Navigating the COVID-19 Therapeutic Landscape: Unveiling Novel Perspectives on FDA-Approved Medications, Vaccination Targets, and Emerging Novel Strategies.

Amidst the ongoing global challenge of the SARS-CoV-2 pandemic, the quest for effective antiviral medications remains paramount. This comprehensive review delves into the dynamic landscape of FDA-approved medications repurposed for COVID-19, categorized as antiviral and non-antiviral agents. Our focus extends beyond conventional narratives, encompassing vaccination targets, repurposing efficacy, clinical studies, innovative treatment modalities, and future outlooks.

A DFT investigation on the potential of beryllium oxide (Be12O12) as a nanocarrier for nucleobases.

The study of the interactions between biomolecules and nanostructures is quite fascinating. Herein, the adsorption propensity of beryllium oxide (Be12O12) nanocarrier toward nucleobases (NBs) was investigated. In terms of DFT calculations, the adsorption tendency of Be12O12 toward NBs, including cytosine (NB-C), guanine (NB-G), adenine (NB-A), thymine (NB-T), and uracil (NB-U), was unveiled through various configurations.

An evaluation of a student-led nursing leadership symposium.

This paper evaluates an innovative student-led nursing leadership symposium at a Southern California university, specifically designed to bridge educational and practical leadership gaps in nursing with a focus on students from underrepresented groups. Integrating Quality and Safety Education for Nurses (QSEN) competencies, the symposium encouraged active participation, self-reflection, and teamwork. It featured interactive panel discussions with nurse leaders and collaborative learning opportunities aimed at developing leadership knowledge, skills, and action.

Biogenic Sulfide-Mediated Iron Reduction at Low pH.

Acid mine drainage (AMD) pollutes natural waters, but some impacted systems show natural attenuation. We sought to identify the biogeochemical mechanisms responsible for the natural attenuation of AMD. We hypothesized that biogenic sulfide-mediated iron reduction is one mechanism and tested this in an experimental model system.

S.3827 and a Systematic Review of State-Level Multisector Plans for Aging: How Incorporating Volunteer Caregiving Can Mitigate Service Gaps.

Recognizing the growing need to establish and enhance the necessary service infrastructure to better address the diverse needs of a rapidly aging US population, S.3827 (ie, Strategic Plan for Aging Act) seeks to provide federal support for the creation and implementation of Multisector Plans for Aging (MPAs). Passage of S.

Subjective Well-Being, Positive Affect, Life Satisfaction, and Happiness With Multiple Sclerosis: A Scoping Review of the Literature.

Purpose: People with multiple sclerosis (MS) may face challenges maintaining their subjective well-being, life satisfaction, happiness, and positive emotions. This scoping review's purpose was to summarize studies on these positive psychological constructs among people with MS.

Methods: Observational and interventional studies that included measures of subjective well-being, life satisfaction, happiness, or positive affect were identified.

Data-Driven Hypothesis Generation in Clinical Research: What We Learned from a Human Subject Study?

Hypothesis generation is an early and critical step in any hypothesis-driven clinical research project. Because it is not yet a well-understood cognitive process, the need to improve the process goes unrecognized. Without an impactful hypothesis, the significance of any research project can be questionable, regardless of the rigor or diligence applied in other steps of the study, e.

The quality of data-driven hypotheses generated by inexperienced clinical researchers: A case study.

Objectives: We invited inexperienced clinical researchers to analyze coded health datasets and develop hypotheses. We recorded and analyzed their hypothesis generation process. All the hypotheses generated in the process were rated by the same group of seven experts by using the same metrics.

Evaluation of direct point dose estimation based on the distribution of the size-specific dose estimate.

The aim of this study was to evaluate the point doses using a distribution of the size-specific dose estimate (SSDE) from axial CT images of in-house phantoms having diameters from 8 to 40 cm. In-house phantoms made of polyester-resin (PESR) mixed with methyl ethyl ketone peroxide (MEKP) were used. The phantoms were built with different diameter sizes of 8, 16, 24, 32, and 40 cm.

Parent Explanatory Model Personalization as a Method of Reducing Risk for Poor Engagement and Outcomes in PCIT among Culturally Diverse Families.

Evidence supports the efficacy of Behavioral Parent Training (BPT) interventions such as Parent-Child Interaction Therapy (PCIT) for treating child behavior problems; however, treatment engagement and outcomes vary across ethnic groups. Risk for poor treatment engagement and outcomes may be attributed in part to misalignment between parent explanatory model components (PEMs) and the traditional BPT model, including treatment expectations, etiological explanations, parenting styles, and family support for treatment. The present study aims to examine whether personalized treatment adaptations addressing these PEM-BPT misalignments reduce risk for poor treatment engagement and outcomes.

Cannabis And College Students: Self-Perceived Mental Health Prior to, During, and After the Pandemic.

Introduction: College students demonstrated changes in levels of mental wellbeing as they and the world experienced new levels of stress and anxiety due to the COVID-19 pandemic. As access to healthcare became limited, students turned to alternative methods of coping, which included cannabis use.

Objective: To determine if an association between cannabis use and self-perceived mental wellbeing during the pandemic among college students exists.

A Comparative DFT Investigation of the Adsorption of Temozolomide Anticancer Drug over Beryllium Oxide and Boron Nitride Nanocarriers.

Herein, attempts were made to explore the adsorption prospective of beryllium oxide (BeO) and boron nitride (BN) nanocarriers toward the temozolomide (TMZ) anticancer drug. A systematic investigation of the TMZ adsorption over nanocarriers was performed by using quantum chemical density functional theory (DFT). The favorability of BeO and BN nanocarriers toward loading TMZ was investigated through A↔D configurations.

Water Availability and Temperature as Modifiers of Evaporative Water Loss in Tropical Frogs.

Water plays a notable role in the ecology of most terrestrial organisms due to the risks associated with water loss. Specifically, water loss in terrestrial animals happens through evaporation across respiratory tissues or the epidermis. Amphibians are ideal systems for studying how abiotic factors impact water loss since their bodies often respond quickly to environmental changes.

A Practical Method for Slice Spacing Measurement Using the American Association of Physicists in Medicine Computed Tomography Performance Phantom.

Background: The slice spacing has a crucial role in the accuracy of computed tomography (CT) images in sagittal and coronal planes. However, there is no practical method for measuring the accuracy of the slice spacing.

Purpose: This study proposes a novel method to automatically measure the slice spacing using the American Association of Physicists in Medicine (AAPM) CT performance phantom.

A novel method for developing contrast-detail curves from clinical patient images based on statistical low-contrast detectability.

. To develop a method to extract statistical low-contrast detectability (LCD) and contrast-detail (C-D) curves from clinical patient images..

Aluminium phosphide (AlP) nanocage as a potential sensor for volatile organic compounds: A DFT study.

The efficacy of aluminium phosphide (AlP) nanocage toward sensing methanol (MeOH) and ethanol (EtOH) volatile organic compounds (VOCs) was herein thoroughly elucidated utilizing various density functional theory (DFT) computations. In this perspective, MeOH⋯ and EtOH⋯AlP complexes were investigated within all plausible configurations. According to the energetic features, the EtOH⋯AlP complexes exhibited larger negative values of adsorption and interaction energies with values up to -27.

RPEM: Randomized Monte Carlo parametric expectation maximization algorithm.

Inspired from quantum Monte Carlo, by sampling discrete and continuous variables at the same time using the Metropolis-Hastings algorithm, we present a novel, fast, and accurate high performance Monte Carlo Parametric Expectation Maximization (MCPEM) algorithm. We named it Randomized Parametric Expectation Maximization (RPEM). We compared RPEM with NONMEM's Importance Sampling Method (IMP), Monolix's Stochastic Approximation Expectation Maximization (SAEM), and Certara's Quasi-Random Parametric Expectation Maximization (QRPEM) for a realistic two-compartment voriconazole model with ordinary differential equations using simulated data.

Correction: Hamilton et al. Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer. 2017, , 2305.

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Protocol to study circadian food-anticipatory poking in mice using the feeding experimentation device version 3.

Food-anticipatory nose poking is a unique food-seeking behavior driven by the food-entrainable oscillator. Here, we present a protocol to record a novel food-seeking nose poking behavior in mice under temporally restricted feeding followed by food deprivation using the open-source feeding experimentation device version 3 (FED3). We describe steps for setting up the FED3 and cage, training, and habituation.

Bellwethers of change: population modelling of North Pacific humpback whales from 2002 through 2021 reveals shift from recovery to climate response.

For the 40 years after the end of commercial whaling in 1976, humpback whale populations in the North Pacific Ocean exhibited a prolonged period of recovery. Using mark-recapture methods on the largest individual photo-identification dataset ever assembled for a cetacean, we estimated annual ocean-basin-wide abundance for the species from 2002 through 2021. Trends in annual estimates describe strong post-whaling era population recovery from 16 875 (± 5955) in 2002 to a peak abundance estimate of 33 488 (± 4455) in 2012.

Data-driven hypothesis generation among inexperienced clinical researchers: A comparison of secondary data analyses with visualization (VIADS) and other tools.

Objectives: To compare how clinical researchers generate data-driven hypotheses with a visual interactive analytic tool (VIADS, a visual interactive analysis tool for filtering and summarizing large datasets coded with hierarchical terminologies) or other tools.

Methods: We recruited clinical researchers and separated them into "experienced" and "inexperienced" groups. Participants were randomly assigned to a VIADS or control group within the groups.

A challenge and solution for automatic thin slice thickness measurements on images of the Catphan phantom.

. The use of the Hough transform for angle detection is quite accurate for relatively wide slice thickness. However, the Hough transform fails to accurately detect the angle for thin slice thickness.

Elicitation and aggregation of multimodal estimates improve wisdom of crowd effects on ordering tasks.

We present a wisdom of crowds study where participants are asked to order a small set of images based on the number of dots they contain and then to guess the respective number of dots in each image. We test two input elicitation interfaces-one elicits the two modalities of estimates jointly and the other independently. We show that the latter interface yields higher quality estimates, even though the multimodal estimates tend to be more self-contradictory.