1,155,777 results match your criteria: "Canada; and Research Centre on Aging[Affiliation]"

Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell size checkpoints, which delay cell cycle progression in small cells, and size-dependent regulation of mass accumulation rates (Ginzberg et al., 2018).

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Background: We aimed to identify the central lifestyle, the most impactful among lifestyle factor clusters; the central health outcome, the most impactful among health outcome clusters; and the bridge lifestyle, the most strongly connected to health outcome clusters, across 29 countries to optimise resource allocation for local holistic health improvements.

Methods: From July 2020 to August 2021, we surveyed 16 461 adults across 29 countries who self-reported changes in 18 lifestyle factors and 13 health outcomes due to the pandemic. Three networks were generated by network analysis for each country: lifestyle, health outcome, and bridge networks.

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The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and II to prefrontal regions. This differential connectivity pattern leads to the hypothesis that individual differences in structure should be related, especially for connected regions.

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MXenes, have been considered as a new generation anode material in lithium-ion batteries for lower lithium-ion diffusion barriers and superior conductivity. Unfortunately, their structures are prone to aggregation and stacking, hindering further shuttle of lithium ions and electrons, resulting in lower discharge capacity. Therefore, the introduction of interlayer spacers for the preparation of MXene-based hybrids has attracted much attention.

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Linking the macroscopic flow properties and nanoscopic structure is a fundamental challenge to understanding, predicting, and designing disordered soft materials. Under small stresses, these materials are soft solids, while larger loads can lead to yielding and the acquisition of plastic strain, which adds complexity to the task. In this work, we connect the transient structure and rheological memory of a colloidal gel under cyclic shearing across a range of amplitudes a generalized memory function using rheo-X-ray photon correlation spectroscopy (rheo-XPCS).

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This review examines the role of the canine blood-brain barrier (BBB) in health and disease, focusing on the impact of the multidrug resistance (MDR) transporter P-glycoprotein (P-gp) encoded by the gene. The BBB is critical in maintaining central nervous system homeostasis and brain protection against xenobiotics and environmental drugs that may be circulating in the blood stream. We revise key anatomical, histological and functional aspects of the canine BBB and examine the role of the gene mutation in specific dog breeds that exhibit reduced P-gp activity and disrupted drug brain pharmacokinetics.

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Chronic physical conditions (CPC) and alcohol and substance use disorders (SUD) frequently co-occur, but this has not been examined perinatally. We explored the combined effects of CPC and prepregnancy SUD on perinatal SUD-related adverse events and outpatient care. This population-based study comprised 77,474 people with and 664,751 without CPC with a birth in Ontario, Canada, 2013-2020.

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Beyond the Surface: Tracing the Evolution of Inflammatory Mechanism in Depression through Bibliometric Analysis.

Endocr Metab Immune Disord Drug Targets

January 2025

Department of Stress Medicine, Faculty of Psychology, Second Military Medical University, Shanghai 200433, China.

Background: Depression is a common mental illness that has become a major economic burden worldwide. Recently, increasing evidence has highlighted the inflammatory mechanism of depression. In order to understand the research status of this field, this study used the bibliometric analysis method to overview the research content and progress, as well as analyze the development trend and limitations.

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Background: Alterations in cellular metabolism affect cancer survival and can manifest in metrics of body composition. We investigated the effects of various body composition metrics on survival in patients with glioblastoma (GBM).

Methods: We retrospectively analyzed patients who had an abdominal and pelvic computed tomography (CT) scan performed within 1 month of diagnosis of GBM (178 participants, 102 males, 76 females, median age: 62.

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Quantum walks on photonic platforms represent a physics-rich framework for quantum measurements, simulations and universal computing. Dynamic reconfigurability of photonic circuitry is key to controlling the walk and retrieving its full operation potential. Universal quantum processing schemes based on time-bin encoding in gated fibre loops have been proposed but not demonstrated yet, mainly due to gate inefficiencies.

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Autonomic dysfunction is a common and early complication among patients with systemic sclerosis, suggesting that it may play a role in the pathogenesis of the disease and be a potential target for therapeutic interventions. Although the true prevalence of autonomic dysfunction among patients with systemic sclerosis is still unclear, it is estimated that as many as 80% of patients may be affected. Autonomic dysfunction may lead to widespread multi-organ dysfunction through its effects on the cardiovascular system, gastrointestinal tract, urinary tract, sweat and salivary glands, and pupils.

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Valve-sparing aortic root replacements have acceptable reintervention rates in patients with failed pulmonary autografts after a Ross procedure. In our 50-year-old patient with post-Ross valve-sparing aortic root replacement, we report preoperative and postoperative 4-dimensional flow magnetic resonance imaging capturing changes in peak systolic velocity, 3-dimensional systolic flow profiles, and aortic wall shear stress that may predict a decreased risk of aortic dilation, a common complication in repeated Ross procedures.

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A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery.

Ann Thorac Surg Short Rep

September 2023

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York.

Background: This analysis was conducted to characterize contemporary randomized controlled trials (RCTs) in cardiothoracic surgery.

Methods: We selected randomized controlled trials published in the journals with the highest impact factor in medicine, general surgery, and cardiothoracic surgery and published between 2008 and 2020. Trial characteristics as well as measures of reporting and quality were summarized and compared.

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Stent Graft Migration Causing Two Aortic Wall Injuries 10 Years After Type II Hybrid Arch Repair.

Ann Thorac Surg Short Rep

September 2023

Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.

Hybrid arch repair (HAR) combines surgical reconstruction of the ascending aorta and arch debranching with stent graft deployment into the descending thoracic aorta in an effort to reduce the morbidity associated with conventional open total arch replacement. We describe a case of delayed presentation for 2 thoracic aortic wall injuries caused by stent graft migration after type II HAR. This report highlights an important late complication of HAR and the need for careful device selection.

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#ExploratoryAnalysisOfSentimentTowardABAonTwitter.

Behav Anal Pract

December 2024

Faculty of Education, Western University, 1137 Western Road, London, Ontario N6G 1G7 Canada.

Naturalistic observation of verbal behavior on social media is a method of gathering data on the acceptability of topics of social interest. In other words, online social opinion may be a modern-day measure of social validity. We sought to gain an objective understanding of online discourse related to the field of applied behavior analysis (ABA).

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Doctors' knowledge, practices, challenges, and limitations regarding disclosure of bad news: A multicentre study from Pakistan.

J Family Med Prim Care

December 2024

Department of Research Development and Cooperation, Pakistan Medical Research Council, Islamabad, Pakistan.

Background: Breaking bad news is one of the most difficult tasks for practicing doctors, especially for those working in health care specialties where life-threatening diseases are diagnosed and managed routinely. Our aim was to elicit the knowledge and practices of doctors and identify barriers faced by them in disclosure of bad news across the provinces of Pakistan.

Methods: Cross-sectional, multi-centered study supported by an external grant in 15 Government and Private Hospitals across Pakistan.

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The tightly-regulated spatial and temporal distribution of zinc ion concentrations within cellular compartments is controlled by two groups of Zn transporters: the 14-member ZIP/SLC39 family, facilitating Zn influx into the cytoplasm from the extracellular space or intracellular organelles; and the 10-member ZnT/SLC30 family, mobilizing Zn in the opposite direction. Genetic aberrations in most zinc transporters cause human syndromes. Notably, previous studies demonstrated osteopenia and male-specific cardiac death in mice lacking the ZnT5/ zinc transporter, and suggested association of two homozygous frameshift variants with perinatal mortality in humans, due to hydrops fetalis and hypertrophic cardiomyopathy.

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Engaging or Deterring the Next Generation? An Analysis of Fees for Cardiac Surgery Conferences.

Ann Thorac Surg Short Rep

December 2023

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Background: Conferences are valuable platforms for academic discourse. However, trainees, individuals with lower income backgrounds, and attendees from low- and middle-income countries (LMICs) often face significant financial barriers that may limit accessibility to conferences. This study evaluates fees for attending international cardiac surgery conferences to better understand potential financial barriers.

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Background: The objective of this study was to report the 5-year outcomes of hybrid arch frozen elephant trunk (FET) procedures with a multibranched hybrid graft.

Methods: Between 2014 and 2020, 50 consecutive patients (63 ± 15 years old; 34% women) underwent hybrid arch FET with Thoraflex hybrid graft (Terumo Aortic) at a single center. Indications included aortic aneurysm (n = 48 [96%]), acute aortic dissection (n = 10 [20%]), and chronic dissection (n = 20 [40%]).

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Ex vivo lung perfusion (EVLP) is used to evaluate donor lungs prior to lung transplantation. Development of pulmonary edema during EVLP is generally thought to represent inflammatory breakdown of the air-fluid barrier and these lungs are declined for transplant. We present the case of a donor lung that underwent stapled wedge resection during cold storage for air leak and the subsequent development of profound (∼650 mL) pulmonary edema around the staple line during EVLP.

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Neoadjuvant Targeted Therapy in Non-Small Cell Lung Cancer and Its Impact on Surgical Outcomes.

Ann Thorac Surg Short Rep

March 2023

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada.

Background: The evidence for neoadjuvant targeted therapy in non-small cell lung cancer is limited, with 2 phase 3 trials currently recruiting and no approved indications.

Methods: We describe our experience with the use of neoadjuvant targeted therapy for patients with operable non-small cell lung cancer.

Results: Our focus is on surgical outcomes, which represent an underreported aspect of the patient trajectory.

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Task Sharing in Global Cardiac Surgery: A Scoping Review.

Ann Thorac Surg Short Rep

March 2023

Division of Cardiothoracic Surgery, Department of Surgery, University of California, San Francisco, San Francisco, California.

Background: Access to cardiac surgical services is limited in low- and middle-income countries. The shortage of cardiac surgical care providers is a major contributor to this limited access to lifesaving care. Task shifting and task sharing allow nonspecialists to perform roles typically reserved for specialists such as cardiothoracic surgeons, cardiac anesthesiologists, and other health care workers with specific training in cardiac surgical care.

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Atypical Vertebral Hemangioma in a Patient With Newly Diagnosed Pulmonary Nodule.

Ann Thorac Surg Short Rep

March 2023

Department of Radiology and Diagnostic Imaging, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Vertebral hemangiomas (VHs) are common, benign angiomatous lesions of the spine with an incidence rate of 10% to 12% in the population. VHs have a characteristic appearance on imaging; however, a subset demonstrate atypical features that resemble more sinister pathologic processes, such as malignant neoplasms or metastatic disease. We report a case of an atypical VH that was initially thought to be a metastasis in a 75-year-old patient with a newly diagnosed pulmonary nodule.

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