpretation of the BPNSFS can be debated, we support the continued use of the BPNSFS as a psychometrically sound instrument.

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Continental glaciations during the Pleistocene Epoch created complex systems of aquifers and aquitards across many northern regions of the Earth. The low hydraulic conductivities of glacial till aquitards suggest that limited recharge will reach the underlying aquifers, potentially preserving old groundwaters. Here, we characterize the recharge history in intertill and buried valley aquifers in Saskatchewan, Canada using C, H, He δH, δO, and major ions.

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Rapidly spreading with OXA-48-like carbapenemases.

J Clin Microbiol

January 2025

Division of Microbiology, Alberta Precision Laboratories, Calgary, Alberta, Canada.

(mostly , ) with OXA-48-like carbapenemases (e.g., OXA-48, -181, -232, -244) are undermining the global efficiency of carbapenem therapy.

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