1,157,365 results match your criteria: "Canada; and †Rockyview General Hospital[Affiliation]"
Front Child Adolesc Psychiatry
August 2024
Department of Psychology, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.
Background: Child maltreatment is a significant social problem impacting both health and society, with severe and enduring consequences. Certain children, such as those with neurodevelopmental conditions like autism, may be more at risk of experiencing maltreatment. However, little research has examined the characteristics of these children.
View Article and Find Full Text PDFFront Child Adolesc Psychiatry
June 2024
Department of Psychology, Bishop's University, Sherbrooke, QC, Canada.
Background: Children with speech, language, and communication disorders require specialized support in response to their emotional expression challenges. Not only is such support key for their development, but it is also essential for their mental well-being. Art making emerges as a valuable tool for enabling these children to convey emotions both verbally and non-verbally, fostering a positive self-concept.
View Article and Find Full Text PDFFront Child Adolesc Psychiatry
July 2024
Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Introduction: Autism is characterized by social communication differences and repetitive behaviors, affecting 1%-2% of children. Irritability is a disabling condition affecting 19%-80% of autistic children. While extensive research has focused on interventions to reduce irritability symptoms, the underlying correlates remain poorly understood.
View Article and Find Full Text PDFFront Child Adolesc Psychiatry
May 2024
Counselling Psychology, Faculty of Education, University of Ottawa, Ottawa, ON, Canada.
Introduction: Bullying victimization is associated with numerous mental health difficulties yet studies from early in the COVID-19 pandemic revealed significant decreases in bullying victimization but significant increases in mental health difficulties for many children and adolescents. It is unclear whether the decrease in bullying victimization early in the pandemic translated to weaker associations between bullying victimization and mental health difficulties.
Methods: Using a population-based design, we examined whether the correlations between bullying victimization and mental health difficulties were significantly weaker in magnitude during the COVID-19 pandemic compared to before the pandemic in a sample of 6,578 Canadian students in grades 4-12.
Front Child Adolesc Psychiatry
July 2024
School of Psychology, University of Ottawa, Ottawa, ON, Canada.
As societies worldwide addressed the numerous challenges associated with the COVID-19 pandemic, a troubling concern emerged-the possible rise of child maltreatment, which is a pernicious risk factor for child and adolescent mental health difficulties. This narrative review aims to provide a comprehensive understanding of how the many changes and challenges associated with the pandemic influenced worldwide occurrences of child maltreatment and, subsequently, the mental health of children and adolescents. First, we present the well-established evidence regarding the impact of child maltreatment on the mental health of children and adolescents both before and during the COVID-19 pandemic.
View Article and Find Full Text PDFOncoscience
January 2025
McGill Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
Importance: Cervical cancer is the fourth most common cancer among women globally and a significant cause of cancer-related deaths. Understanding the impact of cervical cancer diagnosed during pregnancy on maternal, delivery, and neonatal outcomes is crucial for improving clinical management and outcomes for affected women and their children.
Objective: To determine the effects of cervical cancer diagnosed during pregnancy on maternal, delivery, and neonatal outcomes using a population based, American database.
Front Aging Neurosci
January 2025
Department of Biomedical Engineering and Science, Florida Institute of Technology, Melbourne, FL, United States.
Blink-related oscillations (BROs) are newly discovered neurophysiological brainwave responses associated with spontaneous blinking, and represent environmental monitoring and awareness processes as the brain evaluates new visual information appearing after eye re-opening. BRO responses have been demonstrated in healthy young adults across multiple task states and are modulated by both task and environmental factors, but little is known about this phenomenon in aging. To address this, we undertook the first large-scale evaluation of BRO responses in healthy aging using the Cambridge Centre for Aging and Neuroscience (Cam-CAN) repository, which contains magnetoencephalography (MEG) data from a large sample ( = 457) of healthy adults across a broad age range (18-88) during the performance of a simple target detection task.
View Article and Find Full Text PDFFront Aging Neurosci
January 2025
Department of Chemistry, Memorial University of Newfoundland, St. John's, NL, Canada.
Introduction: Early detection of neurodegeneration is essential for optimizing interventions. The highly reproducible progression of neurodegeneration in the decrepit () mouse allows investigation of early biomarkers and mechanisms of brain injury.
Methods: Using high-frequency ultrasound, the common carotid arteries of female and male and control mice were imaged longitudinally at time points bracketing the disease progression (50, 75, and 125 days of age) ( = 6 mice/group/sex).
Front Aging Neurosci
January 2025
Laboratory for Brain Development, Modulation and Repair, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, United States.
Cognitive changes associated with PASC may not be uniform across populations. We conducted individual-level pooled analyses and meta-analyses of cognitive assessments from eight prospective cohorts, comprising 2,105 patients and 1,432 controls from Argentina, Canada, Chile, Greece, India, Italy, Russia, and the UK. The meta-analysis found no differences by country of origin.
View Article and Find Full Text PDFFront Nutr
January 2025
Clinical Nutrition and Dietetics, San Camillo Forlanini Hospital, Rome, Italy.
Front Nutr
January 2025
MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Purpose: The Healthy Eating Index-Canada 2015 (HEI-C 2015), Diet Quality Index-International (DQI-I), and Healthy Eating Food Index 2019 (HEFI-2019) are commonly used to summarize the quality of Canadian diets. This paper sought to compare these three diet quality indices with respect to their ability to capture diets of different quality in Canadian children and to discriminate between population subgroups.
Methods: Data were collected in school-based surveys from grade 4-6 students (9-12 years old) in western Canada through 24-h dietary recall in 2016 ( = 336), 2018 ( = 454), and 2020/2021 ( = 909).
Front Health Serv
January 2025
Canadian Institute for Advancements in Mental Health, Toronto, ON, Canada.
Introduction: Family caregivers of people living with serious mental illness such as bipolar disorder, psychosis and schizophrenia, are continuously burdened with caregiving, following the complexities of navigating the mental health system for their loved ones. The aim of the study was to understand the perspectives of caregivers about care coordination for people living with serious mental illness, highlighting the current landscape and new directions across Canada.
Methods: In this co-designed participatory qualitative research, caregivers of people living with serious mental illness, and service providers were engaged and purposively sampled across Canada.
Clin Pract Epidemiol Ment Health
December 2024
Laboratory of Panic and Respiration, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro (UFRJ). Rio de Janeiro, RJ, Brazil.
Background: Many pharmacological treatments are considered effective in the treatment of panic disorder (PD), however, about 20 to 40% of the patients have treatment-resistant PD. Pharmacogenetics could explain why some patients are treatment-resistant.
Objective: Our objective was to gather preliminary data on the clinical usefulness of pharmacogenetic testing in this disorder.
Front Psychiatry
January 2025
Department of Medical Science, School of Health and Welfare, Dalarna University, Falun, Sweden.
Background: The COVID-19 pandemic presented a 'double-edged sword' for older adults: not only were they more susceptible to the virus, but its broader consequences also exacerbated other challenges, particularly those related to psychosocial well-being. Limited evidence exists on how older adults perceive the pandemic and its impact on their well-being and the role of social workers in addressing these challenges, particularly in resource-limited settings like Nigeria.
Aim: This study explored older adults' perceived risks regarding COVID-19, its impact on their psychosocial well-being, and the role of social workers in addressing these challenges in Nigeria.
Front Microbiol
January 2025
Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, China.
[This corrects the article DOI: 10.3389/fmicb.2023.
View Article and Find Full Text PDFQuant Imaging Med Surg
January 2025
Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.
Background: Clinical severity and progression of lung disease in cystic fibrosis (CF) are significantly influenced by the degree of lung inflammation. Non-invasive quantitative diagnostic tools are desirable to differentiate structural and inflammatory lung changes in order to help prevent chronic airway disease. This might also be helpful for the evaluation of longitudinal effects of novel therapeutics.
View Article and Find Full Text PDFParasitology
January 2025
Tropical Medicine Unit, Hospital Universitario Poniente, Ctra. de Almerimar 31, 04700 El Ejido, Spain.
Different agencies have emphasized the need to evaluate current serological methods for screening patients with suspected urogenital schistosomiasis. However, there is still a lack of evidence regarding the most appropriate methods for this purpose. Here we assessed the diagnostic efficacy of a newly developed serological technique that utilizes the recombinant protein -TSP-2, applied to the urine and serum of migrants suspected of having urogenital schistosomiasis.
View Article and Find Full Text PDFLipids
January 2025
Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Canada.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent a novel approach for reducing cholesterol and, accordingly, the burden of atherosclerosis. However, limited data are available regarding the possible effects of PCSK9 inhibitors on atherosclerotic plaque. To evaluate the efficacy of PCSK9 inhibitors in reducing carotid plaque progression in individuals with high-risk carotid atherosclerotic disease.
View Article and Find Full Text PDFMultivariate Behav Res
January 2025
Department of Psychology, University of British Columbia, Vancouver, BC, Canada.
In this tutorial, we clarify the distinction between estimated factor scores, which are weighted composites of observed variables, and true factor scores, which are unobservable values of the underlying latent variable. Using an analogy with linear regression, we show how predicted values in linear regression share the properties of the most common type of factor score estimates, regression factor scores, computed from single-indicator and multiple indicator latent variable models. Using simulated data from 1- and 2-factor models, we also show how the amount of measurement error affects the reliability of regression factor scores, and compare the performance of regression factor scores with that of unweighted sum scores.
View Article and Find Full Text PDFBioconjug Chem
January 2025
Departments of Chemistry and Toxicology, University of Guelph, Guelph, Ontario N1G 2W1,Canada.
The ability to label synthetic oligonucleotides with fluorescent probes has greatly expanded their nanotechnological applications. To continue this expansion, it is essential to develop approachable, modular, and tunable fluorescent platforms. In this study, we present the synthesis and incorporation of an amino-formyl-thieno[3,2-]thiophene (AFTh) handle at the 5'-position of DNA oligonucleotides.
View Article and Find Full Text PDFBr J Math Stat Psychol
January 2025
Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Recent technological advancements have enabled the collection of intensive longitudinal data (ILD), consisting of repeated measurements from the same individual. The threshold autoregressive (TAR) model is often used to capture the dynamic outcome process in ILD, with autoregressive parameters varying based on outcome variable levels. For ILD from multiple individuals, multilevel TAR (ML-TAR) models have been proposed, with Bayesian approaches typically used for parameter estimation.
View Article and Find Full Text PDFJ Hosp Med
January 2025
Divisions of General Internal Medicine and Hospital Medicine, Sinai Health, Toronto, Canada.
Mol Ther
January 2025
Immune Health, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia; Centre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, New South Wales, Australia. Electronic address:
Vitronectin (VTN) is an important extracellular matrix protein in tissue remodeling, but its role in COPD is unknown. We show that VTN regulates tissue remodeling through urokinase plasminogen activator (uPA) signaling pathway in COPD. In human COPD airways and bronchoepithelial cells and the airways of mice with cigarette smoke (CS)-induced experimental COPD, VTN protein was not changed, but downstream uPA signaling was altered (increased plasminogen activator inhibitor-1, uPAR) that induced collagen and airway remodeling.
View Article and Find Full Text PDFJ Neuroimaging
January 2025
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Background And Purpose: The central vein sign (CVS) is a diagnostic imaging biomarker for multiple sclerosis (MS). FLAIR* is a combined MRI contrast that provides high conspicuity for CVS at 3 Tesla (3T), enabling its sensitive and accurate detection in clinical settings. This study evaluated whether CVS conspicuity of 3T FLAIR* is reliable across imaging sites and MRI vendors and whether gadolinium (Gd) contrast increases CVS conspicuity.
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