2 results match your criteria: "Campus University Clinic Brandenburg[Affiliation]"
Angiotensin-converting enzyme inhibitors stimulate cerebral arteriogenesis.
Acta Physiol (Oxf)
February 2022
Brandenburg Medical School Theodor Fontane (MHB), Deutsche Angiologie Zentrum Brandenburg-Berlin (DAZB), Department for Angiology, Center for Internal Medicine I, Campus University Clinic Brandenburg, Brandenburg an der Havel, Germany.
Article Synopsis
- - The study aimed to understand how angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) affect the growth of cerebral collateral blood vessels during cerebral ischaemia using a rat model.
- - Measurements showed that ACEi significantly increased blood flow and vessel diameter, suggesting it stimulates arteriogenesis, while ARB did not demonstrate an inhibitory effect on this process.
- - The findings indicate that ACEi enhances cell viability and migration related to vessel growth, possibly through bradykinin receptor pathways, highlighting its potential as a treatment for improving cerebral blood flow in ischaemic conditions.
Effect of ACEI and ARB treatment on nitric oxide-dependent endothelial function.
Vasa
November 2021
Department for Angiology, Center for Internal Medicine I, Brandenburg Medical School Theodor Fontane, Campus University Clinic Brandenburg, Deutsches Angiologie Zentrum Brandenburg-Berlin (DAZB), Brandenburg an der Havel, Germany.
Angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are widely used as a first-line therapy for the treatment of cardiovascular disease. Here, ACEI modulate the bradykinin receptor (BDKRB1 and BDKRB2) system and NO-dependent endothelial function, thus determining cardiovascular health and regenerative arteriogenesis. The current study aims at evaluating nitric oxide-dependent endothelial function, and gene expression of bradykinin receptors in peripheral blood mononuclear cells (PBMC) from patients with ACEI or ARB treatment.
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