Children's palliative care perceptions and educational needs among healthcare professionals in humanitarian settings.

Objectives: Explore humanitarian healthcare professionals' (HCPs) perceptions about implementing children's palliative care and to identify their educational needs and challenges, including learning topics, training methods, and barriers to education.

Methods: Humanitarian HCPs were interviewed about perspectives on children's palliative care and preferences and needs for training. Interviews were transcribed, coded, and arranged into overarching themes.

Atrial Fibrillation Related Titin Truncation Is Associated With Atrial Myopathy in Patient-Derived Induced Pluripotent Stem Cell Disease Models.

Background: Protein-truncating mutations in the titin gene are associated with increased risk of atrial fibrillation. However, little is known about the underlying pathophysiology.

Methods: We identified a heterozygous titin truncating variant (TTNtv) in a patient with unexplained early onset atrial fibrillation and normal ventricular function.

Novel Real-Time Fluoroscopic Assessment Method of Transcatheter Heart Valve Expansion Following Balloon-Expandable TAVR.

Background: Transcatheter heart valve (THV) underexpansion after transcatheter aortic valve replacement may be associated with worse outcomes. THV expansion can be assessed fluoroscopically using a pigtail for calibration; however, the accuracy of this technique specific to transcatheter aortic valve replacement is unknown. We assessed the accuracy and reproducibility of a novel fluoroscopic method to assess THV expansion using the THV commissural post for calibration.

Effect of Sequential, Colocalized Radiofrequency and Pulsed Field Ablation on Cardiac Lesion Size and Histology.

Background: Sequential application of radiofrequency with pulsed field (PF) ablation may increase lesion depth while preserving the advantages of PF. The study's aim was to determine lesion dimensions of sequential, colocalized radiofrequency and PF ablation.

Methods: A preclinical study using swine (n=4) performed lesions in the right/left ventricles.

The top 100 most-cited total knee arthroplasty publications.

The object is to objectively identify the 100 most influential scientific publications in total knee arthroplasty (TKA) and provide an analysis of their main characteristics. The Clarivate Analytics Web of Knowledge database was used to obtain data and metrics of TKA research. The search list was sorted by the number of citations, and articles were included or excluded based on relevance to TKA.

Third age fitness: the connective materiality of a major movement in Brazil.

Since 2006, simple outdoor gyms have been installed on public squares all over Brazil. From the beginning, they were mainly conceived as for use by older people - especially women - within an international movement of 'healthy cities'. Based on an ethnography in Rio de Janeiro, our aim is to show in particular the politico-commercial dimensions of the fitness equipment.

Genetic Variants in the SCN9A Gene are Detected in a Minority of Erythromelalgia Patients.

Gain-of-function variants in the voltage-gated sodium channel Nav1.7, encoded by the SCN9A gene, have previously been identified in patients with erythromelalgia, a clinical diagnosis defined by intermittent attacks of painful, hot, swollen, and red skin, predominantly involving the hands and feet. Symptoms are induced or aggravated by warming and relieved by cooling.

Prevalence and concentration of aflatoxin M1 in milk and dairy products: an umbrella review of meta-analyses.

Background: Aflatoxin M1 (AFM1) is a derivative of aflatoxin B1 and a significant contaminant of milk and dairy products. In this study, we implemented an umbrella review of all existing systematic reviews and meta-analyzing studies to apprise and summarize the worldwide prevalence and level of AFM1 in milk and dairy products.

Methods: We conducted a systematic review of structured review and meta-analysis articles published in English until January 2024, with no time limit.

Progressive systemic inflammation precedes decompensation in compensated cirrhosis.

Background & Aims: Systemic inflammation is a driver of decompensation in cirrhosis with unclear relevance in the compensated stage. We evaluated inflammation and bacterial translocation markers in compensated cirrhosis and their dynamics in relation to the first decompensation.

Methods: This study is nested within the PREDESCI trial, which investigated non-selective beta-blockers for preventing decompensation in compensated cirrhosis and clinically significant portal hypertension (CSPH: hepatic venous pressure gradient ≥10 mmHg).

The association between total social exposure and incident multimorbidity: A population-based cohort study.

Background: Multimorbidity, the co-occurrence of two or more chronic conditions, is associated with the social determinants of health. Using comprehensive linked population-representative data, we sought to understand the combined effect of multiple social determinants on multimorbidity incidence in Ontario, Canada.

Methods: Ontario respondents aged 20-55 in 2001-2011 cycles of the Canadian Community Health Survey were linked to administrative health data ascertain multimorbidity status until 2022.

Dynamic-budget superpixel active learning for semantic segmentation.

Introduction: Active learning can significantly decrease the labeling cost of deep learning workflows by prioritizing the limited labeling budget to high-impact data points that have the highest positive impact on model accuracy. Active learning is especially useful for semantic segmentation tasks where we can selectively label only a few high-impact regions within these high-impact images. Most established regional active learning algorithms deploy a static-budget querying strategy where a fixed percentage of regions are queried in each image.

Fully automated coronary artery calcium score and risk categorization from chest CT using deep learning and multiorgan segmentation: A validation study from National Lung Screening Trial (NLST).

Background: The National Lung Screening Trial (NLST) has shown that screening with low dose CT in high-risk population was associated with reduction in lung cancer mortality. These patients are also at high risk of coronary artery disease, and we used deep learning model to automatically detect, quantify and perform risk categorisation of coronary artery calcification score (CACS) from non-ECG gated Chest CT scans.

Materials And Methods: Automated calcium quantification was performed using a neural network based on Mask regions with convolutional neural networks (R-CNN) for multiorgan segmentation.

Breeding Partners Have Dissimilar Foraging Strategies in a Long-Lived Arctic Seabird.

For long-lived species with biparental care, coordination and compatibility in the foraging behavior of breeding mates may be crucial to successfully raise offspring. While high foraging success is clearly important to reproductive success, it might be equally important that the mate has a complementary foraging strategy. We test whether breeding partners have similar or dissimilar foraging strategies in a species where both partners share breeding responsibilities and exhibit high mate fidelity (thick-billed murre; ).

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Probing the transient and time-variable sky.

The study of transient and variable events, including novae, active galactic nuclei, and black hole binaries, has historically been a fruitful path for elucidating the evolutionary mechanisms of our universe. The study of such events in the millimeter and submillimeter is, however, still in its infancy. Submillimeter observations probe a variety of materials, such as optically thick dust, which are hard to study in other wavelengths.

Successful treatment of severe acrodermatitis continua of hallopeau with Bimekizumab: A case report.

Acrodermatitis continua of Hallopeau is a rare form of pustular psoriasis affecting the acral fingers and toes, characterized by recurrent eruptions of sterile pustules that lead to significant pain and potentially irreversible destruction of the nail apparatus. Symptoms are often refractory to topical and systemic therapies for psoriasis. This case report presents a healthy 23-year-old female with severe acrodermatitis continua of Hallopeau, destructing all 10 fingernails.

Abdominal pseudohernia caused by thoracic disk herniation: case series and review of the literature.

Intervertebral thoracic disk herniation (TDH) is a rare occurrence and presents with a wide variety of symptoms. Errors in diagnosis are thought to be frequent due to the variable clinical presentations. We herein present two unusual cases of TDH presenting with abdominal pseudohernias, abdominal pain, and hypoesthesia along the T11-T12 dermatomes due to TDH at the same level.

Clarifying the Relation between Alcohol Demand and Alcohol-Related Relative Reinforcement and Driving after Drinking in a Canadian Community Sample.

Objective: Previous studies examining associations between elevated behavioural economic alcohol demand and rates of driving after drinking (DAD) have primarily focused on university students in the United States. It is unclear whether similar associations exist in community adults and in other locations. Furthermore, the role of proportionate alcohol reinforcement (e.

Balancing act: optimizing blue light for melanogenesis while minimizing cellular damage in primary human skin cells.

Introduction: Recent findings show that visible light, particularly blue light, stimulates melanogenesis in human skin, though the underlying mechanisms remain debated. This study aimed to determine the cell damage threshold of non-ionizing blue light on keratinocytes while preserving their ability to stimulate melanogenesis.

Methods: Human keratinocytes (N = 3) and melanocytes (N = 3) were isolated from skin samples of varying Fitzpatrick skin phototypes and irradiated with blue light (λpeak = 457 nm) and UVA light (λpeak = 385 nm).

Human talocrural contributions to ankle joint complex kinematics during walking, running, and hopping.

The human ankle joint complex, consisting of calcaneus, talus, and tibia, is often simplified as a single functional ankle joint, neglecting the motion of the talus. Understanding the individual contributions of the talus and calcaneus is crucial for comprehending ankle joint complex function in healthy populations, and alterations in function that may exist in clinical conditions. To achieve accurate bone kinematics, high-resolution biplanar videoradiography was used with participants engaged in walking and running (n = 9) and hopping (n = 9) with no overlap in participants.

Ichnologic and sedimentologic datasets from the Ediacaran-Cambrian Chapel island formation, Newfoundland, Canada.

Extensive ichnologic and sedimentologic datasets were gathered from six localities (Fortune Head, Fortune North, Grand Bank Head, Lewin's Cove, Little Dantzic Cove, and Point May) of the Ediacaran-Cambrian Chapel Island Formation at Burin Peninsula, southeastern Newfoundland, eastern Canada. 1708.2 m of sedimentary strata were logged at a centimeter scale (1:40) using a Jacob staff, in addition to 11.

Unexplored avenues: a narrative review of cognition and mood in postmenopausal African women with female genital circumcision/mutilation/cutting.

Recent ageing research has projected the lifespan and proportion of postmenopausal women living in low- and middle-income countries to substantially increase over the years, especially on the African continent. An important subgroup within the African postmenopausal population is those with female genital circumcision/mutilation/cutting (FGC). Practised across 31 African nations, FGC holds cultural significance as it is deemed essential to marriage and successful womanhood.

The Fem cell-surface signaling system is regulated by ExsA in and affects pathogenicity.

Bacterial interspecies interactions shape microbial communities and influence the progression of polymicrobial infections. FemI-FemR-FemA, a cell-surface signaling system, in , is involved in the uptake of iron-chelating mycobactin produced by spp. In this report, we present the data that indicates the -PA1909 operon is positively regulated by ExsA, a master regulator for the type three secretion system (T3SS), connecting the Fem system with T3SS.

Utility of Noninvasive Testing Before Invasive Coronary Angiography in the Assessment for Revascularization.

Objective: To examine the role of noninvasive testing (NIT) before invasive coronary angiography (ICA) by evaluating the association between a positive myocardial perfusion imaging (MPI) or computed tomography angiography (CTA) result and the decision to perform coronary revascularization.

Patients And Methods: We screened all patients who received ICA between August 1, 2015, and July 31, 2019, and identified those who received MPI or CTA within the preceding 12 months. We considered MPI to be a positive result if it found moderate or severe ischemia in a specific coronary territory and CTA to be a positive result if it identified a stenosis greater than 50% in any major coronary artery.

Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA.

Gene therapy targeting ischemic heart disease is a promising therapeutic avenue, but it is mostly restricted to viral-based delivery approaches which are limited due to off-target immunological responses. Focused ultrasound presents a non-viral, image-guided technique in which circulating intravascular microbubble contrast agents can reversibly enhance vascular permeability and gene penetration. Here, we explore the influence of flow rate on the microbubble-assisted delivery of miR-126, a potent pro-angiogenic biologic, using a custom acoustically coupled pressurized mesenteric artery model.