786 results match your criteria: "Calicut Medical College & PVS Hospital Kozhikode[Affiliation]"

Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .

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Background: Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine conditions that significantly impact the life quality of reproductive-aged women. In the Indian population, its prevalence varies from 3.7 to 22.

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Low-dose methotrexate in Rheumatology: A reinvented drug.

J R Coll Physicians Edinb

January 2025

Department of Rheumatology, Centre for Rheumatology, Calicut, Kerala, India.

Low-dose methotrexate (LD-MTX) is the anchor drug used in the treatment of various rheumatological illnesses. There are a lot of misconceptions associated with the long-term use of MTX in the minds of practitioners. The origin of most of these myths stems from the ill effects associated with high-dose MTX used in cancer chemotherapy.

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Despite the recent advances in vaccination and treatment strategies, cervical cancer continues to claim numerous lives every year. Owing to the fact that non-coding RNAs (ncRNAs) such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) interact with coding transcripts, and effectuate key roles in the tumorigenesis and metastasis of cervical cancer, there has been extensive research in recent years to explore their potential as biomarkers for early detection, or as therapeutic targets. Through this review, we aim to provide a comprehensive overview of the recent advancements in discoveries about cervical cancer-associated lncRNA-miRNA-mRNA axes, their dysregulation, and their roles in various signaling pathways associated with the growth, survival, invasion, and metastasis of cervical cancer cells.

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This hospital-based cross-sectional study aimed to screen newborns for sickle cell anemia immediately after birth and validate dried blood spot (DBS) samples against conventional venous blood samples (CBS) for hemoglobin variant analysis by HPLC. Among 751 newborns, 2.93% were found to have sickle cell trait.

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Background: Thalassemia is a hemoglobinopathy-associated genetic disease resulting due to defective synthesis of globin chains, causing defects in the skeletal and oral structures.

Aim: This cross-sectional study was designed to analyze the prevalence of dental caries, oral health status, malocclusion status, and dental treatment needs in thalassemic children.

Materials And Methods: Institutional Ethical committee clearance was obtained before starting the study.

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Aim: To demonstrate how workshop and mentoring across a network of radiotherapy centers helped in transitioning from point A to volume-based image guided brachytherapy in carcinoma cervix.

Materials And Methods: Based on discussion with different centers across the network, the lapses in cervical cancer treatment were identified and a workshop was designed to change the practice pattern. The main focus of the workshop was to streamline EBRT dose prescription protocols and implement volume based image guided brachytherapy through mentoring and hands on training.

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Background: Indoor air pollution is a critical global health concern and is associated with an increased incidence of respiratory infections. Despite the introduction of a subsidiary scheme, the adoption of clean fuel remains limited in rural India.

Objectives: The current study investigated the fuel preferences and its association with participants characteristics, particulate matter (PM2.

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Aim: The aim of the present study was to compare the effectiveness of low-level laser therapy and intralesional injection in oral submucous fibrosis (OSMF) patients.

Materials And Methods: The present study comprised of 52 grade II OSMF patients aged between 20 and 60 years. A pretreatment assessment was done for each patients.

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Indian Trial of Tranexamic acid in Spontaneous Intracerebral Hemorrhage study protocol.

Int J Stroke

January 2025

Indian Council of Medical Research, Non-Communicable Diseases Section, New Delhi, India.

Rationale: Early mortality in intracerebral hemorrhage (ICH) is due to hematoma volume (HV) expansion, and there are no effective treatments available other than reduction in blood pressure. Tranexamic acid (TXA) a hemostatic drug that is widely available and safe can be a cost-effective treatment for ICH, if proven efficacious.

Hypothesis: Administration of TXA in ICH patients when given within 4.

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Cardiovascular Health and Adverse Pregnancy Outcomes in Autoimmune Rheumatic Diseases.

J Rheumatol

January 2025

V. Ravindran, MD, Centre for Rheumatology, Calicut, Kerala, and Department of Medicine, Kasturba Medical College, MAHE, Manipal, Karnataka, India.

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As genetic testing becomes increasingly accessible and affordable, the uniform and accurate interpretation of genetic variants becomes essential. The ACMG/AMP joint guidelines provide the basis for systematic and uniform interpretation of pathogenicity of genetic variants. However, the application of these in routine clinical interpretation at-scale has largely been limited by the lack of resources providing harmonized data especially at a population-scale.

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Article Synopsis
  • This study is the first to report on caprine forestomach native collagen (CFNC) modified with silver nanowires (AgNWs) to create scaffolds intended for wound healing dressings.
  • The CFNC/AgNWs scaffolds demonstrated a porous 3D structure with favorable physical and chemical properties, showing antibacterial effects and mechanical properties that varied based on AgNW concentration.
  • However, higher concentrations of Ag ions were found to cause cytotoxicity in L929 fibroblast cells, indicating the need to balance antibacterial efficacy with biocompatibility when selecting AgNW dosages for optimal wound dressing performance.
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  • Chronic tympanic membrane perforations, often caused by conductive hearing loss and repeated otitis media, typically require surgical intervention known as tympanoplasty, which faces challenges due to limitations in graft material availability.
  • A synthetic graft material, primarily made from polyvinyl alcohol (PVA) and enhanced with cross-linked gelatin, has been developed to meet the needs for better cell adhesion, biocompatibility, and desired mechanical properties.
  • The new graft material demonstrates tunable mechanical strength and favorable acoustic properties, making it a promising candidate for clinical applications in treating chronic tympanic membrane perforations.
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Inflammation is a physiological condition that when unattended causes serious health concerns over the long term. Several phytocompounds have emerged as promising sources of anti-inflammatory agents. is a traditional medicine for inflammatory and toxicity insults; however, this has not been scientifically confirmed.

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 Seroma formation is a common complication following axillary dissection. The pathogenesis of seroma is poorly understood. Various chemical and mechanical methods have been tried to reduce seroma with varying results.

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  • The study investigated the effectiveness of 10% dextrose prolotherapy for treating temporomandibular joint disorders (TMDs) in 30 patients who had symptoms for over six months and didn't respond to other treatments.
  • The treatment involved four injection sessions over three months, with assessments made on pain, joint locking, and mouth opening at each visit.
  • Results showed significant improvement in TMD symptoms, suggesting that dextrose prolotherapy could be a viable alternative to long-term medications or surgery.
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Background And Aim: Ageing often leads to the deterioration of physiological functions, including a decline in antioxidant defences, which can result in various health complications. Exogenous antioxidants have been recognised for their potential to alleviate these age-related health complications. Virgin coconut oil (VCO), known for its antioxidant, anti-inflammatory and anti-lipidemic efficacies, has gained recognition as a functional food with promising benefits.

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  • The research addresses Dry Eye Syndrome (DES) by developing ocular inserts using advanced manufacturing technologies like hot-melt extrusion (HME) and CaliCut to improve management options.
  • Key ingredients such as hydroxypropyl cellulose, polyethylene glycol, castor oil, and dexamethasone are formulated to target tear film layers and inflammation.
  • The study demonstrates that these innovative inserts offer preservative-free treatment, sustained drug delivery, and increased patient compliance, showing promise for effectively managing DES.
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Background: Faculty development programs (FDPs) in health professions education (HPE) are instrumental in supporting, promoting, and improving HPE curricula and activities that target individual- and system-level capacity strengthening. FAIMER, a division of Intealth, has been offering FDPs for global health professions educators in HPE and leadership for over two decades through the International FAIMER Institute in the USA and FAIMER Regional Institutes located globally. This paper explores perceptions of former program participants (Fellows) of FAIMER global FDPs by eliciting their success stories.

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