Discovery of a novel benzimidazole conjugated quinazolinone derivative as a promising SARS-CoV-2 3CL protease inhibitor.

This report presents the design and synthesis of quinazolinone-based derivatives as promising SARS-CoV-2 3CL protease inhibitors. Two novel series, namely, febrifugine analogues 4a-i and quinazolinone conjugated benzimidazoles 9a-c, were successfully synthesized starting from isatoic anhydride. The synthesized quinazolinone derivatives were evaluated for their cytotoxicity against cancer cell lines and SARS-CoV-2 3CL inhibitory activity.

The Second Hip Fracture is not an Independent Predictor of Poor Outcomes in Elderly Patients - A Case-Control Study.

Introduction: Hip fracture is particularly seen in elderly patients with frailty and osteoporosis and leads to diminished functional independence and quality of life. Despite the susceptibility of these patients to a second hip fracture (SHF), the literature insufficiently discussed its impact leading to poor outcomes. This study aims to directly assess the outcomes of elderly patients with initial hip fractures (IHF) vs those experiencing an SHF within a well-matched group with similar characteristics.

Electric field enhances the electronic and diffusion properties of penta-graphene nanoribbon anodes in lithium-ion batteries.

Enhancement of the ionic conductivity and reduction of diffusion barriers of lithium-ion batteries are crucial for improving the performance of the fast-growing energy storage devices. Recently, the fast-charging capability of commercial-like lithium-ion anodes with the smallest modification of the current manufacturing technology has been of great interest. We used first principles methods computations with density functional theory and the climbing image-nudged elastic band method to evaluate the impact of an external electric field on the stability, electronic band gap, ionic conductivity, and lithium-ion diffusion coefficient of penta-graphene nanoribbons upon lithium adsorption.

Characteristics and predictors of cardiovascular events related to CYP2C19 gene polymorphisms following acute coronary syndrome.

Objective: Cardiovascular events prognosis based on CYP2C19 gene polymorphisms had many applications in clinical practice. Assessed characteristics and predictive performance of cardiovascular events in acute coronary syndrome patients with CYP2C19 gene polymorphisms.

Patients And Methods: The patients were analyzed for CYP2C19 gene polymorphisms by real-time polymerase chain reaction (PCR).

Efficacy of High Flow Nasal Cannula in the Treatment of Patients with COVID-19 with Acute Respiratory Distress Syndrome: Results of Single Centre Study in Vietnam.

Introduction: Most hospitalized patients required invasive or non-invasive ventilation and High Flow Nasal Cannula (HFNC). Therefore, this study was conducted to describe the characteristics of patients with severe Coronavirus Disease-2019 (COVID-19) treated by HFNC and its effectiveness for reducing the rate of intubated-mechanical ventilation in the Intensive Care Unit (ICU) of Phu Chanh COVID-19 Department-Binh Duong General Hospital.

Methods: It was a cross-sectional and descriptive study.

Prevalence, Predictors, and Treatment Outcomes of Anemia in Vietnamese School-Age Children With Helicobacter pylori Infection.

Background A growing number of studies suggest that anemia caused by () infection is prevalent in developing countries. A combination of eradication and iron supplementation may be effective in treating iron deficiency anemia (IDA) caused by infection. The aim of this study is to assess the prevalence, risk factors, and treatment outcomes of anemia in Vietnamese school-age children infected with H.

Modulation of gill surface area does not correlate with oxygen loss in .

Air-breathing fish risk losing aerially sourced oxygen to ambient hypoxic water since oxygenated blood from the air-breathing organ returns through the heart to the branchial basket before distribution. This loss is thought to help drive the evolutionary reduction in gill size with the advent of air-breathing. In many teleost fish, gill size is known to be highly plastic by modulation of their anatomic diffusion factor (ADF) with inter-lamellar cell mass (ILCM).

Predictions of Lattice Parameters in NiTi High-Entropy Shape-Memory Alloys Using Different Machine Learning Models.

This work applied three machine learning (ML) models-linear regression (LR), random forest (RF), and support vector regression (SVR)-to predict the lattice parameters of the monoclinic B19' phase in two distinct training datasets: previously published ZrO-based shape-memory ceramics (SMCs) and NiTi-based high-entropy shape-memory alloys (HESMAs). Our findings showed that LR provided the most accurate predictions for a, a, b, and c in NiTi-based HESMAs, while RF excelled in computing β for both datasets. SVR disclosed the largest deviation between the predicted and actual values of lattice parameters for both training datasets.

Diabetes self-care intervention strategies and their effectiveness in Sub-Saharan Africa: A systematic review.

Background: Diabetes poses a significant public health challenge, predominantly affecting low-and middle-income countries (LMICs), including in Sub-Saharan Africa (SSA). The evolving landscape characterized by resource constraints, gaps in availability and functionality of healthcare system, and socio-demographic impediments has compounded these challenges. As an example, self-care interventions have played a crucial role in diabetes care.

Behavioral factors associated with medication adherence among hypertensive patients using the theoretical domains framework.

Background: Theoretical exploration of the behavioral factors associated with adherence to medication in hypertensive patients has been limited in previous studies.

Objectives: This study aims to understand the associations between demographic and health characteristics and behavioral factors for medication taking, and how these predict medication adherence.

Methods: A cross-sectional survey was conducted in hypertensive outpatients, with a sample size of 399 participants.

Optimising antidiabetic medication management for type 2 diabetes and renal dysfunction in Can Tho City, Vietnam.

Introduction: The research aimed to delineate and investigate the utilisation of antidiabetic drugs in type 2 diabetes patients with kidney failure at a hospital in Can Tho City, Vietnam.

Material And Methods: The research analysed the use of antidiabetic drugs at various time points, determined the drug interaction rate, and evaluated the appropriate use of drugs and the relationship with the achievement of target blood glucose and HbA levels. A two-tailed Student's t-test was employed to compare continuous variables, an ANOVA test was used to assess multiple values, and an χ test was utilised to evaluate categorical variables.

Impact of foam-mat drying conditions of "Gấc" aril on drying rate and bioactive compounds: Optimization by novel statistical approaches.

This study was conducted to optimize the foam-mat drying conditions to maximize quality [β-carotene and total polyphenol content (TPC)] and drying rate of "Gấc" aril powder by using two novel statistical techniques as Response Surface Methodology (RSM) and Artificial Neural Network (ANN) couple with Genetic Algorithm (GA). During production process, level of egg albumin (EA) used for foaming process and drying temperature mainly influenced the drying rate and content of antioxidant compounds in powder. ANN model of 3-10-3 showed more accuracy and faster prediction capacity than RSM model did.

Taiwan Chingguan Yihau may improve post-COVID-19 respiratory complications through PI3K/AKT, HIF-1, and TNF signaling pathways revealed by network pharmacology analysis.

The emergence of new SARS-CoV-2 variants with a higher contagious capability and faster transmissible speed has imposed an incessant menace on global health and the economy. The SARS-CoV-2 infection might reoccur and last much longer than expected. Thence, there is a high possibility that COVID-19 can cause long-term health problems.

Adaptation mechanism of Phan Rang sheep to salinity in drinking water under tropical conditions.

The aims of this study were to determine adaptation mechanism of sheep to salinity in drinking water. A group of 10 male sheep were used in a 6-week of experiment, with 1 week for pre-treatment period (Week 1), 4 weeks for during treatment period (Week 2 to Week 5), and 1 week for posttreatment period (Week 6). During the pre- and posttreatment periods, sheep consumed with fresh water.

The attitude, intention, and related factors of purchasing antibiotics without prescription: a survey in Vietnam.

Background: The abuse of antibiotics is a global problem, and the form of abuse varies among different countries and cultures. The study explored antibiotic self-medication attitudes and intentions to use antibiotics among the public in Can Tho City, Vietnam.

Study Design: Questionnaire survey on a sample of volunteers.

Synbiotic effects of Lactobacillus plantarum CMT1 and Morinda citrifolia on the growth performance and disease resistance of whiteleg shrimp.

This study assesses the effects of a prebiotic derived from Morinda citrifolia (noni fruit) extract and a probiotic of Lactobacillus plantarum CMT1 alone and in combination on the survival, growth performance, digestive enzymes, and disease resistance of whiteleg shrimp. A total of 1200 juvenile shrimp were randomly allocated to four treatments: control (not supplemented with noni fruit extract or L. plantarum CMT1), Treatment 1 (TRT1) (supplemented with 1 % noni fruit extract), Treatment 2 (TRT2) (supplemented with 10 CFU/kg L.

Methanotrophic Communities and Cultivation of Methanotrophs from Rice Paddy Fields Fertilized with Pig-livestock Biogas Digestive Effluent and Synthetic Fertilizer in the Vietnamese Mekong Delta.

Biogas digestive effluent (BDE) has been applied to rice fields in the Vietnamese Mekong Delta (VMD). However, limited information is available on the community composition and isolation of methanotrophs in these fields. Therefore, the present study aimed (i) to clarify the responses of the methanotrophic community in paddy fields fertilized with BDE or synthetic fertilizer (SF) and (ii) to isolate methanotrophs from these fields.