Time-Reversal Symmetry Breaking Superconductivity in HfRhGe: A Noncentrosymmetric Weyl Semimetal.

Weyl semimetals are a novel class of topological materials with unique electronic structures and distinct properties. HfRhGe stands out as a noncentrosymmetric Weyl semimetal with unconventional superconducting characteristics. Using muon-spin rotation and relaxation (µSR) spectroscopy and thermodynamic measurements, a fully gapped superconducting state is identified in HfRhGe that breaks time-reversal symmetry at the superconducting transition.

Challenges and Strategies of Low-Pressure All-Solid-State Batteries.

All-solid-state batteries (ASSBs) are regarded as promising next-generation energy storage technology owing to their inherent safety and high theoretical energy density. However, achieving and maintaining solid-solid electronic and ionic contact in ASSBs generally requires high-pressure fabrication and high-pressure operation, posing substantial challenges for large-scale production and application. In recent years, significant efforts are made to address these pressure-related challenges.

Impact of Climate Change on Adolescents' Health Outcomes: An Evidence Gap Map Review.

Background: The evolving impact of climate change on adolescents' health is a pressing global concern. Climate change's effects on their physical, mental, and social well-being worsen unique developmental challenges for adolescents. This study aims to map existing evidence, identify gaps, and highlight research and intervention needs.

Immune checkpoint inhibitor-associated diabetic ketoacidosis and insulin-dependent diabetes: a case report.

Background: Immunotherapy, including the use of immune checkpoint inhibitors such as nivolumab, is increasingly common in cancer treatment and can lead to various immune-related adverse effects, including rare cases of diabetic ketoacidosis. This case report highlights an unique instance of nivolumab-induced diabetic ketoacidosis in a patient without prior history of diabetes, emphasizing the importance of careful monitoring even in those without traditional risk factors.

Case Presentation: We report a case of a 70-year-old Caucasian male with metastatic esophageal adenocarcinoma who developed diabetic ketoacidosis 3 weeks after stopping nivolumab therapy.

Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells.

Background: Clear cell renal cell carcinoma (ccRCC) is a type of cancer characterized by a vast intracellular accumulation of lipids that are critical to sustain growth and viability of the cells in the tumour microenvironment. Stearoyl-CoA 9-desaturase 1 (SCD-1) is an essential enzyme for the synthesis of monounsaturated fatty acids and consistently overexpressed in all stages of ccRCC growth.

Methods: Human clear cell renal cell carcinoma lines were treated with small-molecule inhibitors of protein kinase CK2.

CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis.

Central nervous system (CNS) resident memory CD8 T cells (T) that express IFN-γ contribute to neurodegenerative processes, including synapse loss, leading to memory impairment. Here, we show that CCR2 signaling in CD8 T that persist within the hippocampus after recovery from CNS infection with West Nile virus (WNV) significantly prevents the development of memory impairments. Using CCR2-deficient mice, we determined that CCR2 expression is not essential for CNS T cell recruitment or virologic control during acute WNV infection.

The sexual dysfunction in women with thyroid disorders: a meta-analysis.

Background: Thyroid disorders are common endocrine conditions impacting multiple organs, including the reproductive system and often lead to sexual dysfunction. These effects can vary by gender; for example, women with hypothyroidism frequently experience reduced libido. Low thyroid hormone levels are also linked to vaginal dryness, causing discomfort, especially during intercourse.

Frequency and antimicrobial susceptibility of isolated from clinical bovine mastitis cases in British Columbia, Canada.

is one of the most important bacteria responsible for clinical bovine mastitis globally, leading to significant economic losses in the dairy industry. Antimicrobials used to treat and prevent mastitis can lead to antimicrobial resistance (AMR) in . We retrospectively evaluated AMR of isolates from clinical bovine mastitis cases submitted to the Animal Health Centre in British Columbia from 2013 to May 2024.

Plasticity of Mouse Dorsal Root Ganglion Neurons by Innate Immune Activation Is Influenced by Electrophysiological Activity.

The complex relationship between inflammation, its effects on neuronal excitability and the ensuing plasticity of dorsal root ganglion (DRG) sensory neurons remains to be fully explored. In this study, we have employed a system of experiments assessing the impact of inflammatory conditioned media derived from activated immune cells on the excitability and activity of DRG neurons and how this relates to subsequent growth responses of these cells. We show here that an early phase of increased neuronal activity in response to inflammatory conditioned media is critical for the engagement of plastic processes and that neuronal excitability profiles are linked through time to the structural phenotype of individual neurons.

Visible light-driven photocatalytic degradation of atrazine in aqueous phase: impact of the g-CN/TiO/NiFeO nanocomposite activated by potassium peroxymonosulfate.

The present investigation focused on the photocatalytic degradation of aqueous atrazine over g-CN/TiO/NiFeO composite in the presence of peroxymonosulfate (PMS) under visible light irradiation. The ternary photocatalyst was synthesized and characterized using XRD, FTIR, nitrogen sorption, SEM, UV-Vis, and photoluminescence spectroscopy. This catalyst exhibited full absorption in the visible spectrum at 815 nm and a high specific surface area of 105 m/g.

VZV IE4 downregulates cellular surface MHC-I via sequestering it to the Golgi complex.

Varicella-zoster virus (VZV) infection downregulates surface major histocompatibility complex class I (MHC-I) expression and retains MHC-I in the Golgi complex of infected cells. However, the underlying mechanism is not fully understood. The VZV IE4 protein is a multifunctional protein that is essential for VZV infection.

Performance investigation of MVMD-MSI algorithm in frequency recognition for SSVEP-based brain-computer interface and its application in robotic arm control.

This study focuses on improving the performance of steady-state visual evoked potential (SSVEP) in brain-computer interfaces (BCIs) for robotic control systems. The challenge lies in effectively reducing the impact of artifacts on raw data to enhance the performance both in quality and reliability. The proposed MVMD-MSI algorithm combines the advantages of multivariate variational mode decomposition (MVMD) and multivariate synchronization index (MSI).

Evaluation of a cognition-sensitive spatial virtual reality game for Alzheimer's disease.

Spatial impairment characterizes Alzheimer's disease (AD) from its earliest stages. We present the design and preliminary evaluation of "Barn Ruins," a serious virtual reality (VR) wayfinding game for early-stage AD. Barn Ruins is tailored to the cognitive abilities of this population, featuring simple controls and error-based scoring system.

Three-dimensional spatial localization and volume estimation of prostate tumors using F-PSMA-1007 PET/CT versus multiparametric MRI.

Purpose: Fluorine-18 prostate-specific membrane antigen-1007 positron emission tomography/computed tomography (F-PSMA-1007 PET/CT) has been shown to be superior to multiparametric magnetic resonance imaging (MRI) for the locoregional staging of intermediate-risk and high-risk prostate tumors. This study aims to evaluate whether it is also superior in estimating tumor parameters, such as three-dimensional spatial localization and volume.

Methods: 134 participants underwent F-PSMA-1007 PET/CT and MRI prior to radical prostatectomy as part of the validating paired-cohort Next Generation Trial (NCT05141760).

Psychometric evaluation and item response theory analysis of the COVID Stress Scales in an older adult population.

Objectives: The COVID Stress Scales (CSS) represent a widely used self-report measure of stress and anxiety-related responses to COVID-19. Although the CSS have been validated across various nations and languages, their psychometric properties have not been assessed at the factor- or item-level with older adults. We aimed to psychometrically evaluate the CSS in older adults.

A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [F]fallypride positron emission tomography.

Background: Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward-related cues but results published to date have been inconsistent.

Methods: Young social drinkers (age 18.

Outbreak investigations of and frozen raw breaded chicken: the mitigation of a significant public health issue in Canada.

In May 2017, whole-genome sequencing (WGS) became the primary subtyping method for in Canada. As a result of the increased discriminatory power provided by WGS, 16 multi-jurisdictional outbreaks of associated with frozen raw breaded chicken products were identified between 2017 and 2019. The majority (15/16) were associated with , while the remaining outbreak was associated with Heidelberg.

First Report of Causing Heart Rot Disease of in China.

Styphnolobium japonicum (L.) Schott, is an ornamental species of Leguminosae, widely planted as a roadside tree in north regions of China (Kite et al. 2007).

Empagliflozin in acute myocardial infarction in patients with and without type 2 diabetes: A pre-specified analysis of the EMPACT-MI trial.

Aims: In the EMPACT-MI trial, empagliflozin reduced heart failure (HF) hospitalizations but not mortality in acute myocardial infarction (MI). Contemporary reports of clinical event rates with and without type 2 diabetes mellitus (T2DM) in acute MI trials are sparse. The treatment effect of empagliflozin in those with and without T2DM in acute MI is unknown.

Feed additives for methane mitigation: Regulatory frameworks and scientific evidence requirements for the authorization of feed additives to mitigate ruminant methane emissions.

This article describes the regulatory and evidence requirements necessary for the authorization of antimethanogenic feed additives (AMFA) aimed at mitigating enteric methane (CH) emissions from ruminants. It outlines the legislation and legal procedures in Australia, Canada, the European Union, New Zealand, South Korea, the United Kingdom, and the United States as illustrative examples, offering insights for applicants seeking authorization. Additionals objectives are to highlight consequential similarities and differences in regulations and evidence requirements and offer recommendations for scientists and applicants.

Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants.

This publication aims to provide guidelines of the knowledge required and the potential research to be conducted in order to understand the mode of action of antimethanogenic feed additives (AMFA). In the first part of the paper, we classify AMFA into 4 categories according to their mode of action: (1) lowering dihydrogen (H) production; (2) inhibiting methanogens; (3) promoting alternative H-incorporating pathways; and (4) oxidizing methane (CH). The second part of the paper presents questions that guide the research to identify the mode of action of an AMFA on the rumen CH production from 5 different perspectives: (1) microbiology; (2) cell and molecular biochemistry; (3) microbial ecology; (4) animal metabolism; and (5) cross-cutting aspects.

Feed additives for methane mitigation: Modeling the impact of feed additives on enteric methane emission of ruminants-Approaches and recommendations.

Over the past decade, there has been considerable attention on mitigating enteric methane (CH) emissions from ruminants through the utilization of antimethanogenic feed additives (AMFA). Administered in small quantities, these additives demonstrate potential for substantial reductions of methanogenesis. Mathematical models play a crucial role in comprehending and predicting the quantitative impact of AMFA on enteric CH emissions across diverse diets and production systems.

Putting Trainees at the Center of the Family Medicine Research Workforce of Tomorrow.

The Family Medicine Research Summit culminated in a strategic action plan to enhance research in family medicine and expand the primary care research workforce. The strategic plan focuses on infrastructure, mentorship, and funding objectives needed for robust family medicine research. Trainees play a central role in the success of the strategic plan.

Developing standards for the implementation of stepped care in child and youth mental health service settings: protocol for a multi-method, delphi-based study.

Introduction: Canadian youth mental health (YMH) systems have the potential to urgently tackle the mental health treatment gap currently impacting young people, and stepped care (SC) is one model that can address this need. The adoption of SC models can guide the development of better-connected YMH systems by simplifying transitions and care pathways. To do so requires robust standards that are co-created across stakeholder groups, including with lived experience experts, to ensure the effective implementation of SC models.