23 results match your criteria: "California (Dr Eapen); and David Geffen School of Medicine at UCLA[Affiliation]"
Prenatal Diet and Infant Growth From Birth to Age 24 Months.
JAMA Netw Open
November 2024
Division of Research and Center for Upstream Prevention of Adiposity and Diabetes Mellitus, Kaiser Permanente Northern California, Pleasanton.
Article Synopsis
- The study investigates how prenatal dietary quality, assessed through the Healthy Eating Index (HEI) and Empirical Dietary Inflammatory Pattern (EDIP), impacts infant sizes at birth and growth patterns up to age 24 months.
- Researchers analyzed data from 2854 parent-child pairs participating in a long-term health program, highlighting the diverse racial and ethnic backgrounds of the participants.
- Results revealed that a healthier diet during pregnancy (high HEI score) is linked to lower likelihoods of having large infants at birth and experiencing rapid growth, suggesting that dietary choices may play a vital role in combating obesity later in life.
Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity.
JAMA Pediatr
November 2024
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
Article Synopsis
A Patch Wearable Cardioverter-Defibrillator for Patients at Risk of Sudden Cardiac Arrest.
J Am Coll Cardiol
August 2024
Baylor Scott and White Research Institute, Dallas, Texas, USA; Department of Medicine, University of Mississippi, Jackson, Mississippi, USA. Electronic address:
Background: For many patients, sudden cardiac arrest (SCA) risk is elevated temporarily. Wearable cardioverter-defibrillators (WCDs) can monitor and treat SCA during these temporary periods. Traditional WCDs can be uncomfortable, require frequent maintenance, and cannot be used when showering, resulting in poor compliance and avoidable SCA deaths.
View Article and Find Full Text PDFComparison of Patient Health Questionnaire-9, Edinburgh Postnatal Depression Scale and Hospital Anxiety and Depression - Depression subscale scores by administration mode: An individual participant data differential item functioning meta-analysis.
J Affect Disord
September 2024
Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada; Department of Medicine, McGill University, Montréal, Québec, Canada; Department of Psychiatry, McGill University, Montréal, Québec, Canada; Department of Psychology, McGill University, Montréal, Québec, Canada; Biomedical Ethics Unit, McGill University, Montréal, Québec, Canada.
Article Synopsis
- * Statistically significant differential item functioning (DIF) was found for most questionnaire items, but this had minimal impact on total scores.
- * Researchers and clinicians can choose the administration method based on what works best for patients, considering preferences, feasibility, or cost, as score differences were negligible.
Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci.
medRxiv
March 2024
Department of Community Health and Epidemiology and Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada.
Article Synopsis
- Obsessive-compulsive disorder (OCD) affects about 1% of people and has a strong genetic component, but previous studies have not fully explained its genetic causes or biological mechanisms.
- A large genome-wide association study (GWAS) analyzed data from over 53,000 OCD cases and over 2 million control participants, identifying 30 significant genetic markers related to OCD and suggesting a 6.7% heritability from SNPs.
- The research also found 249 candidate risk genes linked to OCD, particularly in specific brain regions, and showed genetic correlations with various psychiatric disorders, laying the groundwork for further studies and potential treatments.
Simvastatin in Critically Ill Patients with Covid-19.
N Engl J Med
December 2023
From the Medical Research Institute of New Zealand, Wellington (T.E.H., S. McGuinness, A.M.T., C.J.M.), and Middlemore Hospital (T.E.H.), Te Toka Tumai Auckland City Hospital (T.E.H., S. McGuinness, R.L.P., C.J.M.), and the School of Nursing, University of Auckland (R.L.P.), Auckland - all in New Zealand; Berry Consultants, Austin, TX (E.L., L.R.B., M.A.D., M.F., A.M., C.T.S., R.J.L., S.M.B.); Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (M. Shyamsundar, C.M.O., D.F.M.), the Department of Critical Care, Belfast Health and Social Care Trust (M. Shyamsundar, D.F.M.), and the Centre for Public Health, Queen's University Belfast, Belfast Health and Social Care Trust, and the Department of Health (I.S.Y.), Belfast, Imperial College London (F.A.-B., A.C.G.), the Intensive Care National Audit and Research Centre (C.A., D.A.H., L.L., A.J.M., P.R.M., K.M.R.), University College London Hospitals (R.H.), and Imperial College Healthcare NHS Trust (A.C.G.), London, the Institute for Regeneration and Repair (A. Beane) and the Centre for Inflammation Research (R.H., M.S.-H.), University of Edinburgh, Edinburgh, the Faculty of Health Sciences, University of Bristol, and Bristol Haematology and Oncology Centre, University Hospitals Bristol and Weston NHS Trust, Bristol (C.A.B.), and NHS Blood and Transplant, Oxford (L.J.E.) - all in the United Kingdom; Institut Hospitalo-Universitaire Prometheus, University Paris-Saclay, the Department of Intensive Care, Raymond Poincaré Hospital, Assistance Publique-Hôpitaux de Paris, University Versailles Saint Quentin-University Paris-Saclay, the Laboratory of Infection and Inflammation-Unité 173, School of Medicine Simone Veil, University Versailles Saint Quentin-University Paris-Saclay, INSERM, and Fédération Hospitalo-Universitaire SEPSIS (Saclay and Paris Seine Nord Endeavor to Personalize Interventions for Sepsis) - all in Garches, France (D. Annane); King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia (Y.A.); Nepal Intensive Care Research Foundation, Kathmandu (D. Aryal); Mahidol Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand (D. Aryal, A. Beane); Unity Health Toronto (Z.B., J.C.M., M. Santos), the Interdepartmental Division of Critical Care Medicine, University of Toronto, and Toronto General Hospital Research Institute (E.C.G.), Peter Munk Cardiac Centre at University Health Network (P.R.L.), and Keenan Centre for Biomedical Research (J.C.M.), Toronto, Université de Sherbrooke, Sherbrooke, QC (F.L.), McGill University Health Centre, Montreal (P.R.L.), the Faculty of Medicine, University of British Columbia, Vancouver (S. Murthy), the Population Health and Optimal Practices Research Unit, Centre Hospitalier Universitaire de Québec-Université Laval Research Center, and the Department of Anesthesiology and Critical Care Medicine, Université Laval, Quebec City (A.F.T.), and the University of Manitoba and CancerCare Manitoba, Winnipeg (R.Z.) - all in Canada; Julius Center for Health Sciences and Primary Care (M. Bonten, L.P.G.D.) and the Intensive Care Center (L.P.G.D.), University Medical Center Utrecht, Utrecht University, and the European Clinical Research Alliance on Infectious Diseases (M. Bonten), Utrecht, and Radboud University Medical Center, Nijmegen (F.V.) - all in the Netherlands; the Department of Anesthesiology and Intensive Care Medicine (F.M.B., S.W.) and the Institute for Infection Disease and Infection Control (S.W.), Jena University Hospital, Friedrich-Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (S.W.) - both in Jena, Germany; the School of Public Health and Preventive Medicine (A. Burrell, A.C.C., C.G., A.M.H., Z.K.M., A.D.N., J.C.P., C.J.M., S.A.W.) and the School of Clinical Sciences (A.C.C.), Monash University, Alfred Hospital (A. Burrell, A.D.N.), and Monash Health (A.C.C., Z.K.M.), Melbourne, VIC, the Faculty of Medicine, University of Queensland, and the Intensive Care Unit, Princess Alexandra Hospital, Brisbane (P.S.K.), and St. John of God Health Care, Perth, WA (S.A.W.) - all in Australia; the Global Coalition for Adaptive Research, Larkspur (M. Buxton), the Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, and the Department of Anesthesia, University of California, San Francisco, San Francisco (C.S.C.), and Harbor-UCLA Medical Center, Torrance (R.J.L.) - all in California; the Department of Biomedical Sciences, Humanitas University, and IRCCS Humanitas Research Hospital, Milan (M.C.); National University Hospital Singapore, Singapore (M.E.C.); Dr. Kamakshi Memorial Hospital (D.J.) and Apollo Speciality Hospitals (E.R.) - both in Chennai, India; the University of Antwerp, Antwerp, Belgium (H.G.); National Intensive Care Surveillance-MORU, Colombo, Sri Lanka (R.H.); Ziauddin University, Karachi, Pakistan (M.H.); the University of Pittsburgh (D.T.H., B.J.M., M.D.N., C.W.S., D.C.A.) and the University of Pittsburgh Medical Center (D.T.H., B.J.M.) - both in Pittsburgh; Jikei University School of Medicine and the University of Tokyo, Tokyo (N.I.), and St. Marianna University School of Medicine, Yokohama Seibu Hospital, Yokohama (H.S.) - all in Japan; University College Dublin Clinical Research Centre, St. Vincent's University Hospital, Dublin (A.D.N.); Universidad de La Sabana and Clínica Universidad de La Sabana - both in Chia, Colombia (L.F.R.); the Division of Clinical and Translational Research, Division of Critical Care, Department of Anesthesiology, Washington University School of Medicine, St. Louis (P.S.); and the Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (B.T.T.).
Article Synopsis
- The study aimed to evaluate the effectiveness of simvastatin in critically ill Covid-19 patients compared to a control group not receiving statins.
- A total of 2684 patients were analyzed, showing a median of 11 organ support-free days in the simvastatin group versus 7 in the control group, with a high probability indicating simvastatin’s potential superiority.
- However, the study was halted due to decreasing Covid-19 cases, and while simvastatin had some benefits, it also led to more reported serious adverse effects, such as elevated liver enzymes.
Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
JAMA
November 2023
Research Centre of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
Importance: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.
Objective: To determine whether vitamin C improves outcomes for patients with COVID-19.
Design, Setting, And Participants: Two prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support in intensive care units (90 sites) and patients who were not critically ill (40 sites) between July 23, 2020, and July 15, 2022, on 4 continents.
No impact of CD34 cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma.
Bone Marrow Transplant
December 2023
Mott Children's Hospital, University of Michigan Medical Center, Ann Arbor, MI, USA.
Article Synopsis
- Overactivation of the renin-angiotensin system (RAS) could lead to worse outcomes for COVID-19 patients, prompting a study to see if ACE inhibitors or ARBs could help.
- In a clinical trial with 721 patients, participants were randomly assigned to receive either an ACE inhibitor, an ARB, or no RAS inhibitor to evaluate their effects on patient recovery.
- Results showed no significant improvement in organ support-free days among the treatment groups compared to the control, leading to the discontinuation of enrollment due to safety concerns.
Effect of Autograft CD34 Dose on Outcome in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplant for Central Nervous System Tumors.
Transplant Cell Ther
June 2023
Mott Children's Hospital, University of Michigan Medical Center, Ann Arbor, Michigan.
Consolidation with autologous hematopoietic stem cell transplantation (HSCT) has improved survival for patients with central nervous system tumors (CNSTs). The impact of the autologous graft CD34+ dose on patient outcomes is unknown. We wanted to analyze the relationship between CD34 dose, total nucleated cell (TNC) dose, and clinical outcomes, including overall survival (OS), progression-free survival (PFS), relapse, non-relapse mortality (NRM), endothelial-injury complications (EIC), and time to neutrophil engraftment in children undergoing autologous HSCT for CNSTs.
View Article and Find Full Text PDFLipid-lowering treatment among older patients with atherosclerotic cardiovascular disease.
J Am Geriatr Soc
April 2023
Duke Clinical Research Institute, Durham, North Carolina, USA.
Background: The contemporary uptake of lipid-lowering therapies (LLT), including more intensive treatment with high-intensity statins and non-statin LLT, among U.S. older adults (≥75 years old) with ASCVD is unknown.
View Article and Find Full Text PDFResearch Letter: Long-Term Outcomes Following Cognitive Rehabilitation for Mild Traumatic Brain Injury: A 5-Year Follow-Up of a Cohort From the SCORE Randomized Clinical Trial.
J Head Trauma Rehabil
November 2022
Traumatic Brain Injury Center of Excellence (TBICOE), Neurology Service, Department of Medicine, Brooke Army Medical Center, Joint Base San Antonio, San Antonio, Texas (Dr Kennedy and Ms Shelton); Polytrauma Rehabilitation Center, Audie Murphy Veterans Hospital, and Departments of Psychiatry and Rehabilitation Medicine, UT Health San Antonio, San Antonio, Texas (Dr Cooper); Department of Psychology, University of South Florida, Tampa (Dr Curtiss); Brain Injury Rehabilitation Service, Department of Rehabilitation, Brooke Army Medical Center, Joint Base San Antonio, San Antonio, Texas (Dr Bowles); Department of Neurology, University of Utah School of Medicine, Salt Lake City (Dr Tate); Physical Medicine and Rehabilitation, VA Greater Los Angeles Healthcare System, Los Angeles, California (Dr Eapen); and Department of Psychiatry and Neurosciences, College of Medicine, University of South Florida, Tampa (Dr Vanderploeg).
Objective: To examine the functioning of military service members 5 years after completing a randomized controlled trial (RCT) of cognitive rehabilitation for mild traumatic brain injury (mTBI).
Setting: Home-based telephonic interview and internet-based self-ratings.
Participants: Sixty-nine of the 126 (55%) active-duty service members who were enrolled in a 4-arm RCT of cognitive rehabilitation 3 to 24 months after mTBI and were successfully contacted by phone 5 years later.
Cognitive Behavioral Therapy for Veterans With Comorbid Posttraumatic Headache and Posttraumatic Stress Disorder Symptoms: A Randomized Clinical Trial.
JAMA Neurol
August 2022
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center San Antonio, San Antonio.
Importance: Posttraumatic headache is the most disabling complication of mild traumatic brain injury. Posttraumatic stress disorder (PTSD) symptoms are often comorbid with posttraumatic headache, and there are no established treatments for this comorbidity.
Objective: To compare cognitive behavioral therapies (CBTs) for headache and PTSD with treatment per usual (TPU) for posttraumatic headache attributable to mild traumatic brain injury.
High-Intensity Statin Use Among Patients With Atherosclerosis in the U.S.
J Am Coll Cardiol
May 2022
Duke Clinical Research Institute, Durham, North Carolina, USA. Electronic address:
Background: Preventive therapy among patients with established atherosclerotic cardiovascular disease (ASCVD) is generally underused. Whether new guideline recommendations and a focus on implementation have improved the use of high-intensity statins is unknown.
Objectives: This study sought to evaluate the patterns and predictors of statin use among patients with ASCVD.
Health Conditions Among Special Operations Forces Versus Conventional Military Service Members: A VA TBI Model Systems Study.
J Head Trauma Rehabil
July 2022
Mental Health and Behavioral Sciences Section (MHBSS) (Drs Garcia, Kretzmer, Miles, Bajor, and Silva) and Physical Medicine & Rehabilitation Service (Dr Merritt), James A. Haley Veterans' Hospital, Tampa, Florida; Traumatic Brain Injury Center of Excellence (TBI CoE), Tampa, Florida (Dr Garcia); Departments of Neurology (Dr Dams-O'Connor) and Rehabilitation and Human Performance (Dr Dams-O'Connor), Icahn School of Medicine at Mount Sinai, New York City, New York; Departments of Psychiatry and Behavioral Neurosciences (Drs Miles, Bajor, Belanger, and Silva), Internal Medicine (Dr Silva), and Psychology (Dr Silva), University of South Florida, Tampa, Florida; Harvard Medical School, Boston, Massachusetts (Dr Bajor); Tampa VA Research and Education Foundation, Inc, Temple Terrace, Florida (Dr Tang); United States Special Operations Command (USSOCOM), Tampa, Florida (Dr Belanger); St Michael's Inc, Woodbridge, Virginia (Dr Belanger); VA Greater Los Angeles Healthcare System, Los Angeles, California (Dr Eapen); National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center (WRNMMC), Bethesda, Maryland (Dr McKenzie-Hartman); and F. Edward Hébert School of Medicine (SOM), Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland (Dr McKenzie-Hartman).
Objective: To examine traumatic brain injury (TBI) characteristics and comorbid medical profiles of Special Operations Forces (SOF) Active Duty Service Member/Veterans (ADSM/Vs) and contrast them with conventional military personnel.
Setting: The 5 Veterans Affairs (VA) Polytrauma Rehabilitation Centers.
Participants: A subset of participants in the VA TBI Model Systems multicenter longitudinal study with known SOF status.
The Military Injuries: Understanding Post-Traumatic Epilepsy Study: Understanding Relationships among Lifetime Traumatic Brain Injury History, Epilepsy, and Quality of Life.
J Neurotrauma
October 2021
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Understanding risk for epilepsy among persons who sustain a mild (mTBI) traumatic brain injury (TBI) is crucial for effective intervention and prevention. However, mTBI is frequently undocumented or poorly documented in health records. Further, health records are non-continuous, such as when persons move through health systems (e.
View Article and Find Full Text PDFDemographic and Mental Health Predictors of Arrests Up to 10 Years Post-Traumatic Brain Injury: A Veterans Affairs TBI Model Systems Study.
J Head Trauma Rehabil
October 2021
Mental Health and Behavioral Sciences, James A. Haley Veterans' Hospital, Tampa, Florida (Drs Miles, Silva, and Nakase-Richardson); Department of Psychiatry & Behavioral Neurosciences, University of South Florida, Tampa, Florida (Drs Miles and Silva); Department of Internal Medicine, Division of Pulmonary and Sleep Medicine, University of South Florida, Tampa, Florida (Drs Silva and Nakase-Richardson); Defense and Veterans Brain Injury Center, James A. Haley Veterans' Hospital, Tampa, Florida (Drs Silva and Nakase-Richardson); Department of Psychology, University of South Florida, Tampa, Florida (Dr Silva); Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, Indiana (Dr Neumann); Rehabilitation Hospital of Indiana, Indianapolis, Indiana (Dr Neumann); Rehabilitation & Mental Health Counseling Program, Department of Child & Family Studies, University of South Florida, Tampa, Florida (Dr Dillahunt-Aspillaga); Research Service, James A. Haley Veterans' Hospital, Tampa, Florida (Dr Dillahunt-Aspillaga); Department of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, Ohio (Dr Corrigan); Tampa VA Research and Education Foundation, Inc, Tampa, Florida (Dr Tang); Department of Physical Medicine and Rehabilitation, VA Greater Los Angeles Health Care System, Los Angeles, California (Dr Eapen); and David Geffen School of Medicine at UCLA, Los Angeles, California (Dr Eapen).
Objective: Examine rates and predictors of arrests in Veterans and Service Members (V/SM) who received inpatient rehabilitation for traumatic brain injury (TBI).
Setting: Veterans Administration (VA) Polytrauma Rehabilitation Centers.
Participants: A total of 948 V/SM drawn from the VA TBI Model Systems cohort with arrest data up to 10 years post-TBI.
Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.
Brain Imaging Behav
April 2021
Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Traumatic brain injury (TBI) is common among military personnel and the civilian population and is often followed by a heterogeneous array of clinical, cognitive, behavioral, mood, and neuroimaging changes. Unlike many neurological disorders that have a characteristic abnormal central neurologic area(s) of abnormality pathognomonic to the disorder, a sufficient head impact may cause focal, multifocal, diffuse or combination of injury to the brain. This inconsistent presentation makes it difficult to establish or validate biological and imaging markers that could help improve diagnostic and prognostic accuracy in this patient population.
View Article and Find Full Text PDFCause of Death in Patients With Acute Heart Failure: Insights From RELAX-AHF-2.
JACC Heart Fail
December 2020
Division of Cardiology and Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA. Electronic address:
Objectives: This study sought to better understand the discrepant results of 2 trials of serelaxin on acute heart failure (AHF) and short-term mortality after AHF by analyzing causes of death of patients in the RELAX-AHF-2 (Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF-2) trial.
Background: Patients with AHF continue to suffer significant short-term mortality, but limited systematic analyses of causes of death in this patient population are available.
Methods: Adjudicated cause of death of patients in RELAX-AHF-2, a randomized, double-blind, placebo-controlled trial of serelaxin in patients with AHF across the spectrum of ejection fraction (EF), was analyzed.
Health Phenotypes and Neurobehavioral Symptom Severity Among Post-9/11 Veterans With Mild Traumatic Brain Injury: A Chronic Effects of Neurotrauma Consortium Study.
J Head Trauma Rehabil
October 2021
Department of Health and Exercise Science, Appalachian State University, Boone, North Carolina (Dr Bouldin); Department of Psychology, University of Texas at San Antonio (Dr Swan); Speech-Language Pathology Program, School of Health Professions, University of Texas Health Science Center at San Antonio (Dr Norman); George E. Whalen VA Medical Center, Salt Lake City, Utah (Dr Tate); Departments of Neurology (Dr Tate) and Internal Medicine (Dr Pugh), University of Utah School of Medicine, Salt Lake City; Lees-McRae College, Banner Elk, North Carolina (Ms Tumminello); VA Salt Lake City Health Care System, Informatics, Decision-Enhancement, and Analytic Sciences Center, Salt Lake City, Utah (Mss Amuan and Trevino and Dr Pugh); Department of Physical Medicine and Rehabilitation, VA Greater Los Angeles Health Care System, and Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California (Dr Eapen); and Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio (Dr Wang).
Objective: To evaluate whether neurobehavioral symptoms differ between groups of veterans with mild traumatic brain injury (mTBI) classified by health characteristics.
Participants: A total of 71 934 post-9/11 veterans with mTBI from the Chronic Effects of Neurotrauma Consortium Epidemiology warfighter cohort.
Design: Cross-sectional analysis of retrospective cohort.
Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders.
J Allergy Clin Immunol
January 2018
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:
Background: Rare DNA breakage repair disorders predispose to infection and lymphoreticular malignancies. Hematopoietic cell transplantation (HCT) is curative, but coadministered chemotherapy or radiotherapy is damaging because of systemic radiosensitivity. We collected HCT outcome data for Nijmegen breakage syndrome, DNA ligase IV deficiency, Cernunnos-XRCC4-like factor (Cernunnos-XLF) deficiency, and ataxia-telangiectasia (AT).
View Article and Find Full Text PDFGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy
October 2016
kb Emory University, School of Medicine, Department of Microbiology and Immunology , Atlanta , GA , USA.
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
Am J Psychiatry
January 2015
From the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston; the Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Mass.; the Department of Psychiatry, University of California, San Francisco; the Department of Neurology, Massachusetts General Hospital, Boston; the Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Boston; the Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago; the Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam; the Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles; the Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Md.; the Genomic and Bioinformatic Unit, Filarete Foundation, Milan, Italy; the Department of Health Sciences, Graduate School of Nephrology, University of Milan, Milan; the Toronto Western Research Institute, University Health Network, Toronto; Hospital for Sick Children, Toronto; Università Vita-Salute San Raffaele, Milan; the Herman Dana Division of Child and Adolescent Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem; Universidad de Antioquia, Universidad Pontificia Bolivariana, Medellín, Colombia; the Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore; the Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City; the Child Study Center and the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn.; the Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil; North Shore-Long Island Jewish Medical Center and North Shore-Lo
Objective: Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmental disorders that are thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex disorders remains elusive. The authors report a combined genome-wide association study (GWAS) of Tourette's syndrome and OCD.
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