183 results match your criteria: "Calcutta National Medical College and Hospital[Affiliation]"

Introduction: Olecranon fractures account for 5-7% of elbow fractures, making them a common injury. The majority of these fractures are treated surgically because they are intra-articular and can disrupt the elbow extensor mechanism. Mayo Type II fractures are displaced with a stable ulnohumeral joint, indicating intact ligamentous structures, particularly the anterior portion of the medial collateral ligament.

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Chronic osteomyelitis of the maxillofacial bones (i.e., jaw bones) is a persistent infection that requires effective treatment.

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Evidence of "Silent" Hepatitis B Virus Infection in Psoriasis, Vitiligo, and Cases: A Pilot Study.

Indian J Dermatol

October 2024

From the Division of Biological Sciences, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Background: Psoriasis (PS), vitiligo (VT), and (PR) are chronic skin diseases often occurring as a consequence of exaggerated immune responses. These skin manifestations can be triggered as a result of the molecular mimicry between viral protein (s) and host protein (s), which could generate auto-antibodies. In addition, it can be hypothesised that skin diseases are manifestations of the reduced immunity that is observed in chronic hepatitis B virus (HBV)-infected individuals.

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Managing pruritic conditions is essential due to their significant impact on patients' quality of life. Chronic urticaria (CU), characterized by persistent itching and hives, severely affects daily activities and sleep. CU includes chronic inducible urticaria and chronic spontaneous urticaria, with the latter lacking identifiable triggers, making treatment especially challenging.

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Article Synopsis
  • Aplastic anemia (AA) is a condition that leads to low blood cell counts and is linked to issues with telomeres, which are protective caps on chromosomes.
  • A study of eleven AA patients between ages one and twelve revealed clinical symptoms like upper limb anomalies and short stature, alongside significantly shorter telomere lengths compared to healthy peers.
  • The research indicates that the telomere maintenance pathway is compromised in these patients, with treatments involving androgen and prednisolone reducing the levels of TERRA, suggesting a connection between telomere dysfunction and AA in younger patients.
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Introduction Liver abscesses are one of the most concerning healthcare issues in Western countries, with a prevalence rate of three per 100,000. Although with the improvement in the socio-economic status and the health care system, its incidence has decreased in developed nations, pyogenic and amoebic liver abscesses are still high in resource-poor countries. Low socioeconomic conditions, improper hygiene, lack of awareness, and often a delay in diagnosis can lead to fatal complications and high mortality.

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Dupilumab is the first US FDA-approved biologic for moderate to severe atopic dermatitis (AD) in adults and children of age more than six months. It is a fully monoclonal antibody that inhibits interleukin (IL)-4 and IL-13 signal transmission. The initial product monograph mentioned major side effects like hypersensitivity reactions and eye problems like conjunctivitis, dry eye, and keratitis.

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Background Breast cancer is the most frequently diagnosed cancer in women worldwide, accounting for more than one in ten new cancer cases each year. It ranks as the second leading cause of cancer-related mortality among women. The majority of patients present with palpable breast lumps.

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  • Snakebite envenoming (SBE) causes over 500,000 deaths or serious injuries annually, and a phase II clinical trial was conducted to evaluate the safety and efficacy of varespladib methyl, an oral treatment, in patients bitten by venomous snakes.
  • The trial, which was double-blind and placebo-controlled, enrolled patients in emergency departments in the USA and India, assessing changes in severity of snakebite symptoms using the Snakebite Severity Score (SSS) after treatment.
  • Results indicated no significant difference in SSS improvement between the varespladib and placebo groups overall, but early treatment (within 5 hours of the bite) showed potential benefits in illness severity and recovery outcomes.
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  • PGx factors play a crucial role in how patients react to antipsychotic medications, prompting a systematic review to compare PGx-assisted treatment with standard care in schizophrenia.
  • Five randomized controlled trials (RCTs) were analyzed, all showing high risk of bias, with mixed findings on safety, efficacy, and medication adherence.
  • The meta-analysis highlighted significant differences in side effects and symptom severity between the two treatment methods, but overall, the evidence is limited and inconsistent, indicating a need for further research.
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In India, the SARS-CoV-2 Delta wave (2020-2021) faded away with the advent of the Omicron variants (2021-present). Dengue incidences were observed to be less in Southeast Asia during the active years of the pandemic (2020-2021). However, dengue virus type 3 (DV3) cases were increasingly reported in this region (including India) concurrent with the progression of the Omicron waves since 2022.

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COVID-19 tended to be less aggressive in dengue endemic regions. Conversely, dengue cases plummeted in dengue endemic zones during the active years of the pandemic (2020-2021). We and others have demonstrated serological cross-reactivity between these two viruses of different families.

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The nose is a common site for many dermatological disorders and even skin cancers. Herein, we report a case of an elderly man who presented with papular lesions on his nose. A 64-year-old man presented with a cluster of four to five skin-colored papules on his nose for the last two years which were gradually increasing in size.

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Article Synopsis
  • - The study focuses on the surgical management of diseased thyroids, emphasizing the importance of evaluating anatomical variations and relationships of two key nerves, the External Branch of Superior Laryngeal Nerve (EBSLN) and the Recurrent Laryngeal Nerve (RLN), during thyroidectomy to ensure successful surgery with minimal nerve damage.
  • - Researchers conducted a prospective observational study with 50 goitre patients, documenting the anatomical courses and variations of the EBSLN and RLN, finding that the majority of EBSLN were of Cernea type 1 and that 72% of RLN passed behind the Inferior Thyroid Artery.
  • - The findings highlight important anatomical relationships which aid in the safe dissection
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Nasal Bone Fracture Reduction Under Local Anaesthesia: A Holistic Approach to Nasal Blocks and a Comparison with General Anaesthesia.

Indian J Otolaryngol Head Neck Surg

February 2024

Dept of ENT and Head & Neck Surgery, Calcutta National Medical College and Hospital, Kolkata West Bengal University of Health Sciences, Flat 6E, 117A, Rashbehari avenue, Natural Sarvapriya, Kolkata, 700029 India.

To compare the pain scores in closed reduction of nasal bone fractures under local anaesthesia (LA) and general anaesthesia (GA), and to outline the blocks that should be used for the same based on their nerve supply. A prospective study was conducted with 40 patients with Class 1 and 2 nasal bone and septal fracture. 20 patients underwent the procedure under LA and 20 under GA.

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Introduction: Homeopathic medicines have been used for decades in the prevention and treatment of infectious diseases. However, the preventive efficacy of specific homeopathic medicines in COVID-19 is not well characterized. This study aimed to evaluate the comparative efficacy of prespecified homeopathic medicines in preventing COVID-19.

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Topical calcineurin inhibitors (TCIs) and topical corticosteroids (TCS) are the mainstays of flare management for atopic eczema or atopic dermatitis (AD). Tacrolimus (an immunomodulator), belongs to the class of calcineurin inhibitors, with promising efficacy in AD. We performed this systematic review to obtain an up-to-date coverage map of controlled clinical trials of sequential or intermittent treatments with TCI as a therapeutic intervention for AD.

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Background: Around 80% of preterm births (PTBs) occur spontaneously. Various biomarkers are being evaluated to assess the possible role of chorioamniotic inflammation in PTBs.

Aim: The aim of this study was to establish the accuracy of serum bio-markers( cut off values of ferritin and alpha-fetoprotein [AFP] at midtrimester) along with cervical length [CL] assessment to predict preterm delivery among low-risk women.

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Trends in Thyroid Nodules and Malignancy: A Two-Year Retrospective Study in a Tertiary Care Centre.

Indian J Otolaryngol Head Neck Surg

June 2023

Department of ENT and Head and Neck Surgery, Calcutta National Medical College and Hospital, 32, Gorachand Road, Kolkata, 700014 India.

Thyroid nodules are one of the most common presentations faced by ENT clinicians, and the prevalence of differentiated thyroid cancer is increasing worldwide. We found no other study showing a clear occurence of cancer in thyroid nodules in the state of West Bengal. Hence, we undertook this study to determine the occurence of thyroid cancer among people with thyroid nodules.

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