Examining Health Care Provider Experiences With Patient Portal Implementation: Mixed Methods Study.

Background: Health systems are increasingly offering patient portals as tools for patients to access their health information with the goal of improving engagement in care. However, understanding health care providers' perspectives on patient portal implementation is crucial.

Objective: This study aimed to understand health care providers' experiences of implementing the MyChart patient portal, perspectives about its impact on patient care, clinical practice, and workload, and opportunities for improvement.

Ultraprocessed Food Consumption and Obesity Development in Canadian Children.

Importance: Ultraprocessed foods (UPF), characterized as shelf-stable but nutritionally imbalanced foods, pose a public health crisis worldwide. In adults, UPF consumption is associated with increased obesity risk, but findings among children are inconsistent.

Objectives: To examine the associations among UPF intake, anthropometric adiposity indicators, and obesity status in Canadian children.

Quantifying the Relationship Between At-Home Shoulder Physiotherapy Participation and Outcome: What can a Watch Tell Us?

Introduction: Exercise-based physiotherapy is an established treatment of rotator cuff injury. Objective assessment of at-home exercise is critical to understand its relationship with clinical outcomes. This study uses the Smart Physiotherapy Activity Recognition System to measure at-home physiotherapy participation in patients with rotator cuff injury based on inertial sensor data captured from smart watches.

Corticosteroids in Cardiogenic Shock: A Retrospective Analysis of the Medical Information Mart for Intensive Care-IV Database.

Importance: While corticosteroid administration in septic shock has been shown to result in faster shock reversal and lower short-term mortality, the role of corticosteroids in the management of cardiogenic shock (CS) remains unexplored.

Objectives: Determine the impact of corticosteroid administration on 90-day mortality (primary outcome) in patients admitted to a critical care unit with CS.

Design, Setting, And Participants: In this retrospective cohort study, we used the critical care database of Medical Information Mart for Intensive Care-IV, and included all adult patients diagnosed with CS excluding repeated admissions, patients with adrenal insufficiency, those receiving baseline corticosteroids, and those requiring extracorporeal life support.

Novel Cellulosic Fiber Composites with Integrated Multi-Band Electromagnetic Interference Shielding and Energy Storage Functionalities.

In an era where technological advancement and sustainability converge, developing renewable materials with multifunctional integration is increasingly in demand. This study filled a crucial gap by integrating energy storage, multi-band electromagnetic interference (EMI) shielding, and structural design into bio-based materials. Specifically, conductive polymer layers were formed within the 2,2,6,6-tetramethylpiperidine-1-oxide (TEMPO)-oxidized cellulose fiber skeleton, where a mild TEMPO-mediated oxidation system was applied to endow it with abundant macropores that could be utilized as active sites (specific surface area of 105.

Which Training Intensity Distribution Intervention will Produce the Greatest Improvements in Maximal Oxygen Uptake and Time-Trial Performance in Endurance Athletes? A Systematic Review and Network Meta-analysis of Individual Participant Data.

Background: Endurance athletes tend to accumulate large training volumes, the majority of which are performed at a low intensity and a smaller portion at moderate and high intensity. However, different training intensity distributions (TID) are employed to maximize physiological and performance adaptations.

Objective: The objective of this study was to conduct a systematic review and network meta-analysis of individual participant data to compare the effect of different TID models on maximal oxygen uptake (VO) and time-trial (TT) performance in endurance-trained athletes.

Mechanical Characterization of Amniotic-Based Scaffolds Containing Silk Fibroin and Sodium Alginate Nanofibers.

Due to its availability and biocompatibility, the human amniotic membrane (hAM) is being investigated by a large number of researchers with the goal of gaining a better understanding of the materials' mechanical behavior and structural integrity and optimizing them for various Tissue Engineering applications. In this research, biopolymers sodium alginate (SA) and silk fibroin (SF) were electrospun onto a decellularized hAM, resulting in two types of hybrid scaffolds: hAM/SF and hAM/SF/SA. The mechanical characteristics of these nanofibers were then analyzed to guide scaffold optimization for applications using these materials.

A Composite Endpoint of Liver Surgery (CELS): Development and Validation of a Clinically Relevant Endpoint Requiring a Smaller Sample Size.

Background: The feasibility of trials in liver surgery using a single-component clinical endpoint is low because single endpoints require large samples due to their low incidence. The current study sought to develop and validate a novel composite endpoint of liver surgery (CELS) to facilitate the generation of more feasible and robust high-level evidence in the field of liver surgery.

Methods: Patients who underwent curative-intent hepatectomy for hepatocellular carcinoma, intrahepatic cholangiocarcinoma, or colorectal liver metastasis were identified using a multi-institutional database.

MRI features of hepatocellular adenomas in children: clinical and radiological review.

Background: Hepatocellular adenomas (HCAs) are rare, benign hepatic tumors in children, with limited imaging data available for pediatric cases.

Objective: To describe the magnetic resonance imaging (MRI) and clinical features of histologically proven HCAs in children.

Materials And Methods: Single-center retrospective review of pathology-proven HCA from January 2004 to February 2024.

Evaluating the Benefit of a Urogynecologic Telehealth Consultation after Obstetric Anal Sphincter Injury.

Introduction: Obstetric anal sphincter injuries (OASI) are associated with significant risk of complications, including pain, infection, and long-term pelvic floor dysfunction. The primary aim of this study was to evaluate the utility and acceptability of a postpartum telehealth consultation focused on pelvic floor health for patients after OASI.

Methods: This prospective study used a pre-post design comparing standard postpartum care versus standard postpartum care plus a telehealth urogynecology consultation focused on pelvic floor recovery.

Acute and chronic cannabis vapor exposure produces immediate and delayed impacts on phases of fear learning in a sex specific manner.

Rationale: Current treatment options for PTSD have unreliable efficacy, with many individuals unable to achieve complete remission. Cannabis and cannabinoids that act through the endogenous cannabinoid (endocannabinoid) system to help promote trauma recovery by means of enhanced extinction learning are potential therapeutic, pharmacological candidates. Using a preclinical model of translationally-relevant cannabis administration in rodents, we examined the impact of cannabis exposure on aversive memory.

Lipid Profile, PCSK9, ANGPTL3 and Lipoprotein (a) Levels in Men Diagnosed With Localized High-Grade Prostate Cancer and Men At-Risk of Prostate Cancer.

Background: Some cancers have been found to require abundant supplies of lipids for their development. One example is prostate cancer (PCa). To date, lipid-modifying factors, such as proprotein convertase subtilisin/kexin type 9 (PCSK9), angiopoietin-like 3 protein (ANGPTL3), and lipoprotein(a) or Lp(a), have not been reported in men with PCa.

Discovery of the Novel HLA-C*01:282 Allele by Next-Generation Sequencing.

The novel allele HLA-C*01:282 has a single non-synonymous mutation compared to HLA- C*01:02:01:01 in codon 100 in Exon 3.

Arterial Stiffness and Markers of Atrial Myopathy.

Background: Arterial stiffness, measured using carotid-femoral pulse wave velocity (c-f PWV) and heart rate-corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (AF). In this cross-sectional study, we aimed to investigate whether arterial stiffness is associated with markers of atrial myopathy, which refers to structural and electrical changes in the atria that indicate increased AF risk.

Methods: We included 1050 participants (age 57 ± 4.

Extended-release pharmacotherapies for substance use disorders in incarcerated populations: A systematic review.

Background And Aims: Substance use (SU) is prevalent among individuals in the criminal justice system (CJS). However, there is often poor access to treatment. We aimed to assess the effectiveness of two medications, extended-release naltrexone (XR-NTX) and extended-release buprenorphine (XR-BUP) for the prison population.

(Re)assessment of the COSMED Quark CPET and VO2Master Pro Systems for Measuring Pulmonary Gas Exchange and Ventilation.

We assessed the validity, reliability, and transferability of gas exchange and ventilatory variables from two commonly used metabolic measurement systems (COSMED Quark and VO2Master Pro). Two identical devices from each system were independently connected to a metabolic simulator (VacuMed), and 2 min of steady-state data was recorded at simulated oxygen uptake (V̇O) of 1, 2, 3, and 4 L∙min achieved through minute ventilation (V̇) of 30, 60, 105, and 150 L∙min. Each metabolic analyzer recorded data three times for each "intensity" in a randomized order, and assessments were completed on two separate days.

The Effect of Cryopreservation on the Bone Healing Capacity of Endothelial Progenitor Cells in a Bone Defect Model.

Endothelial progenitor cells (EPCs) have proven to be a highly effective cell therapy for critical-sized bone defects. Cryopreservation can enable long-term storage of EPCs, allowing their immediate availability on demand. This study compares the therapeutic potential of EPCs before and after cryopreservation in a small animal critical-sized bone defect model.

Novel Insights in Perioperative Neuroprotection in Neonatal Congenital Heart Disease.

Congenital heart disease (CHD) includes defects of intrauterine cardiac development that result in alterations to the morphology and/or physiology of the heart, usually expressed early in fetal or postnatal life. This group represents one of the most common congenital anomalies of all living newborns worldwide. Neurodevelopmental deficits are a reality in patients with CHDs and may contribute to significant sequela and long-term morbidity beginning in infancy and extending into adulthood.

Conus medullaris termination: Assessing safety of spinal anesthesia in the L2-L3 interspace.

Background: Classic teaching is that spinal anesthesia is safe at or below the L2-L3 interspace. To evaluate this, we sought to determine the percentage of individuals with a conus medullaris termination (CMT) level at or below the L1-L2 interspace. Further, the relationship of CMT level to age, sex, body mass index (BMI), and spinal pathology was examined, as was the reliability of using Tuffier's line (TL) as an anatomical landmark.

Healthcare use is elevated two decades before a first demyelinating event and differs by age and sex.

Objective: Elevated healthcare use before multiple sclerosis (MS) onset suggests earlier opportunity to identify MS. Yet their timing and sociodemographic effects are unclear. We examined rates of healthcare use (and by age/sex) for >two decades pre-MS onset.

Happiness depletes me: Seeking happiness impairs limited resources and self-regulation.

People seek happiness when they try to experience as much positive emotion (and as little negative emotion) as possible. A growing body of research suggests that seeking happiness, rather than resulting in yet more happiness, often leads to negative consequences, like less happiness and less available time. Adding to this happiness paradox, the current research examines whether seeking happiness leads to the impairment of self-regulation due to the depletion of regulatory resources.

Color-shifting Crystalline Colloidal Arrays from Polymers With Upper Critical Solution Temperature.

Crystalline colloidal arrays (CCAs) composed of core-shell microspheres with thermoresponsive structural iridescence governed by Bragg's law have garnered significant attention for diverse applications. While core-shell microspheres with lower critical solution temperature (LCST) properties are extensively studied, upper critical solution temperature (UCST) counterparts remain unexplored, offering the potential to expand the application scope of thermoresponsive CCAs. In this study, poly(N-acryloyl glycinamide) (PNAGA), a UCST homopolymer, is employed for the first time to synthesize core-shell microspheres.

Impact of a Nurse Navigator Program on Referral Rates and Use of Fertility Preservation Among Female Cancer Patients: A 14-Year Retrospective Cohort Study.

Introduction: Given the known detrimental impact of cancer treatment on fertility, fertility preservation (FP) is recommended for reproductive age patients who are newly diagnosed with cancer. However, the rate of referral to fertility specialists remains suboptimal. The objective of this study was to determine the impact of a dedicated Nurse Navigator Program (NNP) on the rate of referrals and utilization of FP services.

School Satisfaction Predicts Quality of Life for Children With Severe Developmental Disabilities and Their Families.

Background: Children with severe developmental disabilities are frequently excluded from research, and little is known about their quality of life (QoL). Using a mixed-methods approach, this study examined relationships between school factors and QoL for these children and their families.

Method: 171 parents of children with severe developmental disabilities completed questionnaires.