Exploring the genetic progression of MDR1 in : A decade of multi-regional genetic analysis (2014-2024).

Background: The genetic progression of the MDR1 gene in , a key factor in drug resistance, presents significant challenges for malaria control. This study aims to elucidate the genetic diversity and evolutionary dynamics of P. falciparum, particularly focusing on the MDR1 gene across multi-regional populations.

Cervical Precancer Treatment Outcomes in Cameroon.

Background And Objective: The ablative and excision treatment procedures are effective, accessible, and affordable in resource-constrained settings, but the rollout and posttreatment follow-up are not remarkable. The outcomes of treatment procedures among women treated for precancerous lesions of the cervix have not been adequately studied in Cameroon. This study assessed the outcome of ablative and excisional treatment procedures.

The safety and efficacy of Baricitinib for systemic lupus erythematosus: a systematic review and meta-analysis of randomized controlled trials.

Background And Objective: Baricitinib is a JAK1 and JAK2 inhibitor approved for treating active rheumatoid arthritis and atopic dermatitis. Therefore, the authors aim to evaluate the safety and efficacy of once-daily oral Baricitinib 2 mg or 4 mg versus placebo in active SLE patients receiving standard care.

Methods: The authors synthesized randomized controlled studies (RCTs) from MEDLINE, Scopus, EMBASE, PubMed, and Cochrane Library until 20 March 2023.

Geochemical dataset of laterites soils in Koubou gold district (Zone A) East Cameroon: Implication for identification of gold pathfinder elements.

The study zone (A) located in the Koubou Gold district is situated between latitudes 4° 36' to 4° 42' N and longitudes 14° 08' to 14° 11' E, composing of mostly Gneiss and Granodiorite bed rocks. To determine the relationship between gold and selected pathfinder elements (As, Mo, Ag, Sn, Sb, Te, W, Bi, Ni, Cu, Sb, Nb, Ta, Fe, Mn, Cu, Zn, Ni, and Pb) in the laterite soils of the Koubou gold district, East region of Cameroon, a lithogeochemical dataset from the laterites were utilized. The lithogeochemical dataset were realized through the inductively coupled plasma mass spectrometry (ICP-MS) method, while multi-statistical methods of factor analyses, principal component analyses and hierarchical clustering employed to show the relationship between the gold mineral and selected pathfinder minerals.

Environmental impact assessment of SONARA's oil sludge landfill in BATOKE, south-west Cameroon.

The focus of this study was to assess the environmental impact of the BATOKE oil sludge dump. A field visit was conducted to evaluate the condition of the site, followed by the sampling of oil sludge, BATOKE river water, soil, and locally grown manioc and macabo tubers. Subsequent physico-chemical characterization revealed parameters such as pH, electrical conductivity, total hydrocarbons, COD, BOD5, TSS, major cations and anions, as well as heavy metals including iron, copper, zinc, nickel, chromium, lead, cadmium, mercury, arsenic, calcium, potassium, titanium, zirconium, and rubidium.

Sonication-assisted activation of empty fruit bunches to produce activated carbon for supercapacitor's electrodes: Surface chemistry and morphology characterization.

Thermochemical treatment of empty fruit bunches (EFBs) had been proven to be the fastest way of converting this agro-industrial waste into value. Two-step carbonization and activation was used to convert the EFB to activated carbon with high specific surface area (SSA) and porosity. Hydrothermal carbonization was done at 225 to 275 ; at retention time of 1-3 h.

prevents seizures and memory deficit via inhibition of oxidative stress and neuronal loss in the hippocampus.

Mesiotemporal lobe epilepsy is the most refractory form of epilepsy. The management of this condition relies on the use of antiepileptic drugs known to provide symptomatic relief. Herbal remedies are therefore an alternative to finding a cure for epilepsy.

Assessment of Heckl value chain and its contribution to the livelihoods of local populations in Eastern Cameroon.

The value chain analyses of a product can provide vital information for improving the production, value addition, market organization and boost the contribution of the product to the income of the stakeholders involved. Hence, this study was carried out on the value chain in Belabo, Cameroon. Twenty-three focus group discussions were held, and semi-structured surveys were administered to 135 stakeholders engaged in the value chain in the Belabo municipality.

Typology of Tomato Cropping Systems and Determinants of Preharvest Losses in Western Cameroon.

Preharvest losses, which are often neglected, limit the availability of fresh tomato fruit to varying degrees in tomato-based cropping systems in Cameroon. Increasing tomato yields requires identifying, understanding, and controlling the factors responsible for preharvest losses in the identified cropping systems. Field surveys were conducted in three production areas of western Cameroon (, , and ) to characterize cropping systems and growers, quantify production losses, and identify causal factors associated with losses and proffer solutions.

Improving Access to PMTCT Through the Involvement of Traditional Birth Attendants in Program Activities in the Far North Region of Cameroon: A Retrospective Cohort Study.

Background: Majority of deliveries occurring in the Cameroon part of the Lake Chad basin is assisted by traditional birth attendants (TBA). The aim of the present study was to assess if training and involving TBA in community-based Prevention of Mother to Child Transmission (PMTCT) interventions can contribute in improving targeted population access to these interventions.

Methods: This was a retrospective cohort study that assessed among mothers of children aged 0-24 months the effect of training and involving TBA in PMTCT activities.

Growth response of O1 and non O1/non O139 strains to algae extracts from stream water in far north Cameroon.

Background And Objectives: O1 or non O1/non O139 is found in water ecosystems where it colonizes phytoplankton and has different lifestyle. This study aimed to investigate the impact of some algae extracts on the survival/growth of both strains.

Materials And Methods: Algae extracts consisting of three fractions, F1 containing chlorophyll-a, F2 containing chlorophyll-b, and F3 containing carotenoids, and raw extract (RAE) were obtained from the algal bloom collected in the Kaliao stream (Maroua, Cameroon).

SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad.

Background: Chad with 7,698 confirmed cases of infection and 194 deaths since the beginning of the COVID-19 pandemic, is one of the African countries with the lowest reported case numbers. However, this figure likely underestimates the true spread of the virus due to the low rate of diagnosis. The high rate of asymptomatic infections reflects the reality of SARS-CoV-2 transmission in Chad.

Kerstinginone, a new flavanone derivative from Commiphora kerstingii Engl. (Burseraceae) with potent apoptosis-inducing activity and inhibition of AKT/mTOR signaling pathway in non-sensitive prostate cancer cells.

Ethnopharmacological Relevance: Commiphora kerstingii Engl is a tree which is 20-30 m in height and commonly called "ararrabi" in Hausa. It is found in the Sahelian region (Cameroon, Chad, and Nigeria) where it is utilized for the treatment of several ailments including cancer.

Aim Of The Study: This study was aimed at investigating the chemical constituents and cytotoxic effect of extracts and isolates from the stem barks and leaves of C.

Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis.

Background: The population structure of the malaria parasite Plasmodium falciparum can reveal underlying adaptive evolutionary processes. Selective pressures to maintain complex genetic backgrounds can encourage inbreeding, producing distinct parasite clusters identifiable by population structure analyses.

Methods: We analysed population structure in 3783 P falciparum genomes from 21 countries across Africa, provided by the MalariaGEN Pf7 dataset.

Some ecological aspects of Monogeneans (Platyhelminthes) ectoparasites of Enteromius guirali Thominot, 1886 (Pisces: Cyprinidae) from Cesala River in Cameroon.

Fish are exposed to various parasites such as monogeneans which are flatworms that preferentially affect the gills and skin of these hosts. This study represents the first investigation concerning the distribution of monogenean infracommunities of Enteromius guirali in Cameroon. A total of 100 fish were collected from Cesala River and preserved in 8% formalin solution.

Prevention of Overhead Shoulder Injuries in Throwing Athletes: A Systematic Review.

(1) Background: Shoulder pathologies are mostly found in overhead sports. Many risk factors have been identified, in particular a deficit in the kinetic chain. The aim of this review was to find out whether prevention by strengthening the kinetic chain can have an impact on the rate of shoulder injury in overhead pitching athletes.

Evaluation of Green Strategies for Prolonging the Lifespan of Linear Wireless Sensor Networks.

Battery-powered sensor nodes encounter substantial energy constraints, especially in linear wireless sensor network (LWSN) applications like border surveillance and road, bridge, railway, powerline, and pipeline monitoring, where inaccessible locations exacerbate battery replacement challenges. Addressing these issues is crucial for extending a network's lifetime and reducing operational costs. This paper presents a comprehensive analysis of the factors affecting WSN energy consumption at the node and network levels, alongside effective energy management strategies for prolonging the WSN's lifetime.

Seroprevalence of Viral Hepatitis B and Occult Hepatitis B Among Blood Donors in Africa: A Systematic Review and Meta-Analysis.

Hepatitis B virus (HBV) Infection remains a public health problem and a threat to blood transfusion safety. The aim of this study was to summarise the scientific literature on the seroprevalence of HBV and occult HBV among blood donors in Africa. Searches were carried out in PubMed, Science Direct, Global Index Medicus and African Journals Online from 2012 to 2022.

Traditional, complementary and integrative medicine therapies for the treatment of mild/moderate acute COVID-19: protocol for a systematic review and network meta-analysis.

Background: Increasing evidence has emerged for traditional, complementary and integrative medicine (TCIM) to treat COVID-19 which requires systematic summaries of the net benefits of interventions against standard care and one another. The study aims to conduct a systematic review and network meta-analysis (NMA) regarding TCIM therapies for treating mild/moderate acute COVID-19, potentially informing the WHO guideline development and clinical decision-making.

Methods And Analysis: We will search Embase, MEDLINE, Virtual Health Library on Traditional Complementary and Integrative Medicine, Cochrane Central Register of Controlled Trials, WHO's International Clinical Trials Registry Platform with additional searches of Chinese and Korean literature sources for randomised controlled trials comparing TCIM with placebo, standard care, no treatment or with an alternate type of TCIM to treat COVID-19.

Acceptability, barriers and facilitators of using dried blood spots-point-of-care testing for sickle cell disease in Africa: an implementation science protocol for a multinational qualitative study.

Background: Sickle cell disease (SCD) is a prevalent inherited blood disorder. Globally, approximately 515 000 babies are born with SCD annually, with 75% of these births occurring in Africa. Integrating newborn screening (NBS) for SCD into primary healthcare structures, such as immunisation programmes, holds significant promise, with dried blood spots (DBS)-point-of-care technologies (POCT) like HaemoTypeSC offering cost-effective screening solutions.