The impacts on population health by China's regional health data centers and the potential mechanism of influence.

Background: China recently established a series of pilot regional health data centers with a mandate to acquire, consolidate, analyze, and translate data into evidence for health policy decision-making. This experiment with "big data" has the potential to influence population health and is the focus of this study.

Methods: This study used national longitudinal survey data from the China Family Panel Studies over the period 2014-2020 to empirically assess the impact of China's establishment of pilot regional health data centers on population health and health inequality.

Effect of Replacing Inorganic Copper, Zinc, and Selenium with Chelated Minerals on Productive Performance, Nutrient Utilization, Tibia Morphology, and Intestinal Histology of Growing Japanese Quail ().

This study evaluated the impact of replacing inorganic mineral sources of Cu, Zn, and Se with chelated organic minerals (OM) on performance, nutrient and mineral utilization rates, and intestinal morphometry in growing Japanese quails (). A total of 150 nine-day-old quails were randomly assigned to receive one of the following diets over 4 weeks: CTRL (100% inorganic minerals), OM33 (replacement of 33% inorganic minerals), OM67 (replacement of 67% inorganic minerals), and OM100 (100% organic minerals). Quails fed the OM67 diet exhibited higher ( < 0.

Mechanism study on the enhancement of bile acid-binding capacity in corn by-product juice via HY127 fermentation.

Hyperlipidemia is a common endocrine metabolic disease in humans. Long-term medications often have adverse effects, making the search for safer and more effective treatments crucial. This study aimed to explore the impacts and mechanisms of HY127 fermentation on enhancing bile acid-binding capacity (BABC).

Is provisioning rate of parents and helpers influenced by the simulated presence of novel individuals?

Abstract: Cooperative behaviour is widespread in animals and is likely to be the result of multiple selective pressures. A contentious hypothesis is that helping enhances the probability of obtaining a sexual partner (i.e.

A Systematic Review of Knowledge, Attitude, and Perception Towards Electroconvulsive Therapy (ECT) in Africa.

Background: Despite growing evidence showing ECT's efficacy and efficiency in the management of severe mental health conditions, the knowledge, attitude, and perceptions (KAP) towards ECT vary around the globe. However, KAP guarantees the extent to which ECT is accepted and administered efficiently. This review sheds light on the KAP toward ECT in Africa.

Do coastal salt mudflats (sabkhas) contribute to the blue carbon sequestration?

Unlabelled: Blue carbon represents the organic carbon retained in marine coastal ecosystems. (an Arabic for "mudflats"), formed in tidal environments under arid conditions, have been proposed to be capable of carbon sequestrating. Despite the growing understanding of the critical role of blue carbon ecosystems, there is a current dispute about whether sabkhas around the Persian Gulf can contribute to carbon retention as a blue carbon ecosystem.

Outcomes of a non-diffractive extended depth of focus intraocular lens in patients with well-controlled glaucoma and ocular hypertension.

Aim: To assess visual outcomes and satisfaction of a non-diffractive extended depth of focus (EDOF) intraocular lens (IOL) in individuals with ocular hypertension (OHT) and well-controlled mild glaucoma undergoing cataract surgery.

Methods: An investigator-initiated, single-center, prospective, interventional, noncomparative study conducted in Montreal, Canada. The study enrolled 31 patients (55 eyes) with OHT or mild glaucoma who received a non-diffractive EDOF IOL (Acrysof IQ Vivity).

Characterization of the Porosity and Permeability of Gasified Coal in UCG Process: An Experimental and Simulation Study.

Under the environment of energy transformation in the world, underground coal gasification (UCG) is an important means to realize the green and clean development and utilization of deep coal resources. Due to a series of complex chemical reactions, the porosity and permeability of coal have changed significantly. Accurately characterizing the porosity and permeability of gasified coal is of great significance to the field screening, production control, and numerical simulation of the UCG project.

Controlled PVA Release from Chemical-Physical Interpenetrating Networks to Treat Dry Eyes.

Dry eye disease is becoming increasingly prevalent, and lubricating eye drops, a mainstay of its treatment, have a short duration of time on the ocular surface. Although there are various drug delivery methods to increase the ocular surface residence time of a topical lubricant, the main problem is the burst release from these delivery systems. To overcome this limitation, herein, a chemical-physical interpenetrating network (IPN) was fabricated to take control over the release of poly(vinyl alcohol) (PVA), a well-known therapeutic agent used to stabilize tear film, from gelatin methacrylate (GelMA) hydrogels.

Determining the Starting Time of CO Injection and Its Implications for the CO-ECBM Process.

Determining the starting time of the CO injection is the key factor affecting the effect of CO injection and CH production. This study uses the Panyidong mine in the Huainan mining area as an example. First, fully coupled mathematical models are established.

Selected Ion Extraction of Peptides with Heavy Isotopes and Hydrogen Loss Reduces the Type II Error in Plasma Proteomics.

Naturally occurring peptides display a wide mass distribution after ionization due to the presence of heavy isotopes of C, H, N, O, and S and hydrogen loss. There is a crucial need for sensitive methods that collect as much information as possible about all plasma peptide forms. Statistical analysis of the delta mass distribution of peptide precursors from MS/MS spectra that were matched to 63,077 peptide sequences by X!TANDEM revealed Gaussian peaks representing heavy isotopes and hydrogen loss at integer delta mass values of -3, -2, -1, 0, +1, +2, +3, +4, and +5 Da.

Improving the Stability of Gas Diffusion Electrodes for CO Electroreduction to Formate with Sn and In-Based Catalysts at 500 mA cm: Effect of Electrode Design and Operation Mode.

The electrochemical carbon dioxide reduction reaction (CORR) using renewable electricity sources could provide a sustainable solution for generating valuable chemicals, such as formate salt or formic acid. However, an efficient, stable, and scalable electrode generating formate at industrially viable current densities (>100 mA cm) is yet to be developed. Sn or In-based catalysts in gas diffusion electrodes (GDE) can efficiently produce formate.

Coupled 4D Flow-Geomechanics Simulation to Characterize Dynamic Fracture Propagation in Tight Sandstone Reservoirs.

Although China's low-permeability and tight oil reservoir utilization and newly proven reserves are growing annually, the overall recovery of such reservoirs is generally low. One of the main factors influencing the low recovery is the effect of intricate dynamic fracture propagations on the remaining oil distribution. Constrained by the evolution of an in situ stress field and the accumulation of fluid injection volumes, the growth of dynamic fractures allows a production profile of water breakthrough.

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights From Comprehensive Multicenter Preclinical Studies.

Background: Pulmonary arterial hypertension (PAH) is characterized by obliterative vascular remodeling of the small pulmonary arteries (PAs) and progressive increase in pulmonary vascular resistance leading to right ventricular failure. Although several drugs are approved for the treatment of PAH, mortality rates remain high. Accumulating evidence supports a pathological function of integrins in vessel remodeling, which are gaining renewed interest as drug targets.

Association between oral feeding versus enteral feeding and cerumen impaction in older hospitalized adults: A retrospective cohort study.

Background: Chewing involves jaw movements that propel cerumen along the ear canal. This mechanism may be reduced in dysphagia, especially for older individuals who are enterally fed. Those patients may be at a higher risk for cerumen impaction and may require longer hospital stays.

Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.

Aims: Despite receiving guideline-directed medical heart failure (HF) therapy, patients with pulmonary hypertension associated with left heart disease (PH-LHD) experience higher mortality and hospitalization rates than the general HF population. AZD3427 is a functionally selective, long-acting mimetic of relaxin, a hormone that has the potential to induce vasodilation and prevent fibrosis. In a phase 1b study conducted in patients with HF, AZD3427 demonstrated a favourable safety and pharmacokinetic profile.

A Joint Bayesian Model for Change-Points and Heteroskedasticity Applied to the Canadian Longitudinal Study on Aging.

Maintaining homeostasis, the regulation of internal physiological parameters, is essential for health and well-being. Deviations from optimal levels, or 'sweet spots,' can lead to health deterioration and disease. Identifying biomarkers with sweet spots requires both change-point detection and variance effect analysis.

In-Hospital Outcomes after Robotic Open Radical Nephroureterectomy.

To test whether the contemporary robot-assisted nephroureterectomy (RNU) is associated with more favorable in-hospital outcomes than historical RNU, relative to the same endpoints in open NU (ONU). Within the National Inpatient Sample (2008-2019), we identified RNU and ONU patients. Multivariable logistic and Poisson regression models were fitted.

Comprehensive DFT investigation of small-molecule adsorption on the paradigm M-MOF-74 family of metal-organic frameworks.

The capture of toxic chemicals such as NH, HS, NO and SO is essential due to the tremendous threats they pose to human health and the environment. The M-MOF-74 family of metal-organic frameworks has recently gained attention as a promising category of sorbent materials for the capture of toxic chemicals; however, no clear and comprehensive relationships have been established between the capability of the M-MOF-74 to capture all target toxic chemicals and their properties such as the nature and magnetic state of the metal sites. Density-functional theory (DFT) is employed to investigate the binding energy of target molecules on M-MOF-74 with different metals including Mg, Ti, V, Cr, Mn, Fe, Co, Ni, Cu and Zn.

Prospective study on time-to-tertiary care in alcohol-associated hepatitis: space-time coordinates as prognostic tool and therapeutic target.

Background And Aims: Alcohol-associated hepatitis (AH) frequently triggers acute decompensation (AD) in cirrhosis, with severe AH linked to high short-term mortality, especially in acute-on-chronic liver failure. Current corticosteroid treatments have limited efficacy, highlighting the need for new therapies. We hypothesized that severe AH outcomes are influenced by early specialized care; thus, we examined the impact of time-to-tertiary care (TTTc).

Combinatorial Nanoparticle-Bound ssDNA Oligonucleotide Library Synthesized by Split-and-Pool Synthesis.

Synthetic ssDNA oligonucleotides hold great potential for various applications, including DNA aptamers, DNA digital data storage, DNA origami, and synthetic genomes. In these contexts, precise control over the synthesis of the ssDNA strands is essential for generating combinatorial sequences with user-defined parameters. Desired features for creating synthetic DNA oligonucleotides include easy manipulation of DNA strands, effective detection of unique DNA sequences, and a straightforward mechanism for strand elongation and termination.

Methods for data extraction and data transformation in convergent integrated mixed methods systematic reviews.

Objective: The objective of this guidance paper is to describe data transformation involving qualitization, including when and how to undertake this process, and to clarify how it aligns with data extraction in order to expand on the current guidance for JBI convergent integrated mixed methods systematic reviews (MMSRs).

Introduction: The convergent integrated approach to MMSRs involves combining extracted data from both quantitative studies (including the quantitative components of mixed methods studies) and qualitative studies (including the qualitative components of mixed methods studies). This process requires data transformation, which can occur either by converting qualitative data into quantitative data (ie, quantitizing) or converting quantitative data into qualitative data (ie, qualitizing).

Preservation of sexual function with Optilume-a novel treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia.

Background: The Optilume benign prostatic hyperplasia (BPH) catheter system is a novel minimally invasive paclitaxel-coated dilation system that has demonstrated substantial and durable results in urinary flow and symptoms.

Aim: We now assess the impact of Optilume BPH procedure on sexual function.

Methods: Prior published results have described the methods of data collection during the PINNACLE study, which demonstrated durable improvement in urinary symptoms.

A Bayesian joint bent-cable model for longitudinal measurements and survival time with heterogeneous random-effects distributions.

Biomarkers are measured repeatedly in clinical studies until a pre-defined endpoint, such as death from certain causes, is reached. Such repeated measurements may present a dynamic process for understanding when to expect the study's endpoint. Joint modelling is often employed to handle such a model.

Update to the PRISMA guidelines for network meta-analyses and scoping reviews and development of guidelines for rapid reviews: a scoping review protocol.

Objective: The objective of this scoping review is to develop a list of items for potential inclusion in the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) reporting guidelines for network meta-analysis (NMA), scoping reviews (ScRs), and rapid reviews (RRs).

Introduction: The PRISMA extensions for NMA and ScRs were published in 2015 and 2018. However, since then, their methodologies and innovations, including automation, have evolved.