1,879 results match your criteria: "Calciphylaxis"

Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare disorder with many unknown treatment and diagnostic aspects. It is characterized by calcification and thrombosis of small blood vessels. This disease leads to progressive skin calcification, necrotizing ulcers, and infections and is associated with a high mortality rate.

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Background Calcific uremic arteriolopathy (CUA) is a rare but debilitating disease affecting patients with kidney disease. Reported risk factors of CUA in the literature include female sex, obesity, diabetes mellitus, and vitamin K antagonists' (VKAs) usage. CUA prevalence in Malaysia is unknown and has not been reported before.

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Background: Calciphylaxis is a serious, potentially fatal condition resulting in pathological calcification of soft tissues. While associated with chronic kidney disease, data regarding anticoagulant involvement remain limited.

Research Design And Methods: The United States Food and Drug Administration Adverse Event Reporting System (USFDA AERS) database was searched to identify calciphylaxis reports linked to anticoagulants from 2004 to 2024.

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Calciphylaxis is a rare but life-threatening complication of end-stage renal disease (ESRD), most often seen in patients undergoing hemodialysis. This condition is driven by calcium deposition in small blood vessels, leading to restricted blood flow, tissue ischemia, and often severe pain. While calciphylaxis typically affects areas with increased adiposity, such as the abdomen and proximal extremities, it can manifest on any skin surface, including rare sites like the genital region.

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Background: The effects of hyperbaric oxygen therapy (HBOT) on wound healing have been demonstrated mainly in diabetic foot ulcer.

Objectives: To study the efficacy and safety of HBOT in chronic painful wounds, excluding diabetic foot ulcers.

Methods: From 2008 to 2021, patients with chronic wounds showing no clinical improvement for more than 1 month, who were in pain despite the use of level 2 or 3 analgesics, and who had undergone HBOT sessions, were included in a monocentric retrospective study.

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Background: Microvascular thrombosis is key to the pathogenesis of calciphylaxis. C5b-9-mediated microvascular injury reflective of complement pathway activation could be a key pathophysiologic event.

Methods: We conducted a retrospective multicenter study of 24 patients who have had biopsy-supported calciphylaxis from the 2010-2022 data base from Emory where C5b-9 immunohistochemistry (IHC) had not been conducted and the 2019-2023 data base from Cornell where C5b-9 IHC was done as part of the routine calciphylaxis work up.

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Background: Calciphylaxis is a rare and serious complication in patients with kidney disease. It has few treatment options and poor prognosis. Hyperbaric oxygen therapy (HBOT) may improve wound healing and was added to our conventional care in 2012.

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Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare and severe condition that predominantly affects individuals with end-stage kidney disease (ESKD). It manifests through vascular calcifications that precipitate tissue necrosis, with cutaneous manifestations being common. However, gastrointestinal involvement is an infrequent but gravely serious occurrence.

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Background: Calciphylaxis is a rare and life-threatening condition characterized by cutaneous necrosis resulting from vessel calcification and thrombosis. Commonly associated with end-stage renal disease and hyperparathyroidism, calciphylaxis presents as retiform purpura evolving into necrotic eschars.

Case Report: This report details an atypical case of non-nephrogenic unilateral bullous calciphylaxis in a 71-year-old female, emphasizing the importance of considering calciphylaxis in the differential diagnosis of bullous disorders.

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Article Synopsis
  • Calciphylaxis leads to vascular calcification and blockage in small-to-medium-sized blood vessels, which can cause significant complications like vision loss.
  • A case study of a 64-year-old woman initially suspected to have anterior ischemic optic neuropathy due to giant cell arteritis (GCA) was later diagnosed with calciphylaxis, confirmed by histology.
  • Since calciphylaxis has no cure and requires different management than GCA, it's crucial for doctors to conduct thorough examinations and histopathological tests to differentiate between these conditions.
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Penile calciphylaxis is a rare and life-threatening condition, most commonly seen in patients with end-stage renal disease (ESRD) undergoing dialysis. The pathophysiology includes calcification of small blood vessels, leading to ischemic changes, most commonly affecting the extremities. Treatment modalities vary based on the history and condition of the patient.

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Article Synopsis
  • Calciphylaxis is a rare and severe condition that causes blood vessel calcification, leading to tissue death, often appearing in areas with more body fat like the abdomen and breasts.
  • An elderly woman with end-stage kidney disease experienced severe breast pain and nodules, leading to a diagnosis of calciphylaxis through clinical assessments and imaging.
  • After standard treatments failed, glucocorticoids were used effectively, showing significant improvement, but she experienced a relapse after three months, requiring treatment again.
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[Endogenous skin overloads].

Ann Pathol

November 2024

Département de Pathologie, université Paris Est Créteil (UPEC), hôpital Henri-Mondor, AP-HP, 1, rue Gustave Eiffel, 94000 Créteil, France. Electronic address:

Article Synopsis
  • * Some skin lesions can be subtle, often categorized as "invisible" dermatoses, like primary macular cutaneous amyloidosis and calciphylaxis, necessitating detailed examination.
  • * Certain conditions have significant prognostic implications, indicating potential underlying diseases like monoclonal gammopathies or association with visceral damage, underscoring the importance of clinical-pathological comparison to differentiate between serious conditions.
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Inositol Hexaphosphate in Bone Health and Disease.

Biomolecules

August 2024

Department of Medical and Research Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Article Synopsis
  • Dietary phytic acid (IP6) was traditionally seen as an antinutrient due to its ability to hinder mineral absorption, but new evidence highlights its potential health benefits like anti-inflammatory and anticancer properties.
  • IP6 is found in both plants and human cells and may help prevent harmful conditions like vascular calcification by inhibiting the growth of certain crystals.
  • While there are concerns that IP6 might interfere with bone mineralization, recent studies suggest it may actually promote bone health, indicating a need for more research on its effects.
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Article Synopsis
  • - Calciphylaxis is a serious condition characterized by the calcification of small blood vessels, leading to tissue damage and ulcers, often seen in individuals with end-stage renal disease but can also affect those without kidney issues.
  • - Risk factors for calciphylaxis include diabetes, hyperparathyroidism, certain cancers, use of warfarin, liver disease, and autoimmune disorders, making it essential to recognize these factors for effective diagnosis and treatment.
  • - A case study describes a 58-year-old man with end-stage renal disease who developed penile calciphylaxis, leading to rapid tissue necrosis; he chose conservative treatment over surgery, opting for local wound care and antibiotics instead.
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Article Synopsis
  • Penile calciphylaxis is a rare but serious condition seen in patients with end-stage renal disease (ESRD), particularly those on dialysis.
  • A 50-year-old man with a history of hypertension, diabetes, and ESRD experienced severe penile pain and was diagnosed after a circumcision revealed necrotic tissue.
  • Despite treatment efforts, his condition progressed to gangrene, leading to a partial penectomy, highlighting the need for awareness of calciphylaxis in ESRD patients with penile symptoms.
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Calciphylaxis in a 30-Year-Old Woman With Alcoholic Cirrhosis: A Case Report.

Cureus

September 2024

Department of Radiology and Nuclear Medicine, Jackson Memorial Hospital, Miami, USA.

Article Synopsis
  • Calciphylaxis is a rare but serious condition affecting patients with end-stage renal disease (ESRD), leading to poor outcomes due to calcium and phosphorus buildup in blood vessels and soft tissues.
  • Diagnosis can be made through skin biopsies or imaging techniques like X-ray and bone scintigraphy, emphasizing the significance of these methods.
  • This report discusses a case of a 30-year-old woman with calciphylaxis, pointing out the effectiveness of bone scintigraphy for diagnosis and the crucial role of organ transplant for adequate treatment.
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Article Synopsis
  • The CALCIPHYX trial tested hexasodium fytate, a potential treatment for calciphylaxis, a rare condition causing painful skin lesions, in a double-blind, placebo-controlled setting.
  • Out of the randomised patients, both those receiving hexasodium fytate and the placebo group showed similar improvements in wound assessment and pain scores after 12 weeks, indicating no significant benefit from the treatment over placebo.
  • Serious adverse events were lower in the fytate group compared to the placebo group, suggesting that hexasodium fytate may be safer, but there was no substantial difference in healing or pain reduction between the two groups.
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Updated solution for diagnosis and management of calcinosis cutis: A retrospective review.

Medicine (Baltimore)

August 2024

Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea.

Article Synopsis
  • Calcinosis cutis has five types (dystrophic, metastatic, idiopathic, iatrogenic, calciphylaxis) and can be misdiagnosed as cancer, making management difficult.
  • A study of 7 patients, treated between 2013-2022, highlighted successful diagnoses and complete mass excisions without significant complications, leading to full recovery.
  • The use of imaging techniques (X-rays, ultrasound, CT, MRI) was crucial for accurate diagnosis and treatment, promoting safer, less invasive procedures and preventing recurrences.
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Article Synopsis
  • Calcinosis cutis is the buildup of calcium in the skin, mainly due to chronic inflammation linked with collagen issues. !* -
  • Surgical options exist, but evidence for effective treatments is limited; intravenous sodium thiosulfate has shown promise in treating calciphylaxis and may help stabilize dystrophic calcinosis cutis in some cases. !* -
  • Higher skin absorption of sodium thiosulfate may enhance its effectiveness, supported by its success in calciphylaxis treatment according to previous reports. !*
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Article Synopsis
  • Leg ulcers, primarily located below the knee, can stem from various causes with around 80% resulting from chronic venous insufficiency (CVI) or peripheral arterial occlusive disease (PAOD), necessitating diverse medical specialists for treatment.
  • The diagnostic approach follows the ABCDE rule, which includes personalized history-taking, bacteriological testing, clinical exams, and additional tests to accurately identify the cause of the ulcer, such as vascular issues or other diseases.
  • Effective treatment relies on prompt differential diagnosis, highlighting the need for collaboration among different medical specialties due to the complexity of leg ulcers and the challenges posed by limited high-quality research.
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