29,744 results match your criteria: "Calif; David Geffen School of Medicine at UCLA Medical Center[Affiliation]"

Background: The decisions and components of a career in medicine have changed. Historically, a career selection was often a decision between joining an institution or academic center versus the fiscal risks associated with private practice. This created a relatively simple risk versus reward equation: those in private practice made more money if it went well.

View Article and Find Full Text PDF

Bias, Prejudice, Discrimination, Racism, and Social Determinants: The Impact on the Health and Well-Being of Latino Children and Youth.

Acad Pediatr

October 2024

Department of Pediatrics (G Flores), University of Miami Miller School of Medicine, and Holtz Children's Hospital, Jackson Health System, Mailman Center for Child Development, Miami, Fla.

This narrative review focuses on the impact of bias, prejudice, discrimination, racism (BPDR), social determinants of health, and structural racism on Latino children's health and well-being. The race/ethnicity, country of origin, immigrant/generational status, limited English proficiency (LEP), acculturation level, and social class of Latino children and their parents can heighten or modify the impact of BPDR. These differences have been shown to affect BPDR among Latino adults and presumably for their children.

View Article and Find Full Text PDF

This narrative review examines the impact of racism in academic pediatrics. We begin with our challenges in diversifying the pediatric physician workforce and the downstream impact of selection and recruitment practices compounded by disparities in resident dismissal rates. We present best practices in recruitment and resources from academic societies and institutions, including examples of successful holistic review processes.

View Article and Find Full Text PDF

There are well-documented inequities in the quality of care and health outcomes of minoritized youth. Patient safety and quality improvement (QI) work with an equity focus has been identified as an important strategy to remedy these existing inequities. In this article, we will present evidence of inequities in pediatric hospital-based care, describe root causes with a focus on structural racism, highlight existing frameworks for applying equity principles to patient safety and QI, and provide best practices and recommendations on evaluating patient safety and QI data towards advancing equity in pediatric hospital-based care.

View Article and Find Full Text PDF

We open this article by asking you to consider that the magnitude of racism present in clinical spaces is much larger and more in depth than we can ever begin to cover. In this spirit, we are going to provide you with some context to think about the problem of racism and mental health and disability and ways to deconstruct the problem through the lens of structural violence and structural racism. We offer you a brief discussion on and a definition of structural violence and structural racism and then tie them to two case studies to help contextualize how racism currently exists within the medical field.

View Article and Find Full Text PDF

This paper discusses how anti-Asian American, Native Hawaiian, and Pacific Islander (AANHPI) racism affects pediatric training, research, and clinical practice. Extant research shows that racism and discrimination are social determinants of health that impact AANHPI populations, including youth. AANHPI youth face significant health disparities and a wide range of barriers to health care access.

View Article and Find Full Text PDF

Firearm-Related Unintentional Childhood Injury in Israel.

J Community Health

October 2024

Beterem Safe Kids, Petah Tikwa, Israel.

The rise in demand for firearm licenses in Israel due to the ongoing 2023-2024 Israel-Gaza War, coupled with the easing of regulations for issuing weapons, is expected to lead to a significant increase in the incidence of firearms among civilians. This situation calls for a special awareness of civilian populations of the dangers posed to children by the high prevalence of firearms. We therefore present trends in firearm-related incidents resulting in unintentional mortality and morbidity of children ages 0-17 between the years 2008-2023 in Israel.

View Article and Find Full Text PDF

Digoxin Discontinuation in Patients With HFrEF on Beta-Blockers: Implication for Future 'Knock-Out Trials' in Heart Failure.

Am J Med

October 2024

Veterans Affairs Medical Center, Washington, DC; Georgetown University, Washington, DC; George Washington University, Washington, DC. Electronic address:

Background: National heart failure guidelines recommend quadruple therapy with renin-angiotensin system inhibitors, beta-blockers, mineralocorticoid receptor antagonists, and sodium-glucose cotransporter 2 inhibitors for patients with heart failure with reduced ejection fraction (HFrEF), most of whom also receive loop diuretics. However, the guidelines are less clear about the safe approaches to discontinuing older drugs whose decreasing or residual benefit is less well understood. The objective of this study was to examine whether digoxin can be safely discontinued in patients with HFrEF receiving beta-blockers.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to compare the compressive strength of traditional open-faced stainless-steel crowns (OFSSC) with a new type called preformed OFSSC (POFSSC) that uses various restorative materials.
  • A total of 75 3D-printed models were tested, divided into five groups based on the type of crown and restorative material used, followed by rigorous thermocycling and compressive strength testing using Instron.
  • Results showed that the POFSSC with restorative composite (G2) had the highest compressive strength, significantly outperforming the traditional crowns (G1), while the POFSSC with resin-reinforced glass-ionomer (G5) exhibited the lowest strength and the highest failure rate in
View Article and Find Full Text PDF

Postterm pregnancy is defined as a pregnancy that has reached 42 weeks' gestation and late-term pregnancy includes 41 weeks' and 0 days' to 41 weeks' and 6 days' gestation. Accurate first-trimester dating is essential for determining or verifying gestational age. Ideal management of late-term and postterm pregnancy involves shared decision-making on timing of planned delivery based on risks and preferences.

View Article and Find Full Text PDF

MASLD: What We Have Learned and Where We Need to Go-A Call to Action.

Radiographics

November 2024

From the Department of Radiology, UC San Diego Altman Clinical and Translational Research Institute Liver Imaging Group, University of California San Diego, 9452 Medical Center Dr, La Jolla, CA 92037 (S.H.S., V.F.M., T.W., J.T.W., L.C., K.J.F., C.B.S.); Pacific Rim Pathology, San Diego, Calif (C.B.); Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY (V.C.); Department of Radiology, Stanford University School of Medicine, Stanford, Calif (A.E.K.); Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (A.A.B.); Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Va (A.H.); and Department of Radiology, University of California San Francisco, Calif (K.W.).

Article Synopsis
View Article and Find Full Text PDF
Article Synopsis
  • - Since the 1960s, over 350,000 new chemicals have been introduced, impacting both humans and animals, yet our understanding of their health risks is still limited.
  • - The "epithelial barrier theory" indicates that genetic factors and various exposures lead to damaged epithelial barriers, contributing to allergic and autoimmune diseases in both humans and pets.
  • - This review highlights the effects of impaired epithelial barriers on companion animals, discussing the rise of less regulated cosmetic and food products for pets, and aligns with the "One Health" concept, emphasizing the connection between human, animal, and environmental health.
View Article and Find Full Text PDF

Comparison of microbial adhesion and biofilm formation on different orthodontic aligners.

Am J Orthod Dentofacial Orthop

January 2025

Discipline of Orthodontics and Paediatric Dentistry, School of Dentistry, The University of Sydney, Sydney, Australia. Electronic address:

Article Synopsis
  • This study compared biofilm formation and microbial adhesion on six different clear aligner systems, including Invisalign and ClearCorrect, using specific bacteria as test subjects.
  • The research used statistical analysis to track bacterial growth at various time intervals (from 0 to 240 hours), finding significant differences in biofilm formation among the aligners.
  • The findings indicate that increased biofilm formation poses clinical risks, suggesting orthodontists and patients should be cautious of microbial accumulation with prolonged use of aligners.
View Article and Find Full Text PDF

Prediction of Ischemic Stroke Functional Outcomes from Acute-Phase Noncontrast CT and Clinical Information.

Radiology

October 2024

From the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).

Article Synopsis
  • The study aims to improve prediction of 90-day functional outcomes in ischemic stroke patients using a deep learning model that combines non-contrast CT images and clinical data, potentially aiding healthcare planning and clinical trials.
  • The dataset included 1,335 patients from multiple trials and registries, and the model demonstrated superior accuracy in predicting outcomes compared to models using only imaging or clinical data alone.
  • The fused model achieved a mean absolute error (MAE) of 0.94 for mRS score prediction and an AUC of 0.91 for identifying unfavorable outcomes, indicating it significantly outperforms existing methods.
View Article and Find Full Text PDF

Testing the Ability and Limitations of ChatGPT to Generate Differential Diagnoses from Transcribed Radiologic Findings.

Radiology

October 2024

From the Department of Radiological Sciences, UCI Medical Center, University of California, Irvine, 101 The City Dr S, Orange, CA 92868 (S.H.S., K.H., G.C., R. Hill, J.T., R. Houshyar, V.Y., M.T.); Anaheim, Calif (L.Y.); and Division of Research, Kaiser Permanente of Northern California, Pleasanton, Calif (A.L.N.).

Background The burgeoning interest in ChatGPT as a potentially useful tool in medicine highlights the necessity for systematic evaluation of its capabilities and limitations. Purpose To evaluate the accuracy, reliability, and repeatability of differential diagnoses produced by ChatGPT from transcribed radiologic findings. Materials and Methods Cases selected from a radiology textbook series spanning a variety of imaging modalities, subspecialties, and anatomic pathologies were converted into standardized prompts that were entered into ChatGPT (GPT-3.

View Article and Find Full Text PDF

External Validation of a Previously Developed Deep Learning-based Prostate Lesion Detection Algorithm on Paired External and In-House Biparametric MRI Scans.

Radiol Imaging Cancer

November 2024

From the Molecular Imaging Branch (E.C.Y., S.A.H., M.J.B., Y.L., D.G.G., K.B.O., N.S.L., P.E., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (E.P.H.), Center for Interventional Oncology (L.A.H., C.G., B.J.W.), Department of Radiology, Clinical Center (L.A.H., C.G., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Bldg 10, Rm B3B85, Bethesda, MD 20892; Department of Radiology, Singapore General Hospital, Singapore (Y.M.L.); and NVIDIA Corporation, Santa Clara, Calif (D.Y., Z.X., J.T., D.X.).

Article Synopsis
  • A study evaluated an AI model's ability to detect prostate cancer in scans done at different institutions, focusing on biparametric MRI (bpMRI) scans from both an external and an in-house setup.
  • This research included 201 male patients and showed that the AI detected a greater percentage of lesions on in-house scans compared to external ones (56.0% vs. 39.7% for intraprostatic lesions and 79% vs. 61% for clinically significant prostate cancer).
  • Factors that improved the AI's detection rates included higher PI-RADS scores, larger lesion sizes, and better quality of diffusion-weighted MRI images.
View Article and Find Full Text PDF

Background: The paucity of pain management options in resource-limited settings is a significant and systemically unaddressed problem. To improve global health equity, it is important to bridge this gap in care without introducing the peril of opioid dependence. We present a proof-of-concept case series wherein virtual reality (VR) was successfully used to manage discomfort in patients undergoing burn dressing changes in sub-Saharan Africa.

View Article and Find Full Text PDF

Thin-film implants for bioelectronic medicine.

MRS Bull

September 2024

Electrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, UK.

Bioelectronic medicine offers a revolutionary approach to treating disease by stimulating the body with electricity. While current devices show safety and efficacy, limitations, including bulkiness, invasiveness, and scalability, hinder their wider application. Thin-film implants promise to overcome these limitations.

View Article and Find Full Text PDF

Soluble mesothelin-related peptide as a prognosticator in pleural mesothelioma patients receiving checkpoint immunotherapy.

J Thorac Cardiovasc Surg

October 2024

Systems Onco-Immunology Laboratory, David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; Division of Hemato-Oncology, Department of Medicine, Baylor College of Medicine, Houston, Tex; David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex. Electronic address:

Article Synopsis
  • Immune checkpoint therapy (ICT) has changed the treatment landscape for malignant pleural mesothelioma (MPM), but nearly half of patients do not see benefits, emphasizing the need for predictive biomarkers.
  • This study evaluated the prognostic value of serum soluble mesothelin-related peptide (SMRP) and PD-L1 levels in 125 MPM patients undergoing ICT, using statistical analyses to determine their impact on overall survival (OS).
  • Results showed that higher pre-ICT SMRP levels are linked to poorer prognosis, with low levels indicating better survival outcomes, suggesting that SMRP could serve as a valuable biomarker for future MPM treatment studies.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigated the feasibility and safety of active surveillance for patients with multiple ground glass opacities (GGOs) in the lungs, which are a common concern in medical imaging.
  • A total of 337 patients, primarily older adults with a significant history of smoking, were enrolled and monitored over time, with each GGO documented via CT scans every 6 to 12 months.
  • Preliminary findings suggest that active surveillance is a viable management option for patients, with ongoing assessments planned to evaluate long-term safety and outcomes over five years.
View Article and Find Full Text PDF

Background: Primary care physicians (PCPs) may rely upon factors other than screening test scores in making referral decisions to developmental services. This study investigated which patient, provider, and screening test factors predict a PCP's IDEA Part C Early Intervention (EI) referral after a positive screening test result.

Methods: Child demographics, developmental screening test results and EI referral decisions were collected via medical record review of 2756 15-, 18-, 24- and 30-month well-child checks conducted at seven community primary care clinics in four Oregon counties, in 2020-2021.

View Article and Find Full Text PDF