3 results match your criteria: "Campbell University Jerry Wallace School of Osteopathic Medicine[Affiliation]"
Novel molecular mechanisms of doxorubicin cardiotoxicity: latest leading-edge advances and clinical implications.
Mol Cell Biochem
May 2024
Department of Physiology and Pathophysiology, Campbell University Jerry Wallace School of Osteopathic Medicine, Buies Creek, NC, 27560, USA.
Doxorubicin (Dox) is among the most widely used cancer chemotherapeutic drugs. The clinical use of Dox is, however, limited due to its cardiotoxicity. Studies over the past several decades have suggested various mechanisms of Dox-induced cardiotoxicity (DIC).
View Article and Find Full Text PDFCardiovascular Protection by Metformin: Latest Advances in Basic and Clinical Research.
Cardiology
August 2023
Department of Pharmacology, Campbell University Jerry Wallace School of Osteopathic Medicine, Buies Creek, North Carolina, USA.
Article Synopsis
- Metformin is a widely used diabetes medication known for its effectiveness in lowering blood glucose and has a strong safety profile, making it the first-line treatment for type 2 diabetes.
- Recent studies have shown that metformin also offers additional health benefits, particularly in protecting cardiovascular health, which is highlighted through various experimental and clinical research findings.
- Despite promising evidence supporting metformin's cardiovascular protective effects, more large-scale clinical trials are needed to confirm its efficacy in patients with heart disease and heart failure.
Role of Peroxiredoxins in Protecting Against Cardiovascular and Related Disorders.
Cardiovasc Toxicol
October 2020
Department of Medical Education, Tufts University School of Medicine, Boston, MA, 02111, USA.
Peroxiredoxin (Prx) refers to a family of thiol-dependent peroxidases that decompose hydrogen peroxide, lipid hydroperoxides, as well as peroxynitrite, and protect against oxidative and inflammatory stress. There are six mammalian Prx isozymes (Prx1-6), classified as typical 2-Cys, atypical 2-Cys, or 1-Cys Prxs based on the mechanism and the number of cysteine residues involved during catalysis. In addition to their well-established peroxide-scavenging activity, some Prxs also participate in the regulation of various cell signaling pathways.
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