Dysregulation of Agmatine Deiminase Expression in Alzheimer's Disease.

Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, with a significant burden on global health. AD is characterized by a progressive cognitive decline and memory loss. Emerging research suggests a potential link between periodontitis, specifically the presence of oral bacteria such as (), and AD progression.

THz mobility and polarizability: impact of transformation and dephasing on the spectral response of excitons in a 2D semiconductor.

We introduce a response theory based transformation for excitonic polarizability into mobility, which allows an in-depth analysis of optical pump-THz probe conductivity experiments, and compare the results with those of a conventional oscillator model. THz spectroscopy is of high interest for investigations in high bandwidth and low noise nanoelectronics or solar energy harvesting nanomaterials. In contrast to simple scaling of estimated static polarizability, suggested in the literature, an appropriate transformation of the spectral response into mobility can be achieved in principle forward and backward due to the presence of dephasing, as we show for the exemplary system of CdSe nanoplatelets.

Influence of zirconia addition in TiO and TiO-CeO aerogels on the textural, structural and catalytic properties of supported vanadia in chlorobenzene oxidation.

This paper studies the effect of the direct incorporation of ZrO in TiO and TiO-CeO aerogel supports prepared by sol-gel route on the physico-chemical and catalytic properties of supported vanadia catalysts in the total oxidation of chlorobenzene. The obtained catalysts have been characterized by means of ICP-AES, N adsorption-desorption at 77 K, XRD, XPS, H-TPR and NH-TPD. The results revealed that Zr-doped VO based catalyst is beneficial for the improvement of catalytic properties in chlorobenzene total oxidation.

Phenolic Compounds of L. Extracts and Their Effect as Antioxidant and Cytotoxic Activities.

L. () is acknowledged as an aromatic plant. For its excellent biological properties, it was used as a traditional medicine.

Tuning optoelectronic response of lateral core-alloyed crown nanoplatelets: type-II CdSe-CdSeTe.

We present a theoretical study showing that the exciton emission in the CdSe-CdSeTecore-alloyed crown heterostructure results from the tunable quasi-type II to pure type II behavior by adjusting the Te to Se ratio. We suggest that the direct crown exciton or interface indirect exciton or a dual emission can be tuned due to the altered conduction band offset. We also found that these different emissions are red-shifted with increasing the nanoplatelets (NPLs) monolayer (ML) thickness due to the quantum confinement effect.

Optimization of thermostable proteases production under agro-wastes solid-state fermentation by a new thermophilic Mycothermus thermophilus isolated from a hydrothermal spring Hammam Debagh, Algeria.

The present work investigates for the first time the presence and isolation of the thermophilic fungi from hydrothermal spring situated at the locality of Guelma, in the Northeast of Algeria. The production of the thermostable proteases and the optimization of culture conditions under agro-wastes solid-state fermentation to achieve optimal production capacity were explored. A statistical experimental approach consisting of two designs was used to determine the optimum culture conditions and to attain the greatest enzyme production.

Dielectric properties of poly-(3-octylthiophene) thin films mixed with oleic acid capped cadmium selenide nanoparticles.

Hybrid heterojunction thin films, based on poly-(3-octylthiophene) (P3OT) polymer and oleic acid (OA)-capped cadmium selenide (CdSe) nanoparticles (NPs) are prepared by a spin-coating method. The structural and morphological properties of the CdSe NPs and of the hybrid thin films are investigated. The results of the dielectric characterization show that conductivity of the hybrid thin films is dependent on frequency and CdSe NP concentration.

Hepatitis a virus infection in Central-West Tunisia: an age structured model of transmission and vaccination impact.

Background: The epidemiological pattern of hepatitis A infection has shown dynamic changes in many parts of the world due to improved socio-economic conditions and the accumulation of seronegative subjects, which leads to possible outbreaks and increased morbidity rate. In Tunisia, the epidemiological status of hepatits A virus is currently unknown. However, over the past years higher numbers of symptomatic hepatitis A virus infection in school attendants and several outbreaks were reported to the Ministry of Health, especially from regions with the lowest socio-economic levels in the country.

Coordination complexes of 4-methylimidazole with Zn and Cu in gas phase and in water: a DFT study.

A quantum chemistry study of mononuclear metal coordination with four 4-methylimidazole ligands (4-MeIm) was investigated. The four complexes [Cu(4-MeIm)], [Cu(4-MeIm), HO], [Zn(4-MeIm)] and [Zn(4-MeIm), HO] were studied with particular attention to the Nπ or Nτ possible coordinations of the 4-MeIm ring with the metals, using different DFT methods. The results suggest that the Nτ coordination of 4-MeIm ring to Zn or Cu is more favorable whatever the level of calculation.

H,K-ATPase type 2 contributes to salt-sensitive hypertension induced by K(+) restriction.

In industrialized countries, a large part of the population is daily exposed to low K(+) intake, a situation correlated with the development of salt-sensitive hypertension. Among many processes, adaptation to K(+)-restriction involves the stimulation of H,K-ATPase type 2 (HKA2) in the kidney and colon and, in this study, we have investigated whether HKA2 also contributes to the determination of blood pressure (BP). By using wild-type (WT) and HKA2-null mice (HKA2 KO), we showed that after 4 days of K(+) restriction, WT remain normokalemic and normotensive (112 ± 3 mmHg) whereas HKA2 KO mice exhibit hypokalemia and hypotension (104 ± 2 mmHg).

Melanin and humic acid-like polymer complex from olive mill waste waters. Part I. Isolation and characterization.

A water soluble humic acid and melanin-like polymer complex (OMWW-ASP) was isolated from olive mill waste waters (OMWW) by ammonium sulfate fractionation to be used as natural additive in food preparations. The dark polymer complex was further characterized by a variety of biochemical, physicochemical and spectroscopic techniques. OMWW-ASP is composed mainly of proteins associated with polyphenols and carbohydrates and the distribution of its relative molecular size was determined between about 5 and 190 kDa.

Comparison of iso-eluotropic mobile phases at different temperatures for the separation of triacylglycerols in Non-Aqueous Reversed Phase Liquid Chromatography.

Triacylglycerols (TAGs) are a large class of neutral lipids that naturally occur in both plant and animal oils and fats. Their analyses in Non-Aqueous Reversed Phase Liquid Chromatography (NARP) require a mixture of weak solvent (mostly acetonitrile) and strong solvent. In the present work, we have established eluotropic solvent strength scale of several binary mobile phases on C18 bonded silica at different temperatures (acetonitrile/methylene chloride, acetonitrile/acetone, acetonitrile/ethyl acetate, acetonitrile/propan-2-ol, and acetonitrile/butan-1-ol at 25°C, 43°C, 63°C and 85°C); it is based on the methylene selectivity and the use of homologous series.

Ethylene response factor Sl-ERF.B.3 is responsive to abiotic stresses and mediates salt and cold stress response regulation in tomato.

Sl-ERF.B.3 (Solanum lycopersicum ethylene response factor B.

Expanding hybrid zone between Solea aegyptiaca and Solea senegalensis: genetic evidence over two decades.

Several marine hybrid zones have been described and studied during the last years. Assessing the movements of extending hybrid zones is central to improve our understanding of evolutionary processes. We have re-examined the hybrid zone between Solea aegyptiaca and Solea senegalensis that was first described 22 years ago in northern Tunisia when introgressed S.

An expeditious synthesis of [1,2]isoxazolidin-5-ones and [1,2]oxazin-6-ones from functional allyl bromide derivatives.

Reaction of allyl bromide (Z)-1 and (Z)-2 with N-substituted hydroxylamine hydrochlorides in presence of tert-butoxide in tert-butanol at reflux provides a short and effective route to [1,2]isoxazolidin-5-ones 3 and [1,2]oxazin-6-ones 4.

3020insC insertion in NOD2/CARD15 gene, a prevalent variant associated with anti-Saccharomyces cerevisiae antibodies and ileal location of Crohn's disease in Tunisian population.

Objective: Our aim is to investigate the relation between CARD15 3020insC mutation, anti-Saccharomyces cerevisiae antibodies (ASCA) and disease phenotype, in Tunisian inflammatory bowel disease (IBD) patients.

Materials: A hundred Tunisian patients with IBD (75 Crohn's disease CD and 25 ulcerative colitis UC) and 60 matched healthy controls were studied.

Methods: CARD15 mutation was analysed by using an allele-specific polymerase chain reaction and sequencing.

Screening for anti-listerial bacteriocin-producing lactic acid bacteria from "Gueddid" a traditionally Tunisian fermented meat.

Forty eight lactic acid bacteria strains isolated from "Gueddid", a traditionally Tunisian fermented meat, were screened for bacteriocin production. Four strains named MMZ 04, 09, 13, and 17 showed antimicrobial activity and were identified as Enterococcus faecium by molecular methods based on the 16S-23S rDNA ISR, PCR-RFLP analysis of the 16S-23S rDNA ISR and species-specific primers. The four antimicrobial compounds were heat stable (121°C for 15min), active over a wide pH range (3-9) and the antimicrobial activity was lost after treatment with trypsin, α-chymotrypsin and proteinase K but not by lysozyme and lipase.

Somatic mutation of MutYH in Tunisian patients with sporadic colorectal cancer.

The MutYH gene is an adenine-specific DNA glycosylase that prevents G/T transversions. Germline mutation in this gene causes MYH-associated polyposis (MAP) that predispose to hereditary colorectal cancer (CRC). This study describes for the first time the association of the MutYH mutation with sporadic CRC.

A convenient synthesis of gamma-functionalized cyclopentenones.

The synthesis of gamma-functionalized cyclopentenones was carried out in a few steps, starting firstly with the preparation of nitroketonic intermediates 2, which were readily transformed into 1,4-diketones using the Nef conversion. The intramolecular cyclization of the gamma-diketones 3 in a basic medium, led to the functionalized cyclopentenones 4.

Distribution of Y chromosome lineages in Jerba island population.

We have analysed Y chromosome polymorphism on six STR markers (DYS19, DYS389I, DYS390, DYS391, DYS392, and DYS393) and eight classical UEP markers (SRY10831a, YAP, SRY4064, M2, 92R7, M9, SRY2627 and 12f2) in three distinct ethnical, linguistic and cultural groups of Jerba island (Berbers, Arabs and a Jerban group of Sub-Saharan origin). Fst genetic distance and principal co-ordinate analysis based on STR haplotype frequencies, showed a genetic differentiation between the three Jerban groups and a genetic relationship between Jerban Berbers and Mozabites (a well defined Berber group in Algeria). Compound use of UEP and STR markers have increased discriminatory capacity.

Morphological and phylogenetic studies of marine Myxobolus spp. from mullet in Ichkeul Lake, Tunisia.

Six species of the genus Myxobolus (Myxozoa) from the marine environment were collected from two species of mullet (Mugil cephalus and Liza ramada) in Ichkeul Lake, Tunisia. Four of these species were described previously (Myxobolus bizerti, Myxobolus ichkeulensis, Myxobolus spinacurvatura, and Myxobolus episquamalis) and two (Myxobolus exiguus and Myxobolus muelleri) are redescribed. The small subunit ribosomal (18S rDNA) sequences of these six myxozoans were obtained and compared to traditional criteria used in the identification and taxonomy of myxozoan species (such as spore morphology, host specificity, and tissue tropism).