31 results match your criteria: "California. University of California[Affiliation]"
Eliciting Patient Preferences for Hepatocellular Carcinoma Screening: A Choice-Based Conjoint Analysis.
J Am Coll Radiol
April 2022
Editor-in-Chief of the JACR; and Department of Radiology, Michigan Medicine, Ann Arbor, Michigan.
Background: Abbreviated MRI (AMRI), proposed as an alternative imaging modality for hepatocellular carcinoma screening, provides higher sensitivity than ultrasound. It is, however, unknown how patients weigh the higher sensitivity of AMRI against its higher cost and potentially less desirable testing experience.
Purpose: To assess patient preferences for hepatocellular carcinoma screening test attributes including sensitivity, false-positive rate, test-related anxiety, cost, and need for intravenous catheterization and contrast use, measured by choice-based conjoint analysis.
Merkel cell carcinoma: long-term follow-up of a single institution series and clinical outcomes by immunological status.
Dermatol Online J
February 2019
Lucy Curci Cancer Center, Eisenhower Medical Center, Rancho Mirage, California University of California San Diego, La Jolla, California.
Merkel cell carcinoma (MCC) usually arises in sun-exposed areas of older patients and might be more aggressive in the immunocompromised. We performed a retrospective chart review of 40 consecutive MCC patients treated at our institution between the years 2006-2017. Clinical and epidemiologic data were utilized and therapy and survival were analyzed.
View Article and Find Full Text PDF18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.
Anesthesiology
April 2018
From the Department of Anesthesiology (R.Y.K., T.B., M.B., N.T., M.F.N., J.P.M.), Department of Radiology (O.G.J., S.B.-N.), Department of Biostatistics and Bioinformatics (Y.-J.L., W.Q.), and the Department of Psychiatry and Behavioral Science (P.M.D.), Duke University, Durham, North Carolina. University of California, San Francisco University of Southern California University of California, San Francisco University of Southern California Mayo Clinic, Rochester Mayo Clinic, Rochester University of California, Berkeley University of Pennsylvania University of Southern California University of California, Davis Brigham and Women's Hospital/Harvard Medical School Indiana University Washington University St. Louis University of Pennsylvania Prevent Alzheimer's Disease 2020 (Chair) Siemens Alzheimer's Association University of Pittsburgh Washington University St. Louis Cornell University Albert Einstein College of Medicine of Yeshiva University AD Drug Discovery Foundation Acumen Pharmaceuticals Washington University St. Louis Northwestern University National Institute of Mental Health Brown University Eli Lilly (Chair) BWH/HMS (Chair) University of Washington (Chair) Mayo Clinic, Rochester (Core Principal Investigator) University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, Davis (Core Principal Investigator) University of California, Davis University of California, San Diego Mayo Clinic, Rochester (Core Principal Investigator) Mayo Clinic, Rochester University of London University of California, Los Angeles School of Medicine University of California, San Francisco Magnetic Resonance Imaging University of California, Davis Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic University of California, Berkeley (Core Principal Investigator) University of Michigan University of Utah Banner Alzheimer's Institute Banner Alzheimer's Institute University of Pittsburgh University of California, Berkeley Washington University St. Louis Washington University St. Louis Washington University St. Louis Washington University St. Louis (ASCP) - Past Investigator University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Pennsylvania School of Medicine University of Southern California (Core Principal Investigator) University of Southern California University of Southern California Indiana University Indiana University University of California, Irvine Indiana University Indiana University Indiana University Indiana University University of California, San Francisco University of California, San Diego Prevent Alzheimer's Disease 2020 University of California, San Diego National Institute on Aging University of California, San Francisco Brown University National Institute of Mental Health Cornell University Johns Hopkins University Richard Frank Consulting Prevent Alzheimer's Disease 2020 National Institute on Aging Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University Oregon Health & Science University University of Southern California University of Southern California University of Southern California University of Southern California University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of Michigan University of Michigan Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Mayo Clinic, Rochester Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Baylor College of Medicine Columbia University Medical Center Columbia University Medical Center Columbia University Medical Center 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California, Los Angeles University of California, Los Angeles University of California, Los Angeles University of California, Los Angeles Mayo Clinic, Jacksonville Mayo Clinic, Jacksonville Mayo Clinic, Jacksonville Indiana University Indiana University Indiana University Indiana University Indiana University Yale University School of Medicine Yale University School of Medicine Yale University School of Medicine Yale University School of Medicine McGill Univ., Montreal-Jewish General Hospital McGill Univ., Montreal-Jewish General Hospital McGill Univ., Montreal-Jewish General Hospital Sunnybrook Health Sciences, Ontario Sunnybrook Health Sciences, Ontario Sunnybrook Health Sciences, Ontario UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders UBC Clinic for AD & Related Disorders Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cognitive Neurology - St. Joseph's, Ontario Cleveland Clinic Lou Ruvo Center for Brain Health Cleveland Clinic Lou Ruvo Center for Brain Health Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Northwestern University Premiere Research Inst (Palm Beach Neurology) Premiere Research Inst (Palm Beach Neurology) Georgetown University Medical Center Georgetown University Medical Center Georgetown University Medical Center Brigham and Women's Hospital Brigham and Women's Hospital Brigham and Women's Hospital Stanford University Stanford University Stanford University Stanford University Stanford University Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Boston University Boston University Boston University Boston University Boston University Howard University Howard University Howard University Case Western Reserve University Case Western Reserve University Case Western Reserve University Case Western Reserve University University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento University of California, Davis - Sacramento Neurological Care of CNY Parkwood Hospital Parkwood Hospital Parkwood Hospital University of Wisconsin University of Wisconsin University of Wisconsin University of California, Irvine - BIC University of California, Irvine - BIC University of California, Irvine - BIC Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Banner Alzheimer's Institute Dent Neurologic Institute Dent Neurologic Institute Dent Neurologic Institute Ohio State University Ohio State University Ohio State University Albany Medical College Albany Medical College Albany Medical College Hartford Hospital, Olin Neuropsychiatry Research Center Hartford Hospital, Olin Neuropsychiatry Research Center Hartford Hospital, Olin Neuropsychiatry Research Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Dartmouth-Hitchcock Medical Center Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Wake Forest University Health Sciences Rhode Island Hospital Rhode Island Hospital Rhode Island Hospital Butler Hospital Butler Hospital Butler Hospital UC San Francisco UC San Francisco UC San Francisco Medical University South Carolina Medical University South Carolina Medical University South Carolina St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care St. Joseph's Health Care Nathan Kline Institute Nathan Kline Institute Nathan Kline Institute University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine University of Iowa College of Medicine Cornell University Cornell University Cornell University Cornell University University of South Florida: USF Health Byrd Alzheimer's Institute University of South Florida: USF Health Byrd Alzheimer's Institute University of South Florida: USF Health Byrd Alzheimer's Institute University of California, San Francisco University of Southern California University of California, San Francisco University of Southern California Mayo Clinic, Rochester Brigham and Women's Hospital/ Harvard Medical School University of California, Davis Mayo Clinic, Rochester University of California, Berkeley Washington University St. Louis Indiana University Perelman School of Medicine, University of Pennsylvania University of Southern California Perelman School of Medicine, University of Pennsylvania University of California, San Francisco Rehabilitation Institute of Chicago, Feinberg School of Medicine, Northwestern University University of Washington (Chair) Core Principal Investigator Mayo Clinic, Rochester (Core Principal Investigator) University of Southern California University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Diego University of California, San Francisco University of California, San Francisco University of California, San Francisco Neylan Davis (Core Principal Investigator) Neylan San Diego Mayo Clinic, Rochester (Core Principal Investigator) Mayo Clinic, Rochester Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Mayo Clinic Senjem Berkeley (Core Principal Investigator) University of Michigan University of Utah Banner Alzheimer's Institute Banner Alzheimer's Institute Senjem Berkeley Washington University, St. Louis Washington University, St. Louis Washington University, St. Louis Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania Perelman School of Medicine, University of Pennsylvania University of Southern California (Core Principal Investigator) University of Southern California University of Southern California Indiana University Indiana University University of California, Irvine Indiana University Indiana University Indiana University Indiana University University of California, San Francisco Department of Defense (retired) University of Southern California University of Southern California University of Southern California University of California, San Diego University of California, San Diego Columbia University Medical Center Columbia University Medical Center Columbia University Medical Center Rush University Medical Center Rush University Medical Center Rush University Medical Center Wien Center Wien Center Wien Center Duke University Medical Center University of Rochester Medical Center University of Rochester Medical Center University of Rochester Medical Center University of California, Irvine University of California, Irvine University of California, Irvine Medical University South Carolina Medical University South Carolina Medical University South Carolina Premiere Research Institute (Palm Beach Neurology) Premiere Research Institute (Palm Beach Neurology) Premiere Research Institute (Palm Beach Neurology) University of California, San Francisco University of California, San Francisco University of California, San Francisco University of California, San Francisco Georgetown University Medical Center Georgetown University Medical Center Georgetown University Medical Center Brigham and Women's Hospital Brigham and Women's Hospital Brigham and Women's Hospital Banner Sun Health Research Institute Banner Sun Health Research Institute Banner Sun Health Research Institute Howard University Howard University Howard University University of Wisconsin University of Wisconsin University of Wisconsin University of Washington University of Washington University of Washington Stanford University Stanford University Stanford University Stanford University Cornell University Cornell University Cornell University.
Background: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively.
Methods: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9).
Copy number variants in Ebstein anomaly.
PLoS One
January 2018
Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America.
Background: Ebstein anomaly (EA) is a rare congenital defect characterized by apical displacement of the septal tricuspid leaflets and atrialization of the right ventricle. The etiology of EA is unclear; however, recurrence in families and the association of EA with genetic syndromes and copy number variants (CNVs) suggest a genetic component.
Objective: We performed a population-based study to search for recurrent and novel CNVs in a previously unreported set of EA cases.
Commentary on Overview of ATX-101 (Deoxycholic Acid Injection).
Dermatol Surg
November 2016
American Board of Dermatology American College of Mohs Surgery David Geffen School of Medicine, UCLA, Los Angeles, California University of California, Irvine, Irvine, California.
Primary Care Patient Experience with Naloxone Prescription.
Ann Fam Med
September 2016
San Francisco Department of Public Health, San Francisco, California University of California San Francisco, San Francisco, California.
Purpose: Notwithstanding a paucity of data, prescription of the opioid antagonist naloxone to patients prescribed opioids is increasingly recommended in opioid stewardship guidelines. The aim of this study was to evaluate chronic pain patients' attitudes toward being offered a naloxone prescription and their experience with naloxone.
Methods: We interviewed 60 patients who received naloxone prescriptions across 6 safety-net primary care clinics (10 patients per clinic) from October 2013 to October 2015.
Deconstructing Chronic Low Back Pain in the Older Adult-Step by Step Evidence and Expert-Based Recommendations for Evaluation and Treatment: Part IX: Anxiety.
Pain Med
August 2016
*Geriatric Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania Department of Psychiatry Department of Anesthesiology Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania **Division of Geriatric Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
Objective: As a part of a series of articles designed to deconstruct chronic low back pain (CLBP) in older adults, this article focuses on anxiety-a significant contributor of reduced health-related quality of life, increased use of medical services, and heightened disability in older adults with CLBP.
Methods: A modified Delphi technique was used to develop an algorithm for the screening and clinical care of older adults with CLBP and anxiety. A 4-member content expert panel and a nine-member primary care panel were involved in this iterative development process.
Point-of-Care Ultrasound to Evaluate a Teenager with Presyncope.
West J Emerg Med
March 2016
Rady Children's Hospital, Division of Emergency Medicine, San Diego, California University of California at San Diego, Department of Emergency Medicine, San Diego, California.
A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.
Mol Cancer Res
March 2016
Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, California. University of California, Los Angeles, Los Angeles, California.
Unlabelled: Multiple myeloma is incurable and invariably becomes resistant to chemotherapy. Although the mechanisms remain unclear, hypoxic conditions in the bone marrow have been implicated in contributing to multiple myeloma progression, angiogenesis, and resistance to chemotherapy. These effects occur via adaptive cellular responses mediated by hypoxia-inducible transcription factors (HIF), and targeting HIFs can have anticancer effects in both solid and hematologic malignancies.
View Article and Find Full Text PDFAlcohol Consumption Levels and All-Cause Mortality Among Women Veterans and Non-Veterans Enrolled in the Women's Health Initiative.
Gerontologist
February 2016
VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), VA Greater Los Angeles Healthcare System, California. University of California, Los Angeles.
Purpose: To address research gaps regarding women Veterans' alcohol consumption and mortality risk as compared to non-Veterans, the current study evaluated whether alcohol consumption amounts differed between women Veterans and non-Veterans, whether Veterans and non-Veterans within alcohol consumption groups differed on all-cause mortality, and whether Veteran status modified the association between alcohol consumption and all-cause mortality.
Design And Methods: Six alcohol consumption groups were created using baseline data from the Women's Health Initiative Program (N = 145,521): lifelong abstainers, former drinkers, less than 1 drink/week (infrequent drinkers), 1-7 drinks/week (moderate drinkers), 8-14 drinks/week (moderately heavy drinkers), and 15 or more drinks/week (heavy drinkers). The proportions of Veteran and non-Veteran women within each alcohol consumption category were compared.
Military Generation and Its Relationship to Mortality in Women Veterans in the Women's Health Initiative.
Gerontologist
February 2016
VA Palo Alto Health Care System, Sierra Pacific MIRECC and Center for Innovation to Implementation, California. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California.
Purpose Of The Study: Women's military roles, exposures, and associated health outcomes have changed over time. However, mortality risk-within military generations or compared with non-Veteran women-has not been assessed. Using data from the Women's Health Initiative (WHI), we examined all-cause and cause-specific mortality by Veteran status and military generation among older women.
View Article and Find Full Text PDFIdentify-Isolate-Inform: A Modified Tool for Initial Detection and Management of Middle East Respiratory Syndrome Patients in the Emergency Department.
West J Emerg Med
September 2015
University of California, Irvine, Department of Emergency Medicine, Irvine, California. University of California, Irvine, Center for Disaster Medical Sciences, Irvine, California.
Middle East respiratory syndrome (MERS) is a novel infectious disease caused by a coronavirus (MERS-CoV) first reported in Saudi Arabia in September 2012. MERS later spread to other countries in the Arabian Peninsula, followed by an outbreak in South Korea in 2015. At least 26 countries have reported MERS cases, and these numbers may increase over time.
View Article and Find Full Text PDFCellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers.
Shock
December 2015
*Blood Systems Research Institute, San Francisco, California †University of California San Francisco, San Francisco, California ‡Combat Casualty Care Research Program, Fort Detrick, Maryland §Booz Allen Hamilton, Rockville, Maryland ||Department of Surgery, University of Texas, Houston, Texas ¶United States Army Institute of Surgical Research, Fort Sam Houston, Texas.
Trauma is a leading cause of death in both military and civilian populations worldwide. Although medical advances have improved the overall morbidity and mortality often associated with trauma, additional research and innovative advancements in therapeutic interventions are needed to optimize patient outcomes. Cell-based therapies present a novel opportunity to improve trauma and critical care at both the acute and chronic phases that often follow injury.
View Article and Find Full Text PDFSurvival among HIV-infected and HIV-uninfected individuals with common non-AIDS-defining cancers.
Cancer Epidemiol Biomarkers Prev
August 2015
Kaiser Permanente Northern California, Oakland, California.
Background: Non-AIDS-defining cancers increasingly contribute to mortality among human immunodeficiency virus (HIV)-infected individuals. However, few studies have compared cancer prognosis by HIV status with adjustment for risk factors.
Methods: We conducted a cohort study of HIV-infected and HIV-uninfected adults in Kaiser Permanente California during 1996 to 2011, following subjects diagnosed with Hodgkin lymphoma or anal, prostate, colorectal, or lung cancers.
Attentional Bias in Youth With Clinical Anxiety: The Moderating Effect of Age.
J Cogn Psychother
January 2015
University of California, Los Angeles, Semel Institute for Neuroscience and Human Behavior.
Cognitive models of anxiety suggest that threat-related attentional biases are associated with youth anxiety disorders. Although meta-analyses suggest that anxious youths display a bias toward threat, there is variability among studies, with youths displaying either an attention bias toward or away from threat. One possibility that may account for these discrepancies is the effect of youth age.
View Article and Find Full Text PDFConsensus Statement by the American Association of Clinical Endocrinologists/American College of Endocrinology insulin pump management task force.
Endocr Pract
May 2014
Grunberger Diabetes Institute, Bloomfield Hills, Michigan.
Family Intervention: Telephone Tracking (FITT): a pilot stroke outcome study.
Top Stroke Rehabil
May 2014
Brown University, Providence, Rhode Island Department of Psychiatry, Rhode Island Hospital, Providence, Rhode Island.
Objective: The goal of this study was to preliminarily test the efficacy of a telephone intervention, Family Intervention: Telephone Tracking, designed to assist stroke survivors and their primary caregivers during the first 6 months after stroke.
Method: Forty-nine stroke survivors and their caregivers were randomly assigned to treatment as usual or treatment as usual plus the telephone intervention. Global outcomes are reported for health care utilization, family functioning, and general functioning.
Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice.
Carcinogenesis
February 2012
Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, University of Southern California-University of California, Los Angeles, CA 90033, USA.
Chronic inflammation is an underlying risk factor for colon cancer. Tumor necrosis factor alpha (TNF-α) plays a critical role in the development of inflammation-induced colon cancer in a mouse model. S-adenosylmethionine (SAMe) and its metabolite methylthioadenosine (MTA) can inhibit lipopolysaccharide-induced TNF-α expression in macrophages.
View Article and Find Full Text PDFEarly pyloric stenosis: a case control study.
Pediatr Surg Int
December 2009
Division of Pediatric Surgery, Miller Children's Hospital, Long Beach, California & University of California, Irvine School of Medicine, Orange, CA, USA.
Objective: Pyloric stenosis (PS) is rare in the first 2 weeks of life, often leading to delays in diagnosis and treatment. We conducted a case control study to delineate the characteristics of patients with early PS (EPS). In addition, we tested the hypothesis that patients with EPS present with a smaller pylorus than older patients.
View Article and Find Full Text PDFAnatomy and biomechanics of the elbow joint.
Tech Hand Up Extrem Surg
December 2003
Orthopaedic Biomechanics Laboratory VA Healthcare System Long Beach, California University of California Irvine, California.
The elbow joint is a complex structure that provides an important function as the mechanical link in the upper extremity between the hand, wrist and the shoulder. The elbow's functions include positioning the hand in space for fine movements, powerful grasping and serving as a fulcrum for the forearm. Loss of elbow function can severely affect activities of daily living.
View Article and Find Full Text PDFAbnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis.
Alcohol Clin Exp Res
January 2004
Division of Gastroenterology and Liver Diseases, University of Southern California Liver Disease Research Center, University of Southern California/University of California, USA.
Background: Abnormal methionine metabolism occurs in animals fed ethanol and in end-stage cirrhotic patients. Expected consequences of these abnormalities include reduced hepatic S-adenosylmethionine and glutathione (GSH) levels, impaired transmethylation, and reduced homocysteine catabolism, resulting in the often-observed hyperhomocystinemia in cirrhotic patients. These parameters have not been examined simultaneously in patients with less advanced alcoholic liver disease.
View Article and Find Full Text PDFNonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas.
Gastroenterology
December 2003
University of Southern California-University of California Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA.
Background & Aims: The mechanisms involved in ethanol-induced pancreas fibrosis are poorly understood. Here we show that fatty acid ethyl esters (FAEEs), nonoxidative ethanol metabolites, increase extracellular matrix (ECM) protein levels in pancreas.
Methods: Rat pancreatic acini were incubated for 1-4 hours with FAEEs or acetaldehyde.
Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county.
Alcohol Clin Exp Res
November 2003
Department of Pathology, University of Southern California/University of California-Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, 90033, USA.
Background: This study sought to identify demographic characteristics of hospitalized patients with alcoholic liver disease (ALD) in Los Angeles County for the purpose of implementing new preventive and educational programs. Another specific aim of the study was to characterize demographic and comorbid differences between patients with ALD and patients with pancreatitis, another alcohol-related disease.
Methods: Analyses were performed on discharge data from all nonfederal short-stay hospitals within Los Angeles County, released for the year 1999 by the Office of Statewide Health Planning and Development.
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
Diabetes
January 2003
Medical Research Institute, San Francisco, California. University of California at San Francisco, San Francisco, California 94107, USA.
In both type 1 and type 2 diabetes, diabetic complications in target organs arise from chronic elevations of glucose. The pathogenic effect of high glucose, possibly in concert with fatty acids, is mediated to a significant extent via increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and subsequent oxidative stress. ROS and RNS directly oxidize and damage DNA, proteins, and lipids.
View Article and Find Full Text PDFMechanism of staurosporine-induced apoptosis in murine hepatocytes.
Am J Physiol Gastrointest Liver Physiol
May 2002
University of Southern California Research Center for Liver Diseases, University of Southern California/University of California at Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine, 90033, USA.
Staurosporine (STS) induces apoptosis in various cell lines. We report in this study that primary cultured mouse hepatocytes are less sensitive to STS compared with Jurkat cells and Huh-7 cells. In contrast to the cell lines, no apparent release of cytochrome c or loss of mitochondrial transmembrane potential was detected in primary hepatocytes undergoing STS-induced apoptosis.
View Article and Find Full Text PDF