A new monopartite begomovirus infecting Melochia tomentosa in Burkina Faso.

This is the first description of the complete genome sequence of a newly characterized monopartite begomovirus isolated from an asymptomatic uncultivated plant, Melochia tomentosa, collected in Burkina Faso. The sequence was obtained through rolling-circle amplification, cloning, and Sanger sequencing. The provisional species name "Begomovirus melochiae" and common virus name "melochia associated virus" (MeAV) are proposed.

A single mutation G454A in the P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy.

Metabolic mechanisms conferring pyrethroid resistance in malaria vectors are jeopardizing the effectiveness of insecticide-based interventions, and identification of their markers is a key requirement for robust resistance management. Here, using a field-lab-field approach, we demonstrated that a single mutation G454A in the P450 CYP9K1 is driving pyrethroid resistance in the major malaria vector Anopheles funestus in East and Central Africa. Drastic reduction in CYP9K1 diversity was observed in Ugandan samples collected in 2014, with the selection of a predominant haplotype (G454A mutation at 90%), which was completely absent in the other African regions.

Dynamic factors associated with COVID-19 vaccine uptake in Cameroon between 2021 and 2022.

Background: Little is known about attitudes towards COVID-19 vaccination in sub-Saharan Africa, where immunisation coverage is the lowest in the world.

Aim: The study aimed to identify factors associated with COVID-19 vaccine hesitancy and uptake in Cameroon, and assess changes in these factors over a period of time.

Setting: The study was conducted in the ten regions of Cameroon.

Electoral participation of people with and without disabilities in urban communities in Cameroon and Senegal.

Background: The right to participate in political processes is fundamental to democratic governance, economic development and human rights.

Objectives: We assessed participation in political processes and also explored factors associated with voting at the most recent election for people with and without disabilities.

Method: We conducted cross-sectional survey in four cities in Senegal and three in Cameroon in 2021.

Malaria and HIV/AIDS Coinfection in Patients Under Highly Active Antiretroviral Therapy at the Regional Hospital of Bafoussam (West Cameroon).

Malaria and HIV/AIDS are the two most common infections responsible for morbidity and mortality in sub-Saharan Africa. The studies were carried out worldwide. However, no study has targeted HIV-positive patients at the Bafoussam Regional Hospital (West Cameroon), one approved treatment center, where patients are adhering well to their HIV treatment.

European anchovy's abundance, more affected by climatic conditions than fishing activities in the northwest African waters.

The marine waters off the coast of northwest Africa are known for being highly productive upwelling regions in the Eastern Atlantic Ocean. The present study evaluated the combined effects of climate change and sustainable fishing levels on the long-term sustainability of European anchovy (Engraulis encrasicolus), a target pelagic species found along the West African coastal waters. The present study used survey biomass time series from survey vessels and species catch time series from commercial fisheries operating in the region.

Assessment of Facility Readiness for Pediatric Emergency and Critical Care Utilizing a 2-Phase Survey Conducted in Six Hospitals in Uganda and Cameroon: A Quality Improvement Study.

Objectives: Each year, 5.3 million children under 5 years of age die in low-resource settings, often due to delayed recognition of disease severity, inadequate treatment, or a lack of supplies. We describe the use of a comprehensive digital facility-readiness survey tool, recently developed by the Pediatric Sepsis Data CoLaboratory, which aims to identify target areas for quality improvement related to pediatric emergency and critical care.

StreptomeDB 4.0: a comprehensive database of streptomycetes natural products enriched with protein interactions and interactive spectral visualization.

Streptomycetes remain an important bacterial source of natural products (NPs) with significant therapeutic promise, particularly in the fight against antimicrobial resistance. Herein, we present StreptomeDB 4.0, a substantial update of the database that includes expanded content and several new features.

Effects of some anti-ulcer and anti-inflammatory natural products on cyclooxygenase and lipoxygenase enzymes: insights from in silico analysis.

Unlabelled: Gastric and duodenal ulcers are increasingly becoming global health burdens. The side effects of conventional treatments such as non-steroid anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), antibiotics, and cytoprotective agents have necessitated the search for new medications. Plants are a rich source of active metabolites and herbal medicines have been used in the treatment of ulcers and cancers.

Antiepileptic and anti-inflammatory effects of moldenke (Verbenaceae) in mice model of chronic temporal lobe epilepsy induced by pilocarpine.

Moldenke (Verbenaceae) is an aromatic plant used as a popular medicine with antidepressant, antispasmodic, antifungal, anti-inflammatory, and antioxidant properties. In this study, we explored the effects of in mice chronic model of temporal lobe epilepsy induced by pilocarpine and kindled with pentylenetetrazol. Mice were divided into 7 groups of 10 animals, and received a single dose of pilocarpine (360 mg/kg, i.

Impact of air pollution on mortality: Geo-epidemiological study in French-speaking Africa.

According to the World Health Organization, air pollution is responsible for 90 % of deaths in Africa. However, limited data on exposure to air pollution is available, and studies are rare, particularly in French-speaking Africa. This study aims to investigate the impact of air pollution on mortality in 12 French-speaking African countries (Algeria, Burkina Faso, Burundi, Cameroon, Guinea, Ivory Coast, Madagascar, Mali, Morocco, Democratic Republic of Congo, Senegal, Tunisia).

Call for elimination program of Malaria among children under 5 years old living in refugee camps in eastern Democratic Republic of Congo.

Malaria is a significant public health challenge in the Democratic Republic of the Congo (DR Congo), with a high prevalence and mortality rate, particularly among children under five years old. This study examines the impact of malaria in eastern DR Congo, where armed conflict and humanitarian crises have resulted in overcrowded refugee and internally displaced persons (IDP) camps, exacerbating malaria transmission. Malnutrition, limited access to healthcare, and poor living conditions makes children under the age of five particularly vulnerable.

Spread of the meningococci group C isolates of the clonal complex 10217 beyond the African meningitis belt.

Objectives: To monitor the spread of invasive meningococcal disease due to group C of the clonal complex 10217 isolates beyond the sub-Saharan African meningitis belt.

Methods: Cases were confirmed by real-time polymerase chain reaction in blood or cerebrospinal fluid samples and further characterized by multi-locus sequence typing that defined sequence type and clonal complexes. Sequencing of gene (encoding the penicillin-binding protein 2) was also used to predict susceptibility to β-lactams.

Taxonomic review of the grasshopper genus Karsch, 1891 (Orthoptera, Acrididea, Catantopinae) with description of three new species and a preliminary phylogeny of the Cameroonian species.

The Afrotropical grasshopper genus Karsch, 1891, is reviewed. Some species present in Cameroon are described, Donskoff, 1981, is recorded for the first time in the country, and three new species are described from Cameroon, Yetchom & Husemann, , Yetchom & Husemann, and Yetchom & Husemann, , increasing the number of species in Cameroon from eight to 12, and overall to 30 species in Central Africa. An updated key of is provided.

A picture speaks a thousand words: A case of ocular .

The 'African eye worm', also known as Loa loa, is filarial nematode that is commonly, transmitted by deer flies. A history of recent travel to endemic countries near western, Africa is common in patients with Loiasis. While a majority of patients infected with Loa, loa are asymptomatic, common presentations of Loiasis include localized areas of, edema, Calbar swellings, and ocular symptoms secondary to the migration of worms, through the spaces within the eye.

The application of medical ethics in the developing countries - A neurosurgical perspective.

Introduction: Neurosurgery is one of the rapidly evolving specialities of medical science, where the neurosurgeons have to provide evidence-based interventions in life threatening conditions maintaining the ethical standards.

Research Question: This narrative review sheds light on the current hindrances of the ethical aspects of neurosurgical practice in low and middle-income countries (LMICs) and provide some feasible solutions for future.

Material And Methods: A literature search was conducted using PubMed, Scopus and ISI web of knowledge focused on articles in English with the words "medical ethics" together with the words "neurosurgery", "ethical practice", "low and middle-income countries", "surgical innovation", "randomized clinical trials" and "outcome" alone or in combination.

Can machine learning assist in systemic sclerosis diagnosis and management? A scoping review.

This scoping review aims to summarize the existing literature on how machine learning can be used to impact systemic sclerosis diagnosis, management, and treatment. Following Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) reporting guidelines, Embase, Web of Science, Medline (PubMed), IEEE Xplore, and ACM Digital Library were searched from inception to 3 March 2024, for primary literature reporting on machine learning models in any capacity regarding scleroderma. Following robust triaging, 11 retrospective studies were included in this scoping review.

Data sharing considerations and practice among health researchers in Africa: A scoping review.

Objective: To examine the way African health researchers share data. It summarized the types of data collected, the data sharing platforms, and how the geographical distribution of the African-based health researchers influenced data sharing practices. Ethical, legal, and social aspects were considered.

Anthelmintic activity of crude and separated extract of (Xanthorrhoeaceae) against bovine adults parasites of and infected larvae of drug resistant strains of the free-living nematode .

Human onchocerciasis is caused by the filarial worm. is a parasite that forms nodules under the skin. The aim of this work was to assess the nematicidal activities of on and and to determine the phytochemical compounds.

Trans-Oral Protrusion of the Distal End of a Ventriculoperitoneal Shunt: A Case Report of an Unusual Complication.

Ventriculoperitoneal shunting (VPS) is the surgical technique of choice to manage pediatric hydrocephalus. Despite having good results, it is prone to complications, some of which are rare. This is the case report of a 2-year-old male, with an uncomplicated VPS done at 6 months of age, presenting with vomiting, irritability, anorexia, and drooling.

Ethanolic and aqueous extracts of show antiepileptic and anxiolytic effects by inhibiting the ferroptosis pathway in kainate-treated mice.

In Cameroon, epilepsy is one of the most common neurological diseases. Available anti-epileptic medication, on the other hand, have been associated with pharmacological toxicity and emotional impairment. The identification of a more efficient replacement is critical.

Haematological Profile and Antibiotic Resistance of Bacteria Responsible for Enteric Infections Isolated From Patients Suffering From Malaria and Enteric Infections on Consultation at the Dschang Regional Hospital.

Malarial and bacterial coinfections in low-income countries are a serious cause of morbidity and mortality, necessitating coadministration of antibiotics and antimalarials. This study investigated the relationship between malaria infection and bacterial drug resistance in malaria and nonmalaria patients on consultation at the Dschang Regional Hospital. A follow-up study was carried out from October 2020 to December 2021 on 127 malaria and 174 nonmalaria patients having enteric infections.

Investigating intermittent immersion during osmotic dehydration of mango ( L. Moench). Part B mathematical modeling of D2I and D3I kinetics in mango ( L. Moench) slices.

This work aims to investigate the dynamics of water loss (WL) and solute gain (SG) during dehydration impregnation by immersion (D2I) and intermittent immersion (D3I). WL and SG of mango slices, 4 1 1 cm in size, during dehydration immersion impregnation (D2I) and dehydration impregnation by intermittent immersion (D3I) were determined at 35, 45 and 55 °C for 270 min. Mango slices were immersed in a hypertonic sucrose solution of (61.