The Effects of alfapump on Ascites Control and Quality of Life in Patients with Cirrhosis and Recurrent or Refractory Ascites.

Aim: To assess the safety and efficacy of alfapump on ascites control and quality of life in these patients.

Methods: Patients with cirrhosis and RA requiring ≥2 TPs 30 days prior were enrolled and followed for 24 months (M) post-implant. Primary efficacy endpoint assessed at 6M was reduction in paracentesis requirement; safety end point was device related adverse events resulting in intervention, explant, or death.

The Basic Psychological Need Satisfaction and Frustration Scale: Some Satisfying and Frustrating Findings.

As a tool for operationalizing basic psychological needs theory (an aspect of self-determination theory), the Basic Psychological Needs Satisfaction and Frustration Scale (BPNSFS) has become the primary self-report measure. Here, with a sample of 807 Canadian military members, we confirm the BPNSFS six content factor structure and, in supporting that structure, demonstrate the differential association of satisfaction and frustration scales with psychological functioning variables that are external to the factor analysis. Although the specific content interpretation of the BPNSFS can be debated, we support the continued use of the BPNSFS as a psychometrically sound instrument.

Groundwater Ages in Intertill and Buried Valley Aquifers in Saskatchewan, Canada.

Continental glaciations during the Pleistocene Epoch created complex systems of aquifers and aquitards across many northern regions of the Earth. The low hydraulic conductivities of glacial till aquitards suggest that limited recharge will reach the underlying aquifers, potentially preserving old groundwaters. Here, we characterize the recharge history in intertill and buried valley aquifers in Saskatchewan, Canada using C, H, He δH, δO, and major ions.

Rapidly spreading with OXA-48-like carbapenemases.

(mostly , ) with OXA-48-like carbapenemases (e.g., OXA-48, -181, -232, -244) are undermining the global efficiency of carbapenem therapy.

Subchronic Exposure to Regulated Trihalomethanes and Haloacetic Acids: Do We Need to Refine Our Exposure Assessment? A Full-Scale Case Study in a Canadian Municipality.

Regulated disinfection byproducts (e.g., trihalomethanes and haloacetic acids) in drinking water networks fluctuate spatially and temporally, depending on water sources and treatment practices with higher concentrations during the summer.

Effects of genotype and environment on the physiochemical properties of Canadian oat varieties.

Background: The relationship between oat grain composition and physical attributes as influenced by oat genotype and Canadian growing environments was investigated. Thirty Canadian oat (Avena sativa L.) genotypes, grown in three Canadian growing locations (Brandon, Manitoba; Portage la Prairie, Manitoba; and Lacombe, Alberta) over 2 consecutive years (2020-2021), were analyzed.

Vasa previa guidelines and their supporting evidence.

Introduction: Vasa previa (VP) is a serious pregnancy complication in which fetal vessels, unprotected by the umbilical cord, run across or within close proximity to the internal cervical os, which can potentially result in fetal exsanguination in the event of membrane rupture. There is global consensus that women with antenatally diagnosed VP should have caesarean delivery prior to onset of labour to prevent the catastrophic complications of VP. However, there is variability in the approach to management of these women antenatally, particularly regarding hospitalisation and timing of steroid administration and delivery.

The Impact of Chronic Temporomandibular Disorders on Fatigue and Daily Life: A Qualitative Phenomenological Study.

Introduction: Chronic temporomandibular disorders (TMDs) affect a notable portion of the population, with a prevalence of 5% to 12%. These conditions often lead individuals to adopt a soft-food diet to manage pain, but such dietary adjustments can inadvertently cause nutritional deficiencies. This issue may be compounded by medications used to manage TMD symptoms, which can contribute to fatigue and reduced daily functioning.

Associations Between Vocational Interests and Personality "Beyond" the Big-Five.

This investigation explores the relationships between vocational interests and personality dimensions suggested to be "beyond" the Big Five or Five Factor Model. Participants (653 adults; 125 men and 528 women, with a mean age of 40.57 years, = 16.

Thyroid hormones reversibly inhibit metamorphic development in ophiuroid larvae.

The timing of metamorphosis and settlement is critical for the survival and reproductive success of marine animals with biphasic life cycles. Thyroid hormones (THs) regulate developmental timing in diverse groups of chordates, including the regulation of metamorphosis in amphibians, teleosts, lancelets, tunicates, and lampreys. Recent evidence suggests a role for TH regulation of metamorphosis outside of the chordates, including echinoderms, annelids, and molluscs.

Trends in Demographic, Clinical, Socioeconomic, and Facility-Specific Factors Linked to Eyelid Melanoma Survival: A National Cancer Database Analysis.

Purpose: This study aimed to analyze demographic, clinical, socioeconomic, and facility-specific factors affecting the survival outcomes of patients diagnosed with eyelid melanoma (EM) between 2004 and 2017 using data from the National Cancer Database.

Methods: Cases of EM diagnosed between 2004 and 2017 were identified using the National Cancer Database. Patient demographic data, tumor stage (American Joint Committee on Cancer TNM classification), treatment modalities, and socioeconomic variables were collected.

Skin Tape Stripping Reveals Distinct Biomarker Profiles in Chronic Hand Eczema of Patients With and Without Comorbid Atopic Dermatitis.

Introduction: Chronic hand eczema (CHE) is a highly prevalent inflammatory skin condition which is often resistant to conventional treatments. Molecular insights of CHE remain limited. Tape stripping combined with high-throughput RNA sequencing can now provide a better insight into CHE pathogenesis in a minimally invasive fashion.

Skin Picking Disorder: A Canadian Retrospective Study of 83 Patients.

Background: Skin picking disorder (SPD) is classified as a primary psychodermatologic disorder, in which lesions are self-induced. It is frequently encountered by dermatologists, but the management is still a source of discomfort for the majority.

Objectives: The first objective is to determine the characteristics of the SPD patients in our centre: the demographics, the psychiatric comorbidities, clinical and histopathological characteristics of SPD patients, treatments and follow-up.

Adherence to the 24-h Movement Behaviors Guidelines and Associations With Cognitive and Behavioral Self-Regulation Among Brazilian Preschoolers.

Background: Adherence to 24-h movement guidelines has been associated with early health benefits, including neurodevelopmental outcomes. However, the associations between these guidelines and Cognitive (CSR) and Behavioral (BSR) self-regulation in preschoolers are underexplored. This study investigated the associations between adherence to 24-h movement guidelines and CSR and BSR in Brazilian preschoolers.

Effects of an Extreme Weather Event on Primate Populations.

Objectives: With contemporary, human-induced climate change at a crisis point, extreme weather events (e.g., cyclones, heatwaves, floods) are becoming more frequent, intense, and difficult to predict.

Human Growth Hormone (GH) use by Athletes with Short Stature without GH Deficiency: Therapeutic Use Exemptions.

Organized sports are governed by specific rules which aim to create or preserve fair play. An unfair advantage can be obtained by the use of specific substances or methods, also referred to as doping. The World Anti-Doping Agency (WADA) leads the international doping-free sport movement and annually publishes the List of Prohibited Substances and Methods (List), that is used by most sport federations and organizations around the world.

Using high pressure to understand the behavior of organic molecular crystals.

In the recent publication by Zhou et al. [(2025). IUCrJ, 12, https://doi.

Caregivers' Experiences of Nursing Home Restrictions During the COVID-19 Pandemic.

Background: Pandemic-related restrictions in nursing homes have undermined the critical role that family and friend caregivers play in enhancing resident quality of life.

Objective: We examined how family caregiver access restrictions in nursing homes were implemented and how they impacted the mutual well-being of and relationships between residents and their caregivers over time. s Between March 2021 and march 2022, 24 'designated caregivers' in Atlantic Canada were interviewed three times.

Runs of Homozygosity and Inferences in Wild Populations.

Long homozygous chromosome segments are known as runs of homozygosity (ROH); these reflect patterns of identity by descent and can be used to measure individual inbreeding, map recessive traits, and reconstruct demographic histories. Here, we review some key considerations with ROH detection and the inferences pertaining to inbreeding and demographic analyses in wild populations.

Establishing the volatile organic compound profile and detection capabilities of human remain detection dogs to human bones.

The detection of skeletal remains using human remain detection dogs (HRD) is often reported anecdotally by handlers to be a challenge. Limited studies have been conducted to determine the volatile organic compounds (VOCs) emitted from bones, particularly when there is limited organic matter remaining. This study aimed to determine the VOCs emitted from dry, weathered bones and examine the detection performance of HRD dogs on these bones when used as training aids.

Modeling Hydrogen Markets: Energy System Model Development Status and Decarbonization Scenario Results.

Hydrogen can be used as an energy carrier and chemical feedstock to reduce greenhouse gas emissions, especially in difficult-to-decarbonize markets such as medium- and heavy-duty vehicles, aviation and maritime, iron and steel, and the production of fuels and chemicals. Significant literature has been accumulated on engineering-based assessments of various hydrogen technologies, and real-world projects are validating technology performance at larger scales and for low-carbon supply chains. While energy system models continue to be updated to track this progress, many are currently limited in their representation of hydrogen, and as a group they tend to generate highly variable results under decarbonization constraints.