3,053 results match your criteria: "Calcium Pyrophosphate Deposition Disease"

Objective: To develop and validate a patient-reported definition of acute calcium pyrophosphate (CPP) crystal arthritis in people with crystal-proven CPP deposition (CPPD) disease.

Methods: Consecutive patients with crystal-proven CPPD disease from seven centres across four countries were enrolled in a cross-sectional study. In each centre, patient-reported outcomes on the features of acute CPP crystal arthritis were collected.

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Objective: Calcium pyrophosphate deposition (CPPD) disease is associated with an increased risk for cardiovascular (CV) events. We examined the atherosclerotic burden by coronary artery calcium scores (Agatston score) and compared 10-year atherosclerotic CV (ASCVD) risk scores in patients with vs without chondrocalcinosis, a radiographic marker of CPPD.

Methods: We performed a cross-sectional analysis at an academic medical center, 1991-2022.

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Varicella-zoster virus (VZV) can lead to rare complications such as cutaneous vasculitis. We present a unique case of post-zoster cutaneous vasculitis in an 82-year-old male, occurring alongside acute calcium pyrophosphate deposition disease (CPPD), a previously undocumented association. The patient initially presented with a painful zoster rash and hand swelling, treated with oral acyclovir.

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Article Synopsis
  • CPPD disease is a significant cause of arthritis that can resemble other rheumatic conditions, making accurate diagnosis crucial.
  • A deep-learning algorithm was developed and tested to automatically detect CPPD features in hand radiographs, focusing specifically on certain joint areas.
  • The combined model for detecting CPPD showed strong performance metrics, with a mean AUROC of 0.86 and good sensitivity and specificity, while separate models for different joint areas had varying success rates.
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Article Synopsis
  • Calcium pyrophosphate deposition (CPPD) disease, often called "pseudogout," can be mistaken for gout but is a distinct condition in rheumatology.
  • Unlike gout, CPPD cannot be cured and requires symptomatic treatment instead.
  • The text reviews the pathophysiology, diagnosis, and current and emerging therapeutic approaches for managing CPPD.
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[Imaging in crystal arthropathies].

Ther Umsch

September 2024

Institut für Diagnostische und Interventionelle Radiologie, Universitätsspital Zürich.

Article Synopsis
  • * Advancements in radiological techniques, both with and without ionizing radiation, have improved the diagnosis and management of these conditions over recent decades.
  • * The article reviews current evidence on traditional methods (X-ray, ultrasound, MRI) alongside newer techniques (dual-energy CT, photon-counting CT), highlighting their respective benefits and drawbacks based on latest professional guidelines.
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Article Synopsis
  • A study estimated how common chondrocalcinosis and CPPD are in patients with low alkaline phosphatase (ALP) levels and a genetic marker for hypophosphatasia (HPP), compared to those without the genetic marker.
  • Results showed that chondrocalcinosis was significantly more prevalent in the genetically positive (+GT) group (21.4%) than in the negative (-GT) group (5.6%).
  • The findings suggest that chondrocalcinosis is common in HPP patients, and it's important to consider genetic factors when diagnosing related conditions.
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Article Synopsis
  • Three patients with cysts in their acromioclavicular joints, caused by rotator cuff problems, were treated with a specific surgical technique.
  • The procedure involved arthroscopic cyst decompression and removing part of the clavicle, which successfully eliminated the cysts with low chances of them coming back.
  • The study suggests that this surgical approach is a better option than repeatedly draining the cysts or performing traditional open surgery.
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New Developments in Imaging in Crystalline Arthritis.

Rheum Dis Clin North Am

November 2024

Department of Medicine, Allergy/Immunology & Rheumatology Division, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA. Electronic address:

Article Synopsis
  • * Traditional diagnosis relied on joint aspiration and microscopy, but imaging techniques are now preferred and can often suffice.
  • * Recommended imaging methods include ultrasound, dual-energy CT scans, and regular X-rays, which can help locate inflammation and identify crystal deposits effectively.
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Article Synopsis
  • A study was conducted to compare the effectiveness and safety of 10-mg and 30-mg daily doses of prednisolone for treating acute calcium pyrophosphate (CPP) crystal arthritis.
  • In this trial, 79 patients received either dose for 7 days, with the primary focus on symptom resolution time and secondary outcomes including recurrence rates and adverse events.
  • Results showed no significant differences between the two doses in terms of symptom resolution time, recurrence rates, or safety, indicating that both doses are equally effective for managing acute CPP crystal arthritis.
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Adalimumab treatment of resistant chondrocalcinosis.

Reumatol Clin (Engl Ed)

October 2024

Ege University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir, Turkey.

Article Synopsis
  • In this article, the authors discuss a case of chondrocalcinosis that didn't respond to traditional treatments but showed improvement with 40mg of adalimumab, an injection.
  • This is notable because it's the first time adalimumab has been reported to work effectively for severe calcium pyrophosphate dihydrate (CPDD) conditions.
  • The findings suggest that anti-TNF therapies like adalimumab could be a viable second-line treatment for cases of calcium pyrophosphate crystal disease (CPPD).
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Dynamic ultrasonography helps diagnose calcium pyrophosphate deposition disease.

QJM

October 2024

Department of Rheumatology and Immunology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Hunan, China.

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Practical Use of Ultrasound in Modern Rheumatology-From A to Z.

Life (Basel)

September 2024

Department of Propedeutics of Internal Diseases, Faculty of Medicine, Medical University of Plovdiv, 4001 Plovdiv, Bulgaria.

Article Synopsis
  • The use of ultrasound (US) in rheumatology has significantly increased over the past two decades, becoming essential for examining musculoskeletal structures and conducting procedures like aspirations and injections.
  • It is the preferred imaging method for diagnosing inflammatory joint diseases, monitoring treatment effectiveness, and supporting the diagnosis of conditions like osteoarthritis and gout.
  • Recent advancements suggest that US could also effectively assess skin and lung involvement in connective tissue diseases, offering a safer and more cost-effective alternative to traditional imaging methods.
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Diagnostic Accuracy of Hip Joint Ultrasound for Detection of Calcium Pyrophosphate Deposition.

Rheumatology (Oxford)

September 2024

General Direction, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.

Article Synopsis
  • Calcium Pyrophosphate Crystal Deposition (CPPD) disease is a chronic condition affecting joints, and this study investigates the effectiveness of ultrasound (US) for diagnosing it specifically in the hip joint.
  • The research involved patients over 50 years old undergoing hip replacement surgery, comparing ultrasound results against histopathology findings for detecting CPP crystals.
  • The study found that US had high sensitivity (90%) and specificity (82%) for identifying CPP deposits in the hip, indicating that it is a reliable tool for diagnosing hip CPPD.
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The acetabularization index: a novel measure of acromial bone loss prior to reverse shoulder arthroplasty.

Eur J Orthop Surg Traumatol

December 2024

Department of Trauma Surgery, Lörrach District Hospital, Spitalstraße 25, 79539, Lörrach, , Baden-Württemberg, Germany.

Article Synopsis
  • The study investigates acromial stress fractures related to reverse shoulder arthroplasty (RSA), focusing on a new measure called the acetabularization index (AI) to assess preoperative acromial bone loss in patients with cuff tear arthropathy (CTA).
  • Researchers measured several parameters from preoperative radiographs and 2D CT scans of 33 patients, finding significant differences in the AI values and a negative correlation between AI and acromiohumeral interval (AHI), indicating that as AI increases, AHI tends to decrease.
  • The conclusion highlights that AI is a reliable and measurable tool for evaluating acromial bone loss, which could help surgeons in planning RSA
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Article Synopsis
  • Monosodium urate (MSU) and calcium pyrophosphate (CPP) micro-crystals lead to inflammation in conditions like gout and chondrocalcinosis by activating macrophages, which release cytokines like IL-1β.
  • The maturation of IL-1β is driven by the NLRP3 inflammasome, which gets activated in response to these crystals.
  • This activation is dependent on the LRRC8 anion channels, as they help regulate cell volume and trigger ATP release, resulting in IL-1β maturation and inflammation, demonstrating their important role in joint inflammation from crystal deposits.
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Article Synopsis
  • A systematic review examined cases of crystal-induced arthritis (such as gout and calcium pyrophosphate deposition disease) in prosthetic joints, focusing on clinical presentations, diagnoses, treatments, and outcomes.
  • The analysis, which followed PRISMA guidelines, included literature searches from multiple databases and identified 44 relevant cases from 1984 to 2021, predominantly affecting patients with knee arthroplasty.
  • Results revealed that this type of arthritis often appears suddenly as monoarticular arthritis, can be mistaken for infections, and typically responds well to anti-inflammatory treatments within a week.
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Article Synopsis
  • A case report describes a rare occurrence of pseudogout in a 55-year-old man, who presented with severe low-back pain and fever, initially misdiagnosed as a spinal infection.
  • Imaging showed lumbar spondylosis, but an MRI revealed a cystic lesion at the lumbar joint, leading to further testing that confirmed calcium pyrophosphate crystals.
  • Successful treatment with oral colchicine provided rapid pain relief, illustrating the need for thorough investigations to accurately diagnose rare conditions and avoid unnecessary treatments.
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Article Synopsis
  • * There are three types of FHH, with type 1 being the most common, linked to a mutation in the CASR gene, while types 2 and 3 are associated with mutations in the GNA11 and AP2S1 genes, respectively.
  • * Identifying FHH is crucial for distinguishing it from primary hyperparathyroidism, which occurs more frequently; misdiagnosis could lead to unnecessary surgeries, especially since genetic testing can clarify the condition.
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Article Synopsis
  • Raman spectroscopy is introduced as an advanced method for identifying specific crystals (monosodium urate and calcium pyrophosphate) in synovial fluid, but its interpretation typically requires expertise that clinicians may lack.
  • A machine learning approach was developed to automate the classification of Raman spectra from synovial fluid samples collected from 446 patients, using training and validation datasets to improve accuracy.
  • The trained model achieved high classification accuracies (up to 96% for CPP and 92.5% for MSU), demonstrating its effectiveness in distinguishing pathological crystals from other particles, thus providing a more objective diagnostic tool for clinicians.
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Acute Neck Pain from Crowned Dens Syndrome: A Case Report and Clinical Insights.

Am J Case Rep

August 2024

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Article Synopsis
  • Crowned dens syndrome (CDS) is a rare condition where calcium pyrophosphate crystals form a calcified 'crown' on the second cervical vertebra, leading to neck pain and symptoms similar to meningitis.
  • A case report details a 62-year-old man who experienced severe headaches and neck pain, ultimately diagnosed with CDS through CT scan, and responded well to treatment with NSAIDs.
  • The report emphasizes the need for increased awareness of CDS among clinicians to reduce misdiagnosis, especially in older patients with new neck pain and a history of pseudogout, and calls for further research on its diagnosis and treatment.
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Crowned Dens Syndrome-Pseudogout of the Neck.

Acute Med

August 2024

Department of Emergency Medicine, The York Hospital, York, UK.

Article Synopsis
  • A patient experienced neck pain along with episodes of fever.
  • The case highlights a rare presentation of pseudogout affecting the neck area.
  • Pseudogout is a type of arthritis caused by crystal deposition in the joints, leading to inflammation.
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Prevalence and classification of meniscal calcifications in the human knee.

Osteoarthritis Cartilage

November 2024

Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. Electronic address:

Article Synopsis
  • The study aimed to explore meniscal calcifications in individuals with and without knee osteoarthritis (OA), focusing on two types: basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPP).
  • The researchers analyzed 82 meniscal samples from 41 subjects, comparing those with OA (who had knee replacements) to deceased donors without OA, using histological methods and Raman spectroscopy for detailed analysis.
  • Results showed that all OA participants had some calcifications, primarily BCP, while CPP was more common in donor samples, indicating that BCP may play a key role in the OA process deserving further study.
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