Enhancing Pediatric Long COVID Care Through Telementoring: Insights From an ECHO Program.

Long COVID affects a significant number of children, yet clinician knowledge gaps and limited access to specialized care hinder effective management. With fewer than 20 pediatric long COVID clinics in the United States, many families must travel long distances for care. To address these challenges, a pediatric long COVID ECHO (Extension for Community Healthcare Outcomes) program was developed to educate health care professionals on evidence-based care.

Research Review: Help-seeking intentions, behaviors, and barriers in college students - a systematic review and meta-analysis.

Background: The prevalence of mental health problems among college students has increased over the past decade. Even when mental health services are available, many students still struggle to access these services. This systematic review and meta-analysis aimed to identify the rates at which students actively seek or consider using formal help and to determine the main reasons for not seeking help.

Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays.

Uncompetitive inhibition is an effective strategy for suppressing dysregulated enzymes and their substrates, but discovery of suitable ligands depends on often-unavailable structural knowledge and serendipity. Hence, despite surging interest in mass spectrometry-based target identification, proteomic studies of substrate-dependent target engagement remain sparse. Herein, we describe a strategy for the discovery of substrate-dependent ligand binding.

Hemoglobin and Cholesterol Affect Apparent Tacrolimus Clearance in Pediatric Transplant Recipients-A Retrospective Cohort Study.

Background: Tacrolimus has a narrow therapeutic index with substantial inter- and intra-patient variability, requiring therapeutic drug monitoring (TDM). Influences beyond genetic and developmental factors need to be better understood. Recent studies among adult patients suggest that hemoglobin affects the apparent clearance (CL/F) of tacrolimus, whereas this and other potential factors in children are under-investigated.

Urinary Iodine Concentration and Thyroid Hormone Metabolism in Pregnant Women and Neurodevelopment in Their Children: A Longitudinal Canadian Birth Cohort.

: Iodine is essential for thyroid hormone (TH) synthesis, and THs in pregnant women are critical for fetal brain development. It is unclear whether urinary iodine concentrations (UICs) are associated with thyroid parameters in pregnant women and neurodevelopment in their 3-4-year-old children. : In the Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) cohort, we categorized UIC adjusted for urinary creatinine (UIC/Cr) in the first two trimesters as <150, 150-500, or ≥500 µg/g.

Dietary Guidance, Sensory, Health and Safety Considerations When Choosing Low and No-Calorie Sweeteners.

The growing global focus on the adverse health conditions associated with excessive sugar consumption has prompted health and policy organizations as well as the public to take a more mindful approach to health and wellness. In response, food and beverage companies have proactively innovated and reformulated their product portfolios to incorporate low and no-calorie sweeteners (LNCSs) as viable alternatives to sugar. LNCSs offer an effective and safe approach to delivering sweetness to foods and beverages and reducing calories and sugar intake while contributing to the enjoyment of eating.

Characterizing the Phenolic Compounds in Iron Walnut Oil ( Dode) Across Chinese Regions.

This study examines the chemical composition and antioxidant properties of iron walnut oil (IWO) from different Chinese regions, using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for the analysis of phenolic compounds. Regional variations were identified in fatty acid profiles, with elevated α-linolenic acid levels observed in samples from cooler climates (e.g.

Spatiotemporal Patterns in Production and Consumption of Major Foods in Qinghai, China.

Food security is an important foundation of national security. Since China entered a new era in 2012, the supply of agricultural and animal husbandry products in Qinghai has continuously enhanced. However, the implementation of ecological policies such as Grain for Green and Grassland Ecological Compensation restricted the cultivation and grazing areas.

Effect of Melt Treatment and Heat Treatment on the Performance of Aluminum Cylinder Heads.

The present study was performed on real-life I4-aluminum cylinder heads produced industrially by applying the lost foam technique to Al-Si-Mg alloys (356 and 357). This work, in addition, introduces a new Al-Cu alloys coded 220 alloy. The main aim of this study is to analyze the effects of liquid metal treatment on the hardness and tensile properties of such castings.

Integration of Membrane-Based Pretreatment Methods with Pressure-Retarded Osmosis for Performance Enhancement: A Review.

Osmotic energy provides an emerging renewable alternative by leveraging the salinity gradient between two solutions. Among these technologies, pressure-retarded osmosis (PRO) has attracted attention; however, its deployment is hindered by obstacles resulting from impurities in feed and draw solutions and lack of suitable membranes. This review explores the integration of membrane-based pretreatments with PRO, highlighting their influence on resolving the technical drawbacks of standalone PRO systems.

Experimental Study on Hydrogen-Induced Crack Propagation of X80 Steel Under Alternating Pressure Fluctuations.

When hydrogen is transported in a pipeline, the fatigue loading in the pipeline will enhance hydrogen accumulation and diffusion, thus increasing the risk of hydrogen-induced fracture. In this study, specimens are subjected to cyclic loading within an autoclave, where hydrogen gas pressure is varied to examine its impact on fatigue crack growth. The influence of hydrogen pressure and stress variations on the fatigue crack growth rate is investigated.

The Influence of Rare Earth Metals on the Microstructure and Mechanical Properties of 220 and 356.1 Alloys for Automotive Industry.

Application of rare earths (RE) as grain refiners is well-known in the technology of aluminum alloys for the automotive industry. In the current study, Al-2.4%Cu-0.

The Effect of Leisure-Time Exercise on Mental Health Among Adults: A Bibliometric Analysis of Randomized Controlled Trials.

Adequate levels of leisure-time exercise (LTE) are associated with mental health benefits. Despite increased research in recent years through randomized controlled trials (RCTs), a systematic literature review summarizing these findings is lacking. Here, we examined publication trends, impact, and research gaps regarding LTE's effects on mental health in the form of a bibliometric analysis.

Midwives' Knowledge, Attitudes, and Professional Practices Regarding Prenatal Physical Activity.

Prenatal physical activity (PA) offers numerous health benefits for both the mother and her child, yet few pregnant women are sufficiently active enough to obtain these benefits. Midwives play an important role in promoting prenatal PA. However, little is known about the content of the information they share with their clients regarding prenatal PA, how they communicate it, and the personal factors that might influence their counseling.

Navigating Equitable Access to Cancer and Mental Health Services During Pandemics: Stakeholder Perspectives on COVID-19 Challenges and Community-Based Solutions for Immigrants and Refugees-Proceedings from Think Tank Sessions.

Increasing evidence shows that the COVID-19 pandemic has disproportionately impacted certain populations, particularly those facing structural marginalization, such as immigrants and refugees. Additionally, research highlights that structurally marginalized populations living with chronic conditions, such as cancer and/or mental health and addiction (MH&A) disorders, are more vulnerable to the adverse effects of COVID-19. These individuals face higher susceptibility to infection and worse health outcomes, including increased rates of hospitalization, severe illness, and death.

What Key Factors Affect Patient Satisfaction on Online Medical Consultation Platforms? A Case Study from China.

: Online medical consultation (OMC) platforms have become an essential tool for facilitating communication between doctors and patients, providing an efficient way for patients to access healthcare services. However, research on the key drivers of patient satisfaction within this context remains limited. This study aims to identify and prioritize the key factors influencing patient satisfaction on OMC platforms, with a focus on the Chinese "Chunyu Doctor" app as a case study.

Assessment of the Educational Needs of Spanish Nurses in the Care and Management of Patients with Diabetes.

The rising prevalence of chronic diseases such as diabetes poses significant challenges to healthcare systems globally, requiring specialized care and management. Nurses play an essential role in educating and caring for patients, but current continuing education programs often fail to meet the practical needs of clinical settings. This study used a qualitative descriptive-interpretative approach, conducting semi-structured interviews with 24 nurses working in primary care and hospital settings across Spain.

The Clinical Nurse Specialist as the Manager of the Family Medicine Clinic: A Hybrid Solution Between Four Major Commonwealth Realms.

There exist several interconnected issues that hinder the development of family medicine in Commonwealth realms such as the United Kingdom, Canada, New Zealand, and Australia. These issues affect both the medical and nursing professions. Family physicians, in most countries including the United Kingdom, are not considered "specialists" and are called "general practitioners" instead.

A SEIPS-Based Analysis to Understand Safety Culture During Postpartum Hemorrhage.

Maternal mortality occurs at alarming rates in the United States. In 2018, there were 17 maternal deaths for every 100,000 births-double that of other high-income countries, including France and Canada. Postpartum hemorrhage (i.

Perception of Health and Its Predictors Among Saudis at Primary Healthcare Settings in Riyadh: Insights from a Cross-Sectional Survey.

: Despite a link between self-perception of health and morbidity and mortality, data are scarce on factors that can predict one's health perception, particularly in nations like Saudi Arabia. We conducted a needs assessment to evaluate health perception and identify sociodemographic, behavioural, and comorbidity-related factors influencing health perception among Saudi individuals. : We conducted a cross-sectional survey utilizing an electronic questionnaire that was distributed to 14,239 people who visited primary healthcare centers in Riyadh, Saudi Arabia.

Mineral Carbonation for Carbon Sequestration: A Case for MCP and MICP.

Mineral carbonation is a prominent method for carbon sequestration. Atmospheric carbon dioxide (CO) is trapped as mineral carbonate precipitates, which are geochemically, geologically, and thermodynamically stable. Carbonate rocks can originate from biogenic or abiogenic origin, whereby the former refers to the breakdown of biofragments and the latter precipitation out of water.

Insight into crRNA Processing in P42S and Application of SmutCas9 in Genome Editing.

CRISPR-Cas is an adaptive immune system found in bacteria and archaea that provides resistance against invading nucleic acids. Elements of this natural system have been harnessed to develop several genome editing tools, including CRISPR-Cas9. This technology relies on the ability of the nuclease Cas9 to cut DNA at specific locations directed by a guide RNA.

Spatial Gene Expression of Human Coronary Arteries Revealed the Molecular Features of Diffuse Intimal Thickening in Explanted Hearts.

Diffuse intimal thickening (DIT) is a pre-clinical stage of atherosclerosis characterized by thickened intima. The molecular basis of its susceptibility to atherogenesis is unknown, and mechanistic investigations cannot be performed in commonly used mouse models, in which DIT does not exist. Vascular smooth muscle cells (SMCs) are the predominant cell type that occupies the intima and media of DIT.

Anastasis and Other Apoptosis-Related Prosurvival Pathways Call for a Paradigm Shift in Oncology: Significance of Deintensification in Treating Solid Tumors.

What is apoptosis? The Nomenclature Committee on Cell Death and numerous other pioneering cancer/p53 biologists use the terms "apoptosis" and "cell death" interchangeably, disregard the mind-numbing complexity and heterogeneity that exists within a tumor (intratumor heterogeneity), disregard the contribution of polyploid giant cancer cells (PGCCs; the root causes of therapy resistance and relapse) to this heterogeneity, and then propose novel apoptosis-stimulating anticancer strategies. This is shocking for the following three reasons. First, clinical studies reported since the 1990s have revealed that increased apoptosis in solid tumors is associated with increased tumor diversity and poor prognosis.