1,186 results match your criteria: "California 94710; UCSD Center for Advanced Laboratory Medicine (J.A.S.)[Affiliation]"

Evidence of unintended introductions of species into native habitats has become increasingly prevalent in California. If not managed adequately, species can become devastating agricultural and forest plant pathogens. Additionally, California's natural areas, characterized by a Mediterranean climate and dominated by chaparral (evergreen, drought-tolerant shrubs) and oak woodlands, lack sufficient baseline knowledge on biology and ecology, hindering effective management efforts.

View Article and Find Full Text PDF

Comparing the Extent of Methionine Oxidation in the Prion and Native Conformations of PrP.

ACS Omega

January 2025

CIMUS Biomedical Research Institute & Department of Medical Sciences, University of Santiago de Compostela-IDIS, Santiago de Compostela 15782, Spain.

Scrapie is a prion disease of sheep and goats. Prions (PrP) replicate by inducing a natively expressed protein (PrP) to refold into the prion conformation. PrP and PrP contain a disproportionately large number of methionines.

View Article and Find Full Text PDF

Permeability is a measure of the degree to which cells can transport molecules across biological barriers. Units of permeability are distance per unit time (typically cm/s), where accurate measurements are needed to define drug delivery in homeostasis and to model dysfunction occurring during disease. This perspective offers a set of community-led guidelines to benchmark permeability data across multidisciplinary approaches and different biological contexts.

View Article and Find Full Text PDF

Marburg virus (MARV) disease (MVD) is an uncommon yet serious viral hemorrhagic fever that impacts humans and non-human primates. In humans, infection by the MARV is marked by rapid onset, high transmissibility, and elevated mortality rates, presenting considerable obstacles to the development of vaccines and treatments. Bats, particularly , are suspected to be natural hosts of MARV.

View Article and Find Full Text PDF

Quantifying the Molecular Properties of the Elk Chronic Wasting Disease Agent with Mass Spectrometry.

Pathogens

November 2024

Virus and Prion Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA.

Article Synopsis
  • Chronic wasting disease (CWD) is a prion disease that impacts both wild and farmed elk, where infectious proteins cause normal proteins to misfold.
  • A study used mass spectrometry to analyze prion proteins from elk inoculated with CWD, focusing on various peptides to measure prion quantity and composition.
  • Results indicated differing amounts of prion proteins in the elk's brain tissue and highlighted the presence of methionine oxidation, demonstrating how mass spectrometry can help identify prion strains on a molecular level.
View Article and Find Full Text PDF

Many endosymbionts of insects have been shown to manipulate and alter their hosts' reproduction with implications for agriculture, disease transmission, and ecological systems. Less studied are the microbiota of classical biological control agents and the implications of inadvertent endosymbionts in laboratory colonies for field establishment and effects on target pests or nontarget organisms. While native-range field populations of agents may have a low incidence of vertically transmitted endosymbionts, quarantine and laboratory rearing of inbred populations may increase this low prevalence to fixation in relatively few generations.

View Article and Find Full Text PDF

Many petroleum-derived plastic materials are highly recalcitrant and persistent in the environment, posing significant threats to human and ecological receptors due to their accumulation in ecosystems. In recent years, research efforts have focused on advancing biological methods for polymer degradation. Enzymatic depolymerization has emerged as particularly relevant for biobased plastic recycling, potentially scalable for industrial use.

View Article and Find Full Text PDF

Novel str. 1D1416 for Citrus Transformation.

Microorganisms

September 2024

USDA-ARS Crop Improvement and Genetics, Western Regional Research Center, Albany, CA 94710, USA.

Citrus is one of the world's most important and widely produced fruit crops, with over a 100 million metric tons harvested from nearly 10 million hectares in 2023. Challenges in crop maintenance, production, and fruit quality necessitate developing new traits through Agrobacterium-mediated genetic transformation. While a few strains (EHA105, GV3101, LBA4404) are known to transform citrus, many wild strains remain untested.

View Article and Find Full Text PDF

Improving the Efficiency and Safety of Sentinel Stink Bug Eggs Using X-rays.

Insects

October 2024

Invasive Species and Pollinator Health Research Unit, United States Department of Agriculture-Agricultural Research Services, Albany, CA 94710, USA.

Sentinel eggs used to monitor field parasitism of stink bug pests (Hemiptera: Pentatomidae) can only be deployed for a few days to avoid releasing the pest in the monitored area. Using sterile eggs removes the risk of accidental pest introduction and extends deployment time. Freezing the eggs before deployment is one common method of sterilizing sentinel eggs.

View Article and Find Full Text PDF

Coherence in Chemistry: Foundations and Frontiers.

Chem Rev

November 2024

Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.

Article Synopsis
  • Coherence involves the correlations between waves and is crucial in understanding molecular behaviors in chemistry research.
  • The review highlights varying definitions and concepts of "coherence" and "quantum coherence," linking them to interference patterns and their complex nature.
  • By clarifying these definitions, the aim is to improve communication and understanding in the diverse field of molecular sciences.
View Article and Find Full Text PDF

The purpose of this study was to investigate the necessity and importance of dynamic hydration rate and ultimate viscosity control of konjac glucomannan (KGM) for long-term antiobesity effects in C57BL/6J mice on high-fat (HF) diets. KGM supplementation effectively attenuated HF-diet-induced increases in body and tissue weights. The hydration rate and viscosity changes of KGM in the digestive tract were found to have marked impacts on antiobesity effects.

View Article and Find Full Text PDF
Article Synopsis
  • Plants use pattern recognition receptors (PRRs) like EFR and FLS2 to detect bacterial pathogens and activate their immune response via RBOHD.
  • QSK1, identified as a protein associated with the PRR-RBOHD complex, acts as a negative regulator by downregulating EFR and FLS2, leading to suppressed immunity.
  • The bacterial effector HopF2Pto manipulates QSK1 to inhibit immune responses, demonstrating the sophisticated interplay between plant defense mechanisms and pathogen strategies.
View Article and Find Full Text PDF

Emergence of watermelon chlorotic stunt virus in melon and watermelon in the southwestern United States.

Plant Dis

October 2024

University of Arizona-Yuma Agricultural Center, Entomology, Umniversity of Arizona, Yuma AG Center, Yuma, Arizona, United States, 85364;

Article Synopsis
  • In the fall of 2023, watermelon and melon plants in Yuma County, AZ, and Imperial County, CA, showed mosaic symptoms, chlorotic spotting, and yellowing of older leaves, indicating potential viral infections commonly transmitted by whiteflies.
  • Testing identified that most plants were infected with cucurbit yellow stunting disorder virus (CYSDV), prevalent since 2006, but unusual symptoms suggested the presence of another virus.
  • Further analysis found watermelon chlorotic stunt virus (WmCSV) in symptomatic plants, with genetic sequencing revealing high similarity to WmCSV isolates from production areas in Mexico and Palestine.
View Article and Find Full Text PDF

Advancing stem cell technologies for conservation of wildlife biodiversity.

Development

October 2024

Department of Biochemistry, University of Cambridge, Hopkins Building, Downing Site, Tennis Court Road, Cambridge CB2 1QW, UK.

Article Synopsis
  • Wildlife biodiversity helps keep ecosystems healthy and strong.
  • Scientists study this diversity to learn more about life and how it started.
  • Due to the rapid loss of various species, immediate action is needed from conservationists, and new techniques like stem cell technologies could help protect animal diversity.
View Article and Find Full Text PDF

Identification, Purification, and Characterization of Kunitz-Type Protease Inhibitors from White-Fleshed Dragon Fruit () and Red-Fleshed Dragon Fruit () Seeds as Novel Food Allergens.

J Agric Food Chem

October 2024

US Department of Agriculture, Agricultural Research Service, Pacific West Area, Western Regional Research Center, 800 Buchanan Street, Albany 94710, California, United States.

Article Synopsis
  • Clinical reports suggest that dragon fruits can cause allergic reactions, but the specific allergens responsible are not well understood.
  • This study identified two new allergens in dragon fruits by using techniques like LC-MS/MS and cDNA sequencing, leading to the production of recombinant allergens.
  • The findings reveal that these allergens are Kunitz-type protease inhibitors, which show similar structural characteristics to natural allergens and are major triggers of allergy in sensitized individuals.
View Article and Find Full Text PDF

First Report of Impatiens Necrotic Spot Virus (INSV) Infecting Lettuce in Mexico.

Plant Dis

September 2024

USDA ARS, 1636 East Alisal Street, Salinas, Salinas, California, United States, 93905-3097.

Impatiens necrotic spot virus (INSV; Order Bunyavirales, Family Tospoviridae) is transmitted by several thrips species and has emerged as an important pathogen of lettuce (Lactuca sativa) in several countries (Beris et al., 2020 and Hasegawa & Del Pozo-Valdivia, 2023). In 2023, a total of 22,092 hectares of lettuce were planted in Mexico, with a total production of 523,739 tons (Agri-Food and Fisheries Information Service, 2024).

View Article and Find Full Text PDF

CLAVATA3 Signaling Buffers Arabidopsis Shoot Apical Meristem Activity in Response to Photoperiod.

Int J Mol Sci

August 2024

Plant Gene Expression Center, United States Department of Agriculture-Agricultural Research Service, Albany, CA 94710, USA.

Land plants grow throughout their life cycle via the continuous activity of stem cell reservoirs contained within their apical meristems. The shoot apical meristem (SAM) of Arabidopsis and other land plants responds to a variety of environmental cues, yet little is known about the response of meristems to seasonal changes in day length, or photoperiod. Here, the vegetative and reproductive growth of Arabidopsis wild-type and plants in different photoperiod conditions was analyzed.

View Article and Find Full Text PDF

Many factors contribute to the ability of a microbial species to persist when encountering complexly contaminated environments, including time of exposure, the nature and concentration of contaminants, availability of nutritional resources, and possession of a combination of appropriate molecular mechanisms needed for survival. Herein we sought to identify genes that are most important for survival of Gram-negative Enterobacteriaceae in contaminated groundwater environments containing high concentrations of nitrate and metals using the metal-tolerant Oak Ridge Reservation isolate, Pantoea sp. MT58 (MT58).

View Article and Find Full Text PDF

​Fusarium Protein Toolkit: a web-based resource for structural and variant analysis of Fusarium species.

BMC Microbiol

September 2024

USDA, Agricultural Research Service, Corn Insects and Crop Genetics Research Unit, 819 Wallace Rd. Ames, IA, 50011, USA.

Article Synopsis
  • The genus Fusarium is a major threat to food security, causing diseases and mycotoxin contamination in crops, worsened by climate change; thus, innovative tools are necessary for effective control strategies.
  • A new web-based tool called the Fusarium Protein Toolkit (FPT) was developed to analyze protein structures and genetic variants in important Fusarium species, enhancing our understanding of their biology.
  • FPT aims to help identify targets for managing crop diseases and contamination by providing insights into protein variations and their potential impacts, addressing challenges in agriculture related to Fusarium pathogens.
View Article and Find Full Text PDF

Per- and polyfluoroalkyl substances (PFASs) are a class of synthetic organic chemicals of global concern. A group of 36 scientists and regulators from 18 countries held a hybrid workshop in 2022 in Zürich, Switzerland. The workshop, a sequel to a previous Zürich workshop held in 2017, deliberated on progress in the last five years and discussed further needs for cooperative scientific research and regulatory action on PFASs.

View Article and Find Full Text PDF

A total of 65 SNPs associated with resistance to tan spot and septoria nodorum blotch were identified in a panel of 180 cultivated emmer accessions through association mapping Tan spot and septoria nodorum blotch (SNB) are foliar diseases caused by the respective fungal pathogens Pyrenophora tritici-repentis and Parastagonospora nodorum that affect global wheat production. To find new sources of resistance, we evaluated a panel of 180 cultivated emmer wheat (Triticum turgidum ssp. dicoccum) accessions for reactions to four P.

View Article and Find Full Text PDF

Improving the qubit's lifetime (T) is crucial for fault-tolerant quantum computing. Recent advancements have shown that replacing niobium (Nb) with tantalum (Ta) as the base metal significantly increases T, likely due to a less lossy native surface oxide. However, understanding the formation mechanism and nature of both surface oxides is still limited.

View Article and Find Full Text PDF

The rhizosphere constitutes a dynamic interface between plant hosts and their associated microbial communities. Despite the acknowledged potential for enhancing plant fitness by manipulating the rhizosphere, the engineering of the rhizosphere microbiome through inoculation has posed significant challenges. These challenges are thought to arise from the competitive microbial ecosystem where introduced microbes must survive, and the absence of adaptation to the specific metabolic and environmental demands of the rhizosphere.

View Article and Find Full Text PDF

The Radar for Europa Assessment and Sounding: Ocean to Near-surface (REASON) is a dual-frequency ice-penetrating radar (9 and 60 MHz) onboard the Europa Clipper mission. REASON is designed to probe Europa from exosphere to subsurface ocean, contributing the third dimension to observations of this enigmatic world. The hypotheses REASON will test are that (1) the ice shell of Europa hosts liquid water, (2) the ice shell overlies an ocean and is subject to tidal flexing, and (3) the exosphere, near-surface, ice shell, and ocean participate in material exchange essential to the habitability of this moon.

View Article and Find Full Text PDF