29,690 results match your criteria: "Calif; Rady Children's Hospital[Affiliation]"

Background: Fast-track models decrease patient crowding in emergency departments (EDs) by redirecting low-acuity patients to an expedited care pathway. In 2016, this institution's pediatric ED created a fast-track pathway for patients evaluated in a rapid assessment triage area who needed further management in the primary ED. This "Supertrack" designation was intended for patients requiring up to 1 hour of additional care, though means of ensuring these patients were discharged within their anticipated timeframe were lacking.

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Background: Silicone gel removal after breast implant rupture is a difficult task. Silicone is hydrophobic and thus cannot be irrigated effectively with saline. Attempts at mechanical removal with sponges are often partially successful.

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Recent Updates on the Management of Split-thickness Skin Graft Donor Sites.

Plast Reconstr Surg Glob Open

September 2024

Department of Plastic and Reconstructive Surgery, Elite Plastic Surgery, Grand Rapids, Michigan.

Background: This article is a narrative review of split-thickness skin graft donor site (STSG-DS) management since the international guidelines were created in 2018. Although many new interventions have been developed, there is a lack of quality, multicentered clinical trials to produce updated evidence-based recommendations.

Methods: Electronic databases, including Google Scholar, Web of Science, Medline, and PubMed, were searched by two independent researchers for literature regarding STSG-DS management published from 2018 through 2022, using specific terms in the text, title, and abstract.

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Objective: Although national efforts have aimed to improve the safety of inpatient operations, income-based inequities in surgical outcomes persist, and the evolution of such disparities has not been examined in the contemporary setting. We sought to examine the association of community-level household income with acute outcomes of cardiac procedures over the past decade.

Methods: All adult hospitalizations for elective coronary artery bypass grafting/valve operations were tabulated from the 2010-2020 Nationwide Readmissions Database.

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Objective: Robotic thoracic surgery provides another minimally invasive approach in addition to video-assisted thoracoscopic surgery (VATS) that yields less pain and faster recovery compared with open surgery. However, robotic incisions are generally placed more inferiorly, which may increase the risk of intercostal nerve injury that affects the abdominal wall. We hypothesized that a robotic approach causes greater ipsilateral rectus muscle atrophy compared with open and VATS approaches.

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Article Synopsis
  • In February 2024, the FDA approved omalizumab for food allergy treatment, following positive results from the OUtMATCH phase 3 clinical trial.
  • The trial showed significant effectiveness in desensitizing patients to multiple allergens, although some participants did not respond and fewer tolerated all three food allergens compared to single ones.
  • Clinicians are expected to have questions about patient selection and treatment management, indicating a need for further research to enhance real-world application and ensure high-quality outcomes.
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Radiology State-of-the-art Review: Endometriosis Imaging Interpretation and Reporting.

Radiology

September 2024

From the Mayo Clinic Rochester, 200 1st Street SW, Rochester, MN 55905 (W.V.B., T.L.B., Z.K., C.C., P.I.C.A.); Cleveland Clinic, Cleveland, Ohio (M.F., C.K., M.P.); Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.S.S.B., A.K.); University of Michigan, Ann Arbor, Mich (M.D.S.); Mayo Clinic Arizona, Phoenix, Ariz (S.Y., M.Y.); Chamie Imagem da Mulher, São Paulo, Brazil (L.P.C.); University of California San Francisco, San Francisco, Calif (L.G., J.T.R., L.P.); NYU Grossman School of Medicine, New York, NY (N.M.H., A.T., M.T.T.); David Geffen School of Medicine, Los Angeles, Calif (H.D.D.); University of Arizona College of Medicine Phoenix/Banner University Medical Center-Phoenix (R.M.K.); Stanford University School of Medicine, Stanford, Calif (L.S.); Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (K.S.B.); Clinic Izabela Pires Franco, Belém, Brazil (I.V.P.F.); Temerty Faculty of Medicine (P.G.), University of Toronto, Toronto, Ontario, Canada (A.Z.K.); Thomas Jefferson University Hospital, Philadelphia, Pa (L.M.K.); University of Texas Health Science Center at San Antonio, San Antonio, Tex (A.B.); University of Arizona College of Medicine, Banner University Medicine, Tucson, Ariz (H.A.T.); Columbia University Irving Medical Center, New York, NY (S.L.N.); SUNY Upstate Medical University, Syracuse, NY (R.N.); and Department of Radiology, Stanford University School of Medicine, Stanford, Calif (P.J.).

Article Synopsis
  • * Diagnosis may involve imaging techniques like MRI and advanced transvaginal ultrasound, which help identify deep endometriosis and assess associated complications like fibrosis and adhesions.
  • * Radiologists play a crucial role in recognizing the wide range of endometriosis manifestations, including the ability to evaluate features that might indicate malignancy.
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AI for Multistructure Incidental Findings and Mortality Prediction at Chest CT in Lung Cancer Screening.

Radiology

September 2024

From the Departments of Medicine, Division of Artificial Intelligence in Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, 6500 Wilshire Blvd, Los Angeles, CA 90048 (A.M.M., M.B., A.S., B.P.B., A.K., R.J.H.M., V.B., M.L., D.S.B., D.D., P.J.S.); Signal and Image Processing Institute, Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, Calif (A.S.); and Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada (R.J.H.M.).

Background Incidental extrapulmonary findings are commonly detected on chest CT scans and can be clinically important. Purpose To integrate artificial intelligence (AI)-based segmentation for multiple structures, coronary artery calcium (CAC), and epicardial adipose tissue with automated feature extraction methods and machine learning to detect extrapulmonary abnormalities and predict all-cause mortality (ACM) in a large multicenter cohort. Materials and Methods In this post hoc analysis, baseline chest CT scans in patients enrolled in the National Lung Screening Trial (NLST) from August 2002 to September 2007 were included from 33 participating sites.

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Autoimmune diseases are prevalent among people of African ancestry living outside Africa. However, the burden of autoimmune diseases in Africa is not well understood. This article provides a global overview of the current burden of autoimmune diseases in individuals of African descent.

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Clustering of clinical symptoms using large language models reveals low diagnostic specificity of proposed alternatives to consensus mast cell activation syndrome criteria.

J Allergy Clin Immunol

September 2024

Institute for Immunity, Transplantation, and Infection, School of Medicine, Stanford University, Palo Alto, Calif; Department of Medicine, Center for Biomedical Informatics Research, School of Medicine, Stanford University, Palo Alto, Calif.

Article Synopsis
  • - The diagnosis of mast cell activation syndrome (MCAS) has risen, but while there are established consortium criteria, there are also alternative criteria that may not be as specific.
  • - Researchers used advanced language models to analyze diagnostic probabilities and found that alternative criteria led to broader and less precise diagnoses compared to the consortium criteria.
  • - The study concluded that alternative MCAS criteria result in a diverse range of diagnoses, making them less reliable and potentially leading to misclassifications when compared to established conditions like systemic lupus erythematosus.
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Background: Intervention on Type B dissection frequently requires landing the proximal edge of the stent graft between the left common carotid artery and left subclavian artery (LSA). The Gore® TAG® Thoracic Branch Endoprosthesis (TBE) is a technology which allows LSA preservation with a single internal branch.

Methods: This study was a prospective non-randomized single-arm clinical trial of patients with type B aortic dissection that were treated with the single branched device.

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Sinonasal Tumors: What the Multidisciplinary Cancer Care Board Wants to Know.

Radiographics

October 2024

From the Department of Radiology, Division of Neuroradiology (G.D.A., T.A.K.), Department of Otorhinolaryngology (I.J.K.), Department of Pathology, Division of Human Oncology (L.A.E.), Department of Human Oncology (A.R.B.), and Department of Medicine, Division of Human Oncology (J.Y.B.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; Department of Radiology, Medical College of Wisconsin, Milwaukee, Wis (M.A.); California Advanced Imaging Medical Associates, San Francisco, Calif (M.A.M.); and University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin (L.P.).

Sinonasal neoplasms are a remarkably heterogeneous group, reflecting the numerous tissue types present in the nasal cavity and paranasal sinuses. These entities can be relatively benign (ie, respiratory epithelial adenomatoid hamartoma) or can be exceedingly aggressive (ie, NUT carcinoma). Certain sinonasal tumors have a propensity to spread through local invasion and destruction, while others have a high likelihood of perineural spread.

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Background: The Ross procedure has excellent outcomes in the pediatric population. Some series have reported age- and anatomy-dependent outcomes, but a comprehensive analysis stratified by these variables has not been reported to date. We sought to describe the landscape of congenital heart disease (CHD) treated with the Ross procedure and identify the patients best served by this operation.

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Reproducibility and Repeatability of US Shear-Wave and Transient Elastography in Nonalcoholic Fatty Liver Disease.

Radiology

September 2024

From the Center for Ultrasound Research and Translation, Massachusetts General Hospital, 55 Fruit St, White Bldg, Rm 270, Boston, MA 02114 (T.T.P., A.O., X.W., Q.L., D.H., M.M., H.E., A.E.S.); Harvard Medical School, Boston, Mass (T.T.P., A.O., Q.L., A.E.S.); Pfizer, Cambridge, Mass (S.P.S.); Department of Radiology, University of Washington, Seattle, Wash (G.M.C.); Department of Ultrasound, Shenzhen University General Hospital, Shenzhen, China (Q.L.); Department of Radiology, Liver Imaging Group, University of California San Diego, La Jolla, Calif (M.S.M., Y.C., C.B.S., K.J.F.); MGH Fatty Liver Program, Gastrointestinal Unit, Massachusetts General Hospital, Boston, Mass (K.E.C.); BioAge Labs, Richmond, Calif (S.S.S.); Foundation for the National Institutes of Health, North Bethesda, Md (H.H., T.N.K.); Regeneron Pharmaceuticals, Tarrytown, NY (R.A.C.); Department of Medicine, Division of Gastroenterology, NAFLD Research Center, University of California at San Diego, La Jolla, Calif (R.L.); Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.A.O.); and Department of Internal Medicine, Division of Internal Medicine, Division of Gastroenterology, Virginia Commonwealth University Medical Center, Richmond, Va (A.J.S.).

Background US shear-wave elastography (SWE) and vibration-controlled transient elastography (VCTE) enable assessment of liver stiffness, an indicator of fibrosis severity. However, limited reproducibility data restrict their use in clinical trials. Purpose To estimate SWE and VCTE measurement variability in nonalcoholic fatty liver disease (NAFLD) within and across systems to support clinical trial diagnostic enrichment and clinical interpretation of longitudinal liver stiffness.

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Generating Synthetic Data for Medical Imaging.

Radiology

September 2024

From the Delft University of Technology, Delft, the Netherlands (L.R.K.); Segmed, 3790 El Camino Real #810, Palo Alto, CA 94306 (J.W., A.L., M.C., W.A.K., J.P., M.J.W.); Department of Radiology, University of Washington, Seattle, Wash (D.M.); Department of Radiology, OncoRad/Tumor Imaging Metrics Core, Seattle, Wash (D.M.); Harvard University, Cambridge, Mass (J.P.); Department of Radiology, Stanford University School of Medicine, Palo Alto, Calif (A.S.C.); Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, Calif (A.S.C.); Department of Biomedical Informatics, Harvard Medical School, Boston, Mass (P.R.); Microsoft, Redmond, Wash (M.P.L.); and Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Calif (M.P.L.).

Article Synopsis
  • AI models for medical imaging need large and diverse datasets, which are hard to obtain due to privacy concerns and data sharing issues.
  • Synthetic medical imaging data, generated by AI, can help address these shortages while allowing for new applications and professional training.
  • However, using synthetic data raises challenges related to realism, evaluation of model performance, high costs, and the need for updated regulations to ensure ethical use, highlighting the importance of collaboration between regulatory bodies, physicians, and AI developers.
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Background: Seafood allergy (SA), including allergy to shellfish (crustacean and mollusks) and fish, is among the 4 most common food allergies causing anaphylaxis, but there are limited data showing SA clinical management in different countries.

Objective: We sought to characterize a large cohort of patients with fish and shellfish allergy and to facilitate standardization of future care for this increasingly common allergic disease.

Methods: We performed a retrospective, observational, noninterventional study from 945 patients from 2015 to 2019 in 7 hospitals in the United States and the United Kingdom to evaluate SA.

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Atopic Dermatitis (Eczema) Guidelines 2023: Highlights.

J Allergy Clin Immunol Pract

November 2024

Division of Immunology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Mass.

Article Synopsis
  • * The American Academy of Allergy, Asthma & Immunology has released updated guidelines for treating atopic dermatitis, focusing on trustworthy development standards and evidence-based medicine to guide clinical decisions.
  • * The guidelines include recommendations for various treatments like topical therapies, dietary changes, and systemic treatments, emphasizing the importance of considering patient values and preferences in treatment selection.
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Comparing Cortiva Silhouette to AlloDerm for Use in Prepectoral Two-stage Prosthetic Breast Reconstruction.

Plast Reconstr Surg Glob Open

September 2024

From the Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Palo Alto, Calif.

Background: The use of acellular dermal matrices (ADMs) in implant-based breast reconstruction has become increasingly routine during the past 20 years. ADMs improve soft-tissue support, facilitate greater tissue expander (TE) fill volumes, and reduce rates of capsular contracture. As the ADM market continues to grow, outcomes studies are necessary to assess the risks and benefits of each product.

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Mitochondrial DNA copy number variation in asthma risk, severity, and exacerbations.

J Allergy Clin Immunol

September 2024

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Integrated Hospital Care Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Article Synopsis
  • Asthma is linked to mitochondrial dysfunction, indicated by lower levels of mitochondrial DNA copy number (mtDNA-CN), which may serve as a proxy for mitochondrial health.* -
  • A study using data from the UK Biobank and the Severe Asthma Research Program found that individuals with asthma consistently have lower mtDNA-CN levels compared to those without asthma, across all age groups.* -
  • The research suggests that lower mtDNA-CN is associated with an increased risk of asthma exacerbations and is influenced by genetic factors rather than inflammation.*
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Extracorporeal membrane oxygenation (ECMO) has emerged as an important intervention for children both preceding and following cardiac surgery. There is a notable lack of comprehensive information regarding neurodevelopmental outcomes. The Norwood procedure and complex biventricular repairs exhibit the highest prevalence of ECMO usage.

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Article Synopsis
  • Systemic mastocytosis (SM) is a rare disease affecting about 32,000 people in the U.S., often misdiagnosed due to vague symptoms and the necessity for invasive tests.
  • A study of 116 patients revealed that the majority had indolent SM, with a significant average delay of 58.3 months for diagnosis, and some patients progressed to more advanced forms.
  • The findings emphasize the need for better awareness and understanding of SM to improve diagnosis and treatment, suggesting that further studies are necessary to establish effective follow-up care for patients.
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One-food versus 4-food elimination diet for pediatric eosinophilic esophagitis: A multisite randomized trial.

J Allergy Clin Immunol

September 2024

Division of Allergy and Immunology, Department of Pediatrics Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

Background: A 6-food elimination diet in pediatric eosinophilic esophagitis (EoE) is difficult to implement and may negatively affect quality of life (QoL). Less restrictive elimination diets may balance QoL and efficacy.

Objective: We performed a multisite, randomized comparative efficacy trial of a 1-food (milk) elimination diet (1FED) versus 4-food (milk, egg, wheat, soy) elimination diet (4FED) in pediatric EoE.

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Objectives: To assess the influence of Invisalign precision bite ramp use on skeletal deep overbite correction and root length and volume of maxillary anterior teeth.

Materials And Methods: This was a retrospective study of 60 adults with skeletal deep overbite. Patients were divided into three groups: Invisalign (Align Technology, San Jose, Calif) with precision bite ramps (Invisalign with Bite Ramps [IBR] = 12), Invisalign with no bite ramps (INBR = 22), and full-fixed appliances (FFA = 26).

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