From Worker Victory to Policy Reform: Injured Migrant Workers Fight for Return to Work Justice in Workers' Compensation in Ontario, Canada.

This article explores the challenges facing injured migrant farm workers in the workers compensation system in Canada's province of Ontario, with a focus on their fight for return to work justice. Told from the perspective of one of the lawyers who represented the workers, it highlights a recent victory achieved by 4 workers in the Seasonal Agricultural Worker Program in defending their rights to workers' compensation support. The workers' compensation tribunal decided that the workers' compensation board must evaluate these workers ability to return to work, access retraining, and receive compensation based on their labor markets in Jamaica-instead of based on fictional job prospects in Ontario.

Environmental Catalysis for NO Reduction by Manipulating the Dynamic Coordination Environment of Active Sites.

Nowadays, it is challenging to achieve SO-tolerant environmental catalysis for NO reduction because of the thermodynamically favorable transformation of reactive sites to inactive sulfate species in the presence of SO. Herein, we achieve enhanced low-temperature SO-tolerant NO reduction by manipulating the dynamic coordination environment of active sites. Engineered by coordination chemistry, SiO-CeO composite oxides with a short-range ordered Ce-O-Si structure were elaborately constructed on a TiO support.

Interest in Injectable and Oral PrEP for HIV Prevention Among Women and Men Who Inject Drugs.

Background: People who inject drugs (PWID) are at increased risk for human immunodeficiency virus (HIV). Women who inject are a particularly vulnerable group. Preexposure prophylaxis (PrEP) is effective, but access and uptake has been limited.

Tumour-Associated Macrophages in Oral Squamous Cell Carcinoma.

Objective: Tumour-associated macrophages (TAMs) are crucial in the progression and treatment response of oral squamous cell carcinoma (OSCC). TAMs infiltrate OSCC, adopting an M2-like phenotype that promotes tumour growth, metastasis and immune suppression. The current narrative review explored the roles of TAMs in OSCC, focusing on their impact on the tumour microenvironment, invasion, metastasis, angiogenesis, immunosuppression and potential therapeutic targeting.

Gold Nanorods Decorated by Conjugated Microporous Polymers for Infrared Responsive Cytostatic Drug Delivery.

Near-infrared (NIR) controlled drug delivery systems have drawn a lot of attention throughout the past few decades due to the deep penetration depth and comparatively minor side effects of the stimulus. In this study, we introduce an innovative approach for gastric cancer treatment by combining photothermal infrared-sensitive gold nanorods (AuNRs) with a conjugated microporous polymer (CMP) to create a drug delivery system tailored for transporting the cytostatic drug 5-fluorouracil (5-FU). CMPs are fully conjugated networks with high internal surface areas that can be precisely tailored to the adsorption and transport of active compounds through the right choice of chemical functionalities.

Determinants of Familiarity and Experience with HIV Pre-Exposure Prophylaxis in Primary Care Providers in Ontario, Canada.

Background: Despite increased access to HIV pre-exposure prophylaxis (PrEP) in Canada, familiarity and experience among primary care providers (PCPs)-including family doctors and those working with key populations-remains limited. To understand the barriers and facilitators of PrEP familiarity and experience, we conducted a situational analysis in PCPs in sub-urban and rural Ontario.

Methods: We surveyed a non-probabilistic sample of PCPs using an online questionnaire, designed with the Consolidated Framework for Implementation Research (CFIR).

Nano-Metal-Organic Frameworks Isolated in Mesoporous Structures.

As an alternative to bulk counterparts, metal-organic framework (MOF) nanoparticles isolated within conductive mesoporous carbon matrices are of increasing interest for electrochemical applications. Although promising, a "clean" carbon surface is generally associated with poor compatibility and weak interactions with metal/ligand precursors, which leads to the growth of MOFs with inhomogeneous particle sizes on outer pore walls. Here, a general methodology for in situ synthesis of eight nanoMOF composites within mesochannels with high dispersity and stability are reported.

Interfacial Atomic Mechanisms of Single-Crystalline MoS Epitaxy on Sapphire.

The epitaxial growth of molybdenum disulfide (MoS₂) on sapphire substrates enables the formation of single-crystalline monolayer MoS₂ with exceptional material properties on a wafer scale. Despite this achievement, the underlying growth mechanisms remain a subject of debate. The epitaxial interface is critical for understanding these mechanisms, yet its exact atomic configuration has previously been unclear.

Cardiovascular Reactivity to Mental Stress and Adverse Cardiovascular Outcomes in Patients With Coronary Artery Disease.

Background: Acute psychological stress may induce physiological changes predisposing individuals to adverse health outcomes through hemodynamic and vascular effects. We studied the association between the aggregated stress-induced changes in hemodynamic and vascular function tests with adverse cardiovascular outcomes in patients with coronary artery disease, after adjusting for sociodemographic and clinical factors.

Methods And Results: Individuals with stable coronary artery disease from 2 prospective cohort studies were studied.

Ultrahigh Specific Strength by Bayesian Optimization of Carbon Nanolattices.

Nanoarchitected materials are at the frontier of metamaterial design and have set the benchmark for mechanical performance in several contemporary applications. However, traditional nanoarchitected designs with conventional topologies exhibit poor stress distributions and induce premature nodal failure. Here, using multi-objective Bayesian optimization and two-photon polymerization, optimized carbon nanolattices with an exceptional specific strength of 2.

Consensus on Safe Initiation and Monitoring of Transanal Irrigation to Optimize Adherence With Therapy.

Background: Transanal irrigation is a well-established minimally invasive therapy that addresses symptoms of both constipation and incontinence. The therapy has been extended from just neurogenic bowel dysfunction patients to those with disorders of brain-gut interaction and postsurgical conditions.

Aim: To summarized the literature on transanal irrigation and update the contraindication profile.

Newborn screening for common genetic variants associated with permanent hearing loss: Implementation in Ontario and a review of the first 3 years.

Purpose: Universal newborn hearing screening (UNHS) programs using audiometric techniques alone are limited in ability to detect non-congenital childhood permanent hearing loss (PHL). In 2019, Ontario launched universal newborn screening (NBS) for PHL risk factors: congenital cytomegalovirus (cCMV) and 22 common variants in GJB2 and SLC26A4. Here we describe our experience with genetic risk factor screening.

Vertical Graphene Growth on LDH Nanosheets and Carbon Cloth Nanofibers with NiCo Nanoparticles as a Freestanding Host for High-Performance Lithium-Sulfur Batteries.

Lithium-sulfur batteries have been recognized as one of the excellent candidates for next-generation energy storage batteries because of their high energy density and low cost and low pollution. However, lithium-sulfur batteries have been challenged by low conductivity, low sulfur utilization, poor cycle life, and the shuttle effect of polysulfides. To address these problems, we report here an independent mixed sulfur host.

Placental Hypoxia-Induced Ferroptosis Drives Vascular Damage in Preeclampsia.

Background: Iron is an essential micronutrient for cell survival and growth; however, excess of this metal drives ferroptosis. Although maternal iron imbalance and placental hypoxia are independent contributors to the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy, the mechanisms by which their interaction impinge on maternal and placental health remain elusive.

Methods: We used placentae from normotensive and preeclampsia pregnancy cohorts, human H9 embryonic stem cells differentiated into cytotrophoblast-like cells, and placenta-specific preeclamptic mice.

Time perception in bipolar disorder: a systematic review.

Objective: Time distortions characterise severe mental disorders, exhibiting different clinical and neurobiological manifestations. This systematic review aims to explore the existing literature encompassing experimental studies on time perception in patients with bipolar disorder (BD), considering psychopathological and cognitive correlates.

Methods: Studies using an experimental paradigm to objectively measure the capacity to judge time have been searched for.

Trends and Themes in the Study of Value in Orthopedic Surgery: A Systematic Review.

Background: The study of value in orthopedic surgery aims to maximize health outcomes gained per unit cost through various health economic tools but is fragmented across various subspecialties and geographies. Therefore, it is difficult to ascertain whether this research methodology is being used to its full potential across all orthopedic subspecialties and geographies.

Purpose: We sought to assess the distribution of prior health economics literature in orthopedic surgery across subspecialties and geographies.

Thomas precession, relativistic torque, and non-planar orbits.

We analyze the angular momentum balance for a particle undergoing Thomas precession. The relationships among relativistic torque, the center of mass, and the center of inertia for a spinning particle are clarified. We show that spin precession is accompanied by orbital angular momentum precession, and present examples of the resulting out-of-plane motion.

Bone imaging modality precision and agreement between DXA, pQCT, and HR-pQCT.

Quantifying precision error for DXA, peripheral QCT (pQCT), and HR-pQCT is crucial for monitoring longitudinal changes in body composition and musculoskeletal outcomes. Agreement and associations between bone variables assessed using pQCT and second-generation HR-pQCT are unclear. This study aimed to determine the precision of, and agreement and associations between, bone variables assessed via DXA, pQCT, and second-generation HR-pQCT.

Identify biological Alzheimer's disease using a novel nucleic acid-linked protein immunoassay.

Blood-based biomarkers have been revolutionizing the detection, diagnosis and screening of Alzheimer's disease. Specifically, phosphorylated-tau variants (p-tau, p-tau and p-tau) are promising biomarkers for identifying Alzheimer's disease pathology. Antibody-based assays such as single molecule arrays immunoassays are powerful tools to investigate pathological changes indicated by blood-based biomarkers and have been studied extensively in the Alzheimer's disease research field.

Birthing parent adverse childhood experiences and risk of atopic diseases in 5-year-old children.

Following up on previous findings from the All Our Families (AOF) cohort, the current study investigated the relationship between birthing parent history of adverse childhood experiences (ACEs) and child atopy, including asthma, allergy, and eczema, at five years of age. Potential indirect effects were explored. Participants completed the ACEs scale, validated questionnaires of anxiety and depression symptoms, and reported on their and their children's atopic disease history.

"A torch, a rope, a belly laugh": engaging with the multiple voices of support groups for people living with rare dementia.

Purpose: Rare forms of dementia bring unique difficulties related to age of onset, impact on family commitments, employment and finances, and also bring distinctive needs for support and care. The aim of the present study was to explore and better understand what the concept of support means for people living with different rare dementia (PLwRD) and their care-partners who attend ongoing support groups.

Methods: Representing seven types of rare dementia, source material was collected from 177 PLwRD and care-partners attending in-person support groups, with the goal of developing research-informed group poems, co-constructed by a facilitating poet.

Comorbidity between internalizing symptoms and disordered eating is primarily driven by genetic influences on emotion regulation in adult female twins.

Internalizing (e.g., anxiety, depression) and disordered eating (DE; e.

Training healthcare workers and untrained interpreters in remote collaboration amidst COVID-19.

Objective: In the context of the public health emergency response to the COVID-19 pandemic in Quebec in 2020, remote public service interpreting has become, within a few days, an essential practice for maintaining services to migrants and allophone refugees, a particularly vulnerable population. This study aimed to measure the impact of two training courses on remote collaboration for mediated consultations developed for healthcare workers and untrained interpreters.

Methods: A total of 79 healthcare workers and 65 untrained interpreters from the province of Quebec were recruited.